19-nor vitamin-D analogs: A new class of potent inhibitors of proliferation and inducers of differentiation of human myeloid leukemia cell lines

Blood

Volumn 92, Issue 7, 1998, Pages 2441-2449

  Asou, Hiroya ^b   Koike, Michiaki ^b   Elstner, Elena ^b   Cambell, Moray ^b   Le, Jennifer ^b   Uskokovic, Milan R ^b   Kamada, Nanao ^b   Koeffler, H Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CALCITRIOL DERIVATIVE;

ARTICLE; BONE MARROW CELL; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); DOSE RESPONSE; DRUG MECHANISM; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOSIS INHIBITION; PRIORITY JOURNAL;

EID: 0032189828     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.7.2441.2441_2441_2449     Document Type: Article

References (35)

1. Warrell RP, de The H, Wang ZY, Degos L: Review: Acute promyelocytic leukemia. N Engl J Med 329:177, 1993
2. Hong WK, Endicott J, Itri LM, Doos W, Batsakis JG, Bell R, Fofonoff S, Byers R, Atkinson EN, Vaughn C, Toth BB, Kramer A, Dimery IW, Skipper P, Strong S: 13-cis-retinoic acid in the treatment of oral leukoplakia. N Engl J Med 315:1501, 1986
3. 3: In vivo and in vitro effects on human preleukemic and leukernic cells. Cancer Treat Rep 69:1399, 1985
4. Studzinski GP, Bhandal AK, Brelvi ZS: Potentiation by 1-α,25-dihydroxyvitamin D3 of cytotoxicity to HL60 cells produced by cytarabine and hydroxyurea. J Natl Cancer Inst 76:641, 1986
5. 3 analogues and other differentiation inducers in combination with antileukemic drugs: In vitro and in vivo studies. Cancer Res 47:567, 1987
6. Anzano MA, Smith JM, Uskokovic MR, Peer CW, Mullen LT, Letterio, Roberts AB. Sporn MB: 1α,25-Dihydroxy-16-ene-23-yne26,27-hexafluoro-cholecalciferol (Ro24-5531), a new deltanoid (vitamin D analogue) for prevention of breast cancer in the rat. Cancer Res 54:1653, 1994
7. Zhou JY, Norman AW, Lubbert M, Collins ED, Uskokovic MR, Koeffler HP: Novel vitamin D analogs that modulate leukernic cell growth and differentiation with little effect on either intestinal calcium absorption or bone calcium mobilization. Blood 74:82, 1989
8. 3 is a potent antileukemic agent with low potential to cause hypercalcemia. Leukemia Res 18:453, 1994
9. 3 combined with retinoic acid or dexamethasone. Anticancer Drugs 6:562, 1995
10. Brenner RV, Shabahang M, Schumaker LM, Nauta RJ, Uskokovic MR, Evans SR, Buras RR: The antiproliferative effect of vitamin D analogs on MCF-7 human breast cancer cells. Cancer Lett 92:77, 1995
11. James SY, Mackay AG, Binderup L, Colston KW: Effect of a new synthetic vitamin D analogue, EB1089, on the oestrogen-responsive growth of human breast cancer cells. J Endocrinol 144:555, 1994
12. Wali RK, Bissonnette M, Kahre S, Hart J, Sitrin MD, Brasitus TA: 1-alpha,25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a non-calcemic analogue of 1 alpha,25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic tumorigenesis. Cancer Res 55:3050, 1995
13. Shabahang M, Buras RR, Davoodi F, Schumaker LM, Nauta RJ, Uskokovic, Brenner RV, Evans SR: Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3. Cancer Res 54:4057, 1994
14. Yu J, Papavasiliou V, Rhim J, Goltzman D, Kremer R: Vitamin D analogs: New therapeutic agents for the treatment of squamous cancer and its associated hypercalcemia. Anticancer Drugs 6:101, 1995
15. Peehl DM, Skowronski RJ, Leung ST, Wong ST, Stamey TA, Feldman D: Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells. Cancer Res 54:805, 1994
