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Volumn 46, Issue 10, 2007, Pages 4336-4356

1,4,7,10-tetraazacyclododecane metal complexes as potent promoters of carboxyester hydrolysis under physiological conditions

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; COPPER; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ESTER; LIGAND; METAL; NICKEL; ORGANOMETALLIC COMPOUND;

EID: 34249686935     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic070101z     Document Type: Article
Times cited : (46)

References (92)
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    • For a review on thermodynamic and kinetic data for macrocycle interaction with cations, anions, and neutral molecules, see: Izatt, R. M.; Pawlak, K.; Bradshaw, J. S.; Bruening, R. L. Chem. Rev. 1995, 95, 2529.
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    • Chu, F.; Smith, J.; Lynch, V. M.; Anslyn, E. V. Inorg. Chem. 1995, 34, 5689 (the authors propose that in a Zn complex either imidazole or imidazolium might act as an auxiliary group, providing a 1.5-fold increase in the RNA cleavage rate).
    • (d) Chu, F.; Smith, J.; Lynch, V. M.; Anslyn, E. V. Inorg. Chem. 1995, 34, 5689 (the authors propose that in a Zn complex either imidazole or imidazolium might act as an auxiliary group, providing a 1.5-fold increase in the RNA cleavage rate).
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    • and references cited therein
    • (b) Aoki, S.; Kimura, E. Rev. Mol. Biotechnol. 2002, 90, 129 and references cited therein.
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    • The experimental conditions (room temperature) cause higher vibrations of the atoms
    • The experimental conditions (room temperature) cause higher vibrations of the atoms.
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    • -1)- See also eq 7 from the Supporting Information.
    • -1)- See also eq 7 from the Supporting Information.
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    • cat. ± 8.5%.
    • cat. ± 8.5%.
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    • 2 = 0.9998).
    • 2 = 0.9998).
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    • NP using eq 4 from the Supporting Information and then compared to the complex concentration. Correction for the spontaneous hydrolysis of the substrate by the solvent was accomplished by directly measuring a difference between the production of 4-nitrophenolate in the reaction cell and a reference cell containing the same concentration of carboxyester as that in the reaction cell in the absence of the metal complex.
    • NP using eq 4 from the Supporting Information and then compared to the complex concentration. Correction for the spontaneous hydrolysis of the substrate by the solvent was accomplished by directly measuring a difference between the production of 4-nitrophenolate in the reaction cell and a reference cell containing the same concentration of carboxyester as that in the reaction cell in the absence of the metal complex.


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