From dopaminergic genes to psychiatric disorders

Neurotoxicity Research

Volumn 11, Issue 1, 2007, Pages 61-71

  Hoenicka, Janet ^a,b,c   Aragüés, María ^a,b,c   Ponce, Guillermo ^a,b,c   Rodríguez Jiménez, Roberto ^a,b,c   Jiménez Arriero, Miguel A ^a,b,c   Palomo, Tomás ^a,b,c  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

ADHD; Attention deficit hyperactivity disorder; Bipolar disorder; Cognition; Dopamine; Dopamine genes; DRD1; DRD2; DRD3; DRD4; DRD5; Drug abuse; Environment; Genes; Genetic analysis; Psychiatric disorders; Reward; Schizophrenia

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE 5 RECEPTOR; GENE PRODUCT; DOPAMINE; DOPAMINE RECEPTOR;

ARTICLE; ATTENTION DEFICIT DISORDER; BIPOLAR DISORDER; COGNITION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; DOPAMINERGIC SYSTEM; DRUG ABUSE; ENDOCRINE FUNCTION; ENVIRONMENTAL FACTOR; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HEREDITY; HUMAN; MENTAL DISEASE; MOTOR CONTROL; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REWARD; SCHIZOPHRENIA; SEQUENCE ANALYSIS; ANIMAL; GENETICS; PHYSIOLOGY; REVIEW;

ANIMALS; DOPAMINE; HUMANS; MENTAL DISORDERS; RECEPTORS, DOPAMINE; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECEPTORS, DOPAMINE D4; RECEPTORS, DOPAMINE D5;

EID: 34249673358     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033483     Document Type: Article

References (49)

