New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity

European Journal of Medicinal Chemistry

Volumn 42, Issue 6, 2007, Pages 873-879

  Lankau, Hans Joachim ^a   Unverferth, Klaus ^a   Grunwald, Christian ^a   Hartenhauer, Helge ^a   Heinecke, Kristina ^a   Bernöster, Katrin ^a   Dost, Rita ^a   Egerland, Ute ^a   Rundfeldt, Chris ^a  

^a Elbion AG   (Germany)

Author keywords

1,2,4 Oxadiazole derivatives; Anticonvulsant activity; Maximal electroshock seizure test; Pentylenetetrazole test; Synthesis

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; 3 (2 FLUOROPHENYL) 5 [1,2,4]TRIAZOL 1 YLMETHYL[1,2,4]OXADIAZOLE; 3 (3 FLUOROPHENYL) 5 (5 METHYL[1,2,4]TRIAZOL 1 YL)METHYL[1,2,4]OXADIAZOLE; 3 (3 FLUOROPHENYL) 5 [1,2,4]TRIAZOL 1 YLMETHYL[1,2,4]OXADIAZOLE; 3 (3 METHYLPHENYL) 5 [1,2,4]TRIAZOL 1 YLMETHYL[1,2,4]OXADIAZOLE; 3 (4 CHLOROPHENYL) 5 [1,2,4]TRIAZOL 1 YLMETHYL[1,2,4]OXADIAZOLE; 3 (4 CHLOROPHENYL) 5 IMIDAZOL 1 YLMETHYL[1,2,4]OXADIAZOLE; 3 (4 METHYLPHENYL) 5 [1,2,4]TRIAZOL 1 YLMETHYL[1,2,4]OXADIAZOLE; 3 PHENYL 5 [1,2,4]TRIAZOL 1 YLMETHYL[1,2,4]OXADIAZOLE; 5 IMIDAZOL 1 YLMETHYL 3 PHENYL[1,2,4]OXADIAZOLE; 5 PHENYL 3 [1,2,4]TRIAZOL 1 YLMETHYL[1,2,4]OXADIAZOLE; BENZODIAZEPINE; PENTETRAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ELECTRIC SHOCK; NEUROTOXICITY; NONHUMAN; RAT; SEIZURE;

ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXADIAZOLES; RATS; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34249710344     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.12.022     Document Type: Article

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