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Volumn 4, Issue 3, 2007, Pages 215-234

The rejuvenated pressurised metered dose inhaler

Author keywords

Breath actuated inhaler; Dry powder inhaler; Pressurised metered dose inhaler; Spacer device

Indexed keywords

ADRENALIN; ALCOHOL; AMILORIDE; ANTIOXIDANT; BECLOMETASONE DIPROPIONATE; CHLOROFLUOROCARBON; CICLESONIDE; CROMOGLYCATE DISODIUM; CRYOFLUORANE; CYCLOSPORIN A; ERGOTAMINE; EVOHALER; FENOTEROL; FENTANYL; FLAVORING AGENT; FLUNISOLIDE; FLUORINATED HYDROCARBON; FLUTICASONE PROPIONATE; ISOPRENALINE; LACTOSE; LEUPRORELIN; NEDOCROMIL SODIUM; OLEIC ACID; PHENYLEPHRINE; PHOSPHATIDYLCHOLINE; PIRBUTEROL; PIRBUTEROL ACETATE; SALBUTAMOL; SALBUTAMOL SULFATE; UNCLASSIFIED DRUG;

EID: 34248639855     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.4.3.215     Document Type: Review
Times cited : (59)

References (154)
  • 1
    • 33644629923 scopus 로고    scopus 로고
    • History of aerosol therapy; liquid nebulization to MDIs and DPIs
    • ANDERSON PJ: History of aerosol therapy; liquid nebulization to MDIs and DPIs. Respir. Care (2005) 50:1139-1150.
    • (2005) Respir. Care , vol.50 , pp. 1139-1150
    • ANDERSON, P.J.1
  • 3
    • 34248670724 scopus 로고    scopus 로고
    • THIEL CG: From Susie's question to CFC free: an inventor's perspective on forty years of MDI development and regulation. In: Respiratory Drug Delivery V. Dalby RN, Byron PR, Farr SJ (Eds, Interpharm Press, Buffalo Grove (1996):115-123
    • THIEL CG: From Susie's question to CFC free: an inventor's perspective on forty years of MDI development and regulation. In: Respiratory Drug Delivery V. Dalby RN, Byron PR, Farr SJ (Eds). Interpharm Press, Buffalo Grove (1996):115-123.
  • 4
    • 0033942711 scopus 로고    scopus 로고
    • Metered dose inhalers, dry powder inhalers and transitions
    • FINK JB: Metered dose inhalers, dry powder inhalers and transitions. Respir. Care (2000) 45:623-635.
    • (2000) Respir. Care , vol.45 , pp. 623-635
    • FINK, J.B.1
  • 6
    • 33846588739 scopus 로고
    • The challenges in the development of metered-dose inhalation aerosols using ozone-friendly propellants
    • TANSEY IP: The challenges in the development of metered-dose inhalation aerosols using ozone-friendly propellants. Proceedings of the First European Pharm. Tech. Conference, Dusseldorf (1993):182-187.
    • (1993) Proceedings of the First European Pharm. Tech. Conference, Dusseldorf , pp. 182-187
    • TANSEY, I.P.1
  • 7
    • 0037346651 scopus 로고    scopus 로고
    • The inhalers of the future? A review of dry powder devices on the market today
    • SMITH IJ, PARRY-BILLINGS M: The inhalers of the future? A review of dry powder devices on the market today. Pulm. Pharmacol. Ther. (2003) 16:79-95.
    • (2003) Pulm. Pharmacol. Ther , vol.16 , pp. 79-95
    • SMITH, I.J.1    PARRY-BILLINGS, M.2
  • 8
    • 4444364706 scopus 로고    scopus 로고
    • A review of the development of Respimat soft mist inhaler
    • DALBY R, SPALLEK M, VOSHAAR T: A review of the development of Respimat soft mist inhaler. Int. J. Pharm. (2004) 283:1-9.
    • (2004) Int. J. Pharm , vol.283 , pp. 1-9
    • DALBY, R.1    SPALLEK, M.2    VOSHAAR, T.3
  • 9
    • 0036882590 scopus 로고    scopus 로고
    • Medical aerosol propellants
    • NOAKES T: Medical aerosol propellants. J. Fluorine Chem. (2002) 118:35-45.
    • (2002) J. Fluorine Chem , vol.118 , pp. 35-45
    • NOAKES, T.1
  • 11
    • 0001923877 scopus 로고
    • The formulation and evaluation of pressurised metered dose inhalers
    • Ganderton D, Jones T Eds, Ellis Horwood, Chichester
    • HALLWORTH GW: The formulation and evaluation of pressurised metered dose inhalers. In: Drug delivery to the respiratory tract. Ganderton D, Jones T (Eds). Ellis Horwood, Chichester (1987):87-118.
    • (1987) Drug delivery to the respiratory tract , pp. 87-118
    • HALLWORTH, G.W.1
  • 12
    • 33846636423 scopus 로고    scopus 로고
    • Principles of metered-dose inhaler design
    • NEWMAN SP: Principles of metered-dose inhaler design. Respir. Care (2005) 50:1177-1190.
    • (2005) Respir. Care , vol.50 , pp. 1177-1190
    • NEWMAN, S.P.1
  • 13
    • 85142589733 scopus 로고
    • Aerosol formulation, generation and delivery using metered systems
    • Byron PR Ed, CRC Press, Boca Raton
    • BYRON PR: Aerosol formulation, generation and delivery using metered systems. In: Respiratory Drug Delivery. Byron PR (Ed.). CRC Press, Boca Raton (1991):167-205.
    • (1991) Respiratory Drug Delivery , pp. 167-205
    • BYRON, P.R.1
  • 14
    • 0015766020 scopus 로고
    • Variation in delivery of isoprenaline from various pressurized inhalers
    • P
    • BELL JH, BROWN K, GLASBY J: Variation in delivery of isoprenaline from various pressurized inhalers. J. Pharm. Pharmacol. (1973) 25(Suppl.):32P-36P.
    • (1973) J. Pharm. Pharmacol , vol.25 , Issue.SUPPL.
    • BELL, J.H.1    BROWN, K.2    GLASBY, J.3
  • 15
    • 0029926013 scopus 로고    scopus 로고
    • MDIs: Physics of aerosol formation
    • CLARK AR: MDIs: physics of aerosol formation. J. Aerosol Med. (1996) 9(Suppl. 1):S19-S26.
    • (1996) J. Aerosol Med , vol.9 , Issue.SUPPL. 1
    • CLARK, A.R.1
  • 16
    • 0007948246 scopus 로고    scopus 로고
    • Theoretical investigation of the spray from a pressurized metered-dose inhaler
    • DUNBAR CA, WATKINS AP, MILLER JF: Theoretical investigation of the spray from a pressurized metered-dose inhaler. Atomisation and Sprays (1997) 7:417-436.
    • (1997) Atomisation and Sprays , vol.7 , pp. 417-436
    • DUNBAR, C.A.1    WATKINS, A.P.2    MILLER, J.F.3
  • 17
    • 34248657336 scopus 로고    scopus 로고
    • VERSTEEG HK, HARGRAVE GK: Fundamentals and resilience of the original MDI actuator design. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):91-100.
    • VERSTEEG HK, HARGRAVE GK: Fundamentals and resilience of the original MDI actuator design. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):91-100.
  • 18
    • 0016331630 scopus 로고
    • Studies of the factors controlling the action of hair sprays
    • RANCE RW: Studies of the factors controlling the action of hair sprays. J. Soc. Cosmet. Chem. (1974) 25:545-561.
    • (1974) J. Soc. Cosmet. Chem , vol.25 , pp. 545-561
    • RANCE, R.W.1
  • 19
    • 0032764740 scopus 로고    scopus 로고
    • A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers
    • GABRIO BJ, STEIN SW, VELASQUEZ DJ: A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers. Int. J. Pharm. (1999) 186:3-12.
    • (1999) Int. J. Pharm , vol.186 , pp. 3-12
    • GABRIO, B.J.1    STEIN, S.W.2    VELASQUEZ, D.J.3
  • 20
    • 0019825227 scopus 로고
    • Optimal delivery of aerosols from metered dose inhalers
    • DOLOVICH M, RUFFIN RE, ROBERTS R, NEWHOUSE MT: Optimal delivery of aerosols from metered dose inhalers. Chest (1981) 80(Suppl.):911-915.
    • (1981) Chest , vol.80 , Issue.SUPPL. , pp. 911-915
    • DOLOVICH, M.1    RUFFIN, R.E.2    ROBERTS, R.3    NEWHOUSE, M.T.4
  • 21
    • 0019809804 scopus 로고
    • The labelling and monitoring of lung deposition of an inhaled synthetic anticholinergic bronchodilating agent
    • SHORT MD, SINGH CA, FEW JD, STUDDY PT, HEAF PJD, SPIRO SG: The labelling and monitoring of lung deposition of an inhaled synthetic anticholinergic bronchodilating agent. Chest (1981) 80(Suppl.):918-921.
