Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: Analysis of the I1768V SCN5A mutation

Heart Rhythm

Volumn 4, Issue 6, 2007, Pages 768-778

  Flaim, Sarah N ^a   Giles, Wayne R ^a   McCulloch, Andrew D ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Arrhythmia mechanisms; I1768V mutation; Late sodium current; Long QT syndrome; Multiscale model; Transmural heterogeneity

Indexed keywords

CALCIUM ION; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN SUBUNIT; SODIUM CHANNEL; SODIUM ION; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DOG; ENDOCARDIUM; EPICARDIUM; EXTRASYSTOLE; GENE AMPLIFICATION; GENE MUTATION; HEART ARRHYTHMIA; HEART BEAT; HEART DEPOLARIZATION; HEART LEFT VENTRICLE; HEART MUSCLE; HEART MUSCLE POTENTIAL; HEART PACING; HEART RATE; HEART REPOLARIZATION; HEART VENTRICLE TACHYCARDIA; ION CURRENT; MATHEMATICAL MODEL; MUTATIONAL ANALYSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QT INTERVAL; R WAVE; SARCOPLASMIC RETICULUM; SIMULATION; T WAVE; TISSUE SLICE;

ANIMALS; ARRHYTHMIA; CALCIUM CHANNELS; DOGS; ELECTROPHYSIOLOGY; HEART VENTRICLES; LONG QT SYNDROME; MODELS, THEORETICAL; MUTATION; SODIUM CHANNELS; TIME FACTORS;

EID: 34249732449     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2007.02.009     Document Type: Article

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