메뉴 건너뛰기




Volumn 5, Issue 5, 2007, Pages 497-504

Monitoring chronic myelogenous leukemia in the age of tyrosine kinase inhibitors

Author keywords

Bcr abl; Chronic myeloid leukemia; Imatinib mesylate; Molecular monitoring; Treatment monitoring; Tyrosine kinase

Indexed keywords

BCR ABL PROTEIN; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; CYTARABINE; DASATINIB; IMATINIB; INTERFERON; NILOTINIB; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 34249280911     PISSN: 15401405     EISSN: 15401413     Source Type: Journal    
DOI: 10.6004/jnccn.2007.0044     Document Type: Article
Times cited : (6)

References (39)
  • 1
    • 0008947293 scopus 로고    scopus 로고
    • Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia
    • Hansen JA, Gooley TA, Martin PJ, et al. Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia. N Engl J Med 1998;338:962-968.
    • (1998) N Engl J Med , vol.338 , pp. 962-968
    • Hansen, J.A.1    Gooley, T.A.2    Martin, P.J.3
  • 2
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003;348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 3
    • 33644544742 scopus 로고    scopus 로고
    • Chronic myeloid leukemia in 2006: A perspective
    • Mauro MJ, Deininger MW. Chronic myeloid leukemia in 2006: a perspective. Haematologica 2006;91:152-158.
    • (2006) Haematologica , vol.91 , pp. 152-158
    • Mauro, M.J.1    Deininger, M.W.2
  • 4
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355:2408-2417.
    • (2006) N Engl J Med , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 6
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M, Silver RT, Druker, BJ, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 2002; 99:1928-1937.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 7
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in parients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
    • Sawyers CL, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in parients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002;99:3530-3539.
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 8
    • 0022544401 scopus 로고
    • The chtonic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene
    • Ben-Neriah Y, Daley GQ, Mes-Masson AM, et al. The chtonic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science 1986;233:212-214.
    • (1986) Science , vol.233 , pp. 212-214
    • Ben-Neriah, Y.1    Daley, G.Q.2    Mes-Masson, A.M.3
  • 9
    • 0033565561 scopus 로고    scopus 로고
    • The biology of chronic myeloid leukemia
    • Faderl S, Talpaz M, Estrov Z, et al. The biology of chronic myeloid leukemia. N Engl J Med 1999;341:164-172.
    • (1999) N Engl J Med , vol.341 , pp. 164-172
    • Faderl, S.1    Talpaz, M.2    Estrov, Z.3
  • 10
    • 0034693878 scopus 로고    scopus 로고
    • Regulation of cell death by the Abl tyrosine kinase
    • Wang JY. Regulation of cell death by the Abl tyrosine kinase. Oncogene 2000;19:5643-5650.
    • (2000) Oncogene , vol.19 , pp. 5643-5650
    • Wang, J.Y.1
  • 11
    • 3242804413 scopus 로고    scopus 로고
    • Biology of chronic myelogenous leukemia - signaling pathways of initiation and transformation
    • Melo JV, Deininger MW. Biology of chronic myelogenous leukemia - signaling pathways of initiation and transformation. Hematol Oncol Clin North Am 2004;18:545-568.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 545-568
    • Melo, J.V.1    Deininger, M.W.2
  • 12
    • 0028946866 scopus 로고
    • Polymerase chain reaction detection of BCR/ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: Results and implications in 346 patients
    • Radich JP, Gehly G, Gooley T, et al. Polymerase chain reaction detection of BCR/ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood 1995;85:2632-2638.
    • (1995) Blood , vol.85 , pp. 2632-2638
    • Radich, J.P.1    Gehly, G.2    Gooley, T.3
  • 13
    • 0035885940 scopus 로고    scopus 로고
    • The significance of bcr-abl molecular detection in chronic myeloid leukemia patients "late," 18 months or more after transplantation
    • Radich JP, Gooley T, Bryant E, et al. The significance of bcr-abl molecular detection in chronic myeloid leukemia patients "late," 18 months or more after transplantation. Blood 2001;98:1701-1707.
    • (2001) Blood , vol.98 , pp. 1701-1707
    • Radich, J.P.1    Gooley, T.2    Bryant, E.3
  • 14
    • 33745603988 scopus 로고    scopus 로고
    • Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
    • Hughes T, Deininger M, Hochhaus A, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006;108:28-37.
    • (2006) Blood , vol.108 , pp. 28-37
    • Hughes, T.1    Deininger, M.2    Hochhaus, A.3
  • 15
    • 0031840623 scopus 로고    scopus 로고
    • Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukemia patients using real-time quantitative RT-PCR
    • Mensink E, van de Locht A, Schattenberg A, et al. Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukemia patients using real-time quantitative RT-PCR. Br J Haematol 1998;102:768-774.
    • (1998) Br J Haematol , vol.102 , pp. 768-774
    • Mensink, E.1    van de Locht, A.2    Schattenberg, A.3
  • 16
    • 33646590620 scopus 로고    scopus 로고
    • Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplant for chronic myeloid leukemia: An attempt to define patients who may not require further therapy
    • Kaeda J, O'Shea D, Szydlo RM, et al. Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplant for chronic myeloid leukemia: an attempt to define patients who may not require further therapy. Blood 2006;107: 4171-4176.
    • (2006) Blood , vol.107 , pp. 4171-4176
    • Kaeda, J.1    O'Shea, D.2    Szydlo, R.M.3
  • 17
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myelogenous leukemia
    • Hughes TP, Kaeda J, Branford S, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myelogenous leukemia. N Engl J Med 2003;349: 1423-1432.
    • (2003) N Engl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 18
    • 33644535340 scopus 로고    scopus 로고
    • Continuing reduction in level of residual disease after 4 years in patients with CML in chronic phase responding to first-line imatinib in the IRIS study [abstract]
    • Abstract 163
    • Goldman J, Hughes T, Radich J, et al. Continuing reduction in level of residual disease after 4 years in patients with CML in chronic phase responding to first-line imatinib in the IRIS study [abstract]. Blood 2005;106:51a. Abstract 163.
    • (2005) Blood , vol.106
    • Goldman, J.1    Hughes, T.2    Radich, J.3
  • 19
    • 20944442975 scopus 로고    scopus 로고
    • Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate
    • Cortes J, Talpaz M, O'Brien S, et al. Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate. Clin Cancer Res 2005;11:3425-3432.
    • (2005) Clin Cancer Res , vol.11 , pp. 3425-3432
    • Cortes, J.1    Talpaz, M.2    O'Brien, S.3
  • 20
    • 20244365354 scopus 로고    scopus 로고
    • Monitoring patients in complete cytogenetic remission after treatment of CML in chronic phase with imatinib: Patterns of residual leukaemia and prognostic factors for cytogenetic relapse
    • Marin D, Kaeda J, Szydlo R, et al. Monitoring patients in complete cytogenetic remission after treatment of CML in chronic phase with imatinib: patterns of residual leukaemia and prognostic factors for cytogenetic relapse. Leukemia 2005;19:507-512.
    • (2005) Leukemia , vol.19 , pp. 507-512
    • Marin, D.1    Kaeda, J.2    Szydlo, R.3
  • 21
    • 0036738109 scopus 로고    scopus 로고
    • Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response in chronic phase CML patients treated with imatinib after failure of interferon alpha
    • Merx K, Muller MC, Kreil S, et al. Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response in chronic phase CML patients treated with imatinib after failure of interferon alpha. Leukemia 2002;16:1579-1583.
    • (2002) Leukemia , vol.16 , pp. 1579-1583
    • Merx, K.1    Muller, M.C.2    Kreil, S.3
  • 22
    • 0348015863 scopus 로고    scopus 로고
    • The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia
    • Wang L, Pearson K, Ferguson JE, Clark RE. The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia. Br J Haematol 2003;120:990-999.
    • (2003) Br J Haematol , vol.120 , pp. 990-999
    • Wang, L.1    Pearson, K.2    Ferguson, J.E.3    Clark, R.E.4
  • 23
    • 9144264829 scopus 로고    scopus 로고
    • Imatinib produces significantly superior molecular responses compared with interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase
    • Branford S, Rudzki Z, Harper A, et al. Imatinib produces significantly superior molecular responses compared with interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Leukemia 2003;17:2401-2409.
    • (2003) Leukemia , vol.17 , pp. 2401-2409
    • Branford, S.1    Rudzki, Z.2    Harper, A.3
  • 24
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002;2:117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 25
    • 33748680234 scopus 로고    scopus 로고
    • Frequency, distribution and prognostic value of ABL kinase domain (KD) mutations in different subsets of Philadelphia-positive (Ph+) patients (Pts) resistant to imatinib (IM) by the Gimema Working Party on CML [abstract]
    • Abstract 435
    • Soverini S, Colarossi S, Gnani A, et al. Frequency, distribution and prognostic value of ABL kinase domain (KD) mutations in different subsets of Philadelphia-positive (Ph+) patients (Pts) resistant to imatinib (IM) by the Gimema Working Party on CML [abstract]. Blood 2005;106:131a. Abstract 435.