    • (1981) Chest , vol.80 , Issue.SUPPL. , pp. 918-921
    • SHORT, M.D.1    SINGH, C.A.2    FEW, J.D.3    STUDDY, P.T.4    HEAF, P.J.D.5    SPIRO, S.G.6
  • 22
    • 0020317462 scopus 로고
    • Effects of various inhalation modes on the deposition of radioactive pressurised aerosols
    • NEWMAN SP, PAVIA D, GARLAND N, CLARKE SW: Effects of various inhalation modes on the deposition of radioactive pressurised aerosols. Eur. J. Respir. Dis. (1982) 63(Suppl. 119):57-65.
    • (1982) Eur. J. Respir. Dis , vol.63 , Issue.SUPPL. 119 , pp. 57-65
    • NEWMAN, S.P.1    PAVIA, D.2    GARLAND, N.3    CLARKE, S.W.4
  • 23
    • 0027288701 scopus 로고
    • Investigations of an optimal inhaler technique with the use of urinary salbutamol excretion as a measure of relative bioavailability to the lung
    • HINDLE M, NEWTON DAG, CHRYSTYN H: Investigations of an optimal inhaler technique with the use of urinary salbutamol excretion as a measure of relative bioavailability to the lung. Thorax (1993) 48:607-610.
    • (1993) Thorax , vol.48 , pp. 607-610
    • HINDLE, M.1    NEWTON, D.A.G.2    CHRYSTYN, H.3
  • 24
    • 0027478534 scopus 로고
    • Scintigraphic assessment of therapeutic aerosols
    • NEWMAN SP: Scintigraphic assessment of therapeutic aerosols. Crit. Rev. Ther. Drug Carrier Syst. (1993) 10:65-109.
    • (1993) Crit. Rev. Ther. Drug Carrier Syst , vol.10 , pp. 65-109
    • NEWMAN, S.P.1
  • 25
    • 0025951893 scopus 로고
    • Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique
    • NEWMAN SP, WEISZ AWB, TALAEE N, CLARKE SW: Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique. Thorax (1991) 46:712-716.
    • (1991) Thorax , vol.46 , pp. 712-716
    • NEWMAN, S.P.1    WEISZ, A.W.B.2    TALAEE, N.3    CLARKE, S.W.4
  • 26
    • 0016322177 scopus 로고
    • Stratospheric sink for chlorofluoromethanes: Chlorine atomcatalysed destruction of ozone
    • MOLINA MJ, ROWLANDS FS: Stratospheric sink for chlorofluoromethanes: chlorine atomcatalysed destruction of ozone. Nature (1974) 249:1810-1812.
    • (1974) Nature , vol.249 , pp. 1810-1812
    • MOLINA, M.J.1    ROWLANDS, F.S.2
  • 28
    • 84926367529 scopus 로고    scopus 로고
    • Propellants
    • Bisgaard H, O'Callaghan C, Smaldone GC (Eds) Marcel Dekker, New York
    • PARTRIDGE MR, WOODCOCK AA: Propellants. In: Drug Delivery to the Lung. Bisgaard H, O'Callaghan C, Smaldone GC (Eds) Marcel Dekker, New York (2002):371-388.
    • (2002) Drug Delivery to the Lung , pp. 371-388
    • PARTRIDGE, M.R.1    WOODCOCK, A.A.2
  • 29
    • 0020612740 scopus 로고
    • Pressurised aerosol inhaler technique: How important are inhalation from residual volume, inspiratory flow rate and time interval between puffs?
    • LAWFORD P, MCKENZIE D: Pressurised aerosol inhaler technique: how important are inhalation from residual volume, inspiratory flow rate and time interval between puffs? Br. J. Dis. Chest (1983) 77:276-281.
    • (1983) Br. J. Dis. Chest , vol.77 , pp. 276-281
    • LAWFORD, P.1    MCKENZIE, D.2
  • 30
    • 0019434776 scopus 로고
    • How should a pressuriscd β-adrenergic bronchodilator be inhaled?
    • NEWMAN SP, PAVIA D, CLARKE SW: How should a pressuriscd β-adrenergic bronchodilator be inhaled? Eur. J. Respir. Dis. (1981) 62:3-20.
    • (1981) Eur. J. Respir. Dis , vol.62 , pp. 3-20
    • NEWMAN, S.P.1    PAVIA, D.2    CLARKE, S.W.3
  • 31
    • 0018654030 scopus 로고
    • Enhanced responses to aerosolised bronchodilator therapy in asthma using respiratory maneuvers
    • RILEY DJ, LIU RT, EDELMAN NH: Enhanced responses to aerosolised bronchodilator therapy in asthma using respiratory maneuvers. Chest (1979) 76:501-507.
    • (1979) Chest , vol.76 , pp. 501-507
    • RILEY, D.J.1    LIU, R.T.2    EDELMAN, N.H.3
  • 32
    • 0020322578 scopus 로고
    • Problems patients have using pressurised aerosol inhalers
    • CROMPTON GK: Problems patients have using pressurised aerosol inhalers. Eur. J. Respir. Dis. (1982) 63(Suppl. 119):57-65.
    • (1982) Eur. J. Respir. Dis , vol.63 , Issue.SUPPL. 119 , pp. 57-65
    • CROMPTON, G.K.1
  • 33
    • 0141540767 scopus 로고    scopus 로고
    • Assessment of handling of inhaler devices in real life: An observational study in 3811 patients in primary care
    • MOLIMARD M, RAHERISON C, LIGNOT S, DEPONT F, ABOUELFATH A, MOORE N: Assessment of handling of inhaler devices in real life: an observational study in 3811 patients in primary care. J. Aerosol Med. (2003) 16:249-254.
    • (2003) J. Aerosol Med , vol.16 , pp. 249-254
    • MOLIMARD, M.1    RAHERISON, C.2    LIGNOT, S.3    DEPONT, F.4    ABOUELFATH, A.5    MOORE, N.6
  • 34
    • 0023109201 scopus 로고
    • Clinical consequences of inadequate inhalation technique in asthma therapy
    • LINDGREN S, BAKE B, LARSSON S: Clinical consequences of inadequate inhalation technique in asthma therapy. Eur. J. Respir. Dis. (1987) 70:93-98.
    • (1987) Eur. J. Respir. Dis , vol.70 , pp. 93-98
    • LINDGREN, S.1    BAKE, B.2    LARSSON, S.3
  • 35
    • 0036178365 scopus 로고    scopus 로고
    • Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability
    • GIRAUD V, ROCHE N: Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability. Eur. Respir. J. (2002) 19:246-251.
    • (2002) Eur. Respir. J , vol.19 , pp. 246-251
    • GIRAUD, V.1    ROCHE, N.2
  • 36
    • 0015133119 scopus 로고
    • Dry powder aerosols I: A new powder inhalation device
    • BELL JH, HARTLEY PS, COX JSG: Dry powder aerosols I: a new powder inhalation device. J. Pharm. Sci. (1971) 10:1559-1564.
    • (1971) J. Pharm. Sci , vol.10 , pp. 1559-1564
    • BELL, J.H.1    HARTLEY, P.S.2    COX, J.S.G.3
  • 37
    • 0017761983 scopus 로고
    • An improved design of powder inhaler
    • HALLWORTH GW: An improved design of powder inhaler. Br. J. Clin. Pharmacol. (1977) 4:689-690.
    • (1977) Br. J. Clin. Pharmacol , vol.4 , pp. 689-690
    • HALLWORTH, G.W.1
  • 38
    • 0024062977 scopus 로고    scopus 로고
    • Turbuhaler: A new powder inhaler for administration of drugs to the airways
    • WETTERLIN K: Turbuhaler: a new powder inhaler for administration of drugs to the airways. Pharm. Res. (1998) 5:506-508.
    • (1998) Pharm. Res , vol.5 , pp. 506-508
    • WETTERLIN, K.1
  • 41
    • 0344513087 scopus 로고    scopus 로고
    • Pulmonary drug delivery. Part 1: Physiological factors affecting therapeutic effectiveness of aerosolised medications
    • LABIRIS NR, DOLOVICH MB: Pulmonary drug delivery. Part 1: physiological factors affecting therapeutic effectiveness of aerosolised medications. Br. J. Clin. Pharmacol. (2003) 56:588-599.
