Protective effect of oral L-arginine supplementation on cyclosporine induced nephropathy in rats

International Urology and Nephrology

Volumn 37, Issue 3, 2005, Pages 587-594

  Kuruş, Meltem ^a   Eşrefoğlu, Mukaddes ^a   Bay, Aysun ^a   Öztürk, Feral ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

Cyclosporine A; Histopathology; L arginine; N nitro L arginine methyl ester; Nephrotoxicity; Nitric oxide

Indexed keywords

ARGININE; CREATININE; CYCLOSPORIN; DRUG VEHICLE; EOSIN; HEMATOXYLIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROGEN; PARAFFIN; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BODY WEIGHT; CELL DEATH; CELL INFILTRATION; CELL VACUOLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIETARY INTAKE; DISEASE EXACERBATION; FEMALE; FIBROSING ALVEOLITIS; GLOMERULUS FILTRATION RATE; HISTOPATHOLOGY; IN VIVO STUDY; KIDNEY DISEASE; KIDNEY INJURY; LEYDIG CELL; NEPHROTOXICITY; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; RAT; RENAL PROTECTION; SCORING SYSTEM; UREA NITROGEN BLOOD LEVEL;

EID: 28844444512     PISSN: 03011623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11255-004-0011-5     Document Type: Article

References (31)