    • (2005) Blood , vol.106
    • Soverini, S.1    Colarossi, S.2    Gnani, A.3
  • 26
    • 23044458596 scopus 로고    scopus 로고
    • ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S, Martinelli G, Rosti G, et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005;23:4100-4109.
    • (2005) J Clin Oncol , vol.23 , pp. 4100-4109
    • Soverini, S.1    Martinelli, G.2    Rosti, G.3
  • 27
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford S, Rudzki Z, Walsh S, et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003;102:276-283.
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 28
    • 33744461022 scopus 로고    scopus 로고
    • Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: A retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP)
    • Nicolini FE, Corm S, Le QH, et al. Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP). Leukemia 2006;20:1061-1066.
    • (2006) Leukemia , vol.20 , pp. 1061-1066
    • Nicolini, F.E.1    Corm, S.2    Le, Q.H.3
  • 29
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006;354:2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 30
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarajian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006;354:2542-2551.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarajian, H.1    Giles, F.2    Wunderle, L.3
  • 31
    • 33846240316 scopus 로고    scopus 로고
    • MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphoblastic leukemia with the T315I BCR-ABL mutation
    • Giles FJ, Cortes J, Jones D, et al. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphoblastic leukemia with the T315I BCR-ABL mutation. Blood 2007;109:500-502.
    • (2007) Blood , vol.109 , pp. 500-502
    • Giles, F.J.1    Cortes, J.2    Jones, D.3
  • 32
    • 0035929652 scopus 로고    scopus 로고
    • Roots of clinical resistance to STI-571 cancer therapy [abstract]
    • Hochhaus A, Kreil S, Corbin A, et al. Roots of clinical resistance to STI-571 cancer therapy [abstract]. Science 2001;293:2163.
    • (2001) Science , vol.293 , pp. 2163
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.3
  • 33
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S, Rudzki Z, Walsh S, et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 2002;99:3472-3475.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 34
    • 20844447330 scopus 로고    scopus 로고
    • Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations
    • Branford S, Rudzki Z, Parkinson I, et al. Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations. Blood 2004;104:2926-2932.
    • (2004) Blood , vol.104 , pp. 2926-2932
    • Branford, S.1    Rudzki, Z.2    Parkinson, I.3
  • 35
    • 0036051772 scopus 로고    scopus 로고
    • Clonal Ph-negative hematopoiesis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8
    • Andersen MK, Pedersen-Bjergaard J, Kjeldsen L, et al. Clonal Ph-negative hematopoiesis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8. Leukemia 2002;16:1390-1393.
    • (2002) Leukemia , vol.16 , pp. 1390-1393
    • Andersen, M.K.1    Pedersen-Bjergaard, J.2    Kjeldsen, L.3
  • 36
    • 0038092769 scopus 로고    scopus 로고
    • Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority
    • Bumm T, Muller C, Al-Ali HK, et al. Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 2003;101:1941-1949.
    • (2003) Blood , vol.101 , pp. 1941-1949
    • Bumm, T.1    Muller, C.2    Al-Ali, H.K.3
  • 37
    • 0345382731 scopus 로고    scopus 로고
    • Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate
    • O'Dwyer ME, Gatter KM, Loriaux M, et al. Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate. Leukemia 2003;17:481-487.
    • (2003) Leukemia , vol.17 , pp. 481-487
    • O'Dwyer, M.E.1    Gatter, K.M.2    Loriaux, M.3
  • 38
    • 0037352241 scopus 로고    scopus 로고
    • Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex Philadelphia negative clones
    • Chee YL, Vickers MA, Stevenson D, et al. Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex Philadelphia negative clones. Leukemia 2003;17:634-635.
    • (2003) Leukemia , vol.17 , pp. 634-635
    • Chee, Y.L.1    Vickers, M.A.2    Stevenson, D.3
  • 39
    • 85039191633 scopus 로고    scopus 로고
    • O'Brien S, Berman E, Bhalla K, et al. NCCN Chronic myelogenous leukemia clinical practice guidelines in oncology. JNCCN 2007; 5:xxx-xxx.
    • O'Brien S, Berman E, Bhalla K, et al. NCCN Chronic myelogenous leukemia clinical practice guidelines in oncology. JNCCN 2007; 5:xxx-xxx.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.