Enhanced gene expression of Na+/Ca2+ exchanger attenuates ischemic and hypoxic contractile dysfunction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 6 48-6, 2000, Pages

  Hampton, Thomas G ^a,c   Wang, Ju Feng ^a   Deangelis, Joseph ^a   Amende, Ivo ^a   Philipson, Kenneth D ^b   Morgan, James P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Calcium; Excitation contraction; Heart failure; Hypoxia; Ischemia; Sodium

Indexed keywords

CALCIUM ION; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HEART FAILURE; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE ISCHEMIA; HYPOXIA; ION EXCHANGE; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SYSTOLIC BLOOD PRESSURE; TRANSGENIC MOUSE;

EID: 0034533559     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.6.h2846     Document Type: Article

References (51)

1. 2+ exchanger
2. Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle
3. Na-H exchange in myocardium: Effects of hypoxia and acidification on Na and Ca
4. Opposite initial effects of supply and demand ischemia on left ventricular diastolic compliance: The ischemia-diastolic paradox
5. Alterations in sarcoplasmic reticulum gene expression in human heart failure: A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium
6. 2+
7. 2+ exchange directly activate cardiac muscle contraction?
8. Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure
9. 2+ exchanger increases susceptibility of ischemia/reperfusion injury in male, but not female, transgenic mice
10. 2+ exchanger in failing human myocardium
11. 2+-ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy
12. Abnormal intracellular calcium handling in myocardium from patients with endstage heart failure
13. 2+ during hypoxia and reoxygenation in myocardium
14. Intracellular calcium dynamics in mouse model of myocardial stunning
15. Simultaneous measurement of intracellular calcium and ventricular function in the phospholamban-deficient mouse heart
16. Calcium handling proteins in the failing human heart
17. 2+-ATPase in failing and nonfailing human myocardium
18. Calcium cycling proteins and force-frequency relationship in heart failure
19. The effects of cyanide and iodoacetate intoxication and ischemia on enzyme release from the perfused rat heart
20. Energy dependence of enzyme release from hypoxic isolated perfused rat heart tissue
21. Direct measurement of changes in intracellular calcium transients during hypoxia, ischemia, and reperfusion of the mammalian heart
22. Mechanism of early ischemic contractile failure. Inexcitability, metabolite accumulation, or vascular collapse?
23. Role of sodium/calcium exchange in the mechanisms of myocardial stunning: Protective effect of reperfusion with high sodium solution
24. Cardioprotective effects of KB-R7943: A novel inhibitor of the reverse mode of exchanger
25. The sodium/hydrogen exchange system in cardiac cells: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH
26. Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum
27. 2+ exchange in the infarcted heart. Implications for excitation-contraction coupling
28. Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: Studies in adult rabbit ventricular myocytes
29. Effects of ischemia on sarcoplasmic reticulum and contractile myofilament activity in human myocardium
30. Differential effects of reoxygenation on intracellular calcium and isometric tension
31. Contribution of reverse-mode sodium-calcium exchange to contractions in failing human left ventricular myocytes
32. 2+ modulation during postischemic reperfusion in the rat heart
33. Protective effects of 5-(N,N-dimethyl)amiloride on ischemia-reperfusion injury in hearts
34. 2+-ATPase gene expression in the human ventricle during end-stage failure
35. 2+-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium
36. Evaluation of time constant of left ventricular isovolumic relaxation in man
37. 2+ during ischemia and reperfusion
38. Amiloride delays the ischemia-induced rise in cytosolic free calcium
39. Mechanism of altered excitation-contraction coupling in canine tachycardia-induced heart failure. I. Experimental studies
40. Abnormalities in intracellular calcium regulation and contractile function in myocardium from dogs with pacing-induced heart failure
41. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion
42. Heterogeneous coronary perfusion during myocardial hypoxia
43. 2+ exchanger in end-stage human heart failure
44. 2+ exchange
45. 2+ exchanger
46. Ryanodine and caffeine prevent ventricular arrhythmias during acute myocardial ischemia and reperfusion in rat heart
47. 2+ exchange in activation of excitation-contraction coupling in rat ventricular myocytes
48. Myocardial protection with verapamil during ischemia and reperfusion: Disassociation between myocardial salvage and the degree of ATP depletion during ischemia
49. + exchange inhibitor, on ventricular arrhythmia in animal hearts
50. 2+ transients in murine ventricular myocytes
51. Development of a highly sensitive probe for measuring oxygen in biological tissues