메뉴 건너뛰기




Volumn 127, Issue 6, 2007, Pages 1436-1443

C34, a membrane fusion inhibitor, blocks HIV infection of Langerhans cells and viral transmission to T cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; C PEPTIDE C 34; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN GP 41; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 34248593768     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700736     Document Type: Article
Times cited : (14)

References (44)
  • 1
    • 0037223706 scopus 로고    scopus 로고
    • Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C
    • Ball SC, Abraha A, Collins KR, Marozsan AJ, Baird H, Quinones-Mateu ME et al. (2003) Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C. J Virol 77:1021-38
    • (2003) J Virol , vol.77 , pp. 1021-1038
    • Ball, S.C.1    Abraha, A.2    Collins, K.R.3    Marozsan, A.J.4    Baird, H.5    Quinones-Mateu, M.E.6
  • 2
    • 0032433685 scopus 로고    scopus 로고
    • Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target
    • Chan DC, Chutkowski CT, Kim PS (1998) Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target. Proc Natl Acad Sci USA 95:15613-7
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15613-15617
    • Chan, D.C.1    Chutkowski, C.T.2    Kim, P.S.3
  • 3
    • 0030970693 scopus 로고    scopus 로고
    • Core structure of gp41 from the HIV envelope glycoprotein
    • Chan DC, Fass D, Berger JM, Kim PS (1997) Core structure of gp41 from the HIV envelope glycoprotein. Cell 89:263-73
    • (1997) Cell , vol.89 , pp. 263-273
    • Chan, D.C.1    Fass, D.2    Berger, J.M.3    Kim, P.S.4
  • 4
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene
    • Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R et al. (1996) Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856-62
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3    Huttley, G.A.4    Smith, M.W.5    Allikmets, R.6
  • 5
    • 4644225675 scopus 로고    scopus 로고
    • In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission
    • Dezzutti CS, James VN, Ramos A, Sullivan ST, Siddig A, Bush TJ et al. (2004) In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission. Antimicrob Agents Chemother 48:3834-44
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3834-3844
    • Dezzutti, C.S.1    James, V.N.2    Ramos, A.3    Sullivan, S.T.4    Siddig, A.5    Bush, T.J.6
  • 6
    • 0031959601 scopus 로고    scopus 로고
    • Capture of an early fusion-active conformation of HIV-1 gp41
    • Furuta RA, Wild CT, Weng Y, Weiss CD (1998) Capture of an early fusion-active conformation of HIV-1 gp41. Nat Struct Biol 5:276-9
    • (1998) Nat Struct Biol , vol.5 , pp. 276-279
    • Furuta, R.A.1    Wild, C.T.2    Weng, Y.3    Weiss, C.D.4
  • 7
    • 0034598905 scopus 로고    scopus 로고
    • DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    • Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J et al. (2000) DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100:587-97
    • (2000) Cell , vol.100 , pp. 587-597
    • Geijtenbeek, T.B.1    Kwon, D.S.2    Torensma, R.3    van Vliet, S.J.4    van Duijnhoven, G.C.5    Middel, J.6
  • 8
    • 9344239350 scopus 로고    scopus 로고
    • Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors
    • Hartley O, Gaertner H, Wilken J, Thompson D, Fish R, Ramos A et al. (2004) Medicinal chemistry applied to a synthetic protein: development of highly potent HIV entry inhibitors. Proc Natl Acad Sci USA 101:16460-5
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16460-16465
    • Hartley, O.1    Gaertner, H.2    Wilken, J.3    Thompson, D.4    Fish, R.5    Ramos, A.6
  • 9
    • 0034051289 scopus 로고    scopus 로고
    • Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells
