Can intense exercise contribute to cardiovascular disease?

Future Cardiology

Volumn 3, Issue 3, 2007, Pages 243-248

  Majeed, Farhan ^a   Miller, Michael ^a  

^a UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; Endothelial dysfunction; Exercise; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CATECHOLAMINE; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRIC OXIDE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE;

ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CATECHOLAMINE RELEASE; CELL MIGRATION; CELL PROLIFERATION; CORONARY ARTERY DISEASE; CORONARY RISK; CYTOKINE PRODUCTION; DYNAMIC EXERCISE; ENDOTHELIAL DYSFUNCTION; ENERGY EXPENDITURE; EXERCISE INTENSITY; HUMAN; HYPERTENSION; ISOMETRIC EXERCISE; LEUKOCYTE ADHERENCE; MUSCLE INJURY; MUSCLE TRAINING; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROGNOSIS; STATIC EXERCISE; STOMACH MUSCLE; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE AGGREGATION; VASODILATATION;

EID: 34248643473     PISSN: 14796678     EISSN: 17448298     Source Type: Journal    
DOI: 10.2217/14796678.3.3.243     Document Type: Article

References (40)

1. Fletcher GF, Balady GJ, Amsterdam EA et al.: Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association. Cirulation 104(14), 1694-1740 (2001).
2. Powell KE, Blair SN: The public health burdens of sedentary living habits: theoretical but realistic estimates. Med. Sci. Sports Exerc. 26(7), 851-856 (1994).
3. Centers for Disease Control and Prevention: Prevalence of no leisure-time physical activity - 35 States and the District of Columbia, 1988-2002. Morb. Mortal. Wkly Rep. 53(4), 82-86 (2004).
4. Blair SN, Kohl HW, Paffenbarger RS et al.: Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 262 (17), 2395-2401 (1989).
5. Mayer-Davis EJ, D'Agostino, R, Karter AJ et al.: Intensity and amount of physical activity in relation to insulin sensitivity: the insulin resistance atherosclerosis study. JAMA 279(9), 669-674 (1998).
6. Pate RR, Pratt M, Blair SN et al.: Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 273(5), 402-407 (1995).
7. Mastaloudis A, Leonard SW, Traber MG: Oxidative stress in athletes during extreme endurance exercise. Free Radic. Biol. Med. 31(7), 911-922 (2001).
8. Goto C, Higashi Y, Kimura M et al.: Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation 108(5), 530-535 (2003).
9. Jenkins RR: Exercise and oxidative stress methodology: a critique. Am. J. Clin. Nutr. 72(Suppl. 2), S670-S674 (2000).
10. Goel R, Majeed F, Vogel R et al.: Exercise-induced hypertension, endothelial dysfunction, and coronary artery disease in a marathon runner. Am. J. Cardiol. 99(5), 743-744 (2007).
11. Mundal R, Kjeldsen SE, Sandvik L et al.: Exercise blood pressure predicts cardiovascular mortality in middle-aged men. Hypertension 24(1), 56-62 (1994).
12. Caspersen CJ, Powell KE, Christenson GM: Physical activity, exercise, and physical fitness. Public Health Rep. 100(2), 126-131 (1985).
13. Mitchell JH, Haskell W, Snell P, Van Camp SP: 36th Bethesda Conference: Eligibility recommendations for competitive athletes with cardiovascular abnormalities. Task Force 8: classification of sports. J. Am. Coll. Cardiol. 45(8), 1364-1367 (2005).
14. Griendling KK, FitzGerald GA: Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation 108(16), 1912-1916 (2003).
15. Frei B: Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am. J. Med. 97(3A), S5-S13 (1994).
16. Ji LL: Antioxidants and oxidative stress in exercise. Proc. Soc. Exp. Biol. Med. 222(3), 283-292 (1999).
17. Cooper CE, Vollaard NB, Choueiri T, Wilson MT: Exercise, free radicals and oxidative stress. Biochem. Soc. Trans. 30(2), 280-285 (2002).
18. Packer L: Oxidants, antioxidant nutrients and the athlete. J. Sports Sci. 15 (3), 353-363 (1997).
19. Banerjee AK, Mandal A, Chanda D, Chakraborti S: Oxidant, antioxidant and physical exercise. Mol. Cell Biochem. 253(1-2), 307-312 (2003).
20. Koyama K, Kaya M, Ishigaki T et al.: Role of xanthine oxidase in delayed lipid peroxidation in rat liver induced by acute exhausting exercise. Eur. J. Appl. Physiol. Occup. Physiol. 80(1), 28-33 (1999).
21. Janero DR: Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic. Biol. Med. 9(6), 515-540 (1990).
22. Leeuwenburgh C, Heinecke JW: Oxidative stress and antioxidants in exercise. Curr. Med. Chem. 8(7), 829-838 (2001).
23. Loscalzo J: Oxidative stress in endothelial cell dysfunction and thrombosis. Pathophysiol. Haemost. Thromb. 32(5-6), 359-360 (2002).
24. Davignon J, Ganz P: Role of endothelial dysfunction in atherosclerosis. Circulation 109(23 Suppl. 1), III27-III32 (2004).
25. Lundman P, Eriksson MJ, Stuhlinger M et al.: Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine. J. Am. Coll. Cardiol. 38(1), 111-116 (2001).
26. Shinozaki K, Hirayama A, Nishio, Y et al.: Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress. J. Am. Coll. Cardiol. 38(7), 1821-1828 (2001).
27. Poredos P: Endothelial dysfunction and cardiovascular disease. Pathophysiol. Haemost. Thromb. 32(5-6), 274-277 (2002).
28. Luscher TF, Barton M: Biology of the endothelium. Clin. Cardiol. 20(11 Suppl. 2), II3-II10 (1997).
29. Rubbo H, Trostchansky A, Botti H et al.: Interactions of nitric oxide and peroxynitrite with low-density lipoprotein. Biol. Chem. 383(3-4), 547-552 (2002).
30. Kinlay S, Libby P, Ganz P: Endothelial function and coronary artery disease. Curr. Opin. Lipidol. 12(4), 383-389 (2001).
31. Endres M, Laufs U, Huang Z et al.: Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc. Natl Acad. Sci. USA 95(15), 8880-8885 (1998).
32. John S, Schlaich M, Langenfeld M et al.: Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients: a randomized, placebo-controlled, double-blind study. Circulation 98(3), 211-216 (1998).
33. Vita JA, Treasure CB, Nabel EG et al.: Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 81(2), 491-497 (1990).
34. Schachinger V, Britten MB, Elsner M et al.: A positive family history of premature coronary artery disease is associated with impaired endothelium-dependent coronary blood flow regulation. Circulation 100(14), 1502-1508 (1999).
35. Suwaidi JA, Hamasaki S, Higano ST et al.: Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 101(9), 948-954 (2000).
36. Schachinger V, Britten MB, Zeiher AM: Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101(16), 1899-1906 (2000).
37. Kuvin JT, Patel AR, Sliney KA et al.: Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease. J. Am. Coll. Cardiol. 38(7), 1843-1849 (2001).
38. Morales MC, Coplan NL, Zabetakis P, Gleim GW: Hypertension: the acute and chronic response to exercise. Am. Heart J. 122(1 Pt 1), 264-266 (1991).
39. Avolio AP, Deng FQ, Li WQ et al.: Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation 71(2), 202-210 (1985).
40. Gottdiener JS, Brown J, Zoltick J, Fletcher RD: Left ventricular hypertrophy in men with normal blood pressure: relation to exaggerated blood pressure response to exercise. Ann. Intern. Med. 112(3), 161-166 (1990).