1. Basile VS, M Masellis, F Badri, AD Paterson, HY Meltzer, JA Lieberman, SG Potkin, F Macciardi and JL Kennedy (1999) Association of the MscI polymorphism of the dopamine D 3 receptor gene with tardive dyskinesia in schizophrenia. Neuropsychopharmacology 21, 17-27.
2. Basile VS, M Masellis, SG Potkin and JL Kennedy (2002) Pharmacogenomics in schizophrenia: The quest for individualized therapy. Hum. Mol. Genet. 11, 2517-2530.
3. Blum K (1990) Allelic association of human dopamine D 2 receptor gene in alcoholism. JAMA 264, 1807-1809.
4. Bobb AJ, AM Addington, E Sidransky, MC Gornick, JP Lerch, DK Greenstein, LS Clasen, WS Sharp, G Inoff-Germain, F Wavrant-De Vrieze, M Arcos-Burgos, RE Straub, JA Hardy, FX Castellanos and JL Rapoport (2005) Support for association between ADHD and two candidate genes: NET1 and DRD1. Am. J. Med. Genet. B Neuropsychiatr. Genet. 134, 67-72.
5. Centonze D, C Grande, E Saulle, AB Martin, P Gubellini, N Pavon, A Pisani, G Bernardi, R Moratalla and P Calabresi (2003) Distinct roles of D 1 and D 5 dopamine receptors in motor activity and striatal synaptic plasticity. J. Neurosci. 23(24), 8506-8512.
6. 1 receptor gene in addictive behaviors. Mol. Psychiatry 2, 44-56.
7. Comings DE, N Gonzalez, S Wu, G Saucier, P Johnson, R Verde and JP MacMurray (1999) Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence. Mol. Psychiatry 4, 484-487.
8. D'Souza UM, C Russ, E Tahir, J Mill, P McGuffin, PJ Asherson and IW Craig (2004) Functional effects of a tandem duplication polymorphism in the 5′ flanking region of the DRD4 gene. Biol. Psychiatry 56, 691-697.
9. Daly G, Z Hawi, M Fitzgerald and M Gill (1999) Mapping susceptibility loci in attention deficit hyperactivity disorder: Preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol. Psychiatry 4, 192-196.
10. 2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum. Mol. Genet. 12, 205-216.
11. 3 receptor gene is associated with opiate dependence. Mol. Psychiatry 3, 333-336.
12. Dubertret C, P Gorwood, J Ades, J Feingold, JC Schwartz and P Sokoloff (1998) Meta-analysis of DRD3 gene and schizophrenia: Ethnic heterogeneity and significant association in Caucasians. Am. J. Med. Genet. 81, 318-322.
13. Ekelund J, D Lichtermann, MR Jarvelin and L Peltonen (1999) Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample. Am. J. Psychiatry 156, 1453-1455.
14. 5 receptor genes by REF in neuropsychiatric patients reveals a novel missense change at a highly conserved amino acid. Am. J. Med. Genet. 81, 172-178.
15. 4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 13, 208-210.
16. 2 receptor gene and schizophrenia. Mol. Psychiatry 8, 911-915.
17. Goodman AB (1998) Three independent lines of evidence suggest retinoids as causal to schizophrenia. Proc. Natl. Acad. Sci. USA 95, 7240-7244.
18. Gorwood P, F Limosin, P Batel, E Duaux, L Gouya and J Ades (2001) The genetics of addiction: Alcohol-dependence and D 3 dopamine receptor gene. Pathol. Biol. (Paris) 49, 710-717.
19. 2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP. Am. J. Hum. Genet. 45, 778-785.
20. Hamarman S, J Fossella, C Ulger, M Brimacombe and J Dermody (2004) Dopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate dose response in children with attention deficit hyperactivity disorder: A pharmacogenetic study. J. Child Adolesc. Psychopharmacol. 14, 564-574.
21. Kirley A, N Lowe, C Mullins, M McCarron, G Daly, I Waldman, M Fitzgerald, M Gill and Z Hawi (2004) Phenotype studies of the DRD4 gene polymorphisms in ADHD: Association with oppositional defiant disorder and positive family history. Am. J. Med. Genet. B Neuropsychiatr. Genet. 131, 38-42.
22. 1 dopamine-receptor interacting protein calcyon in patients with schizophrenia. Arch. Gen. Psychiatry 60, 311-319.
23. 3 receptor gene variants and substance abuse in schizophrenia. Mol. Psychiatry 3, 337-341.
24. Kustanovich V, J Ishii, L Crawford, M Yang, JJ McGough, JT McCracken, SL Smalley and SF Nelson (2004) Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: Confirmation of association of ADHD with DRD4 and DRD5. Mol. Psychiatry 9, 711-717.
25. 2 receptor is associated with schizophrenia. Schizophr. Res. 73, 31-37.
26. 3 receptor gene and Korean alcohol dependence. Psychiatr. Genet. 12, 173-176.
27. Aγ2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. Am. J. Med. Genet. 114, 329-335.
28. 3 receptor gene and tardive dyskinesia in Chinese schizophrenic patients. Neuropsychobiology 44, 95-98.
29. Lichter JB, CL Barr, JL Kennedy, HH Van Tol, KK Kidd and KJ Livak (1993) A hypervariable segment in the human dopamine receptor D 4 (DRD4) gene. Hum. Mol. Genet. 2, 767-773.
30. Lundstrom Kand MP Turpin (1996) Proposed schizophrenia-related gene polymorphism: Expression of the Ser9Gly mutant human dopamine D 3 receptor with the Semliki Forest virus system. Biochem. Biophys. Res. Commun. 225, 1068-1072.
31. Manor I, M Corbex, J Eisenberg, I Gritsenkso, R Bachner-Melman, S Tyano and RP Ebstein (2004) Association of the dopamine D 5 receptor with attention deficit hyperactivity disorder (ADHD) and scores on a continuous performance test (TOVA). Am. J. Med. Genet. B Neuropsychiatr. Genet. 127, 73-77.
32. 3 dopamine receptor"knockout". Synapse 461, 19-31.
33. 1 gene to attention-deficit/ hyperactivity disorder. Mol. Psychiatry 9, 500-509.
34. 3 receptor gene polymorphism in adult attention-deficit hyperactivity disorder. Behav. Brain Res. 130, 91-95.
35. 5 receptor gene (DRD5) show significant association with schizophrenia but not bipolar disorder. Am. J. Med. Genet. 105, 152-158.
36. Neville MJ, EC Johnstone and RT Walton (2004) Identification and characterization of ANKK1: A novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum. Mutat. 23, 540-545.
37. 1 receptor gene (DRD1) and bipolar disorder. Biol. Psychiatry 52, 1144-1150.
38. 2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am. J. Med. Genet. B Neuropsychiatr. Genet. 116, 103-125.
39. Payton A, J Holmes, JH Barrett, T Hever, H Fitzpatrick, AL Trumper, R Harrington, P McGuffin, M O'Donovan, M Owen, W Ollier, J Worthington and A Thapar (2001) Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: A family-based study. Am. J. Med. Genet. 105, 464-470.
40. Ponce G, MA Jimenez-Arriero, G Rubio, J Hoenicka, I Ampuero, JA Ramos and T Palomo (2003) The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. Eur. Psychiatry 18, 356-360.
41. 1 receptor alleles predict PET metabolic correlates of clinical response to clozapine. Mol. Psychiatry 8, 109-113.
42. Retz W, M Rosler, T Supprian, P Retz-Junginger and J Thome (2003) Dopamine D 3 receptor gene polymorphism and violent behavior: Relation to impulsiveness and ADHD-related psychopathology. J. Neural Transm. 110, 561-572.
43. 3 receptor: Basic and clinical aspects. Clin. Neuropharmacol. 16, 295-314.
44. 1 receptor genes associated with bipolar I disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 134, 37-38.
45. 5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1. Genomics 18, 423-425.
46. 4 dopamine receptor (DRD4) coding region variants and TH microsatellite in the Old Order Amish family (OOA110). Psychiatr. Genet. 4, 95-99.
47. 3 receptor gene polymorphisms and schizophrenia in an isolate population. Schizophr. Res. 73, 49-54.
48. 3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 124, 1-5.
49. 4 (DRD4) exon III polymorphism in Japanese subjects. Am. J. Med. Genet. 88, 469-471.