Free radical scavengers improve the impaired endothelium-dependent responses in aorta and kidneys of diabetic rabbits

Diabetes Research and Clinical Practice

Volumn 61, Issue 3, 2003, Pages 145-153

  Nascimento, N R F ^a,b   Costa E Forti, A ^b   Peter, A A ^b   Fonteles, Manassés C ^a,b  

^a STATE UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Diabetes angiopathy; Diabetic nephropathy; Endothelial dysfunction in the renovascular bed; Oxidative damage

Indexed keywords

ACETYLCHOLINE; ANTIOXIDANT; GLUTATHIONE; SCAVENGER; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM INJURY; KIDNEY; MALE; NONHUMAN; RABBIT; RENAL ARTERY; STATISTICAL ANALYSIS; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0041761152     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(03)00128-1     Document Type: Article

References (55)

1. Cohen R.A. Dysfunction of vascular endothelium in diabetes Mellitus. Circulation. 87:(Suppl. V):1993;V67-V68.
2. Wei M., Gaskill S.P., Haffner S.M., Stern M.P. Effects of diabetes and level of glycemia on all cause and cardiovascular mortality. The San Antonio Heart Study. Diabetes Care. 21:1998;1167-1172.
3. Ginsberg H.N., Huang L.S. The insulin resistance syndrome: impact on lipoprotein metabolism and atherothrombosis. J. Cardiovasc. Risk. 7:2000;325-331. Review.
4. Tesfamariam B., Cohen R.A. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am. J. Physiol. 263:1992;H321-H326.
5. Hsueh W.A., Law R.E. Diabetes is a vascular disease. J. Invest. Med. 46:1998;387-390.
6. Kamata K., Miyata N., Kasuya Y. Impairment of endothelium-dependent relaxation and changes on levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats. Br. J. Pharmacol. 97:1989;614-618.
7. Rodríguez-Mañas L., Angulo J., Peiró C., Liergo J.L., Sanchez-Ferrer A., Lopez-Doriga P., Sanchez-Ferrer C.F. Endothelial dysfunction and metabolic control in streptozotocin-induced diabetic rats. Br. J. Pharmacol. 123:1998;1495-1502.
8. Hattori Y., Kawasaki H., Abe K., Kanno M. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am. J. Physiol. 261:1991;H1086-H1094.
9. Costa e Forti A., Fonteles M.C. Decreased endothelium dependent relaxation (nitric oxide) in diabetic kidneys. Horm. Metab. Res. 30:1998;55-57.
10. Wohaleb A.S., Godin D.V. Alterations in the free radical tissue-defense mechanisms in the streptozocin-induced diabetes in rats. Diabetes. 36:1987;1114-1118.
11. Wolff S.P. The potential role of oxidative stress in diabetes and its complications; novel implications for theory and therapy. Crabbe M.J.C. Diabetic complications; Scientific and Clinical Aspects. 1987;167-221 Churchill Livingstone.
12. Baynes J.W. Role of oxidative stress in development of complications in diabetes. Diabetes. 40:1991;405-412.
13. Giugliano D., Ceriello A., Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care. 19:1996;257-267.
14. Tesfamariam B. Free radicals in diabetic endothelial cell dysfunction. Free Radic. Biol. Med. 16:1994;383-391.
15. Jachec W., Tomasik A., Tarnawski R., Chwalinska E. Evidence of oxidative stress in the renal cortex of diabetic rats: favorable effect of vitamin E. Scand. J. Clin. Lab. Invest. 62:2002;81-88.
16. Dincer Y., Akcay T., Alademir Z., Ilkova H. Effect of oxidative stress on glutathione pathway in red blood cells from patients with insulin-dependent diabetes mellitus. Metabolism. 51:2002;1360-1362.
17. Ueno Y., Kizaki M., Nakagiri R., Kamiya T., Sumi H., Osawa T. Dietary glutathione protects rats from diabetic nephropathy and neuropathy. J. Nutr. 132:2002;897-900.
