Effects of PKA and PKC modulators on high affinity glutamate uptake in primary neuronal cell cultures from rat cerebral cortex

Neuropharmacology

Volumn 38, Issue 3, 1999, Pages 395-402

  Lortet, S ^b   Samuel, D ^a   Had Aissouni, L ^a   Masmejean, F ^a   Kerkerian Le Goff, L ^a   Pisano, P ^b  

^a Lab Neurobiologie Cell Fonct U   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Glutamate uptake; Neuronal cell cultures; Protein kinase A; Protein kinase C

Indexed keywords

CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXCITATORY AMINO ACID; GLUTAMIC ACID; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CONTROLLED STUDY; GLIA CELL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; FETUS; FORSKOLIN; GLUTAMIC ACID; ISOQUINOLINES; KINETICS; NEURONS; PHENANTHRIDINES; PROTEIN KINASE C; RATS; RATS, WISTAR; SULFONAMIDES; TETRADECANOYLPHORBOL ACETATE;

EID: 0033055937     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00193-2     Document Type: Article

References (37)

1. Arriza, J.L., Eliasof, S., Kavanaugh, M.P., Amara, S.G., 1997. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA 94, 4155-4160.
2. Barbour, B., Szatkowski, M., Ingledew, N., Atwell, D., 1989. Arachidonic acid induces a prolonged inhibition of glutamate uptake in glial cells. Nature. 342, 918-920.
3. Bloc, A., Samuel, D., Forni, C., Dusticier, N., Kerkerian-Le Goff, L., 1995. Effects of ionotropic excitatory aminoacid receptor antagonists on glutamate transport and transport-mediated changes in extracellular excitatory aminoacids in the rat striatum. J. Neurochem. 64, 1598-1604.
4. Borowski, B., Hoffman, B.J., 1995. Neurotransmitter transporters: molecular biology, function and regulation. Int. Rev. Neurobiol. 38, 139-198.
5. Casado, M., Benhadan, A., Zafra, F., Danbolt, N., Aragon, C., Gimenez, C., Kanner, B.I., 1993. Phosphorylation and modulation of brain glutamate transporters by protein kinase C. J. Biol. Chem. 268, 27313-27317.
6. Casado, M., Zafra, F., Aragon, C., Gimenez, C., 1991. Activation of high affinity uptake of glutamate by phorbol esters in primary glial cell cultures. J. Neurochem. 57, 1185-1190.
7. Castagna, M., Yakai, Y., Kaibuchi, K., Samo, K., Kikkawa, V., Nishizuka, Y., 1982. Direct activation of calcium-activated, phospholipid-dependent protein kinase C by tumor promoter phorbol esters. J. Biol. Chem. 257, 7847-7851.
8. Chijiwa, T., Mishima, A., Hagiwara, M., Sano, M., Hayashi, K., Inoue, T., Naito, K., Toshioka, T., Hidaka, H., 1990. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthetized selective inhibitor of cyclic AMP-dependent protein kinase, (H89), of PC12D pheochromocytoma cells. J. Biol. Chem. 265, 5267-5272.
9. Conradt, M., Stoffel, W., 1997. Inhibition of the high-affinity brain glutamate transporter GLAST1 via direct phosphorylation. J. Neurochem. 68, 1244-1251.
10. Corey, J.L., Davidson, N., Lester, H.A., Brecha, N., Quick, M.W., 1994. Protein kinase C modulates the activity of a cloned g-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter. J. Biol. Chem. 260, 14759-14767.
11. +-dependent glutamate transport activity in synaptosomes, C6 glioma and Xenopus expressing EAA carrier 1 (EAAC1). Mol. Pharmacol. 49, 465-473.
12. +-dependent L-glutamate transport activity in C6 glioma cells by phorbol ester. J. Neurochem. 67, 508-515.
13. Erecinska, M., 1987. The neurotransmitter aminoacid transport systems. Biochem. Pharmacol. 36 (21), 3547-3555.
14. Fairman, W.A., Vandenberg, R.J., Arriza, J.L., Kavanaugh, M.P., Amara, S.G., 1995. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 375, 599-603.
15. Fonnum, F., 1984. Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42 (1), 1-11.
