메뉴 건너뛰기




Volumn 1, Issue , 2007, Pages 314-329

Synthesis and anti-inflammatory activity of some benzimidazole-2-carboxylic acids

Author keywords

Acute anti inflammatory activity; Benzimidazole 2 carboxylic acids; Carrageenan induced rat paw edema model

Indexed keywords

1 BENZYL BENZIMIDAZOLE ACID; 2 (5 ETHYL 2 PYRIDYL)BENZIMIDAZOLE; 2 (5 NITRO 1H BENZO[D]IMIDAZOL 2 YL)ACETIC ACID; ACETIC ACID DERIVATIVE; ANTIINFLAMMATORY AGENT; BENDAZOL DERIVATIVE; BENZIMIDAZOLE 2 CARBOXYLIC ACID DERIVATIVE; BENZIMIDAZOLE 2 PROPIONIC ACID; BENZIMIDAZOLE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CARRAGEENAN; MEBENDAZOLE; OMEPRAZOLE; PROPIONIC ACID DERIVATIVE; TILOMISOLE; UNCLASSIFIED DRUG; WY 18521;

EID: 34248647612     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (53)

References (46)
  • 1
    • 33749348276 scopus 로고    scopus 로고
    • Primer: Managing NSAID-induced ulcer complications - balancing gastrointestinal and cardiovascular risks
    • Oct;
    • Chan FK. Primer: managing NSAID-induced ulcer complications - balancing gastrointestinal and cardiovascular risks. Nature clinical practice. 2006 Oct;3(10):563-73.
    • (2006) Nature clinical practice , vol.3 , Issue.10 , pp. 563-573
    • Chan, F.K.1
  • 2
    • 4644356963 scopus 로고    scopus 로고
    • Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors
    • Oct 1;
    • Whittle BJ. Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors. Eur J Pharmacol. 2004 Oct 1;500(1-3):427-39.
    • (2004) Eur J Pharmacol , vol.500 , Issue.1-3 , pp. 427-439
    • Whittle, B.J.1
  • 3
    • 1542540203 scopus 로고    scopus 로고
    • The role of cyclooxygenase selective inhibitors in the gastrointestinal tract
    • Dec;
    • Cryer B. The role of cyclooxygenase selective inhibitors in the gastrointestinal tract. Current gastroenterology reports. 2003 Dec;5(6):453-8.
    • (2003) Current gastroenterology reports , vol.5 , Issue.6 , pp. 453-458
    • Cryer, B.1
  • 4
    • 0029758444 scopus 로고    scopus 로고
    • Bjorkman DJ. Nonsteroidal anti-inflammatory drug-induced gastrointestinal injury. The American journal of medicine. 1996 Jul 31;101(1A):25S-32S.
    • Bjorkman DJ. Nonsteroidal anti-inflammatory drug-induced gastrointestinal injury. The American journal of medicine. 1996 Jul 31;101(1A):25S-32S.
  • 5
    • 0026443983 scopus 로고
    • NSAID, ulcers, and prostaglandins
    • Nov;
    • Kimmey MB. NSAID, ulcers, and prostaglandins. The Journal of rheumatology. 1992 Nov;36:68-73.
    • (1992) The Journal of rheumatology , vol.36 , pp. 68-73
    • Kimmey, M.B.1
  • 6
    • 3042701257 scopus 로고    scopus 로고
    • Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: A consensus statement using a meta-analytic approach
    • Jul;
    • Richy F, Bruyere O, Ethgen O, Rabenda V, Bouvenot G, Audran M, et al. Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach. Annals of the rheumatic diseases. 2004 Jul;63(7):759-66.
    • (2004) Annals of the rheumatic diseases , vol.63 , Issue.7 , pp. 759-766
    • Richy, F.1    Bruyere, O.2    Ethgen, O.3    Rabenda, V.4    Bouvenot, G.5    Audran, M.6
  • 9
    • 0010619208 scopus 로고
    • Nonsteroidal antiinflammatory and anti-arthritic drugs
    • Blankley J, editor, New York, Academic press;
    • Gund P, Jensen NP. Nonsteroidal antiinflammatory and anti-arthritic drugs. In: Blankley J, editor. Quantitative structure activity relationships of drugs. New York.: Academic press; 1983. p. 285-326.
