An efficient synthesis of 4-bromo-N-substituted oxindoles by an intramolecular copper-catalyzed amidation reaction

Tetrahedron Letters

Volumn 48, Issue 26, 2007, Pages 4461-4465

  van den Hoogenband, Adri ^a   Lange, Jos H M ^a   den Hartog, Jack A J ^a   Henzen, Remco ^a   Terpstra, Jan Willem ^a  

^a Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DIBROMOPHENYLACETAMIDE DERIVATIVE; ACETAMIDE DERIVATIVE; COPPER DERIVATIVE; OXINDOLE; OXINDOLE DERIVATIVE; PALLADIUM; UNCLASSIFIED DRUG;

AMIDATION; ARTICLE; CATALYSIS; METAL BINDING; MOLECULAR INTERACTION; SUBSTITUTION REACTION; SYNTHESIS;

EID: 34249289677     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.05.009     Document Type: Article

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50. 3): δ 1.32 (s, 9H), 3.94 (s, 2H), 5.15 (br s, 1H), 7.01 (t, J = 8 Hz, 1H), 7.57 (d, J = 8 Hz, 2H).
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56. 3): δ 3.48 (s, 2H), 3.89 (br s, 1H), 4.45 (s, 2H), 6.23 (d, J = 8 Hz, 1H), 6.43 (d, J = 8 Hz, 1H), 7.07 (t, J = 8 Hz, 1H), 7.29-7.33 (m, 1H), 7.35-7.55 (m, 9H).