18. Zanetti M., Sato J., Katusic Z.S., O'Brien T. Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta. Am. J. Physiol. 280:2001;H2516-H2523.
19. Kobayashi T., Kamata K. Relationship among cholesterol, superoxide anion and endothelium-dependent relaxation in diabetic rats. Eur. J. Pharmacol. 367:1999;213-222.
20. Schnackenberg C.G. Oxygen radicals in cardiovascular-renal disease. Curr. Opin. Pharmacol. 2:2002;121-125.
21. Park S.H., Choi H.J., Lee J.H., Woo C.H., Kim J.H., Han H.J. High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1. Kidney Int. 59:2001;1695-1705.
22. Schnackenberg C.G., Wilcox C.S. The SOD mimetic tempol restores vasodilation in afferent arterioles of experimental diabetes. Kidney Int. 59:2001;1859-1864.
23. Heitzer T., Finckh B., Albers S., Krohn K., Kohlschutter A., Meinertz T. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic. Biol. Med. 31:2001;53-61.
24. Keegan A., Cotter M.A., Cameron N.E. Corpus cavernosum dysfunction in diabetic rats: effects of combined alpha-lipoic acid and gamma-linolenic acid treatment. Diabetes Metab. Res. Rev. 17:2001;380-386.
25. Nagamatsu M., Nickander K.K., Schmelzer J.D., Raya A., Wittrock D.A., Tritschler H., Low P.A. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 18:1995;1160-1167.
26. Evans J.L., Goldfine I.D. Lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol. Ther. 2:2000;401-413.
27. Jacob S., Henriksen E.J., Schiemann A.L., Simon I., Clancy D.E., Tritschler H.J., Jung W.I., Augustin H.J., Dietze G.J. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung. 45:1995;872-874.
28. Jacob S., Henriksen E.J., Tritschler H.J., Augustin H.J., Dietze G.J. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp. Clin. Endocrinol. Diabetes. 104:1996;284-288.
29. Jacob S., Ruus P., Hermann R., Tritschler H.J., Maerker E., Renn W., Augustin H.J., Dietze G.J., Rett K. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic. Biol. Med. 27:1999;309-314.
30. Konrad T., Vicini P., Kusterer K., Hoflich A., Assadkhani A., Bohles H.J., Sewell A., Tritschler H.J., Cobelli C., Usadel K.H. alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care. 22:1999;280-287.
31. Haugaard N., Haugaard E.S. Stimulation of glucose utilization by thioctic acid in rat diaphragm incubated in vitro. Biochim. Biophys. Acta. 222:1970;583-586.
32. Estrada D.E., Ewart H.S., Tsakiridis T., Volchuk A., Ramlal T., Tritschler H., Klip A. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes. 45:1996;1798-1804.
33. Ramrath S., Tritschler H.J., Eckel J. Stimulation of cardiac glucose transport by thioctic acid and insulin. Horm. Metab. Res. 31:1999;632-635.
34. Yaworsky K., Somwar R., Ramlal T., Tritschler H.J., Klip A. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. Diabetologia. 43:2000;294-303.
35. Kugiyama K., Ohgushi M., Motoyama T., Hirashima O., Soejima H., Misumi K., Yoshimura M., Ogawa H., Sugiyama S., Yasue H. Intracoronary infusion of reduced glutathione improves endothelial vasomotor response to acetylcholine in human coronary circulation. Circulation. 97:1998;2299-2301.
36. Ghigo D., Alessio P., Foco A., Bussolino F., Costamagna C., Heller R., Garbarino G., Pescarmona G.P., Bosia A. Nitric oxide synthesis is impaired in glutathione-depleted human umbilical vein endothelial cells. Am. J. Physiol. 265:1993;C728-C732.
37. Hecker M., Siegle I., Mcarthur H., Sessa W.C., Vane J.R. Role of intracellular thiols in release of EDRF from cultured endothelial cells. Am. J. Physiol. 262:1992;H888-H896.
