Molecular mimicry in multiple sclerosis

New England Journal of Medicine

Volumn 349, Issue 2, 2003, Pages 185-186

  Wekerle, Hartmut ^a   Hohlfeld, Reinhard ^a  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR; VIRUS ANTIGEN; VIRUS PROTEIN; HLA DR ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CENTRAL NERVOUS SYSTEM; DENDRITIC CELL; DISEASE ASSOCIATION; ENCEPHALITIS; EPSTEIN BARR VIRUS; GENETIC CODE; GENOTYPE; HLA SYSTEM; HUMAN; HYPOTHESIS; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR MECHANICS; MOLECULAR MIMICRY; MULTIPLE SCLEROSIS; MYELIN SHEATH; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SPLEEN CELL; T LYMPHOCYTE; ANIMAL; CELL LINE; GENETICS; IMMUNOLOGY; MOUSE; REVIEW; TRANSGENIC MOUSE;

ANIMALS; CELL LINE; HERPESVIRUS 4, HUMAN; HLA-DR ANTIGENS; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR MIMICRY; MULTIPLE SCLEROSIS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0037775587     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMcibr035136     Document Type: Article

References (5)

1. Lang HLE, Jacobsen H, Ikemizu S, et al. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol 2002;3:940-3.
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3. Oldstone MBA. Molecular mimicry and autoimmune disease. Cell 1987;50:819-20.
4. Madsen LS, Andersson EC, Jansson L, et al. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet 1999;23:343-7.
5. Li Y, Li H, Martin R, Mariuzza RA. Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins. J Mol Biol 2000;304: 177-88.