16. Gegelashvili, G., Civenni, G., Racagni, G., Danbolt, N.C., Schousboe, I., Schousboe, A., 1996. Glutamate receptor agonists up-regulate glutamate transporter GLAST in astrocytes. Neuroreport 1, 261-265.
17. Gilad, G.M., Gilad, V.H., Wyatt, R.J., Tizabi, Y., 1990. Region-selective stress-induced increase of glutamate uptake and release in rat forebrain. Brain Res. 525, 335-338.
18. Hazell, A.S., Itzak, Y., Liu, H., Norenberg, M.D., 1997. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes. J. Neurochem. 68, 2216-2219.
19. Herbert, J.M., Augereau, J.M., Gleye, J., Maffrand, J.P., 1990. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Comm. 172, 993-999.
20. 3H]-staurosporine on various protein kinases. Biophys. Biochem. Res. Comm. 171, 189-195.
21. Hidaka, H., Kobayashi, R., 1993. Use of protein (serine/threonine) kinase activators and inhibitors to study protein phosphorylation in intact cells. In: Hardie, D.G. (Ed.), Protein Phosphorylation. A Practical Approach. IRL Press, Oxford, pp. 87-107.
22. Kanai, Y., Smith, C.G., Hediger, M.A., 1993. A new family of neurotransmitter transporters: the high affinity glutamate transporters. FASEB J. 8, 1450-1459.
23. Lowry, O.H., Rosebrough, N.J., Far, A.R., Randall, R.J., 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
24. McBean, G., Roberts, P.J., 1985. Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. J. Neurochem. 44, 247-254.
25. Nieoullon, A., Kerkerian-Le Goff, L., 1983. Presynaptic control of high affinity glutamate uptake in the striatum. Neurosci. Lett. 43, 191-196.
26. Nieoullon, A., Kerkerian-Le Goff, L., 1992. Cellular interactions in the striatum involving neuronal systems using 'classical neuro-transmitters': possible functions and implications. Mov. Disorders 7, 311-325.
27. Pines, G., Dandolt, N.C., Bjoras, M., Zhang, Y., Bendahan, A., Eide, I., Koepsell, H., Storm-Mathisen, J., Seeberg, E., Kanner, B.I., 1992. Cloning and expression of a rat brain L-glutamate transporter. Nature 360, 464-467.
28. Pisano, P., Samuel, D., Nieoullon, A., Kerkerian-Le Goff, L., 1996. Activation of the adenylate cyclase-dependant protein kinase pathway increases high affinity glutamate uptake into rat striatal synaptosomes. Neuropharmacology 35, 541-547.
29. Robinson, M.B., Djali, S., Buchalter, J.R., 1993. Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures. J. Neurochem. 61, 2099-2103.
30. Rothstein, J.D, Martin, L.J., Kuncl, R.W., 1992. Decreased glutamate transport by brain and spinal cord in amyotrophic lateral sclerosis. New Engl. J. Med. 326, 1464-1468.
31. Rothstein, J.D., Jin, L., Dykes-Hoberg, M., Kuncl, R.W., 1993. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl. Acad. Sci. USA. 90, 6591-6595.
32. Seamon, K.B., Daly, J.W., 1981. Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein. J. Biol. Chem. 256, 9799-9801.
33. +-dependent glutamate/aspartate transporter from rat brain. Proc. Natl. Acad. Sci. USA 89, 10955-10959.
34. Torp, R., Hoover, F., Danbolt, N., Storm-Mathisen, J., Ottersen, O.P., 1997. Differential distribution of the glutamate transporters GLT1 and rEAAC1 in rat cerebral cortex and thalamus: an in situ hybridization analysis. Anal. Embryol. 95, 317-326.
35. Volterra, A., Trotti, D., Racagni, G., 1994. Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms. Mol. Pharmacol. 46, 986-992.
36. Zerangue, N., Arriza, J.L., Amara, S.G., Kavanaugh, M.P., 1995. Differential modulation of human glutamate transporter subtypes by arachidonic acid. J. Biol. Chem. 270, 6433-6435.
37. Wang, G.J., Chung, H.J., Schnuer, J., Pratt, K., Zable, A.C., Kavanaugh, M.P., Rosenberg, P.A., 1998. High affinity glutamate transport in rat cortical neurons in culture. Mol. Pharmacol. 53, 88-96.