1. DH Kang YG Kim TF Andoh et al. 2001 Post-cyclosporine-mediated hypertension and nephropathy: Amelioration by vascular endothelial growth factor Am J Physiol Renal Physiol 280 F727-F736 1:CAS:528:DC%2BD3MXjtV2gsL8%3D
2. NA Bobadilla E Tapia F Jimenez et al. 1999 Dexamethasone increases eNOS gene expression and prevents renal vasoconstriction induced by cyclosporine Am J Physiol 277 F464-F471 1:CAS:528:DyaK1MXmt1Gisbg%3D
3. FS Shibab WM Bennett AM Tanner et al. 1997 Angiotensin II blockade decreases TGF-(beta)-1 and matrix proteins in cyclosporine nephropathy Int Soc Nephrol 52 3 660-673
4. WM Bennett A DeMattes MM Meyer et al.1996 Chronic cyclosporine nephropathy: The Achilles' heel of immunosuppressive therapy Kidney Int 50 4 1089-1100 1:STN:280:ByiD2c7pvFA%3D
5. AK Khanna VR Cairns CG Becker et al. 1999 Transforming growth factor (TGF)-(beta) mimics and anti-TGF-(beta) antibody abrogates in the in vivo effects of cyclosporine: Demonstration of a direct role of TGF-(beta) in immunosuppression and nephrotoxicity of cyclosporine Transplantation 67 6 882-889 1:CAS:528:DyaK1MXisFantbg%3D
6. FS Shibab H Yi WM Bennett et al. 2000 Effect of nitric oxide modulation on TGF-β1 and matrix proteins in chronic cyclosporine nephrotoxicity Kidney Int 58 1174-1185
7. FS Shibab TF Andoh AM Tanner et al. 1996 Role of transforming growth factor-(beta)1 in experimental chronic cyclosporine nephropathy Kidney Int 49 4 1141-1151
8. BA Young EA Burdmann RJ Johnson et al. 1995 Cyclosporin A induced arteriolopathy in a rat model of chronic cyclosporin nephropathy Kidney Int 48 431-438 1:CAS:528:DyaK2MXotFGht7Y%3D
9. BA Young EA Burdmann RJ Johnson et al. 1995 Cellular proliferation and macrophage influx precede interstitial fibrosis in cyclosporine nephrotoxicity Kidney Int 48 439-448 1:CAS:528:DyaK2MXotFGht7c%3D
10. TF Andoh MP Gardner WM. Bennett 1997 Protective effects of dietary L-arginine supplementation on chronic cyclosporine nephrotoxicity Transplantation 64 9 1236-1240 1:CAS:528:DyaK1cXmslOh
11. M Kashiwagi M Shinozaki H Hirakata et al. 2000 Locally activated renin-angiotensin system associated with TGF-β1 as a major factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats J Am Soc Nephrol 11 616-624 1:CAS:528:DC%2BD3cXisFert7o%3D
12. Newman D, Price CP. Renal function and nitrogen metabolites. In: Burtis CA, Ashwood ER, eds. Tietz Textbook of Clinical Chemistry. WB Saunders, 1991: 1204-1217.
13. C Can S Şn N Boztok et al. 2000 Protective effect of oral L-arginine administration on gentamicin-induced renal failure in rats Eur J Pharmacol 390 327-334 10.1016/S0014-2999(00)00025-X 1:CAS:528:DC%2BD3cXhsFKjsbY%3D
14. M Noris G. Remuzzi 1996 Evidence for a role of nitric oxide in hypertension and in renal disease in man Clin Hypertens Nephrol 119 8-15 1:STN:280:BymA2sjnslE%3D
15. NA Bobadilla G Gamba E Tapia et al. 1998 Role of NO in cyclosporine nephrotoxicity: Effects of chronic NO inhibition and NO synthases gene expression Am J Physiol 43 F791-F798
16. WZ Ying PW. Sanders 1998 Dietary salt enhances glomerular endothelial nitric oxide synthase through TGF-β1 Am J Physiol 275 F18-F24
17. L Calo A Semplicini PA Davis et al. 2000 Cyclosporin-induced endothelial dysfunction and hypertension: Are nitric oxide system abnormality and oxidative stress involved? Transplant Int 13 1 S413-S418
18. MP Gardner DC Houghton TF Andoh et al. 1996 Clinically relevant doses and blood levels produce experimental cyclosporin nephrotoxicity when combined with nitric oxide inhibition Transplantation 61 1506-1512 1:CAS:528:DyaK28Xkt1Smurs%3D
19. RH Pichler N Franceschini BA Young et al.1995 Pathogenesis of cyclosporine nephropathy: Roles of angiotensin II and osteopontin J Am Soc Nephrol 6 1186-1196 1:CAS:528:DyaK28XntFQ%3D
20. NK Cortas NW. Wakid 1990 Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method Clin Chem 36 1440-1443 1:CAS:528:DyaK3cXlsVyht78%3D
21. M. Somogy 1930 A method for the preparation of blood filtrates for the determination of sugar J Biol Chem 86 655-663
22. Z Zhong GE Arteel HD Connor et al. 1998 Cylosporine A increases hypoxia and free radical production in rat kidneys: Prevention by dietary glycine Am J Physiol 275 F595-F604 1:CAS:528:DyaK1cXmvFSmtLo%3D
23. C Esposito A Fornoni F Cornacchia et al. 2000 Cyclosporine induces different responses in human epithelial, endothelial, and fibroblast cell cultures Kidney Int 58 1 123-130 10.1046/j.1523-1755.2000.00147.x 1:CAS:528:DC%2BD3cXltVyjtL8%3D
24. FS Shibab TF Andoh AM Tanner WM. Bennett 1997 Sodium depletion enhances fibrosis and the expression of TGF-beta1 and matrix proteins in experimental chronic cyclosporin nephropathy Am J Kidney Dis 30 1 71-81
25. J English A Evan DC Houghton WM. Bennett 1987 Cyclosporin-induced acute renal dysfunction in the rat. Evidence of arteriolar vasoconstriction with preservation of tubular function Transplantation 44 1 135-141 1:CAS:528:DyaL2sXkvV2nu7o%3D
26. P Vallance J. Collier 1994 Forthnightly review. Biology and clinical relevance of nitric oxide Br Med J 309 6952 453-457 1:STN:280:ByqD3czovFQ%3D
27. LA Tome L Yu I Castro et al. 1999 Beneficial and harmful effects of L-arginine on renal ischemia Nephrol Dial Transplant 14 1139-1145 1:CAS:528:DyaK1MXjsFaqsr8%3D
28. M Ketteler WA. Border NA. Noble 1994 Cytokines and L-arginine in renal injury and repair Am J Physiol 267 2 Pt 2 F197-207 1:CAS:528:DyaK2cXlsFCgtLw%3D
29. BC. Kone 1997 Nitric oxide in renal health and disease Am J Kidney Dis 30 3 311-333 1:CAS:528:DyaK2sXmtFGqt78%3D
30. DW Johnson HJ Saunders FJ Johnson et al. 1999 Cylosporin exerts a direct fibrogenic effect on human tubulointerstitial cells: Roles of insulin-like growth factor I, TGF-beta-1 and platelet derived growth factor J Pharmacol Exp Ther 289 1 535-542 1:CAS:528:DyaK1MXit1KnsLc%3D
31. OG Pankewycz L Miao R Isaacs et al. 1996 Increased renal tubular expression of transforming growth factor beta in human allografts correlates with cyclosporine toxicity Kidney Int 50 5 1634-1640 1:CAS:528:DyaK28Xms1yls70%3D