    • (2003) Br. J. Clin. Pharmacol , vol.56 , pp. 588-599
    • LABIRIS, N.R.1    DOLOVICH, M.B.2
  • 42
    • 0001867570 scopus 로고
    • Aerosol dosage forms and formulations
    • Morén F, Dolovich MB, Newhouse MT, Newman SP Eds, Elsevier, Amsterdam
    • MORÉN F: Aerosol dosage forms and formulations. In: Aerosols in Medicine: principles, diagnosis and therapy. Morén F, Dolovich MB, Newhouse MT, Newman SP (Eds). Elsevier, Amsterdam (1993):321-350.
    • (1993) Aerosols in Medicine: Principles, diagnosis and therapy , pp. 321-350
    • MORÉN, F.1
  • 43
    • 0346311616 scopus 로고    scopus 로고
    • New developments in dry powder inhaler technology
    • October:27-45
    • PEART J, CLARKE MJ: New developments in dry powder inhaler technology. Am. Pharm. Rev. (2001) October:27-45.
    • (2001) Am. Pharm. Rev
    • PEART, J.1    CLARKE, M.J.2
  • 44
    • 0344943933 scopus 로고    scopus 로고
    • Pulmonary drug delivery. Part 2: The role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolised medications
    • LABIRIS NR, DOLOVICH MB: Pulmonary drug delivery. Part 2: the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolised medications. Br. J. Clin. Pharmacol. (2003) 56:600-612.
    • (2003) Br. J. Clin. Pharmacol , vol.56 , pp. 600-612
    • LABIRIS, N.R.1    DOLOVICH, M.B.2
  • 45
    • 33644644745 scopus 로고    scopus 로고
    • Dry powder inhalers: An overview
    • ATKINS PJ: Dry powder inhalers: an overview. Respir. Care (2005) 50:1304-1312.
    • (2005) Respir. Care , vol.50 , pp. 1304-1312
    • ATKINS, P.J.1
  • 47
    • 29744453224 scopus 로고    scopus 로고
    • Problems with inhaler use: A call for improved clinician and patient education
    • FINK JB, RUBIN BK: Problems with inhaler use: a call for improved clinician and patient education. Respir. Care (2005) 50:1360-1375.
    • (2005) Respir. Care , vol.50 , pp. 1360-1375
    • FINK, J.B.1    RUBIN, B.K.2
  • 48
    • 33845412883 scopus 로고    scopus 로고
    • The way forward: Dry powder inhalers should only be switched with physician agreement and patient training
    • PRICE D: The way forward: dry powder inhalers should only be switched with physician agreement and patient training. Int. J. Clin. Pract. (2005) 59(Suppl. 59):36.
    • (2005) Int. J. Clin. Pract , vol.59 , Issue.SUPPL. 59 , pp. 36
    • PRICE, D.1
  • 49
    • 0020611366 scopus 로고
    • Physician knowledge in the use of canister nebulisers
    • KELLING JS, STROHL KP, SMITH RL, ALTOSE MD: Physician knowledge in the use of canister nebulisers. Chest (1983) 83:612-614.
    • (1983) Chest , vol.83 , pp. 612-614
    • KELLING, J.S.1    STROHL, K.P.2    SMITH, R.L.3    ALTOSE, M.D.4
  • 50
    • 0027492869 scopus 로고
    • Pharmacist knowledge and ability to use inhaled medication delivery systems
    • KESTEN S, ZIVE K, CHAPMAN KR: Pharmacist knowledge and ability to use inhaled medication delivery systems. Chest (1993) 104:1737-1742.
    • (1993) Chest , vol.104 , pp. 1737-1742
    • KESTEN, S.1    ZIVE, K.2    CHAPMAN, K.R.3
  • 51
    • 33644649189 scopus 로고    scopus 로고
    • Determinants of patient adherence to an aerosol regimen
    • RAU JL: Determinants of patient adherence to an aerosol regimen. Respir. Care (2005) 50:1346-1359.
    • (2005) Respir. Care , vol.50 , pp. 1346-1359
    • RAU, J.L.1
  • 52
    • 33644621503 scopus 로고    scopus 로고
    • The CFC to HFA transition and its impact on pulmonary drug development
    • LEACH CL: The CFC to HFA transition and its impact on pulmonary drug development. Respir. Care (2005) 50:1201-1208.
    • (2005) Respir. Care , vol.50 , pp. 1201-1208
    • LEACH, C.L.1
  • 53
    • 34248649912 scopus 로고    scopus 로고
    • ATKINS PJ: Transition to HFA MDIs: how did we get there and where are we going? In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):83-90.
    • ATKINS PJ: Transition to HFA MDIs: how did we get there and where are we going? In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):83-90.
  • 54
    • 0029091264 scopus 로고
    • The challenge of reformulation
    • SMITH IJ: The challenge of reformulation. J. Aerosol Med. (1995) 8:S19-S27.
    • (1995) J. Aerosol Med , vol.8
    • SMITH, I.J.1
  • 55
    • 0032790248 scopus 로고    scopus 로고
    • Drug-surfactant-propellant interactions in HFA-formulations
    • VERVAET C, BYRON PR: Drug-surfactant-propellant interactions in HFA-formulations. Int. J. Pharm. (1999) 186:13-20.
    • (1999) Int. J. Pharm , vol.186 , pp. 13-20
    • VERVAET, C.1    BYRON, P.R.2
  • 57
    • 0037717965 scopus 로고    scopus 로고
    • Design and utility of a novel class of biocompatible excipients for HFA-based MDIs
    • Dalby RN, Byron PR, Farr SJ, Peart J Eds, Serentec Press, Raleigh
    • STEFELY JS, DUAN DC, MYRDAL PB, ROSS DL, SCHULTZ DW, LEACH CL: Design and utility of a novel class of biocompatible excipients for HFA-based MDIs. In: Respiratory Drug Delivery VII. Dalby RN, Byron PR, Farr SJ, Peart J (Eds). Serentec Press, Raleigh (2000):83-90.
    • (2000) Respiratory Drug Delivery VII , pp. 83-90
    • STEFELY, J.S.1    DUAN, D.C.2    MYRDAL, P.B.3    ROSS, D.L.4    SCHULTZ, D.W.5    LEACH, C.L.6
  • 58
    • 0141823535 scopus 로고    scopus 로고
    • Equipping the MDI for the 21st century by expanding its formulation options
    • Dalby RN, Byron PR, Peart J, Farr SJ Eds, Davis Horwood, Raleigh
    • STEFELY JS, BROWN B, HAMMERBECK DM, STEIN SW: Equipping the MDI for the 21st century by expanding its formulation options. In: Respiratory Drug Delivery VIII. Dalby RN, Byron PR, Peart J, Farr SJ (Eds). Davis Horwood, Raleigh (2002):207-214.
    • (2002) Respiratory Drug Delivery VIII , pp. 207-214
    • STEFELY, J.S.1    BROWN, B.2    HAMMERBECK, D.M.3    STEIN, S.W.4
  • 59
    • 0033894918 scopus 로고    scopus 로고
    • Pharmaceutical transition to non-CFC pressurized metered dose inhalers
    • CRIPPS A, RIEBE M, SCHULZE M, WOODHOUSE R: Pharmaceutical transition to non-CFC pressurized metered dose inhalers. Respir. Med. (2000) 94(Suppl. B):S3-S9.
    • (2000) Respir. Med , vol.94 , Issue.SUPPL. B
    • CRIPPS, A.1    RIEBE, M.2    SCHULZE, M.3    WOODHOUSE, R.4
  • 60
    • 14844363292 scopus 로고    scopus 로고
    • Development and performance of a new hydrofluoroalkane (HFA-134a) based metered dose inhaler of salbutamol
    • PEYRON ID, BRITTO IL, BENISSAN LB, TARDIEU BZ: Development and performance of a new hydrofluoroalkane (HFA-134a) based metered dose inhaler of salbutamol. Respir. Med. (2005) 99(Suppl. A):S20-S30.
    • (2005) Respir. Med , vol.99 , Issue.SUPPL. A
    • PEYRON, I.D.1    BRITTO, I.L.2    BENISSAN, L.B.3    TARDIEU, B.Z.4
  • 61
    • 0036036475 scopus 로고    scopus 로고
    • Lung deposition of hydrofluroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: A cross-over study in healthy volunteers
    • LEACH CL, DAVIDSON PJ, HASSELQUIST BE, BOUDREAU RJ: Lung deposition of hydrofluroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: a cross-over study in healthy volunteers. Chest (2002) 122:510-516.
