Mitochondrial-derived ROS in edelfosine-induced apoptosis in yeasts and tumor cells

Acta Pharmacologica Sinica

Volumn 28, Issue 6, 2007, Pages 888-894

  Zhang, Hui ^a,b,c   Gajate, Consuelo ^c,d   Yu, Li Ping ^b   Fang, Yun Xiang ^a   Mollinedo, Faustino ^c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b XIANGNAN UNIVERSITY   (China)

^c CSIC   (Spain)

^d HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

Author keywords

Alkyl lysophospholipid analog; Antitumor drug; Apoptosis; Bcl 2; Edelfosine; Mitochondria; Reactive oxygen species; Tumor cell; Yeast

Indexed keywords

ALPHA TOCOPHEROL; DNA FRAGMENT; EDELFOSINE; NITROBLUE TETRAZOLIUM; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; ROTENONE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOFLUOROMETRY; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NICK END LABELING; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; SACCHAROMYCES CEREVISIAE; TUMOR CELL; YEAST; YEAST CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; HUMANS; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOSPHOLIPID ETHERS; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE;

EID: 34249318785     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00568.x     Document Type: Article

References (35)

1. Mollinedo F, Martinez-Dalmau R, Modolell M. Early and selective induction of apoptosis in human leukemic cells by the alkyl-lysophospholipid ET-18-OCH3. Biochem Biophys Res Commun, 1993 192 : 603 9.
2. Mollinedo F, Fernandez-Luna JL, Gajate C, Martin-Martin B, Benito A, Martinez-Dalmau R, et al. Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfo-sine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-XL. Cancer Res, 1997 57 : 1320 8.
3. Gajate C, Mollinedo F. Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospho-lipid ET-18-OCH3 (edelfosine), a proapoptotic agent in tumor cells. Curr Drug Metab, 2002 3 : 491 525.
4. Mollinedo F, Gajate C, Martin-Santamaria S, Gago F. ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr Med Chem, 2004 11 : 3163 84.
5. Hanson PK, Malone L, Birchmore JL, Nichols JW. Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. J Biol Chem, 2003 278 : 36041 50.
6. Zaremberg V, Gajate C, Cacharro LM, Mollinedo F, McMaster CR. Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition. J Biol Chem, 2005 280 : 38047 58.
7. Gajate C, Mollinedo F. The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells. Blood, 2001 98 : 3860 3.
8. Gajate C, Del Canto-Janez E, Acuna AU, Amat-Guerri F, Geijo E, Santos-Beneit AM, et al. Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis. J Exp Med, 2004 200 : 353 65.
9. Gajate C, Santos-Beneit AM, Macho A, Lazaro M, Hernandez-De Rojas A, Modolell M, et al. Involvement of mitochondria and caspase-3 in ET-18-OCH3-induced apoptosis of human leukemic cells. Int J Cancer, 2000 86 : 208 18.
10. Vrablic AS, Albright CD, Craciunescu CN, Salganik RI, Zeisel SH. Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defec-tive hepatocytes. FASEB J, 2001 15 : 1739 44.
11. Nieto-Miguel T, Gajate C, Mollinedo F. Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells. J Biol Chem, 2006 281 : 14833 40.
12. Green DR, Reed JC. Mitochondria and apoptosis. Science, 1998 281 : 1309 12.
13. Richter C, Gogvadze V, Laffranchi R, Schlapbach R, Schweizer M, Suter M, et al. Oxidants in mitochondria: from physiology to diseases. Biochim Biophys Acta, 1995 1271 : 67 74.
14. Castedo M, Macho A, Zamzami N, Hirsch T, Marchetti P, Uriel J, et al. Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo. Eur J Immunol 1995 25 : 3277 84.
15. Hug H, Strand S, Grambihler A, Galle J, Hack V, Stremmel W, et al. Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells. J Biol Chem, 1997 272 : 28191 3.
16. Quillet-Mary A, Jaffrezou J P, Mansat V, Bordier C, Naval J, Laurent G. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J Biol Chem, 1997 272 : 21388 95.
17. Shaha C. Apoptosis in Leishmania species and its relevance to disease pathogenesis. Indian J Med Res, 2006 123 : 233 44.
18. Madeo F, Engelhardt S, Herker E, Lehmann N, Maldener C, Proksch A, et al. Apoptosis in yeast: a new model system with applications in cell biology and medicine. Curr Genet, 2002 41 : 208 16.
19. Phillips AJ, Sudbery I, Ramsdale M. Apoptosis induced by environmental stresses and amphotericin B in Candida albicans. Proc Natl Acad Sci USA, 2003 100 : 14327 32.
20. Geley S, Hartmann BL, Kofler R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Lett, 1997 400 : 15 8.
21. Rook GA, Steele J, Umar S, Dockrell HM. A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by gamma-interferon. J Immunol Methods, 1985 82 : 161 7.
22. Lopez-Barneo J, Ortega-Saenz P, Piruat JI, Garcia-Fernandez M. Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells. Novartis Found Symp, 2006 272 : 54 64.
23. Gajate C, Barasoain I, Andreu JM, Mollinedo F. Induction of apoptosis in leukemic cells by the reversible microtubule-disrupt-ing agent 2-methoxy-5-(2′,3′,4′-trimethoxyphenyl)-2,4, 6-cycloheptatrien-1-one: protection by Bcl-2 and Bcl-XL and cell cycle arrest. Cancer Res, 2000 60 : 2651 9.
24. Madeo F, Frohlich E, Ligr M, Grey M, Sigrist SJ, Wolf DH, et al. Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol, 1999 145 : 757 67.
25. Ribeiro GF, Corte-Real M, Johansson B. Characterization of DNA damage in yeast apoptosis induced by hydrogen peroxide, acetic acid, and hyperosmotic shock. Mol Biol Cell, 2006 17 : 4584 91.
26. Herker E, Jungwirth H, Lehmann KA, Maldener C, Frohlich KU, Wissing S, et al. Chronological aging leads to apoptosis in yeast. J Cell Biol, 2004 164 : 501 7.
27. Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, Diaspro A, et al. Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J Cell Biol 2004 166 : 1055 67.
28. Mollinedo F, Gajate C. Microtubules, microtubule-interfering agents and apoptosis. Apoptosis, 2003 8 : 413 50.
29. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol, 1992 119 : 493 501.
30. Gottlieb RA. Mitochondrial signaling in apoptosis: mitochondrial daggers to the breaking heart. Basic Res Cardiol, 2003 98 : 242 9.
31. Gottlieb RA. Role of mitochondria in apoptosis. Crit Rev Eukaryot Gene Exp, 2000 10 : 231 9.
32. Decaudin D, Marzo I, Brenner C, Kroemer G. Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy. Int J Oncol, 1998 12 : 141 52.
33. Pinkoski MJ, Waterhouse NJ, Green DR. Mitochondria, apoptosis and autoimmunity. Curr Dir Autoimmun, 2006 9 : 55 73.
34. Okun JG, Zickermann V, Zwicker K, Schagger H, Brandt U. Binding of detergents and inhibitors to bovine complex I - a novel purification procedure for bovine complex I retaining full inhibitor sensitivity. Biochim Biophys Acta, 2000 1459 : 77 87.
35. Schuler F, Yano T, Di Bernardo S, Yagi T, Yankovskaya V, Singer TP, et al. NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone. Proc Natl Acad Sci USA, 1999 96 : 4149 53.