Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3480-3485

  Hanessian, Stephen ^a   Ersmark, Karolina ^a   Wang, Xiaotian ^a   Del Valle, Juan R ^a   Blomberg, Niklas ^b   Xue, Yafeng ^b   Fjellström, Ola ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Aeruginosin mimics; Chloroleucine; Thrombin inhibition

Indexed keywords

AERUGINOSIN; AMIDE; CHLORODYSINOSIN A; DYSINOSIN A; INDOLE DERIVATIVE; LEUCINE; NATURAL PRODUCT; OSCILLARIN; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYBRID; HYDROPHOBICITY; IC 50; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMIDES; ANTITHROMBINS; CRYSTALLOGRAPHY, X-RAY; HYDROPHOBICITY; INDOLES; INHIBITORY CONCENTRATION 50; LEUCINE; MODELS, CHEMICAL; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 34249316869     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.075     Document Type: Article

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