    • (2002) Chest , vol.122 , pp. 510-516
    • LEACH, C.L.1    DAVIDSON, P.J.2    HASSELQUIST, B.E.3    BOUDREAU, R.J.4
  • 62
    • 11144283302 scopus 로고    scopus 로고
    • Modulite: A means of designing the aerosols generated by pressurized metered dose inhalers
    • GANDERTON D, LEWIS D, DAVIES R, MEAKIN B, BRAMBILLA G, CHURCH T: Modulite: a means of designing the aerosols generated by pressurized metered dose inhalers. Respir. Med. (2002) 96(Suppl. D):S3-S8.
    • (2002) Respir. Med , vol.96 , Issue.SUPPL. D
    • GANDERTON, D.1    LEWIS, D.2    DAVIES, R.3    MEAKIN, B.4    BRAMBILLA, G.5    CHURCH, T.6
  • 63
    • 0038433196 scopus 로고    scopus 로고
    • The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers
    • SMYTH HDC: The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers. Advanced Drug Delivery Revs. (2003) 55:807-828.
    • (2003) Advanced Drug Delivery Revs , vol.55 , pp. 807-828
    • SMYTH, H.D.C.1
  • 64
    • 33745620446 scopus 로고    scopus 로고
    • Spray pattern analysis for metered dose inhalers: Effect of actuator design
    • SMYTH H, BRACE G, BARBOUR T, GALLION J, GROVE J, HICKEY AJ: Spray pattern analysis for metered dose inhalers: effect of actuator design. Pharm. Res. (2006) 23:1591-1596.
    • (2006) Pharm. Res , vol.23 , pp. 1591-1596
    • SMYTH, H.1    BRACE, G.2    BARBOUR, T.3    GALLION, J.4    GROVE, J.5    HICKEY, A.J.6
  • 65
    • 33747359072 scopus 로고    scopus 로고
    • Theory and practice with solution systems
    • Eds, Davis Healthcare International, River Grove, Illinois
    • LEWIS DA, GANDERTON D, MEAKIN BJ, BRAMBILLA G: Theory and practice with solution systems. In: Respiratory Drug Delivery IX. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2004):109-115.
    • (2004) Respiratory Drug Delivery IX , pp. 109-115
    • LEWIS, D.A.1    GANDERTON, D.2    MEAKIN, B.J.3    BRAMBILLA, G.4
  • 66
    • 0036688484 scopus 로고    scopus 로고
    • Modulite technology: Pharmacodynamic and pharmacokinetic implications
    • WOODCOCK A, ACERBI D, POLI G: Modulite technology: pharmacodynamic and pharmacokinetic implications. Respir. Med. (2002) 96(Suppl. D):S9-S15.
    • (2002) Respir. Med , vol.96 , Issue.SUPPL. D
    • WOODCOCK, A.1    ACERBI, D.2    POLI, G.3
  • 67
    • 34248655966 scopus 로고    scopus 로고
    • LEWIS DA, MEAKIN BJ, BRAMBILLA G: New actuators versus old: reasons and results for actuator modifications for HFA solution MDIs. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):101-110.
    • LEWIS DA, MEAKIN BJ, BRAMBILLA G: New actuators versus old: reasons and results for actuator modifications for HFA solution MDIs. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):101-110.
  • 69
    • 33846642473 scopus 로고
    • Chlorofluorocarbon propellants in self-propelled containers; addition to list of essential uses
    • FOOD AND DRUG ADMINISTRATION
    • FOOD AND DRUG ADMINISTRATION: Chlorofluorocarbon propellants in self-propelled containers; addition to list of essential uses. Federal Register (1993) 58:6086-6088.
    • (1993) Federal Register , vol.58 , pp. 6086-6088
  • 70
  • 71
    • 25844472597 scopus 로고    scopus 로고
    • Comparison of the aerosol velocity and spray duration of Respimat soft mist inhaler and pressurized metered dose inhaler
    • HOCHRAINER D, HÖLZ H, KREHER C, SCAFFIDI L, SPALLEK M, WACHTEL H: Comparison of the aerosol velocity and spray duration of Respimat soft mist inhaler and pressurized metered dose inhaler. J. Aerosol Med. (2005) 18:273-282.
    • (2005) J. Aerosol Med , vol.18 , pp. 273-282
    • HOCHRAINER, D.1    HÖLZ, H.2    KREHER, C.3    SCAFFIDI, L.4    SPALLEK, M.5    WACHTEL, H.6
  • 73
    • 0032438394 scopus 로고    scopus 로고
    • Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone
    • LEACH CL, DAVIDSON PJ, BOUDREAU RJ: Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur. Respir. J. (1998) 12:1346-1353.
    • (1998) Eur. Respir. J , vol.12 , pp. 1346-1353
    • LEACH, C.L.1    DAVIDSON, P.J.2    BOUDREAU, R.J.3
  • 74
    • 0033431716 scopus 로고    scopus 로고
    • Efficacy response of inhaled beclomethasone dipropionate in asthma is proportional to dose and is improved by formulation with a new propellant
    • BUSSE WW, BRAZINSKY S, JACOBSON K et al.: Efficacy response of inhaled beclomethasone dipropionate in asthma is proportional to dose and is improved by formulation with a new propellant. J. Allergy Clin. Immunol. (1999) 104:1215-1222.
    • (1999) J. Allergy Clin. Immunol , vol.104 , pp. 1215-1222
    • BUSSE, W.W.1    BRAZINSKY, S.2    JACOBSON, K.3
  • 75
    • 23744496889 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of inhaled beclomethasone dipropionate delivered via hydrofluoroalkane-containing devices
    • DEROM E, PAUWELS RA: Pharmacokinetic and pharmacodynamic properties of inhaled beclomethasone dipropionate delivered via hydrofluoroalkane-containing devices. Clin. Pharmacokinet. (2005) 44:815-836.
    • (2005) Clin. Pharmacokinet , vol.44 , pp. 815-836
    • DEROM, E.1    PAUWELS, R.A.2
  • 76
    • 0036959184 scopus 로고    scopus 로고
    • Local versus total systemic bioavailability of beclomethasone dipropionate CFC and HEA metered dose inhaler formulations
    • HARRISON LI: Local versus total systemic bioavailability of beclomethasone dipropionate CFC and HEA metered dose inhaler formulations. J. Aerosol Med. (2002) 15:401-406.
    • (2002) J. Aerosol Med , vol.15 , pp. 401-406
    • HARRISON, L.I.1
  • 77
    • 0033801553 scopus 로고    scopus 로고
    • HFA-BDP and its implications for the quiet zone
    • TASHKIN DP: HFA-BDP and its implications for the quiet zone. Respir. Med. (2000) 94(Suppl. D):S37-S39.
    • (2000) Respir. Med , vol.94 , Issue.SUPPL. D
    • TASHKIN, D.P.1
  • 78
    • 34248643776 scopus 로고    scopus 로고
    • Using gamma scintigraphy and single photon emission computed tomography to assess the pulmonary deposition of a new inhaled formulation of flunisolide, The Aerosol Society, Portishead 2002
    • NEWMAN SP, PITCAIRN GR, KALIRAI CS et al.: Using gamma scintigraphy and single photon emission computed tomography to assess the pulmonary deposition of a new inhaled formulation of flunisolide. In: Drug Delivery to the Lungs XIII. The Aerosol Society, Portishead (2002):87-90.
    • Drug Delivery to the Lungs XIII , pp. 87-90
    • NEWMAN, S.P.1    PITCAIRN, G.R.2    KALIRAI, C.S.3
  • 79
    • 33745601984 scopus 로고    scopus 로고
    • Two-dimensional and three-dimensional imaging show ciclesonide has high lung deposition and peripheral distribution: A non-randmized study in healthy volunteers
    • LEACH CT, BETHKE TD, BOUDREAU RJ et al.: Two-dimensional and three-dimensional imaging show ciclesonide has high lung deposition and peripheral distribution: a non-randmized study in healthy volunteers. J. Aerosol Med. (2006) 19:117-126.
    • (2006) J. Aerosol Med , vol.19 , pp. 117-126
    • LEACH, C.T.1    BETHKE, T.D.2    BOUDREAU, R.J.3
  • 80
    • 0037637609 scopus 로고    scopus 로고
    • Distribution of technetium-99m-labelled QVAR delivered using an Aurohaler device in children
    • DEVADASON SG, HUANG T, WALKER S, TROEDSON R, LE SOUEF PN: Distribution of technetium-99m-labelled QVAR delivered using an Aurohaler device in children. Eur. Respir. J. (2003) 21:1007-1011.
    • (2003) Eur. Respir. J , vol.21 , pp. 1007-1011
    • DEVADASON, S.G.1    HUANG, T.2    WALKER, S.3    TROEDSON, R.4    LE SOUEF, P.N.5
  • 81
    • 33846076698 scopus 로고    scopus 로고
    • Degree of throat deposition can explain the variability in lung deposition of inhaled drugs
    • BORGSTRÖM L OLSSON B, THORSSON L: Degree of throat deposition can explain the variability in lung deposition of inhaled drugs. J. Aerosol Med. (2006) 19:473-483.
