Effect of formulation and processing variables on the granulation kinetics of hot melt granulation (HMG) process

Pharmaceutical Development and Technology

Volumn 12, Issue 2, 2007, Pages 145-151

  Sandhu, Harpreet K ^a   Chatterji, Ashish ^a   Shah, Navnit H ^a   Malick, A Waseem ^a   Desai, Dipen ^b   Zia, Hossein ^b  

^a HOFFMANN LA ROCHE INC   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Bulk density; Critical process variables (CPV); Granulation kinetics; Hot melt granulation; Impeller speed; Indomethacin; Melt granulation; Poloxamer 188; Surface area

Indexed keywords

INDOMETACIN; POLOXAMER; RETINOL;

ARTICLE; BINDING KINETICS; BULK DENSITY; DRUG EFFICACY; DRUG FORMULATION; DRUG GRANULATION; HEATING; IMPELLER; MELTING POINT; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS TECHNOLOGY; RESPONSE VARIABLE; SCALE UP; SURFACE PROPERTY; VELOCITY;

CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; HEAT; INDOMETHACIN; LACTOSE; PARTICLE SIZE; POLOXAMER; POVIDONE; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 34249109782     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450701212495     Document Type: Article

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