    • (1983) Quantitative structure activity relationships of drugs , pp. 285-326
    • Gund, P.1    Jensen, N.P.2
  • 10
    • 0002742794 scopus 로고
    • Nonsteroidal antiinflammatory drugs
    • Foye WO, editor, 5th ed. Philadelphia: Lea & Fabiger
    • Borne RF. Nonsteroidal antiinflammatory drugs. In: Foye WO, editor. Principles of medicinal chemistry. 5th ed. Philadelphia: Lea & Fabiger,; 1995, p. 535-79.
    • (1995) Principles of medicinal chemistry , pp. 535-579
    • Borne, R.F.1
  • 11
    • 34248670919 scopus 로고    scopus 로고
    • Preston PN. Benzimidazoles. In: Preston PN, editor. Chemistry of heterocyclic compounds: Benzimidazoles. New York: Wiley-Intrescience; 1980. p. 1-281.
    • Preston PN. Benzimidazoles. In: Preston PN, editor. Chemistry of heterocyclic compounds: Benzimidazoles. New York: Wiley-Intrescience; 1980. p. 1-281.
  • 12
    • 34248631743 scopus 로고
    • Benzoxazoles, Benzothiazoles and Benzimidazoles
    • Arians EJ, editor, New York: Academic press;
    • Cain CK, Reoszkowasky AP. Benzoxazoles, Benzothiazoles and Benzimidazoles. In: Arians EJ, editor. Medicinal Chemistry: Series of monographs. New York: Academic press; 1978. p. 325-57.
    • (1978) Medicinal Chemistry: Series of monographs , pp. 325-357
    • Cain, C.K.1    Reoszkowasky, A.P.2
  • 13
    • 0005471846 scopus 로고
    • Imidazole and it's derivatives
    • New York: Interscience Publishers;
    • Hofmann K. Imidazole and it's derivatives. Chemistry of Heterocyclic compounds. New York: Interscience Publishers; 1953. p. 247-324.
    • (1953) Chemistry of Heterocyclic compounds , pp. 247-324
    • Hofmann, K.1
  • 14
    • 0018878650 scopus 로고
    • Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles
    • Jul;
    • Tsukamoto G, Yoshino K, Kohno T, Ohtaka H, Kagaya H, Ito K. Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles. J Med Chem. 1980 Jul;23(7):734-8.
    • (1980) J Med Chem , vol.23 , Issue.7 , pp. 734-738
    • Tsukamoto, G.1    Yoshino, K.2    Kohno, T.3    Ohtaka, H.4    Kagaya, H.5    Ito, K.6
  • 15
    • 0020081657 scopus 로고
    • The studies of the mechanism of antiinflammatory action of 2-(5- ethylpyridin-2-yl)benzimidazole (KB-1043)
    • Ito K, Kagaya H, Satoh I, Tsukamoto G, Nose T. The studies of the mechanism of antiinflammatory action of 2-(5- ethylpyridin-2-yl)benzimidazole (KB-1043). Arzneimittelforschung. 1982;32(2):117-22.
    • (1982) Arzneimittelforschung , vol.32 , Issue.2 , pp. 117-122
    • Ito, K.1    Kagaya, H.2    Satoh, I.3    Tsukamoto, G.4    Nose, T.5
  • 16
    • 0020042950 scopus 로고
    • Pharmacological studies of a new non-steroidal antiinflammatory drug: 2- (5-ethylpyridin-2-yl)benzimidazole (KB-1043)
    • Ito K, Kagaya H, Fukuda T, Yoshino K, Nose T. Pharmacological studies of a new non-steroidal antiinflammatory drug: 2- (5-ethylpyridin-2-yl)benzimidazole (KB-1043). Arzneimittelforschung. 1982;32(1):49-55.