    • (2006) J. Aerosol Med , vol.19 , pp. 473-483
    • BORGSTRÖM, L.O.B.1    THORSSON, L.2
  • 82
    • 0025890424 scopus 로고
    • Low first-spray drug content in albuterol metered-dose inhalers
    • CYR TD, GRAHAM SJ, LI KYR, LOVERING EG: Low first-spray drug content in albuterol metered-dose inhalers. Pharm. Res. (1991) 8:658-660.
    • (1991) Pharm. Res , vol.8 , pp. 658-660
    • CYR, T.D.1    GRAHAM, S.J.2    LI, K.Y.R.3    LOVERING, E.G.4
  • 83
    • 34248651284 scopus 로고    scopus 로고
    • TOPLISS P, WARD D, SOUTHALL J, PUREWAL T: Pharmaceutical performance of a valve for metered dose inhalers designed to eliminate loss of prime. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):499-502.
    • TOPLISS P, WARD D, SOUTHALL J, PUREWAL T: Pharmaceutical performance of a valve for metered dose inhalers designed to eliminate loss of prime. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):499-502.
  • 84
    • 0032827577 scopus 로고    scopus 로고
    • Advances in metered dose inhaler technology with the development of a chloroflurocarbon-free drug delivery system
    • ROSS DL, GABRIO BJ: Advances in metered dose inhaler technology with the development of a chloroflurocarbon-free drug delivery system. J. Aerosol Med. (1999) 12:151-160.
    • (1999) J. Aerosol Med , vol.12 , pp. 151-160
    • ROSS, D.L.1    GABRIO, B.J.2
  • 85
    • 21344450712 scopus 로고    scopus 로고
    • Investigating the evaporation of metered-dose inhaler formulations in humid air: Single droplet experiments
    • MARTIN AR, KWOK DY, FINLAY WH: Investigating the evaporation of metered-dose inhaler formulations in humid air: single droplet experiments. J. Aerosol Med. (2005) 18:218-224.
    • (2005) J. Aerosol Med , vol.18 , pp. 218-224
    • MARTIN, A.R.1    KWOK, D.Y.2    FINLAY, W.H.3
  • 86
    • 29744435704 scopus 로고    scopus 로고
    • Inhaler treatment options in COPD
    • NEWMAN SP: Inhaler treatment options in COPD. European Respiratory Review (2005) 14:102-108.
    • (2005) European Respiratory Review , vol.14 , pp. 102-108
    • NEWMAN, S.P.1
  • 87
    • 0028814516 scopus 로고
    • Dose emissions from marketed dry powder inhalers
    • HINDLE M, BYRON PR: Dose emissions from marketed dry powder inhalers. Int. J. Pharm. (1995) 116:169-177.
    • (1995) Int. J. Pharm , vol.116 , pp. 169-177
    • HINDLE, M.1    BYRON, P.R.2
  • 88
    • 24944510514 scopus 로고    scopus 로고
    • The future of metered-dose inhalers
    • September:22-31
    • PRITCHARD JN: The future of metered-dose inhalers. Pharm. Tech. Eur. (2005) September:22-31.
    • (2005) Pharm. Tech. Eur
    • PRITCHARD, J.N.1
  • 89
    • 0013679703 scopus 로고
    • An evaluation of some metered dose aerosols using a twin stage impinger sampling device
    • 7P
    • MEAKIN BJ, STROUD N: An evaluation of some metered dose aerosols using a twin stage impinger sampling device. J. Pharm. Pharmacol. (1983) 35(Suppl. 10):7P.
    • (1983) J. Pharm. Pharmacol , vol.35 , Issue.SUPPL. 10
    • MEAKIN, B.J.1    STROUD, N.2
  • 90
    • 34248655188 scopus 로고    scopus 로고
    • STEIN SW, FORSYTH BR, STEFELY JS, CHRISTENSEN JD, ALBAND TD, JINKS PA: Expanding the dosing range of metered dose inhalers through formulation and hardware optimisation. In: Respiratory Drug Delivery IX. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2004):125-133.
    • STEIN SW, FORSYTH BR, STEFELY JS, CHRISTENSEN JD, ALBAND TD, JINKS PA: Expanding the dosing range of metered dose inhalers through formulation and hardware optimisation. In: Respiratory Drug Delivery IX. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2004):125-133.
  • 91
    • 4544242633 scopus 로고    scopus 로고
    • How do patients determine that their metered-dose inhaler is empty?
    • RUBIN BK, DUROTOYE L: How do patients determine that their metered-dose inhaler is empty? Chest (2004) 126:1134-1137.
    • (2004) Chest , vol.126 , pp. 1134-1137
    • RUBIN, B.K.1    DUROTOYE, L.2
  • 93
    • 0035174427 scopus 로고    scopus 로고
    • The misconception of using floating patterns as an accurate means of measuring the contents of metered-dose inhaler devices
    • CAIN WT, OPPENHEIMER JJ: The misconception of using floating patterns as an accurate means of measuring the contents of metered-dose inhaler devices. Ann. Asthma Allergy Immunol. (2001) 87:417-419.
    • (2001) Ann. Asthma Allergy Immunol , vol.87 , pp. 417-419
    • CAIN, W.T.1    OPPENHEIMER, J.J.2
  • 96
    • 34248675543 scopus 로고    scopus 로고
    • BRADSHAW DRS: Developing dose counters: an appraisal based on regulator, pharma and user needs. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):121-131.
    • BRADSHAW DRS: Developing dose counters: an appraisal based on regulator, pharma and user needs. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):121-131.
  • 97
    • 34248632281 scopus 로고    scopus 로고
    • A review of the design and the development of GSK's MDI dose counter
    • The Aerosol Society, Portishead 2005
    • HALLEY M: A review of the design and the development of GSK's MDI dose counter. In: Drug Delivery to the Lungs 16. The Aerosol Society, Portishead (2005):77-80.
    • Drug Delivery to the Lungs 16 , pp. 77-80
    • HALLEY, M.1
  • 98
    • 33748579871 scopus 로고    scopus 로고
    • Fluticasone propionate/salmeterol hydrofluoroalkane via metered dose inhaler with integrated dose counter: Performance and patient satisfaction
    • SHETH K, WASSERNAN RL, LINCOURT WR, LOCANTORE NW, CARRANZA-ROSENZWEIG J, CRIM C: Fluticasone propionate/salmeterol hydrofluoroalkane via metered dose inhaler with integrated dose counter: performance and patient satisfaction. Int. J. Clin. Pract. (2006) 60:1218-1224.
    • (2006) Int. J. Clin. Pract , vol.60 , pp. 1218-1224
    • SHETH, K.1    WASSERNAN, R.L.2    LINCOURT, W.R.3    LOCANTORE, N.W.4    CARRANZA-ROSENZWEIG, J.5    CRIM, C.6
  • 99
    • 34248657335 scopus 로고    scopus 로고
    • Can patient adherence be improved with technology?
    • Eds, Davis Healthcare International, River Grove, Illinois
    • CHRISTENSEN A, DEVINE T: Can patient adherence be improved with technology? In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):479-481.
    • (2006) Respiratory Drug Delivery X , pp. 479-481
    • CHRISTENSEN, A.1    DEVINE, T.2
  • 100
    • 34248677142 scopus 로고    scopus 로고
    • Design, development and analysis of an integrated pMDI dose counter
    • The Aerosol Society, Portishead 2005
    • INGRAM S, NEWELL H, NINAN S, SOUTHWELL J, WARBY R: Design, development and analysis of an integrated pMDI dose counter. In: Drug Delivery to the Lungs 16. The Aerosol Society, Portishead (2005):148-151.
    • Drug Delivery to the Lungs 16 , pp. 148-151
    • INGRAM, S.1    NEWELL, H.2    NINAN, S.3    SOUTHWELL, J.4    WARBY, R.5
  • 101
    • 34248639902 scopus 로고    scopus 로고
    • Selecting a dose counter for pMDIs
    • Eds, Davis Healthcare International, River Grove, Illinois
    • MAHON G, PURKINS G: Selecting a dose counter for pMDIs. In: Respiratory Drug Delivery Europe. Dalby RN, Byron PR, Peart J, Suman JD (Eds), Davis Healthcare International, River Grove, Illinois (2005):165-167.
    • (2005) Respiratory Drug Delivery Europe , pp. 165-167
    • MAHON, G.1    PURKINS, G.2
  • 102
    • 0009231760 scopus 로고
    • Design, development and testing of a new breath actuated inhaler
    • The Medicine Publishing Foundation, Oxford
    • BAUM EA: Design, development and testing of a new breath actuated inhaler. In: Inspiration: Developments in inhalation therapy. The Medicine Publishing Foundation, Oxford (1989):21-30.