16. Skowronski RJ, Peehl DM, Feldman D: Action of vitamin D3 analogs on human prostate cancer cell lines: Comparison with 1,25-dihydroxyvitamin D3. Endocrinology 136:20, 1995
17. 3: Towards an endocrine therapy of brain tumors? J Neurosci Res 37:271, 1994
18. Zhou JY, Norman AW, Chen DL, Sun GW, Uskokovic MR, Koeffler HP: 1,25(OH)2-16ene-23yne-vitamin D3 prolongs survival time of leukemic mice. Proc Natl Acad Sci USA 87:3929, 1990
19. Lannote M, Martin-Thouvenin V, Najman S, Ballerini P, Valensi F, Berger R: NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77:1080, 1991
20. Li YP, Said F, Gallagher RE: Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-α. Blood 83:3298, 1994
21. Asou H, Tashiro S, Hamamoto K, Otsuji A, Kita K, Kamada N: Establishment of a acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosomal translocation. Blood 77:2031, 1991
22. Munker R, Norman A, Koeffler HP: Vitamin D compounds: Effect on clonal proliferation and differentiation of human myeloid cells. J Clin Invest 78:424,1986
23. Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC: Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide. J Exp Med 149:969, 1979
24. Elstner E, Linker-Israeli M, Said J, Umiel T, de Vos S, Shintaku IP, Heber D, Binderup L, Uskokovic M, Koeffler HP: 20-epi-vitamin D3 analogs: A novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines. Cancer Res 55:2822, 1995
25. Selsted ME, Miller CW, Novotny MJ, Morris WL, Koeffler HP: Molecular analysis of myeloperoxidase deficiency shows heterogenous patterns of the complete deficiency state manifested at the genomic, mRNA, and protein levels. Blood 82:1317, 1993
26. Zhang W, Grasso L, McClain CD, Gambel AM, Cha Y, Travail S, Deisseroth AN, Mercer WP: p53-independent induction of WAF/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res 55:668, 1995
27. Cambell MJ, Hirama T, Elstner E, Holden S, Norman AW, Uskokovic M, Koeffler HP: 19-nor-hexafluoride analogs of vitamin D3 are potent inhibitors of in vitro clonal proliferation of prostate cancer cells: PC-3,DU-145 and LNCaP. J Clin Endocrinol 19:15, 1997
28. Koike M, Elstner E, Cambell MJ, Asou H, Uskokovic M, Tsuruoka N, Koeffler HP: 19-nor-hexafluoride analogs of vitamin D3: A new class of potent inhibitors of proliferation and inducers of p27/Kip1 in human breast cancer cell lines. Cancer Res 57:4545,1997
29. 3 analogue (KH1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells. Cancer Res 56:3570, 1996
30. Gianni M, Terao M, Gambacorti-Passerini C, Rambaldi A, Garattini E: Effects of 1,25-dihydroxyvitamin D3 on all-trans retinoic acid sensitive and resistant acute promyelocytic leukemia cells. Biochem Biophy Res Commun 224:50, 1996
31. 3 analogs and 9-cis retinoic acid. J Clin Invest 99:349, 1997
32. 3 in HL-60 cells. Cancer Res 56:264, 1996
33. Wang X, Gorospe M, Huang Y, Holbrook NJ: p27kip-1 overexpression causes apoptotic death of mammalian cells. Oncogene 15:2991, 1997
34. 3-resistant HL60 cells is preceded by reduced growth factor dependence and constitutive up-regulation of Sp1 and AP-1 transcription factors. Cancer Res 56:5513, 1996
35. Norman AW, Zhou JY, Henry HL, Uskokovic MR, Koeffler HP: Structure-function studies on analogues of 1α,25-dihydroxyvitamin D3: Differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption. Cancer Res 50:6857, 1990