    • Hu J, Gardner MB, Miller CJ (2000) Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells. J Virol 74:6087-95
    • (2000) J Virol , vol.74 , pp. 6087-6095
    • Hu, J.1    Gardner, M.B.2    Miller, C.J.3
  • 10
    • 16044367526 scopus 로고    scopus 로고
    • The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
    • Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T et al. (1996) The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 2:1240-3
    • (1996) Nat Med , vol.2 , pp. 1240-1243
    • Huang, Y.1    Paxton, W.A.2    Wolinsky, S.M.3    Neumann, A.U.4    Zhang, L.5    He, T.6
  • 12
    • 3142749905 scopus 로고    scopus 로고
    • PSC-RANTES blocks R5 human immunodeficiency virus infection of Langerhans cells isolated from individuals with a variety of CCR5 diplotypes
    • Kawamura T, Bruse SE, Abraha A, Sugaya M, Hartley O, Offord RE et al. (2004) PSC-RANTES blocks R5 human immunodeficiency virus infection of Langerhans cells isolated from individuals with a variety of CCR5 diplotypes. J Virol 78:7602-9
    • (2004) J Virol , vol.78 , pp. 7602-7609
    • Kawamura, T.1    Bruse, S.E.2    Abraha, A.3    Sugaya, M.4    Hartley, O.5    Offord, R.E.6
  • 13
    • 0034694084 scopus 로고    scopus 로고
    • Candidate microbicides block HIV-1 infection of human immature Langerhans cells within epithelial tissue explants
    • Kawamura T, Cohen SS, Borris DL, Aquilino EA, Glushakova S, Margolis LB et al. (2000) Candidate microbicides block HIV-1 infection of human immature Langerhans cells within epithelial tissue explants. J Exp Med 192:1491-500
    • (2000) J Exp Med , vol.192 , pp. 1491-1500
    • Kawamura, T.1    Cohen, S.S.2    Borris, D.L.3    Aquilino, E.A.4    Glushakova, S.5    Margolis, L.B.6
  • 14
    • 0038153897 scopus 로고    scopus 로고
    • R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms
    • Kawamura T, Gulden FO, Sugaya M, McNamara DT, Borris DL, Lederman MM et al. (2003) R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms. Proc Natl Acad Sci USA 100:8401-6
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8401-8406
    • Kawamura, T.1    Gulden, F.O.2    Sugaya, M.3    McNamara, D.T.4    Borris, D.L.5    Lederman, M.M.6
  • 15
    • 0038576281 scopus 로고    scopus 로고
    • Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America
    • Lalezari JP, Henry K, O'Hearn M, Montaner JS, Piliero PJ, Trottier B et al. (2003) Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America. N Engl J Med 348:2175-85
    • (2003) N Engl J Med , vol.348 , pp. 2175-2185
    • Lalezari, J.P.1    Henry, K.2    O'Hearn, M.3    Montaner, J.S.4    Piliero, P.J.5    Trottier, B.6
  • 16
    • 0037849954 scopus 로고    scopus 로고
    • Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia
    • Lazzarin A, Clotet B, Cooper D, Reynes J, Arasteh K, Nelson M et al. (2003) Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. N Engl J Med 348:2186-95
    • (2003) N Engl J Med , vol.348 , pp. 2186-2195
    • Lazzarin, A.1    Clotet, B.2    Cooper, D.3    Reynes, J.4    Arasteh, K.5    Nelson, M.6
  • 17
    • 33646342770 scopus 로고    scopus 로고
    • Microbicides and other topical strategies to prevent vaginal transmission of HIV
    • Lederman MM, Offord RE, Hartley O (2006) Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat Rev Immunol 6:371-82
    • (2006) Nat Rev Immunol , vol.6 , pp. 371-382
    • Lederman, M.M.1    Offord, R.E.2    Hartley, O.3
  • 18
    • 5644247983 scopus 로고    scopus 로고
    • Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5
    • Lederman MM, Veazey RS, Offord R, Mosier DE, Dufour J, Mefford M et al. (2004) Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science 306:485-7