    • (1989) Inspiration: Developments in inhalation therapy , pp. 21-30
    • BAUM, E.A.1
  • 103
    • 0030603993 scopus 로고    scopus 로고
    • A small volume spacer for use with a breath-operated pressurised metered dose inhaler
    • HARDY JG, JASUJA AK, FRIER M, PERKINS AC: A small volume spacer for use with a breath-operated pressurised metered dose inhaler. Int. J. Pharm. (1996) 142:129-133.
    • (1996) Int. J. Pharm , vol.142 , pp. 129-133
    • HARDY, J.G.1    JASUJA, A.K.2    FRIER, M.3    PERKINS, A.C.4
  • 104
    • 0029059091 scopus 로고
    • Aerosol deposition in the human lung following administration from a microprocessor controlled metered dose inhaler
    • FARR SJ, ROWE AM, RUBSAMEN R, TAYLOR G: Aerosol deposition in the human lung following administration from a microprocessor controlled metered dose inhaler. Thorax (1995) 60:639-644.
    • (1995) Thorax , vol.60 , pp. 639-644
    • FARR, S.J.1    ROWE, A.M.2    RUBSAMEN, R.3    TAYLOR, G.4
  • 105
    • 33846633128 scopus 로고    scopus 로고
    • A new breath operated actuator
    • Dalby RN, Byron PR, Peart J, Farr SJ Eds, Davis Horwood, Raleigh
    • BACON RJ, MCDERMOTT I, BELL J: A new breath operated actuator. In: Respiratory Drug Delivery VIII. Dalby RN, Byron PR, Peart J, Farr SJ (Eds). Davis Horwood, Raleigh (2002):403-406.
    • (2002) Respiratory Drug Delivery VIII , pp. 403-406
    • BACON, R.J.1    MCDERMOTT, I.2    BELL, J.3
  • 106
    • 0141712206 scopus 로고    scopus 로고
    • pMDI aerosol momentum manipulation and biotargeted delivery
    • Dalby RN, Byron PR, Peart J, Farr SJ Eds, Davis Horwood, Raleigh
    • MOHSEN N: pMDI aerosol momentum manipulation and biotargeted delivery. In: Respiratory Drug Delivery VIII. Dalby RN, Byron PR, Peart J, Farr SJ (Eds). Davis Horwood, Raleigh (2002):593-597.
    • (2002) Respiratory Drug Delivery VIII , pp. 593-597
    • MOHSEN, N.1
  • 107
    • 34248663294 scopus 로고    scopus 로고
    • HUSEGAARD C: Consumer electronics to medical devices: a cross-industry perpective on technology development: breathing new life into next generation inhalers, a consumer-inspired next generation pMDI. In: Drug Delivery to the Lungs 17. The Aerosol Society, Portishead (2006):54-58.
    • HUSEGAARD C: Consumer electronics to medical devices: a cross-industry perpective on technology development: breathing new life into next generation inhalers, a consumer-inspired next generation pMDI. In: Drug Delivery to the Lungs 17. The Aerosol Society, Portishead (2006):54-58.
  • 108
    • 0037235266 scopus 로고    scopus 로고
    • Improvement of asthma control with a breath-actuated pressurized metered dose inhaler: A prescribing claim study of 5556 patients using a traditional pressurized metered dose inhaler or a breath-actuated device
    • PRICE D, THOMAS M, MITCHELL G, NIZIOL C, FEATHERSTONE R: Improvement of asthma control with a breath-actuated pressurized metered dose inhaler: a prescribing claim study of 5556 patients using a traditional pressurized metered dose inhaler or a breath-actuated device. Respir. Med. (2003) 97:12-19.
    • (2003) Respir. Med , vol.97 , pp. 12-19
    • PRICE, D.1    THOMAS, M.2    MITCHELL, G.3    NIZIOL, C.4    FEATHERSTONE, R.5
  • 109
    • 34248646602 scopus 로고    scopus 로고
    • BYRON PR: Platform selection for inhaled drugs: biological and regulatory merit of different approaches. In: Respiratory Drug Delivery Europe. Dalby RN, Byron PR, Peart J, Suman JD (Eds). Davis Healthcare International, River Grove, Illinois (2005):1-17.
    • BYRON PR: Platform selection for inhaled drugs: biological and regulatory merit of different approaches. In: Respiratory Drug Delivery Europe. Dalby RN, Byron PR, Peart J, Suman JD (Eds). Davis Healthcare International, River Grove, Illinois (2005):1-17.
  • 110
    • 0027376998 scopus 로고
    • A comparison of breath-actuated and conventional metered dose inhaler inhalation techniques in elderly subjects
    • CHAPMAN KR, LOVE L, BRUBAKER H: A comparison of breath-actuated and conventional metered dose inhaler inhalation techniques in elderly subjects. Chest (1993) 104:1332-1337.
    • (1993) Chest , vol.104 , pp. 1332-1337
    • CHAPMAN, K.R.1    LOVE, L.2    BRUBAKER, H.3
  • 111
    • 0034129205 scopus 로고    scopus 로고
    • Inappropriate inhaler use: Assessment of use and patient preference of seven inhalation devices
    • LENNEY J, INNES JA, CROMPTON GK: Inappropriate inhaler use: assessment of use and patient preference of seven inhalation devices. Respir. Med. (2000) 94:496-500.
    • (2000) Respir. Med , vol.94 , pp. 496-500
    • LENNEY, J.1    INNES, J.A.2    CROMPTON, G.K.3
  • 112
    • 0025288535 scopus 로고
    • Use of different inhalation devices in children
    • PEDERSEN S, MORTENSEN S: Use of different inhalation devices in children. Lung (1990) 168(Suppl.):653-657.
    • (1990) Lung , vol.168 , Issue.SUPPL. , pp. 653-657
    • PEDERSEN, S.1    MORTENSEN, S.2
  • 113
    • 0028278744 scopus 로고
    • Choice of inhalation therapy in paediatrics
    • PEDERSEN S: Choice of inhalation therapy in paediatrics. Eur. Respir. J. (1994) 18:85-88.
    • (1994) Eur. Respir. J , vol.18 , pp. 85-88
    • PEDERSEN, S.1
  • 114
    • 84965272382 scopus 로고
    • Breath-activated aerosol
    • CROMPTON GK: Breath-activated aerosol. Br. Med. J. (1971) 2:652-653.
    • (1971) Br. Med. J , vol.2 , pp. 652-653
    • CROMPTON, G.K.1
  • 115
    • 0025351139 scopus 로고
    • The adult patient difficulties with inhalers
    • CROMPTON GK: The adult patient difficulties with inhalers. Lung (1990) 168(Suppl.):658-662.
    • (1990) Lung , vol.168 , Issue.SUPPL. , pp. 658-662
    • CROMPTON, G.K.1
  • 116
    • 29844448453 scopus 로고    scopus 로고
    • Influence of particle size and patient dosing technique on lung deposition of HFA-beclomethasone from a metered dose inhaler
    • LEACH CL, DAVIDSON PJ, HASSELQUIST BE, BOUDREAU RJ: Influence of particle size and patient dosing technique on lung deposition of HFA-beclomethasone from a metered dose inhaler. J. Aerosol Med. (2005) 18:379-385.
    • (2005) J. Aerosol Med , vol.18 , pp. 379-385
    • LEACH, C.L.1    DAVIDSON, P.J.2    HASSELQUIST, B.E.3    BOUDREAU, R.J.4
  • 118
    • 34248651285 scopus 로고    scopus 로고
    • DALBY R, ZIEGLER L, SOMARAJU S, TSOUKLERIS M, TEETER J: The effect of time delays between inhaler actuation and onset of inhalation on the dose of albuterol exiting Optihaler, Aerochamber and Aerosol Cloud Enhancer spacers. In: Respiratory Drug Delivery V. Dalby RN, Byron PR, Farr SJ (Eds). Interpharm Press, Buffalo Grove (1996):324-326.
    • DALBY R, ZIEGLER L, SOMARAJU S, TSOUKLERIS M, TEETER J: The effect of time delays between inhaler actuation and onset of inhalation on the dose of albuterol exiting Optihaler, Aerochamber and Aerosol Cloud Enhancer spacers. In: Respiratory Drug Delivery V. Dalby RN, Byron PR, Farr SJ (Eds). Interpharm Press, Buffalo Grove (1996):324-326.
