Chlorpromazine exacerbates hepatic insulin sensitivity via attenuating insulin and leptin signaling pathway, while exercise partially reverses the adverse effects

Life Sciences

Volumn 80, Issue 26, 2007, Pages 2428-2435

  Park, Sunmin ^a   Hong, Sang Mee ^a   Lee, Ji Eun ^a   Sung, So Ra ^a  

^a Hoseo University   (South Korea)

Author keywords

Euglycemic hyperinsulinmic clamp; Gluconeogenesis; Insulin resistance; PEPCK

Indexed keywords

CHLORPROMAZINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; LEPTIN; NEUROLEPTIC AGENT; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HORMONE ACTION; HYPERINSULINEMIA; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; CHLORPROMAZINE; IMMUNOBLOTTING; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; LIVER; MALE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PHOSPHOPROTEINS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

RATTUS;

EID: 34249671745     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.04.001     Document Type: Article

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