    • (1982) Arzneimittelforschung , vol.32 , Issue.1 , pp. 49-55
    • Ito, K.1    Kagaya, H.2    Fukuda, T.3    Yoshino, K.4    Nose, T.5
  • 17
    • 0022364666 scopus 로고    scopus 로고
    • Gilman SC, Carlson RP, Chang J, Lewis AJ. The antiinflammatory activity of the immunomodulator Wy-18,251 (3-(p- chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid). Agents Actions. 1985;17(1):53-9.
    • Gilman SC, Carlson RP, Chang J, Lewis AJ. The antiinflammatory activity of the immunomodulator Wy-18,251 (3-(p- chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid). Agents Actions. 1985;17(1):53-9.
  • 18
    • 84907113873 scopus 로고    scopus 로고
    • Gilman SC, Carlson RP, Lewis AJ. Immunomodulatory activity of Wy-18,251 (3-(p-chlorophenyl) thiazolo[3,2- a]benzimidazole-2-acetic acid). J Immunopharmacol. 1985;7(1):79-98.
    • Gilman SC, Carlson RP, Lewis AJ. Immunomodulatory activity of Wy-18,251 (3-(p-chlorophenyl) thiazolo[3,2- a]benzimidazole-2-acetic acid). J Immunopharmacol. 1985;7(1):79-98.
  • 19
    • 0023217782 scopus 로고
    • Benzimidazole derivatives with atypical antiinflammatory activity
    • Lazer ES, Matteo MR, Possanza GJ. Benzimidazole derivatives with atypical antiinflammatory activity. J Med Chem. 1987;30(4):726-9.
    • (1987) J Med Chem , vol.30 , Issue.4 , pp. 726-729
    • Lazer, E.S.1    Matteo, M.R.2    Possanza, G.J.3
  • 20
    • 0027175627 scopus 로고
    • Synthesis and antiinflammatory and analgesic properties of 2-amino-1H-benzimidazole and 1,2-dihydro -2-iminocycloheptimidazole derivatives
    • Taniguchi K, Shigenaga S, Ogahara T, Fujitsu T, Matsuo M. Synthesis and antiinflammatory and analgesic properties of 2-amino-1H-benzimidazole and 1,2-dihydro -2-iminocycloheptimidazole derivatives. Chem Pharm Bull (Tokyo). 1993;41(2):301-9.
    • (1993) Chem Pharm Bull (Tokyo) , vol.41 , Issue.2 , pp. 301-309
    • Taniguchi, K.1    Shigenaga, S.2    Ogahara, T.3    Fujitsu, T.4    Matsuo, M.5
  • 21
    • 0026319790 scopus 로고
    • Preparation and pharmacological activity of some 1-lupinylbenzimidazoles and 1-lupinylbenzotriazoles
    • Jun;
    • Boido A, Vazzana I, Sparatore F, Cenicola ML, Donnoli D, Marmo E. Preparation and pharmacological activity of some 1-lupinylbenzimidazoles and 1-lupinylbenzotriazoles. Farmaco. 1991 Jun;46(6):775-88.
    • (1991) Farmaco , vol.46 , Issue.6 , pp. 775-788
    • Boido, A.1    Vazzana, I.2    Sparatore, F.3    Cenicola, M.L.4    Donnoli, D.5    Marmo, E.6
  • 22
    • 0035818920 scopus 로고    scopus 로고
    • Da Settimo F, Primofiore G, Da Settimo A, La Motta C, Taliani S, Simorini F, et al. [1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors. J Med Chem. 2001;44(25):4359-69.
    • Da Settimo F, Primofiore G, Da Settimo A, La Motta C, Taliani S, Simorini F, et al. [1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors. J Med Chem. 2001;44(25):4359-69.
  • 23
    • 34248651028 scopus 로고    scopus 로고
    • Vogal AI. A Textbook of Practical Organic Chemistry. 3rd ed. London: ELBS & Longman Ltd; 1975. p. 225-36.
