Lycopene, a carotenoid, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rats

Basic and Clinical Pharmacology and Toxicology

Volumn 100, Issue 6, 2007, Pages 372-376

  Ateşşahin, Ahmet ^a   Çeribaşi, Ali Osman ^a   Yilmaz, Seval ^a  

^a FIRAT UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CYCLOSPORIN A; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LYCOPENE; REDIVIVO; SODIUM CHLORIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BASEMENT MEMBRANE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE MARKER; DRUG EFFECT; ENZYME ACTIVITY; HISTOPATHOLOGY; KIDNEY DYSFUNCTION; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY PARENCHYMA; KIDNEY TUBULE NECROSIS; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SODIUM BLOOD LEVEL; TISSUE DEGENERATION; TREATMENT DURATION; UREA BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; CALCIUM; CAROTENOIDS; CATALASE; CREATININE; CYCLOSPORINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE, ACUTE; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; THIOBARBITURIC ACID REACTIVE SUBSTANCES; UREA;

ANIMALIA; RATTUS;

EID: 34248633376     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2007.00060.x     Document Type: Article

References (28)

1. Hagar HH, El Etter E, Arafa M. Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats. Clin Exp Pharmacol Physiol 2006 33 : 189 96.
2. Atasoyu EM, Yildiz S, Cimsit M et al. Investigation of the effect of hyperbaric oxygen on experimental cyclosporine nephrotoxicity. Basic Clin Pharmacol Toxicol 2006 98 : 150 4.
3. Kuruş M, Eşrefoǧlu M, Bay A, Öztürk F. Protective effect of l-arginin supplementation on cyclosporine induced nephropathy in rats. Int Urol Nephrol 2005 37 : 587 94.
4. Origlia N, Migliori M, Panichi V et al. Protective effect of l-propionylcarnitine in chronic cyclosporine-A induced nephrotoxicity. Biomed Pharmacother 2006 60 : 77 81.
5. Yuan J, Zhou J, Chen BC et al. Magnesium supplementation prevents chronic cyclosporine nephrotoxicity via adjusting nitric oxide synthase activity. Transplant Proc 2005 37 : 1892 5.
6. Tirkey N, Kaur G, Vij G, Chopra K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol 2005 5 : 15.
7. Amudha G, Josephine A, Varalakshmi P. Role of lipoic acid in reducing the oxidative stress induced by cyclosporine A. Clin Chim Acta 2006 372 : 134 9.
8. Stahl W, Sies H. Antioxidant activity of carotenoids. Mol Aspects Med 2003 24 : 345 51.
9. Wertz K, Siler U, Goralczyk R. Lycopene: modes of action to promote prostate health. Arch Biochem Biophys 2004 430 : 127 34.
10. Cohen LA. A review of animal model studies of tomato carotenoids, lycopene, and cancer chemoprevention. Exp Biol Med 2002 227 : 864 8.
11. Ateşşahin A, Yilmaz S, Karahan İ, Ceribasi AO, Karaoǧlu A. Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats. Toxicology 2005 212 : 116 23.
12. Ateşşahin A, Türk G, Karahan İ, Yilmaz S, Ceribasi AO, Bulmus O. Lycopene prevents adriamycin-induced testicular toxicity in rats. Fertil Steril 2006 85 (Suppl 1 1216 22.
13. Rezzani R, Buffoli B, Rodella L, Stacchiotti A, Bianchi R. Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver. Int Immunopharmacol 2005 5 : 1397 405.
14. Chung BH, Li C, Sun BK et al. Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats. Am J Transplant 2005 5 : 1856 67.
15. Jonker D, Kuper CF, Frail N, Estrella A, Rodriguez Otero C. Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats. Regul Toxicol Phamacol 2003 37 : 396 406.
16. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979 95 : 351 8.
17. Sedlak J, Lindsay RH. Estimation of total, protein-bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968 25 : 192 205.
18. Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 1976 71 : 952 8.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951 193 : 265 75.
20. Aebi H. Catalase. In : Bergmeyer HU (ed.). Methods in Enzymatic Analysis. Academic Press, New York, 1983 276 86.
21. Wongmekiat O, Thamprasert K. Investigating the protective effects of aged garlic extract on cyclosporine-induced nephrotoxicity in rats. Fundam Clin Pharmacol 2005 19 : 555 62.
22. Walker RJ, Lazzaro VA, Duggin GG, Horvath JS, Tiller DJ. Evidence that alterations in renal metabolism and lipid peroxidation may contribute to cyclosporine nephrotoxicity. Transplantation 1990 50 : 487 92.
23. Ahmed SS, Napoli KL, Strobel HW. Oxygen radical formation during cytochrome P450 catalyzed cyclosporine metabolism in rat and human liver microsomes at varying hydrogen ion concentrations. Mol Cell Biochem 1995 151 : 131 40.
24. Inselmann G, Hannemann J, Baumann K. Cyclosporine A induced lipid peroxidation and influence on glucose-6-phosphatase in rat hepatic and renal microsomes. Res Commun Chem Pathol Pharmacol 1990 68 : 189 203.
25. Zhong Z, Arteel GF, Connor HD. Cyclosporine A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine. Am J Physiol 1998 275 : F595 F604.
26. Yilmaz S, Ateşşahin A, Sahna E, Karahan I, Ozer S. Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity. Toxicology 2006 218 : 164 71.
27. Deman A, Ceyssens B, Pauwels M et al. Altered antioxidant defense in a mouse adriamycin model of glomerulosclerosis. Nephrol Dial Transplant 2001 16 : 147 50.
28. Salvemini F, Franze A, Iervolino A, Filosa S, Salzano S, Ursini MV. Enhanced glutathione levels and oxidoresistance mediated by increased glucose-6-phosphate dehydrogenase expression. J Biol Chem 1999 274 : 2750 7.