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Volumn 62, Issue 6, 1997, Pages 1810-1813

Aeruginosins 205A and -B, serine protease inhibitory glycopeptides from the cyanobacterium Oscillatoria agardhii (NIES-205)

Author keywords

[No Author keywords available]

Indexed keywords

AERUGINOSIN 205A; AERUGINOSIN 205B; SERINE PROTEINASE INHIBITOR; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

EID: 0030894360     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo961902e     Document Type: Article
Times cited : (83)

References (21)
  • 4
    • 8244228945 scopus 로고    scopus 로고
    • Unpublished results. The details of the screening data will be reported elsewhere
    • Unpublished results. The details of the screening data will be reported elsewhere.
  • 5
    • 0003808713 scopus 로고
    • Watanabe, M. M., Nozaki, H., Eds.; Natl. Inst. Environ. Stud.: Tsukuba, Japan
    • Watanabe, M. M.; Satake, K. N. In NIES-collection. List of Strains; Watanabe, M. M., Nozaki, H., Eds.; Natl. Inst. Environ. Stud.: Tsukuba, Japan, 1994; pp 30-80.
    • (1994) NIES-collection. List of Strains , pp. 30-80
    • Watanabe, M.M.1    Satake, K.N.2
  • 10
    • 0027308184 scopus 로고
    • Professor Satoshi Omura (Director of the Kitasato Institute, Research Center of Biological Function, Japan) kindly provided us with three stereoisomers (2S,3S; 2S,3R; 2R,3R) of Hleu out of four possible stereoisomers (Tetrahedron Lett. 1993, 34, 4447-4448). In the HPLC analyses of the samples and the standards derivatized with L-Marfey's reagent, Hleu in 2 was determined to be (2S,3R), but the retention time of that in 1 was not consistent with either of the above three stereoisomers, suggesting that the absolute stereochemistry of Hleu in 1 might be (2R,3S). To clarify this fact, the (2S,3R) isomer was derivatized with D-Marfey's reagent, which is enantiomeric to or chromatographically equivalent to the (2R,3S) isomer derivatized with L-Marfey's reagent. HPLC analysis of the (2S,3R) isomer derivatized with D-Marfey's reagent allowed us to determine the stereochemistry of Hleu in 1 as (2R,3S) unambiguously.
    • (1993) Tetrahedron Lett. , vol.34 , pp. 4447-4448
  • 12
    • 8244246705 scopus 로고    scopus 로고
    • note
    • 2 at 100°C for 10 min, chiral GC analyses were carried out.
  • 20
    • 8244236008 scopus 로고    scopus 로고
    • Retention time of (2R,3S)-Hleu was determined by (2S,3R)-Hleu derivatized with D-FDAA reagent
    • Retention time of (2R,3S)-Hleu was determined by (2S,3R)-Hleu derivatized with D-FDAA reagent.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.