Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine

Journal of Biological Chemistry

Volumn 278, Issue 38, 2003, Pages 36041-36050

  Hanson, Pamela K ^a   Malone, Lynn ^c   Birchmore, Jennifer L ^c   Nichols, J Wylie ^b  

^a BIRMINGHAM SOUTHERN COLLEGE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; DISEASE CONTROL; GENES; MUTAGENESIS; YEAST;

HOMOLOGUES;

DRUG THERAPY;

7 NITROBENZ 2 OXA 1,3 DIAZOL 4 YL; EDELFOSINE; FLUORESCENT DYE; KETOCONAZOLE; MILTEFOSINE; NITROQUINOLINE DERIVATIVE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PROTEIN LEM3P; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RESISTANCE; DRUG TRANSPORT; GENE IDENTIFICATION; GENE MUTATION; MYCOSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN TRANSPORT; PROTOZOAL INFECTION; REPORTER GENE; SACCHAROMYCES CEREVISIAE; STRAIN DIFFERENCE;

ALLELES; ANTIPROTOZOAL AGENTS; BIOLOGICAL TRANSPORT; CELL DIVISION; CELL MEMBRANE; CYCLOHEXIMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; DRUG RESISTANCE, MULTIPLE; ENDOCYTOSIS; GENE DELETION; KETOCONAZOLE; LEISHMANIASIS; LIPID METABOLISM; LYSOPHOSPHATIDYLCHOLINES; MEMBRANE TRANSPORT PROTEINS; MICROSCOPY, FLUORESCENCE; MUTATION; NUCLEAR ENVELOPE; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLSERINES; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPID ETHERS; PHOSPHORYLCHOLINE; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TIME FACTORS;

ANIMALIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0141704333     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305263200     Document Type: Article

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