    • (2004) Science , vol.306 , pp. 485-487
    • Lederman, M.M.1    Veazey, R.S.2    Offord, R.3    Mosier, D.E.4    Dufour, J.5    Mefford, M.6
  • 19
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R et al. (1996) Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367-77
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.A.2    Choe, S.3    Ceradini, D.4    Martin, S.R.5    Horuk, R.6
  • 20
    • 0028834461 scopus 로고
    • A trimeric structural domain of the HIV-1 transmembrane glycoprotein
    • Lu M, Blacklow SC, Kim PS (1995) A trimeric structural domain of the HIV-1 transmembrane glycoprotein. Nat Struct Biol 2:1075-82
    • (1995) Nat Struct Biol , vol.2 , pp. 1075-1082
    • Lu, M.1    Blacklow, S.C.2    Kim, P.S.3
  • 21
    • 0032483021 scopus 로고    scopus 로고
    • Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: Conserved helical interactions underlie the broad inhibitory activity of gp41 peptides
    • Malashkevich VN, Chan DC, Chutkowski CT, Kim PS (1998) Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides. Proc Natl Acad Sci USA 95:9134-9
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9134-9139
    • Malashkevich, V.N.1    Chan, D.C.2    Chutkowski, C.T.3    Kim, P.S.4
  • 22
    • 0037340005 scopus 로고    scopus 로고
    • HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formation
    • Markosyan RM, Cohen FS, Melikyan GB (2003) HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formation. Mol Biol Cell 14:926-38
    • (2003) Mol Biol Cell , vol.14 , pp. 926-938
    • Markosyan, R.M.1    Cohen, F.S.2    Melikyan, G.B.3
  • 23
    • 4344602905 scopus 로고    scopus 로고
    • A randomized Phase I vaginal safety study of three concentrations of C31G vs Extra Strength Gynol II
    • Mauck CK, Weiner DH, Creinin MD, Barnhart KT, Callahan MM, Bax R (2004) A randomized Phase I vaginal safety study of three concentrations of C31G vs Extra Strength Gynol II. Contraception 70:233-40
    • (2004) Contraception , vol.70 , pp. 233-240
    • Mauck, C.K.1    Weiner, D.H.2    Creinin, M.D.3    Barnhart, K.T.4    Callahan, M.M.5    Bax, R.6
  • 24
    • 0034675886 scopus 로고    scopus 로고
    • Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion
    • Melikyan GB, Markosyan RM, Hemmati H, Delmedico MK, Lambert DM, Cohen FS (2000) Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion. J Cell Biol 151:413-23
    • (2000) J Cell Biol , vol.151 , pp. 413-423
    • Melikyan, G.B.1    Markosyan, R.M.2    Hemmati, H.3    Delmedico, M.K.4    Lambert, D.M.5    Cohen, F.S.6
  • 25
    • 0038065763 scopus 로고    scopus 로고
    • Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41
    • Munoz-Barroso I, Durell S, Sakaguchi K, Appella E, Blumenthal R (1998) Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41. J Cell Biol 140:315-23
    • (1998) J Cell Biol , vol.140 , pp. 315-323
    • Munoz-Barroso, I.1    Durell, S.2    Sakaguchi, K.3    Appella, E.4    Blumenthal, R.5
  • 26
    • 0343365487 scopus 로고    scopus 로고
    • Role of the membrane-proximal domain in the initial stages of human immunodeficiency virus type 1 envelope glycoprotein-mediated membrane fusion
    • Munoz-Barroso I, Salzwedel K, Hunter E, Blumenthal R (1999) Role of the membrane-proximal domain in the initial stages of human immunodeficiency virus type 1 envelope glycoprotein-mediated membrane fusion. J Virol 73:6089-92
    • (1999) J Virol , vol.73 , pp. 6089-6092
    • Munoz-Barroso, I.1    Salzwedel, K.2    Hunter, E.3    Blumenthal, R.4
  • 27
    • 2942622122 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles
    • Neurath AR, Strick N, Jiang S, Li YY, Debnath AK (2002) Anti-HIV-1 activity of cellulose acetate phthalate: synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles. BMC Infect Dis 2:6
