Baicalein impairs vascular tone in normal rat aortas: Role of superoxide anions

European Journal of Pharmacology

Volumn 565, Issue 1-3, 2007, Pages 144-150

  Machha, Ajay ^a   Achike, Francis I ^b   Mohd, Mustafa Ali ^a   Mustafa, Mohd Rais ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

Author keywords

Baicalein; Endothelium derived nitric oxide; Oxidative stress; Superoxide anions; Vascular tone

Indexed keywords

ACETYLCHOLINE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BAICALEIN; CATALASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROGEN PEROXIDE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; PROSTAGLANDIN SYNTHASE; PYROGALLOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATTENUATION; BIOAVAILABILITY; BIOLOGICAL ACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG INHIBITION; ENDOTHELIUM; ENZYME ACTIVITY; HEART CONTRACTION; HEART MUSCLE CONTRACTILITY; MALE; MUSCLE RELAXATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; VASCULAR RING; WISTAR KYOTO RAT;

ACETYLCHOLINE; ANIMALS; AORTA; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVANONES; MALE; NAD; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; RATS; RATS, INBRED WKY; SUPEROXIDES; VASOCONSTRICTION;

EID: 34249028240     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.03.009     Document Type: Article

References (33)

1. Ajay M., Cheng H.M., Mustafa A.M., and Mustafa M.R. A comparative study on antioxidant activity of flavonoids: structure-activity relationships. Malays. J. Sci. 24 (2005) 187-190
2. Ajay M., Achike F.I., Mustafa A.M., and Mustafa M.R. Effect of quercetin on altered vascular reactivity in aorta isolated from streptozotocin-induced diabetic rats. Diabetes Res. Clin. Pract. 73 (2006) 1-7
3. Ajay M., Achike F.I., Mustafa A.M., and Mustafa M.R. Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae. Comparative study with ascorbic acid. Clin. Exp. Pharmacol. Physiol. 33 (2006) 345-350
4. Akpaffiong M.J., and Taylor A.A. Antihypertensive and vasodilator actions of antioxidants in spontaneously hypertensive rats. Am. J. Hypertens. 11 (1998) 1450-1460
5. Chen Z.Y., Su Y.L., Lau C.W., Law W.I., and Huang Y. Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery. Eur. J. Pharmacol. 374 (1999) 41-47
6. Chiesi M., and Schwaller R. Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin. Biochem. Pharmacol. 14 (1995) 495-501
7. Cook N.C., and Samman S. Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary sources. Nutr. Biochem. 7 (1996) 66-76
8. Didion S.P., and Faraci F.M. Effects of NADH and NADPH on superoxide levels and cerebral vascular tone. Am. J. Physiol., Heart Circ. Physiol. 282 (2002) H688-H695
9. Feelisch M., and Kelm M. Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells. Biochem. Biophys. Res. Commun. 180 (1991) 286-293
10. 2 in rat aorta. Vascul. Pharmacol. 43 (2005) 128-138
11. Godfraind T., Egleme C., and Osachie A.I. Role of endothelium in the contractile response of rat aorta to alpha-adrenergic agonists. Clin. Sci. 68 (1985) 65s-71s
12. Hamada H., Hiramatsu M., Edamatsu R., and Mori A. Free radical scavenging action of baicalein. Arch. Biochem. Biophys. 306 (1993) 261-266
13. Hansen K., and Nedergaard O.A. Methodological aspects of acetylcholine-evoked relaxation of rabbit aorta. J. Pharmacol. Toxicol. 41 (1999) 153-159
14. Heijnen C.G.M., Haenen G.R.M.M., Wiseman S.A., Tijburg L.B.M., and Bast A. The interaction of tea flavonoids with the NO-system: discrimination between good and bad NO. Food Chem. 70 (2000) 365-370
15. Hertog M.G.L., Feskens E.J.M., Hollman P.C.H., Katan M.B., and Kromhurt D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342 (1993) 1007-1011
16. Huang Y., Wong C.M., Lau C.W., Yao X., Tsang S.Y., Su Y.L., and Chen Z.Y. Inhibition of nitric oxide/ cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings. Biochem. Pharmacol. 67 (2004) 787-794
17. Knekt P., Jarvinen R., Reunanen A., and Maatela J. Flavonoid intake and coronary mortality in Finland: a cohort study. Br. Med. J. 312 (1996) 478-481
18. Kris-Etherton P.M., and Keen C.L. Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr. Opin. Lipidol. 13 (2002) 41-49
19. Liu J.J., Huang T.S., Cheng W.F., and Lu F.J. Baicalein and baicalin are potent inhibitors of angiogenesis: inhibition of endothelial cell proliferation, migration and differentiation. Int. J. Cancer 106 (2003) 559-565
20. Machha A., and Mustafa M.R. Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. J. Cardiovasc. Pharmacol. 46 (2005) 36-40
21. Mian K.B., and Martin W. Hydrogen peroxide-induced impairment of reactivity in rat isolated aorta: potentiation by 3-amino-1, 2, 4-triazole. Br. J. Pharmacol. 121 (1997) 813-819
22. Murad F. Cyclic guanosine monophosphate as a mediator of vasodilation. J. Clin. Invest. 78 (1986) 1-6
23. Nascimento N.R.F., Costa-e-Forti A., Peter A.A., and Fonteles M.C. Free radical scavengers improve the impaired endothelium-dependent responses in aorta and kidneys of diabetic rabbits. Diabetes Res. Clin. Pract. 61 (2003) 145-153
24. Neumann H., Carlsson K., and Brom G. Uptake and localization of O-(betahydroxyethyl)-rutosides in the venous wall, measured by laser scanning microscopy. Eur. J. Clin. Pharmacol. 43 (1992) 423-426
25. Nishio E., and Watanabe Y. Role of lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration. Eur. J. Pharmacol. 336 (1997) 267-273
26. Oltman C.L., Kane N.L., Miller Jr. F.J., Spector A.A., Weintraub N.L., and Dellsperger K.C. Reactive oxygen species mediate arachidonic acid-induced dilation in porcine coronary microvessels. Am. J. Physiol., Heart. Circ. Physiol. 285 (2003) H2309-H2315
27. Scalbert A., and Williamson G. Dietary intake and bioavailability of flavonoids. J. Nutr. 130 (2000) 2073S-2085S
28. Sekiguchi F., Yanamoto A., and Sunamo S. Superoxide dismutase reduces the impairment of endothelium-dependent relaxation in the spontaneously hypertensive rat aorta. J. Smooth Muscle Res. 40 (2004) 65-74
29. Shao Z.H., Vanden Hoek T.L., Qin Y., Becker L.B., Schumacker P.T., Li C.Q., Dey L., Barth E., Halpern H., Rosen G.M., and Yuan C.S. Baicalein attenuates oxidant stress in cardiomyocytes. Am. J. Physiol., Heart Circ. Physiol. 282 (2002) H999-H1006
30. Shieh D.E., Liu L.T., and Lin C.C. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 20 (2000) 2861-2865
31. 2 contributes to the vasodepressor effect of baicalein in hypertensive rats. Hypertension 31 (1998) 866-871
32. Tsang S.Y., Xhen Z.Y., Yao XQ., and Huang Y. Potentiating effects on contraction by purified baicalin and baicalein in the rat mesenteric artery. J. Cardiovasc. Pharmacol. 36 (2000) 263-269
33. Woodman O.L., Meeker W.F., and Boujaoude M. Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships. J. Cardiovasc. Pharmacol. 46 (2005) 302-309