The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury

Brain Research

Volumn 898, Issue 2, 2001, Pages 281-287

  Hewitt, Kimberley E ^a   Stys, Peter K ^a   Lesiuk, Howard J ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Hippocampus; Mexiletine; Neuroprotection; Sodium channel; Stroke

Indexed keywords

MEXILETINE; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOXIA; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; MEMBRANE DEPOLARIZATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; RECEPTOR BLOCKING; SODIUM CALCIUM EXCHANGE; WHITE MATTER;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOOD PRESSURE; BODY TEMPERATURE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; HIPPOCAMPUS; HYPOTENSION; MALE; MEXILETINE; NERVE DEGENERATION; NERVE FIBERS, MYELINATED; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 0035917797     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02195-3     Document Type: Article

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