Protective effect of L-propionylcarnitine in chronic cyclosporine-a induced nephrotoxicity

Biomedicine and Pharmacotherapy

Volumn 60, Issue 2, 2006, Pages 77-81

  Origlia, Nicola ^a   Migliori, Massimiliano ^a   Panichi, Vincenzo ^a   Filippi, Cristina ^a   Bertelli, Aldo ^b   Carpi, Angelo ^a   Giovannini, Luca ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Hypertension; Lipid peroxidation; Nitric oxide

Indexed keywords

CREATININE; CYCLOSPORIN A; LIPID; PROPIONYLCARNITINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CREATININE CLEARANCE; DOSE RESPONSE; DRUG EFFECT; HEMODYNAMICS; HYPERTENSION; KIDNEY; KIDNEY FUNCTION; KIDNEY PARENCHYMA; KIDNEY VASCULAR RESISTANCE; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL PROTECTION; TISSUE INJURY; URINALYSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD PRESSURE; CARNITINE; CREATININE; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY DISEASES; LIPID PEROXIDATION; MALE; RATS; RATS, WISTAR;

EID: 33644900486     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2005.06.014     Document Type: Article

References (24)

1. B.D. Kahan Cyclosporine N. Engl. J. Med. 321 1989 1725 1738
2. J.S. Abraham, F.R. Bentley, R.N. Garrison, and H.M. Cryer Cyclosporine A directly constricts intrarenal arterioles Transplant. Proc. 23 1991 356 359
3. B.D. Myers, J. Ross, L. Newton, J. Luetscher, and M. Perlroth Cyclosporine-associated chronic nephropathy N. Engl. J. Med. 311 1984 699 705
4. B.D. Myers, R. Sibley, L. Newton, S.J. Tomlanovich, C. Boshkos, and E. Stinson The long-term course of cyclosporine-associated chronic nephropathy Kidney Int. 33 1988 590 600
5. F.S. Shihab, H. Yi, W.M. Bennett, and T.F. Andoh Effect of nitric oxide modulation on TGF-beta1 and matrix proteins in chronic cyclosporine nephrotoxicity Kidney Int. 58 2000 1174 1185
6. D. Cattaneo, N. Perico, F. Gaspari, and G. Remuzzi Nephrotoxic aspects of cyclosporine Transplant. Proc. 36 2004 234S 239S
7. T. Parra Cid, J.R. Conejo Garcia, F. Carballo Alvarez, and G. de Arriba Antioxidant nutrients protect against cyclosporine A nephrotoxicity Toxicology 189 2003 99 111
8. B.M. Longoni, L. Giovannini, M. Migliori, A.A. Bertelli, and A. Bertelli Cyclosporine-induced lipid peroxidation and propionyl carnitine protective effect Int. J. Tissue React. 21 1999 7 11
9. L. Giovannini, M. Migliori, S. De Pietro, D. Taccola, V. Panichi, and A.A. Bertelli l-Propionyl carnitine reduces toxicity correlated to cyclosporine-induced intracellular ATP concentrations Drugs Exp. Clin. Res. 25 1999 173 177
10. A. Bertelli, L. Giovannini, R. Palla, M. Migliori, V. Panichi, and B. Andreini Protective effect of l-propionylcarnitine on cyclosporine-induced nephrotoxicity Drugs Exp. Clin. Res. 21 1995 221 228
11. R.J. Walker, V.A. Lazzaro, G.G. Duggin, J.S. Horvath, and D.J. Tiller Evidence that alterations in renal metabolism and lipid peroxidation may contribute to cyclosporine nephrotoxicity Transplantation 50 1990 487 492
12. S.S. Ahmed, K.L. Napoli, and H.W. Strobel Oxygen radical formation during cytochrome P450 catalyzed cyclosporine metabolism in rat and human liver microsomes at varying hydrogen ion concentrations Mol. Cell. Biochem. 151 2 1995 131 140
13. T. Parra, G. De Arriba, I. Arribas, G. Perez de Lema, D. Rodriguez-Puyol, and M. Rodriguez-Puyol Cyclosporine A nephrotoxicity: role of thromboxane and reactive oxygen species J. Lab. Clin. Med. 131 1998 63 70
14. A.M. Mohamadin, H.A. El-Beshbishy, and M.A. El-Mahdy Green tea extract attenuates cyclosporine A-induced oxidative stress in rats Pharmacol. Res. 51 2005 51 57
15. B.M. Longoni, M. Migliori, A. Ferretti, N. Origlia, V. Panichi, and U. Boggi Melatonin prevents cyclosporine-induced nephrotoxicity in isolated and perfused rat kidney Free Rad Res. 36 2002 357 363
16. A.Z. Reznick, V.E. Kagan, R. Ramsey, M. Tsuchiya, S. Khwaja, and E.A. Serbinova Related Articles Antiradical effects in l-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation Arch. Biochem. Biophys. 296 1992 394 401
17. A. Vanella, A. Russo, R. Acquaviva, A. Campisi, C. Di Giacomo, and V. Sorrenti l-Propionylcarnitine as superoxide scavenger, antioxidant, and DNA cleavage protector Cell Biol. Toxicol. 16 2000 99 104
18. B.C. Kone Nitric oxide in renal health and disease Am. J. Kidney Dis. 30 3 1997 311 333
19. N.A. Bobadilla, G. Gamba, E. Tapia, R. Garcia-Torres, A. Bolio, and P. Lopez-Zetina Role of NO in cyclosporin nephrotoxicity: effects of chronic NO inhibition and NO synthases gene expression Am. J. Physiol. 274 1998 F791 F798
20. F.S. Shihab, W.M. Bennett, J. Isaac, H. Yi, and T.F. Andoh Nitric oxide modulates vascular endothelial growth factor and receptors in chronic cyclosporine nephrotoxicity Kidney Int. 63 2003 522 533
21. N.D. Vaziri, Z. Ni, Y.P. Zhang, E.P. Ruzics, P. Maleki, and Y. Ding Depressed renal and vascular nitric oxide synthase expression in cyclosporine-induced hypertension Kidney Int. 54 1998 482 491
22. U. Scherrer, S.F. Vissing, B.J. Morgan, J.A. Rollins, R.S. Tindall, and S. Ring Cyclosporine-induced sympathetic activation and hypertension after heart transplantation N. Engl. J. Med. 323 1990 693 699
23. H. Rauchova, Z. Dobesova, Z. Drahota, J. Zicha, and J. Kunes The effect of chronic l-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats Eur. J. Pharmacol. 342 1998 235 239
24. S. Vasdev, V. Gill, S. Parai, L. Longerich, and V. Gadag Dietary vitamin E supplementation lowers blood pressure in spontaneously hypertensive rats Mol. Cell. Biochem. 238 2002 111 117