    • Vogal AI. A Textbook of Practical Organic Chemistry. 3rd ed. London: ELBS & Longman Ltd; 1975. p. 225-36.
  • 24
    • 0242513246 scopus 로고
    • The preparation and reactions of 2-Benzimidazole carboxylic acid and 2-Benzimidazoleacetic acid
    • Copeland RA, Day AR. The preparation and reactions of 2-Benzimidazole carboxylic acid and 2-Benzimidazoleacetic acid. Journal of American Chemical Society. 1943;65:1072-5.
    • (1943) Journal of American Chemical Society , vol.65 , pp. 1072-1075
    • Copeland, R.A.1    Day, A.R.2
  • 25
    • 34248665051 scopus 로고
    • Synthesis of benzimidazole-2-carboxamides as potential anti-histaminic agents
    • Rastogi R, Sharma S, Iyer RN. Synthesis of benzimidazole-2-carboxamides as potential anti-histaminic agents. Indian Journal of Chemistry. 1979;18B(464-467).
    • (1979) Indian Journal of Chemistry , vol.18 B , Issue.464-467
    • Rastogi, R.1    Sharma, S.2    Iyer, R.N.3
  • 27
    • 17344363481 scopus 로고    scopus 로고
    • Organization for Economic Co-operation and Development, Paris: Environment Directorate, OECD;
    • Organization for Economic Co-operation and Development. Guidance Document on Acute Oral Toxicity Testing. Paris: Environment Directorate, OECD; 2001.
    • (2001) Guidance Document on Acute Oral Toxicity Testing
  • 30
    • 0028808144 scopus 로고
    • Synthesis and inhibitory effects of 2-pyridyl-2-thiobenzoxazole and 2-pyridyl-2-thiobenzimidazole derivatives on arachidonic acid metabolism
    • Nov;
    • Lagorce JF, Fatimi J, Lakhdar M, Chabernaud ML, Buxeraud J, Raby C. Synthesis and inhibitory effects of 2-pyridyl-2-thiobenzoxazole and 2-pyridyl-2-thiobenzimidazole derivatives on arachidonic acid metabolism. Arzneimittelforschung. 1995 Nov;45(11):1207-10.
    • (1995) Arzneimittelforschung , vol.45 , Issue.11 , pp. 1207-1210
    • Lagorce, J.F.1    Fatimi, J.2    Lakhdar, M.3    Chabernaud, M.L.4    Buxeraud, J.5    Raby, C.6
  • 31
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Jun 23;
    • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature: New biology. 1971 Jun 23;231(25):232-5.
    • (1971) Nature: New biology , vol.231 , Issue.25 , pp. 232-235
    • Vane, J.R.1
  • 32
    • 0142165030 scopus 로고    scopus 로고
    • The mechanism of action of aspirin
    • Jun 15;
    • Vane JR, Botting RM. The mechanism of action of aspirin. Thrombosis research. 2003 Jun 15;110(5-6):255-8.
    • (2003) Thrombosis research , vol.110 , Issue.5-6 , pp. 255-258
    • Vane, J.R.1    Botting, R.M.2
  • 33
    • 0031787631 scopus 로고    scopus 로고
    • Anti-inflammatory drugs and their mechanism of action
    • Oct;
    • Vane JR, Botting RM. Anti-inflammatory drugs and their mechanism of action. Inflamm Res. 1998 Oct;47 Suppl 2:S78-87.
    • (1998) Inflamm Res , vol.47 , Issue.SUPPL. 2
    • Vane, J.R.1    Botting, R.M.2
  • 35
    • 24944565385 scopus 로고    scopus 로고
    • Pharmacological intervention of cyclooxygenase-2 and 5-lipoxygenase pathways. Impact on inflammation and cancer
    • Claria J, Romano M. Pharmacological intervention of cyclooxygenase-2 and 5-lipoxygenase pathways. Impact on inflammation and cancer. Current pharmaceutical design. 2005;11(26):3431-47.
