Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex

Molecular Pain

Volumn 3, Issue , 2007, Pages

  Wu, Long Jun ^a   Xu, Hui ^a   Ren, Ming ^a   Cao, Xiaoyan ^a   Zhuo, Min ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

[1 (4 BROMOPHENYL)ETHYLAMINO] (2,3 DIOXO 1,2,3 TETRAHYDOQUINOXALIN 5 YL)METHYLPHOSPHONIC ACID; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NVP AAM 077; UNCLASSIFIED DRUG; 5 (ALPHA METHYL 4 BROMOBENZYLAMINO)PHOSPHONOMETHYL 1,4 DIHYDROQUINOXALINE 2,3 DIONE; 5-(ALPHA-METHYL-4-BROMOBENZYLAMINO)PHOSPHONOMETHYL-1,4-DIHYDROQUINOXALINE-2,3-DIONE; AMINO ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR2A NMDA RECEPTOR; NR2B NMDA RECEPTOR; PIPERIDINE DERIVATIVE; QUINOXALINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CINGULATE GYRUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; EXCITATORY POSTSYNAPTIC POTENTIAL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; SYNAPTIC TRANSMISSION; ANIMAL; C57BL MOUSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; METHODOLOGY; NERVE CELL INHIBITION; ORGAN CULTURE TECHNIQUE; PATCH CLAMP; PHYSIOLOGY;

ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GYRUS CINGULI; MALE; MICE; MICE, INBRED C57BL; NEURAL INHIBITION; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; PIPERIDINES; QUINOXALINES; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 34249326184     PISSN: 17448069     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-8069-3-11     Document Type: Article

References (27)

1. Collingridge GL Bliss TV Memories of NMDA receptors and LTP Trends Neurosci 1995 18 54-56 10.1016/0166-2236(95)93868-X 7537406
2. Zhuo M Glutamate receptors and persistent pain: Targeting forebrain NR2B subunits Drug Discov Today 2002 7 259-267 10.1016/S1359-6446(01)02138-9 11839523
3. Cull-Candy S Brickley S Farrant M NMDA receptor subunits: Diversity, development and disease Curr Opin Neurobiol 2001 11 327-335 10.1016/ S0959-4388(00)00215-4 11399431
4. Sheng M Kim MJ Postsynaptic signaling and plasticity mechanisms Science 2002 298 776-780 10.1126/science.1075333 12399578
5. Sheng M Cummings J Roldan LA Jan YN Jan LY Changing subunit composition of heteromeric NMDA receptors during development of rat cortex Nature 1994 368 144-147 10.1038/368144a0 8139656
6. Wu LJ Toyoda H Zhao MG Lee YS Tang J Ko SW Jia YH Shum FW Zerbinatti CV Bu G Wei F Xu TL Muglia LJ Chen ZF Auberson YP Kaang BK Zhuo M Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation J Neurosci 2005 25 11107-11116 10.1523/ JNEUROSCI.1678-05.2005 16319310
7. Kohr G NMDA receptor function: Subunit composition versus spatial distribution Cell Tissue Res 2006 326 439-446 10.1007/s00441-006-0273-6 16862427
8. Fischer G Mutel V Trube G Malherbe P Kew JN Mohacsi E Heitz MP Kemp JA Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro J Pharmacol Exp Ther 1997 283 1285-1292 9400004
9. Williams K Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors Mol Pharmacol 1993 44 851-859 7901753
10. Auberson YP Allgeier H Bischoff S Lingenhoehl K Moretti R Schmutz M 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition Bioorg Med Chem Lett 2002 12 1099-1102 10.1016/ S0960-894X(02)00074-4 11909726
11. Massey PV Johnson BE Moult PR Auberson YP Brown MW Molnar E Collingridge GL Bashir ZI Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression J Neurosci 2004 24 7821-7828 10.1523/JNEUROSCI.1697-04.2004 15356193
12. Liu L Wong TP Pozza MF Lingenhoehl K Wang Y Sheng M Auberson YP Wang YT Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity Science 2004 304 1021-1024 10.1126/science.1096615 15143284
13. Morishita W Lu W Smith GB Nicoll RA Bear MF Malenka RC Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression Neuropharmacology 2007 52 71-76 10.1016/j.neuropharm.2006.07.005 16899258
14. Bartlett TE Bannister NJ Collett VJ Dargan SL Massey PV Bortolotto ZA Fitzjohn SM Bashir ZI Collingridge GL Lodge D Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus Neuropharmacology 2007 52 60-70 10.1016/ j.neuropharm.2006.07.013 16904707
15. Berberich S Punnakkal P Jensen V Pawlak V Seeburg PH Hvalby O Kohr G Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation J Neurosci 2005 25 6907-6910 10.1523/JNEUROSCI.1905-05.2005 16033900
16. Weitlauf C Honse Y Auberson YP Mishina M Lovinger DM Winder DG Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation J Neurosci 2005 25 8386-8390 10.1523/JNEUROSCI.2388-05.2005 16162920
17. Toyoda H Zhao MG Zhuo M Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex Eur J Neurosci 2005 22 485-494 10.1111/j.1460-9568.2005.04236.x 16045501
18. Zhao MG Toyoda H Lee YS Wu LJ Ko SW Zhang XH Jia Y Shum F Xu H Li BM Kaang BK Zhuo M Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory Neuron 2005 47 859-872 10.1016/j.neuron.2005.08.014 16157280
19. Frizelle PA Chen PE Wyllie DJ Equilibrium constants for (R)- [(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquino xalin-5-yl)-methyl]-phosphonic acid (NVPAAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of synaptic transmission. Mol Pharmacol 2006, 70:1022-1032.
20. Feng B Tse HW Skifter DA Morley R Jane DE Monaghan DT Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid Br J Pharmacol 2004 141 508-516 10.1038/sj.bjp.0705644 14718249
21. Zhuo M Molecular mechanisms of pain in the anterior cingulate cortex J Neurosci Res 2006 84 927-933 10.1002/jnr.21003 16862566
22. Wiltgen BJ Brown RA Talton LE Silva AJ New circuits for old memories: the role of the neocortex in consolidation Neuron 2004 44 101-108 10.1016/j.neuron.2004.09.015 15450163
23. Wu LJ Zhao MG Toyoda H Ko SW Zhuo M Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex J Neurophysiol 2005 94 1805-1813 10.1152/jn.00091.2005 15928066
24. Gerkin RC Lau PM Nauen DW Wang YT Bi GQ Modular Competition Driven by NMDA Receptor Subtypes in Spike-Timing-Dependent Plasticity J Neurophysiol 2007 97 2851-2862 10.1152/jn.00860.2006 17267756
25. Luo J Wang Y Yasuda RP Dunah AW Wolfe BB The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B) Mol Pharmacol 1997 51 79-86 9016349
26. Hatton CJ Paoletti P Modulation of triheteromeric NMDA receptors by N-terminal domain ligands Neuron 2005 46 261-274 10.1016/ j.neuron.2005.03.005 15848804
27. Mallon AP Auberson YP Stone TW Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices Exp Brain Res 2005 162 374-383 10.1007/s00221-004-2193-6 15580338