  • 119
    • 34248630555 scopus 로고    scopus 로고
    • Devices to assist patient co-ordination with pMDIs: A review
    • The Aerosol Society, Portishead 1998
    • HOWLETT D: Devices to assist patient co-ordination with pMDIs: a review. In: Drug Delivery to the Lungs IX. The Aerosol Society, Portishead (1998):184-187.
    • Drug Delivery to the Lungs IX , pp. 184-187
    • HOWLETT, D.1
  • 120
    • 33846583467 scopus 로고    scopus 로고
    • The breath coordinated inhaler (BCI): A new pulmonary drug delivery device for pressurized metered dose inhalers
    • Dalby RN, Byron PR, Farr SJ, Peart J Eds, Serentec Press, Raleigh
    • ZHANG FL, GENOVA PA, TANGUAY JF et al.: The breath coordinated inhaler (BCI): a new pulmonary drug delivery device for pressurized metered dose inhalers. In: Respiratory Drug Delivery VII. Dalby RN, Byron PR, Farr SJ, Peart J (Eds). Serentec Press, Raleigh (2000):323-326.
    • (2000) Respiratory Drug Delivery VII , pp. 323-326
    • ZHANG, F.L.1    GENOVA, P.A.2    TANGUAY, J.F.3
  • 121
    • 85010531118 scopus 로고    scopus 로고
    • The metered-dose inhaler
    • Bisgaard H, O'Callaghan C, Smaldone GC Eds, Marcel Dekker, New York
    • O'CALLAGHAN C, WRIGHT P: The metered-dose inhaler. In: Drug Delivery to the Lung. Bisgaard H, O'Callaghan C, Smaldone GC (Eds). Marcel Dekker, New York (2002):337-370.
    • (2002) Drug Delivery to the Lung , pp. 337-370
    • O'CALLAGHAN, C.1    WRIGHT, P.2
  • 122
    • 0033060047 scopus 로고    scopus 로고
    • Improved targeting of beclomethasone dipropionate (250 μg metered dose inhaler) to the lungs of asthmatics with the Spacehaler
    • NEWMAN SP, STEED KP, HOOPER G, JONES JI, UPCHURCH FC: Improved targeting of beclomethasone dipropionate (250 μg metered dose inhaler) to the lungs of asthmatics with the Spacehaler. Respir. Med. (1999) 93:424-431.
    • (1999) Respir. Med , vol.93 , pp. 424-431
    • NEWMAN, S.P.1    STEED, K.P.2    HOOPER, G.3    JONES, J.I.4    UPCHURCH, F.C.5
  • 123
    • 0027362604 scopus 로고
    • Comparison of the extrapulmonary β-2 adrenoceptor responses and pharmacokinetics of salbutamol metered dose-inhaler and modified actuator device
    • NEWNHAM DM, MCDEVITT DG, LIPWORTH BJ: Comparison of the extrapulmonary β-2 adrenoceptor responses and pharmacokinetics of salbutamol metered dose-inhaler and modified actuator device. Br. J. Clin. Pharmacol. (1993) 36:445-450.
    • (1993) Br. J. Clin. Pharmacol , vol.36 , pp. 445-450
    • NEWNHAM, D.M.1    MCDEVITT, D.G.2    LIPWORTH, B.J.3
  • 124
    • 0027262967 scopus 로고
    • Bronchodilator delivery from Gentlehaler, a new low-velocity pressurized aerosol inhaler
    • NEWMAN SP, CLARKE SW: Bronchodilator delivery from Gentlehaler, a new low-velocity pressurized aerosol inhaler. Chest(1993) 103:1442-1446.
    • (1993) Chest , vol.103 , pp. 1442-1446
    • NEWMAN, S.P.1    CLARKE, S.W.2
  • 125
    • 4243912334 scopus 로고    scopus 로고
    • Pulmonary delivery of ergotamine tartrate using a new breath-actuated pressurized aerosol device, the aerosol drug delivery system
    • Dalby RN, Byron PR, Farr SJ, Peart J Eds, Serentec Press, Raleigh
    • NEWMAN SP, HIRST PH, BACON RE et al.: Pulmonary delivery of ergotamine tartrate using a new breath-actuated pressurized aerosol device, the aerosol drug delivery system. In: Respiratory Drug Delivery VII. Dalby RN, Byron PR, Farr SJ, Peart J (Eds). Serentec Press, Raleigh (2000):471-473.
    • (2000) Respiratory Drug Delivery VII , pp. 471-473
    • NEWMAN, S.P.1    HIRST, P.H.2    BACON, R.E.3
  • 126
    • 34248673759 scopus 로고    scopus 로고
    • Design optimization of a novel MDI actuator
    • Eds, Davis Healthcare International, River Grove, Illinois
    • KAKADE P, VERSTEEG H, DEATON D, HARGRAVE G: Design optimization of a novel MDI actuator. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):663-666.
    • (2006) Respiratory Drug Delivery X , pp. 663-666
    • KAKADE, P.1    VERSTEEG, H.2    DEATON, D.3    HARGRAVE, G.4
  • 127
    • 0029875614 scopus 로고    scopus 로고
    • Effect of add-on devices for aerosol drug delivery: Deposition studies and clinical aspects
    • NEWMAN SP, NEWHOUSE MT: Effect of add-on devices for aerosol drug delivery: deposition studies and clinical aspects. J. Aerosol Med. (1996) 9:55-70.
    • (1996) J. Aerosol Med , vol.9 , pp. 55-70
    • NEWMAN, S.P.1    NEWHOUSE, M.T.2
  • 128
    • 0019930598 scopus 로고
    • Response to bronchodilator drug administration by a new reservoir aerosol delivery system and a review of other auxiliary delivery systems
    • TOBIN MJ, JENOURI G, DANTA I, KIM C, WATSON H, SACKNER MS: Response to bronchodilator drug administration by a new reservoir aerosol delivery system and a review of other auxiliary delivery systems. Am. Rev. Respir. Dis. (1982) 126:670-765.
    • (1982) Am. Rev. Respir. Dis , vol.126 , pp. 670-765
    • TOBIN, M.J.1    JENOURI, G.2    DANTA, I.3    KIM, C.4    WATSON, H.5    SACKNER, M.S.6
  • 129
    • 34248665867 scopus 로고    scopus 로고
    • SCHEUCH G, KOLB T, SOMMERER K, ROEDER S: In vitro evaluation of the novel spacer device Watchhaler and modeling of probable deposition in children. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):385-387.
    • SCHEUCH G, KOLB T, SOMMERER K, ROEDER S: In vitro evaluation of the novel spacer device Watchhaler and modeling of probable deposition in children. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):385-387.
  • 130
    • 2342667615 scopus 로고    scopus 로고
    • Spacer devices for metered dose inhalers
    • NEWMAN SP: Spacer devices for metered dose inhalers. Clin. Pharmacokinet. (2004) 43:349-360.
    • (2004) Clin. Pharmacokinet , vol.43 , pp. 349-360
    • NEWMAN, S.P.1
  • 131
    • 84964219078 scopus 로고    scopus 로고
    • Spacer devices
    • Bisgaard H, O'Callaghan C, Smaldone GC Eds, Marcel Dekker, New York
    • BISGAARD H, ANHOJ J, WILDHABER JH: Spacer devices. In: Drug Delivery to the Lung. Bisgaard H, O'Callaghan C, Smaldone GC (Eds). Marcel Dekker, New York (2002):389-420.
    • (2002) Drug Delivery to the Lung , pp. 389-420
    • BISGAARD, H.1    ANHOJ, J.2    WILDHABER, J.H.3
  • 133
    • 0027316392 scopus 로고
    • Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation and avoiding multiple actuations of drug
    • O'CALLAGHAN C, LYNCH J, CANT M, ROBERTSON C: Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation and avoiding multiple actuations of drug. Thorax (1993) 48:603-606.
    • (1993) Thorax , vol.48 , pp. 603-606
    • O'CALLAGHAN, C.1    LYNCH, J.2    CANT, M.3    ROBERTSON, C.4
  • 134
    • 0029070370 scopus 로고
    • The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler
    • BARRY PW, O'CALLAGHAN C: The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler. Br. J. Clin. Pharmacol. (1995) 40:76-78.
    • (1995) Br. J. Clin. Pharmacol , vol.40 , pp. 76-78
    • BARRY, P.W.1    O'CALLAGHAN, C.2
  • 135
    • 34248670723 scopus 로고    scopus 로고
    • MITCHELL J, MORTON R, SCHMIDT J, SNYDER S, DOYLE C, NAGEL M: Overcoming electrostatic charge retention in a new valved holding chamber (VEC): in vitro performance comparison with current devices. In: Respiratory Drug Delivery IX. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2004):705-707.