    • (2002) BMC Infect Dis , vol.2 , pp. 6
    • Neurath, A.R.1    Strick, N.2    Jiang, S.3    Li, Y.Y.4    Debnath, A.K.5
  • 28
    • 0037311452 scopus 로고    scopus 로고
    • Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES
    • Pastore C, Picchio GR, Galimi F, Fish R, Hartley O, Offord RE et al. (2003) Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES. Antimicrob Agents Chemother 47:509-17
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 509-517
    • Pastore, C.1    Picchio, G.R.2    Galimi, F.3    Fish, R.4    Hartley, O.5    Offord, R.E.6
  • 31
    • 0036039739 scopus 로고    scopus 로고
    • Essential roles for dendritic cells in the pathogenesis and potential treatment of HIV disease
    • Piguet V, Blauvelt A (2002) Essential roles for dendritic cells in the pathogenesis and potential treatment of HIV disease. J Invest Dermatol 119:365-9
    • (2002) J Invest Dermatol , vol.119 , pp. 365-369
    • Piguet, V.1    Blauvelt, A.2
  • 32
    • 0031883832 scopus 로고    scopus 로고
    • Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides
    • Rimsky LT, Shugars DC, Matthews TJ (1998) Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides. J Virol 72:986-93
    • (1998) J Virol , vol.72 , pp. 986-993
    • Rimsky, L.T.1    Shugars, D.C.2    Matthews, T.J.3
  • 33
    • 2442625211 scopus 로고    scopus 로고
    • HIV-1 gp41 as a target for viral entry inhibition
    • Root MJ, Steger HK (2004) HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des 10:1805-25
    • (2004) Curr Pharm Des , vol.10 , pp. 1805-1825
    • Root, M.J.1    Steger, H.K.2
  • 35
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM et al. (1996) Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722-5
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3    Rucker, J.4    Liesnard, C.5    Farber, C.M.6
  • 36
    • 0842343442 scopus 로고    scopus 로고
    • HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters
    • Sugaya M, Lore K, Koup RA, Douek DC, Blauvelt A (2004) HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters. J Immunol 172:2219-24
    • (2004) J Immunol , vol.172 , pp. 2219-2224
    • Sugaya, M.1    Lore, K.2    Koup, R.A.3    Douek, D.C.4    Blauvelt, A.5
  • 40
    • 33748452016 scopus 로고    scopus 로고
    • UNAIDS , December
    • UNAIDS (2006) AIDS epidemic update: December 2006.
    • (2006) AIDS epidemic update
  • 41
    • 0037190597 scopus 로고    scopus 로고
    • Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: A randomised controlled trial
    • Van Damme L, Ramjee G, Alary M, Vuylsteke B, Chandeying V, Rees H et al. (2002) Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet 360:971-7
    • (2002) Lancet , vol.360 , pp. 971-977
    • Van Damme, L.1    Ramjee, G.2    Alary, M.3    Vuylsteke, B.4    Chandeying, V.5    Rees, H.6
  • 42
    • 27744571425 scopus 로고    scopus 로고
    • Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion
    • Veazey RS, Klasse PJ, Schader SM, Hu Q, Ketas TJ, Lu M et al. (2005) Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion. Nature 438:99-102
    • (2005) Nature , vol.438 , pp. 99-102
    • Veazey, R.S.1    Klasse, P.J.2    Schader, S.M.3    Hu, Q.4    Ketas, T.J.5    Lu, M.6
  • 44
    • 0027959493 scopus 로고
    • Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection
    • Wild CT, Shugars DC, Greenwell TK, McDanal CB, Matthews TJ (1994) Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection. Proc Natl Acad Sci USA 91:9770-4
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9770-9774
    • Wild, C.T.1    Shugars, D.C.2    Greenwell, T.K.3    McDanal, C.B.4    Matthews, T.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.