Alpha-methylacyl-CoA racemase/P504S overexpression in colorectal carcinoma is correlated with tumor differentiation

Applied Immunohistochemistry and Molecular Morphology

Volumn 15, Issue 2, 2007, Pages 175-180

  Shi, Xueying ^a   Gong, Encong ^a   Wu, Xiaopan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Alpha methylacyl CoA racemase; Colorectal carcinoma; Tumor differentiation

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ANALYSIS; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR DIFFERENTIATION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CELL DIFFERENTIATION; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; RACEMASES AND EPIMERASES; TUMOR MARKERS, BIOLOGICAL;

EID: 34249741574     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/01.pai.0000213107.20355.d8     Document Type: Article

References (31)

1. Ferdinandusse S, Denis S, Ijlst L, et al. Subcellular localization and physiological role of a α-methylacyl-CoA racemase. J Lipid Res. 2000;41:1890-1896.
2. Schmitz W, Albers C, Fingerhut R, et al. Purification and characterization of an α-methylacyl-CoA racemase from human liver. Eur J Biochem. 1995;231:815-822.
3. Amery L, Fransen M, De Nys K, et al. Mitochondrial and peroxisomal targeting of α-methylacyl-CoA racemase in humans. J Lipid Res. 2000;41:1752-1759.
4. Ferdinandusse S, van Grunsven EG, Oostheim W, et al. Reinvestigation of peroxisomal 3-ketoacyl-CoA thiolase deficiency: identification of the true defect at the level of d-bifunctional protein. Am J Hum Genet. 2002;70:1589-1593.
5. Norat T, Bingham S, Ferrari P, et al. Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst. 2005;97:906-916.
6. Giovannucci E, Willett WC. Dietary factors and risk of colon cancer. Ann Med. 1994;26:443-452.
7. Truswell AS. Meat consumption and cancer of the large bowel. Eur J Clin Nutr. 2002;56(Suppl 1):S19-S24.
8. Willett WC. Diet and cancer. Oncologist. 2000;5:393-404.
9. Jiang Z, Woda BA, Rock KL, et al. P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol. 2001;25:1397-1404.
10. Rubin MA, Zhou M, Dhanasekaran SM, et al. α-Methylacyl coenzyme a racemase as a tissue biomarker for prostate cancer. JAMA. 2002;287:1662-1670.
11. Lou J, Zha S, Gage WR, et al. α-Methylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Res. 2002;62:2220-2226.
12. Jiang Z, Wu CL, Woda BA, et al. P504S/α-methylacyl-CoA racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy. Am J Surg Pathol. 2002;26:1169-1174.
13. Jiang Z, Fanger GR, Banner BF, et al. A dietary enzyme: α-methylacyl-CoA racemase/P504S is overexpressed in colon carcinoma. Cancer Detect Prev. 2003;27:422-426.
14. Zhou M, Chinnaiyan AM, Kleer CG, et al. Alpha-Methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions. Am J Surg Pathol. 2002;26:926-931.
15. Kuefer R, Varambally S, Zhou M, et al. α-Methylacyl-CoA racemase: expression levels of this novel cancer biomarker depend on tumor differentiation. Am J Pathol. 2002;161:841-848.
16. Chen ZM, Ritter JH, Wang HL. Differential expression of alpha-methylacyl coenzyme A racemase in adenocarcinomas of the small and large intestines. Am J Surg Pathol. 2005;29:890-896.
17. Nassar A, Amin MB, Sexton DG, et al. Utility of alpha-methylacyl coenzyme A racemase (p504s antibody) as a diagnostic immunohistochemical marker for cancer. Appl Immunohistochem Mol Morphol. 2005;13:252-255.
18. Logani S, Oliva E, Arnell PM, et al. Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma. Mod Pathol. 2005;18:19-25.
19. Traka M, Gasper AV, Smith JA, et al. Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane. J Nutr. 2005;135:1865-1872.
20. Li LD, Lu FZ, Zhang SW, et al. Analyses of variation trend and short term detection of Chinese malignant tumor mortality during twenty years. Chin J Oncol. 1997;19:3-9.
21. Cai L, Binh Y, Danald M, et al. Cancer trends in Asian Pacific rim region. Tumor. 2004;24:422-426.
22. Wang CN, Liang Z, Wei P, et al. Changes in dietary patterns and certain nutrition-related diseases in urban and rural residents of Jiangsu Province, China, during the 1990s. Biomed Environ Sci. 2002;15:271-276.
23. Zheng S, Cai S. Colorectal cancer epidemiology and prevention study in China. Chin-Grem J Clin Oncol. 2003;2:72-75.
24. You WC, Jin F, Devesa S, et al. Rapid increase in colorectal cancer rates in urban Shanghai, 1972-1997, in relation to dietary changes. J Cancer Epidemiol Prev. 2002;7:143-146.
25. Zhang B, Li X, Nakama H, et al. A case-control study on risk of changing food consumption for colorectal cancer. Cancer Invest. 2002;20:458-463.
26. Cuebas DA, Phillips C, Schmitz W, et al. The role of α-methylacyl- CoA racemase in bile acid synthesis. Biochem J. 2002;363:801-807.
27. Wanders RJ, Vreken P, Ferdinandusse S, et al. Peroxisomal fatty acid α-and β-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases. Biochem Soc Trans. 2001;29:250-267.
28. Xu J, Stolk JA, Zhang X, et al. Identification of differentially expressed genes in human prostate cancer using subtraction and microarray. Cancer Res. 2000;60:1677-1682.
29. Witkiewicz AK, Varambally S, Shen R, et al. Alpha-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysis. Cancer Epidemiol Biomarkers Prev. 2005;14:1418-1423.
30. Rubin MA, Bismar TA, Andren O, et al. Decreased alpha-methylacyl CoA racemase expression in primary prostate cancer is associated with an increased rate of biochemical recurrence and cancer-specific death. Cancer Epidemiol Biomarkers Prev. 2005;14:1424-1432.
31. Clayton PT. Clinical consequences of defects in peroxisomal beta-oxidation. Biochem Soc Trans. 2001;29:298-305.