    • MITCHELL J, MORTON R, SCHMIDT J, SNYDER S, DOYLE C, NAGEL M: Overcoming electrostatic charge retention in a new valved holding chamber (VEC): in vitro performance comparison with current devices. In: Respiratory Drug Delivery IX. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2004):705-707.
  • 136
    • 33644627141 scopus 로고    scopus 로고
    • Optimizing aerosol delivery by pressurized metered-dose inhalers
    • RUBIN BK, FINK JB: Optimizing aerosol delivery by pressurized metered-dose inhalers. Respir. Care (2005) 50:1191-1200.
    • (2005) Respir. Care , vol.50 , pp. 1191-1200
    • RUBIN, B.K.1    FINK, J.B.2
  • 137
    • 0142168669 scopus 로고    scopus 로고
    • Drug delivery in pediatric patients with asthma spacer devices versus nebulizers for β-2 agonlists
    • BRAND PLP, ROORDA RJ: Drug delivery in pediatric patients with asthma spacer devices versus nebulizers for β-2 agonlists. Am. J. Drug Deliv. (2003) 1:61-70.
    • (2003) Am. J. Drug Deliv , vol.1 , pp. 61-70
    • BRAND, P.L.P.1    ROORDA, R.J.2
  • 138
    • 33644661602 scopus 로고    scopus 로고
    • Comparing clinical features of the nebulizer, metered dose inhaler and dry powder inhaler
    • GELLER DE: Comparing clinical features of the nebulizer, metered dose inhaler and dry powder inhaler. Respir. Care (2005) 50:1313-1322.
    • (2005) Respir. Care , vol.50 , pp. 1313-1322
    • GELLER, D.E.1
  • 139
    • 34248644634 scopus 로고    scopus 로고
    • Discussion following NEWMAN SP: Principles of metered-dose inhaler design
    • ATKINS P: Discussion following NEWMAN SP: Principles of metered-dose inhaler design. Respir. Care (2005) 50:1177-1190.
    • (2005) Respir. Care , vol.50 , pp. 1177-1190
    • ATKINS, P.1
  • 140
    • 12344306183 scopus 로고    scopus 로고
    • Propellant-driven metered-dose inhalers for pulmonary drug delivery
    • SMYTH HD; Propellant-driven metered-dose inhalers for pulmonary drug delivery. Expert Opin. Drug Delivery (2005) 2:53-74.
    • (2005) Expert Opin. Drug Delivery , vol.2 , pp. 53-74
    • SMYTH, H.D.1
  • 141
    • 85008523729 scopus 로고
    • Dispersion and size distribution of amiloride by metered dose and dry powder inhalers
    • BOUNDY MG, LEITH D, KNOWLES MR: Dispersion and size distribution of amiloride by metered dose and dry powder inhalers. J. Aerosol Med. (1990) 3:233-241.
    • (1990) J. Aerosol Med , vol.3 , pp. 233-241
    • BOUNDY, M.G.1    LEITH, D.2    KNOWLES, M.R.3
  • 143
    • 0026543325 scopus 로고
    • Bioavailability of leuprolide acetate following nasal and inhalation delivery to rats and healthy humans
    • ADJEI A, SUNDBERG D, MILLER J, CHUN A: Bioavailability of leuprolide acetate following nasal and inhalation delivery to rats and healthy humans. Pharm. Res. (1992) 9:244-249.
    • (1992) Pharm. Res , vol.9 , pp. 244-249
    • ADJEI, A.1    SUNDBERG, D.2    MILLER, J.3    CHUN, A.4
  • 144
    • 0030066647 scopus 로고    scopus 로고
    • Propellant-driven aerosols of proteins
    • BROWN AR: Propellant-driven aerosols of proteins. Aerosol Science and Technology (1996) 24:45-56.
    • (1996) Aerosol Science and Technology , vol.24 , pp. 45-56
    • BROWN, A.R.1
  • 145
    • 33846365332 scopus 로고    scopus 로고
    • Evaluation of metered dose inhaler (MDI) formulations of ciclosporin
    • MARAJANI R, SHAIK MS, CHATTERJEE A, SINGH M: Evaluation of metered dose inhaler (MDI) formulations of ciclosporin. J. Pharm. Pharmacol (2007) 59:15-21.
    • (2007) J. Pharm. Pharmacol , vol.59 , pp. 15-21
    • MARAJANI, R.1    SHAIK, M.S.2    CHATTERJEE, A.3    SINGH, M.4
  • 146
    • 0030905861 scopus 로고    scopus 로고
    • Propellant-driven aerosols of DNA plasmids for gene expression in the respiratory tract
    • BROWN AR, CHOWDHURY SL: Propellant-driven aerosols of DNA plasmids for gene expression in the respiratory tract. J. Aerosol Med. (1997) 10:129-146.
    • (1997) J. Aerosol Med , vol.10 , pp. 129-146
    • BROWN, A.R.1    CHOWDHURY, S.L.2
  • 147
    • 34248666770 scopus 로고    scopus 로고
    • The problem of cough and development of novel and-tussives
    • Epub ahead of print
    • BARNES PJ: The problem of cough and development of novel and-tussives. Pulm. Pharmacol. Ther. (2006) Epub ahead of print.
    • (2006) Pulm. Pharmacol. Ther
    • BARNES, P.J.1
  • 148
    • 34248641729 scopus 로고    scopus 로고
    • PRITCHARD JN, GENOVA P: Adapting the pMDI to deliver novel drugs: insulin and beyond. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):133-141.
    • PRITCHARD JN, GENOVA P: Adapting the pMDI to deliver novel drugs: insulin and beyond. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):133-141.
  • 149
    • 34248642028 scopus 로고    scopus 로고
    • The pMDI - celebrating a golden history, welcoming a bright future
    • The Aerosol Society, Portishead 2006
    • FRADLEY G: The pMDI - celebrating a golden history, welcoming a bright future. In: Drug Delivery to the Lungs 17. The Aerosol Society, Portishead (2006):38-41.
    • Drug Delivery to the Lungs 17 , pp. 38-41
    • FRADLEY, G.1
  • 150
    • 34248646299 scopus 로고    scopus 로고
    • The need to improve inhalation technique in Europe: A report from the aerosol drug management improvement team
    • CROMPTON GK, BARNES PJ, BROEDERS M et al.: The need to improve inhalation technique in Europe: a report from the aerosol drug management improvement team. Respir. Med. (2006) 27:1070-1071.
    • (2006) Respir. Med , vol.27 , pp. 1070-1071
    • CROMPTON, G.K.1    BARNES, P.J.2    BROEDERS, M.3
  • 151
    • 0141886534 scopus 로고    scopus 로고
    • Inhaled corticosteroids for asthma therapy: Patient compliance, devices and inhalation technique
    • COCHRANE MG, BALA MV, DOWNS KE, MAUSKOPF J, BEN-JOSEPH RH: Inhaled corticosteroids for asthma therapy: patient compliance, devices and inhalation technique. Chest (2000) 117:542-550.
    • (2000) Chest , vol.117 , pp. 542-550
    • COCHRANE, M.G.1    BALA, M.V.2    DOWNS, K.E.3    MAUSKOPF, J.4    BEN-JOSEPH, R.H.5
  • 152
    • 13544253826 scopus 로고    scopus 로고
    • Device selection and outcomes of aerosol therapy: Evidence-based guidelines
    • DOLOVICH MB, AHRENS RC, HESS DR et al.: Device selection and outcomes of aerosol therapy: evidence-based guidelines. Chest (2005) 127:335-371.
    • (2005) Chest , vol.127 , pp. 335-371
    • DOLOVICH, M.B.1    AHRENS, R.C.2    HESS, D.R.3
  • 153
    • 33747345377 scopus 로고    scopus 로고
    • BDP and formoterol association within combination HFA solution MDI
    • Eds, Davis Healthcare International, River Grove, Illinois
    • LEWIS D, BRAMBILLA G, CHURCH T, MEAKIN B: BDP and formoterol association within combination HFA solution MDI. In: Respiratory Drug Delivery X. Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ (Eds). Davis Healthcare International, River Grove, Illinois (2006):939-942.
    • (2006) Respiratory Drug Delivery X , pp. 939-942
    • LEWIS, D.1    BRAMBILLA, G.2    CHURCH, T.3    MEAKIN, B.4
  • 154
    • 33747362898 scopus 로고    scopus 로고
    • Beclomethasone dipropionate/formoterol: In an HFA-propelled pressurised metered dose inhaler
    • DHILLON S, KEATING GM: Beclomethasone dipropionate/formoterol: In an HFA-propelled pressurised metered dose inhaler. Drugs (2006) 66:1475-1483.
    • (2006) Drugs , vol.66 , pp. 1475-1483
    • DHILLON, S.1    KEATING, G.M.2


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