38. Murphy M.E., Piper H.M., Watanabe H., Sies H. Nitric oxide production by cultured aortic endothelial cells in response to thiol depletion and replenishment. J. Biol. Chem. 266:1991;19378-19383.
39. Cooke J.P., Stamler J., Andon N., Davies P.F., McKinley G., Loscalzo J. Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol. Am. J. Physiol. 259:1990;H804-H812.
40. Arai K., Lizuka S., Tada Y., Oikawa K., Taniguchi N. Increase in the glucosylated form of erytrocyte CU-Zn-superoxide dismutase in diabetes and close association of the nonenzymatic glucosylation with the enzyme activity. Biochim. Biophys. Acta. 24:1987;292-296.
41. Harlan J.M., Levine J.D., Callahan K.S., Schawrtz B.R., Harker L.A. Glutathione redox cycle protects cultured endothelial cells against lysis by extracellular generation hydrogen peroxide. J. Clin. Invest. 73:1984;706-713.
42. Hawthorne G.C., barlett K., Hetherington C.S., Alberti K.G.M.M. The effect of high glucose on polyol pathway activity and myo-inositol metabolism in cultured human endothelial cells. Diabetologia. 34:1989;163-166.
43. Kamata K., Hosokawa M. Endothelial dysfunction in the perfused kidney from the streptozotocin-induced diabetic rat. Res. Commun. Mol. Pathol. Pharmacol. 96:1997;57-70.
44. Kakoki M., Hirata Y., Hayakawa H., Tojo A., Nagata D., Suzuki E., Kimura K., Goto A., Kikuchi K., Nagano T., Omata M. Effects of hypertension, diabetes mellitus, and hypercholesterolemia on endothelin type B receptor-mediated nitric oxide release from rat kidney. Circulation. 99:1999;1242-1248.
45. Kamata K., Yamashita K. Insulin resistance and impaired endothelium-dependent renal vasodilatation in fructose-fed hypertensive rats. Res. Commun. Mol. Pathol. Pharmacol. 103:1999;195-210.
46. Bucala R., Tracey K.J., Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J. Clin. Invest. 87:1991;432-438.
47. Du X.L., Stocklauser-Farber K., Rosen P. Generation of reactive oxygen intermediates, activation of NF-kappa B, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase. Free Radic. Biol. Med. 27:1999;752-763.
48. Wang Y.-X., Brooks D.P., Edwards R.M. Attenuated glomerular cGMP production and renal vasodilation in streptozotocin-induced diabetic rats. Am. J. Physiol. 264:1993;R952-R956.
49. Packer L., Witt E.H., Tritschler H.J. alpha-Lipoic acid as a biological antioxidant. Free Radic. Biol. Med. 19:1995;227-250.
50. Packer L., Tritschler H.J., Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic. Biol. Med. 22:1997;359-378.
51. Sen C.K., Roy S., Han D., Packer L. Regulation of cellular thiols in human lymphocytes by alpha-lipoic acid: a flow cytometric analysis. Free Radic. Biol. Med. 22:1997;1241-1257.
52. Mugge A., Elwell J.H., Peterson T.E., Harrison D.G. Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity. Am. J. Physiol. 260:1991;C219-C225.
53. Lopez B.L., Snyder J.W., Birenbaum D.S., Ma X.I. N-acetylcysteine enhances endothelium-dependent vasorelaxation in the isolated rat mesenteric artery. Ann. Emerg. Med. 32:1998;405-410.
54. Lawson D.L., Nichols W.W., Mehta P., Mehta J.L. Captopril-induced reversal of nitroglycerin tolerance: role of sulfhydryl group vs. ACE-inhibitory activity. J. Cardiovasc. Pharmacol. 17:1991;411-418.
55. Goldschmidt J.E., Tallarida R.J. Pharmacological evidence that captopril possesses an endothelium-mediated component of vasodilation: effect of sulfhydryl groups on endothelium-derived relaxing factor. J. Pharmacol. Exp. Ther. 257:1991;1136-1145.