Calcitriol derivatives with two different side-chains at C-20. Part 4: Further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 13, 2007, Pages 4444-4455

  Garay, Edward ^a   Jankowski, Pawel ^b   Lizano, Paulo ^a   Marczak, Stanislaw ^b   Maehr, Hubert ^b   Adorini, Luciano ^b   Uskokovic, Milan R ^b   Studzinski, George P ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b Bioxell Inc   (United States)

Author keywords

Gemini; Leukemia; Monocytic differentiation; VDR induced transcription

Indexed keywords

1ALPHA FLUORO HYDROXY (4 HYDROXY 4 METHYL PENTYL) 21 CYCLO CHOLECALCIFEROL; 1ALPHA,25 DIHYDROXY (4 HYDROXY 4 METHYL PENTYL) 21 CYCLO 19 NOR CHOLECALCIFEROL; 1ALPHA,25 DIHYDROXY (4 HYDROXY 4 METHYL PENTYL) 21 CYCLO CHOLECALCIFEROL; 1ALPHA,25 DIHYDROXY (4 HYDROXY 4 METHYL PENTYL)21,22 CIS CYCLO CHOLECALFEROL; 1ALPHA,25 DIHYDROXY (4 HYDROXY 4 TRIFLUOROMETHYL 5 TRIFLUORO 2 PENTYNYL) 21 CYCLO 19 NOR CHOLECALCIFEROL; 1ALPHA,25 DIHYDROXY (4 HYDROXY 4 TRIFLUOROMETHYL 5 TRIFLUORO 2 PENTYNYL) 21 CYCLO CHOLECALCIFEROL; 4 HYDROXY 4 TRIFLUOROMETHYL 5,5,5 TRIFLUOROPENT 2 YNYL; CALCITRIOL; CALCITRIOL DERIVATIVE; CD11B ANTIGEN; CD14 ANTIGEN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; MONOCYTE;

BIOLOGICAL MARKERS; CALCITRIOL; CELL CYCLE; CELL DIFFERENTIATION; HL-60 CELLS; HUMANS; INDICATORS AND REAGENTS; LEUKEMIA; MODELS, MOLECULAR; MONOCYTES; OXIDATION-REDUCTION; RECEPTORS, CALCITRIOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 34248632249     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.04.034     Document Type: Article

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