Differences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndrome

British Journal of Pharmacology

Volumn 132, Issue 1, 2001, Pages 85-92

  Studenik, Christian R ^a   Zhou, Zhengfeng ^b   January, Craig T ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

ATX II; E 4031; Early afterdepolarizations; Fast Fourier transforms; Long QT syndrome; Rabbit ventricular myocytes

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; POTASSIUM CHANNEL BLOCKING AGENT; SEA ANEMONE TOXIN; SODIUM CHANNEL BLOCKING AGENT;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FOURIER TRANSFORMATION; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; INCIDENCE; LONG QT SYNDROME; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT; SODIUM CURRENT;

EID: 0035143074     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703770     Document Type: Article

References (39)

1. Cellular and ionic mechanisms underlying erythromycin-induced long QT intervals and torsade de pointes
2. A guided tour of the fast Fourier transform
3. Pharmacological evaluation of early afterdepolarizations induced by sea anemone toxin (ATX II) in dog heart
4. Early afterdepolarization formation in cardiac myocytes: Analysis of phase plane patterns, action potential, and membrane currents
5. Block of I(Ks) does not induce early afterdepolarization activity but promotes beta-adrenergic agonist-induced delayed afterdepolarization activity
6. + current in cardiac myocytes by dofetilide
7. A quantitative description of the E-4031-sensitive repolarization current in rabbit ventricular myocytes
8. Potassium channel blockers as antiarrhythmic drugs
9. Effects of class III antiarrhythmic agents in an in vitro rabbit model of spontaneous torsades de pointes
10. Experimental models of torsades de pointes
11. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns
12. Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: Detailed analysis of ventricular tridimensional activation patterns
13. Early afterdepolarizations and arrhythmogensis
14. QTU prolongation and polymorphic ventricular tachyarrhythmias due to bradycardia-dependent early afterdepolarizations. Afterdepolarizations and ventricular arrhythmias
15. 2+ window current in heart cells
16. The effects of the Anemone sulcata toxin (ATX II) on membrane currents of isolated mammalian myocytes
17. 2+ current
18. Early afterdepolarizations: Mechanisms and possible role in arrhythmias
19. Tetrodotoxin-insensitive sodium channels. Binding of polypeptide neurotoxins in primary cultures of rat muscle cells
20. Molecular aspects of the structure and mechanism of the voltage-dependent sodium channel
21. ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome
22. New techniques for the study of lens electrophysiology
23. Current status of class III antiarrhythmic drug therapy
24. Kr potassium channel
25. + current. Differential sensitivity to block by class III antiarrhythmic agents
26. Differential effects of β-adrenergic agonists and antagonists in LQTI, LQT2 and LQT3 models of the long QT Syndrome
27. Sodium pentobarbital reduces transmural dispersion of repolarization and prevents torsades de pointes in models of acquired and congenital long QT syndrome
28. Pharmacological models of long QT syndromes: Implications for drug therapy and ion channel defects
29. Differences in cellular electrophysiological and early afterdepolarization properties in two pharmacological models of LQTS
30. HERG, a human inward rectifier in the voltage-gated potassium channel family
31. Torsades de pointes with an antihistamine metabolite: Potassium channel block with desmethylastemizole
32. Effect of sea anemone toxins on the sodium inactivation process in crayfish axons
33. Electrophysiologic features of torsades de pointes: Insights from a new isolated rabbit heart model
34. Influence of genotype on the clinical course of the long-QT syndrome
35. Early afterdepolarizations in cardiac myocytes: Mechanism and rate dependence
36. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature
37. 2+ channels can contribute to excitation-contraction coupling in cardiac Purkinje cells
38. Kr
39. Properties of E-4031-induced early afterdepolarizations in rabbit ventricular myocytes: Studies using a perforated patch method