    • (2005) Current pharmaceutical design , vol.11 , Issue.26 , pp. 3431-3447
    • Claria, J.1    Romano, M.2
  • 37
    • 0023571572 scopus 로고
    • Inflammation and the mechanism of action of anti-inflammatory drugs
    • Aug;
    • Vane J, Botting R. Inflammation and the mechanism of action of anti-inflammatory drugs. Faseb J. 1987 Aug;1(2):89-96.
    • (1987) Faseb J , vol.1 , Issue.2 , pp. 89-96
    • Vane, J.1    Botting, R.2
  • 38
    • 1542751777 scopus 로고    scopus 로고
    • Review in quantitative structure activity relationships on lipoxygenase inhibitors
    • Aug;
    • Eleni P, Dimitra HL. Review in quantitative structure activity relationships on lipoxygenase inhibitors. Mini reviews in medicinal chemistry. 2003 Aug;3(5):487-99.
    • (2003) Mini reviews in medicinal chemistry , vol.3 , Issue.5 , pp. 487-499
    • Eleni, P.1    Dimitra, H.L.2
  • 40
    • 0023164939 scopus 로고
    • Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters
    • Feb;
    • Musser JH, Kubrak DM, Chang J, DiZio SM, Hite M, Hand JM, et al. Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters. J Med Chem. 1987 Feb;30(2):400-5.
    • (1987) J Med Chem , vol.30 , Issue.2 , pp. 400-405
    • Musser, J.H.1    Kubrak, D.M.2    Chang, J.3    DiZio, S.M.4    Hite, M.5    Hand, J.M.6
  • 41
    • 0037527546 scopus 로고    scopus 로고
    • COX-LOX inhibition: Current evidence for an emerging new therapy
    • May;
    • Skelly MM, Hawkey CJ. COX-LOX inhibition: current evidence for an emerging new therapy. International journal of clinical practice. 2003 May;57(4):301-4.
    • (2003) International journal of clinical practice , vol.57 , Issue.4 , pp. 301-304
    • Skelly, M.M.1    Hawkey, C.J.2
  • 42
    • 0034751392 scopus 로고    scopus 로고
    • The ever-emerging anti-inflammatories. Have there been any real advances?
    • Jan-Dec;
    • Rainsford KD. The ever-emerging anti-inflammatories. Have there been any real advances? Journal of physiology, Paris. 2001 Jan-Dec;95(1-6):11-9.
    • (2001) Journal of physiology, Paris , vol.95 , Issue.1-6 , pp. 11-19
    • Rainsford, K.D.1
  • 43
    • 0027282447 scopus 로고
    • Mechanisms of gastrointestinal damage by NSAIDS
    • Rainsford KD. Mechanisms of gastrointestinal damage by NSAIDS. Agents and actions. 1993;44:59-64.
    • (1993) Agents and actions , vol.44 , pp. 59-64
    • Rainsford, K.D.1
  • 45
    • 37049149322 scopus 로고    scopus 로고
    • Chatterjee B. CCCC.-Attempts to find new antimalerials. Part IV. Beta-Benzimidazolylethylamine and beta-5(or 6)-Ethoxybenzimidazolylethylamine. Journal of Chemical Society. 1929:2965-668.
    • Chatterjee B. CCCC.-Attempts to find new antimalerials. Part IV. Beta-Benzimidazolylethylamine and beta-5(or 6)-Ethoxybenzimidazolylethylamine. Journal of Chemical Society. 1929:2965-668.
  • 46
    • 37049143395 scopus 로고
    • Structure and antimelerial activity. Part IV. Benzimidazoles and mercaptodihydroglyoxalines
    • James AT, Turner EE. Structure and antimelerial activity. Part IV. Benzimidazoles and mercaptodihydroglyoxalines. Journal of Chemical Society. 1950:1515-9.
    • (1950) Journal of Chemical Society , pp. 1515-1519
    • James, A.T.1    Turner, E.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.