Advances in metered dose inhaler technology with the development of a chlorofluorocarbon-free drug delivery system

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 12, Issue 3, 1999, Pages 151-160

  Ross, Danna L ^a   Gabrio, Brian J ^a  

^a 3M COMPANY   (United States)

Author keywords

Asthma; Beta agonist; CFC free; Metered dose inhaler; pMDI

Indexed keywords

CHLOROFLUOROCARBON; NORFLURANE; PIRBUTEROL ACETATE; PROPELLANT; SALBUTAMOL; SALBUTAMOL SULFATE;

ARTICLE; ASTHMA; DEVICE; DOSE CALCULATION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG STORAGE; HUMAN; LOW TEMPERATURE; METERED DOSE INHALER; PARTICLE SIZE; TASTE; TEMPERATURE SENSITIVITY;

EID: 0032827577     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.1999.12.151     Document Type: Article

References (11)

1. Ross, D.L. and R.K. Schultz. 1996. Effect of inhalation flow rate on the dosing characteristics of dry powder inhaler (DPI) and metered dose inhaler (MDI) products. J. Aerosol Med. 9:215-226.
2. June, D.S., R.K. Schultz, and N.C. Miller. 1994. A conceptual model for the development of pressurized metered-dose hydrofluoroalkane-based inhalation aerosols. Pharm. Technol. Oct:40-52.
3. Ross, D., S. Carlson, and D. June. 1996. Comparison of a new HFA albuterol metered dose inhaler (MDI) to a marketed CFC albuterol MDI - effect of storage orientation, end of canister life, and temperature on dosing consistency. Am. J. Respir. Crit. Care Med. 153:A62 (Abstract).
4. Tansey, I. 1995. Technological development of airomir (salbutamol sulphate in CFC-free system) MDI. Br. J. Clin. Prac. April (Suppl. 79):13-15.
5. Samper, G.J., E.M. Bonmati, L.M. Bonmati, M.R. Capilla, and M.A. Ciscar Vilanova. 1995. Aerosols: The effect of low temperatures on drug delivery efficiency. Eur. Respir. J. 8 (Suppl 19):200s.
6. Meakin, B., J. Cainey, and P. Woodcock. 1995. Simulated 'in-use' and 'mis-use' aspects of the delivery of terbutaline sulphate from Bricanyl Turbohaler™ dry powder inhalers. Int. J. Pharm. 119:103-108.
7. Crompton, G.K. 1982. Problems patients have using pressurized aerosol inhalers. Eur. J. Respir. Dis. 119: 57-65.
8. Pedersen, S., L. Frost, and T. Arnfred, T. 1986. Errors in inhalation technique and efficiency in inhaler use in asthmatic children. Allergy. 41:118-124.
9. Cyr, T.D., S.J. Graham, K.Y.R. Li, and E.G. Lovering. 1991. Low first spray drug content in albuterol metered dose inhalers. Pharm. Res. 8:658-660.
10. June, D., S. Carlson, and D. Ross. 1996. Reduced effect of temperature on drug delivery characteristics of CFC-free metered dose inhalers. Eur. Respir. J. 9(Suppl 23):255s.
11. Schultz, D., S. Carlson, and D. Ross. 1996. In vitro performance characteristics of two CFC-free metered dose inhalers (MDIs) with large and small volume spacers. Eur. Respir. J. 9(Suppl 23):255s.