Overexpression of the Na+-Ca2+ exchanger leads to enhanced inotropic responsiveness to Na+-channel agonist without sarcoplasmic reticulum protein changes in transgenic mice

Biochemical and Biophysical Research Communications

Volumn 249, Issue 3, 1998, Pages 786-790

  Bäumer, Anselm T ^a   Flesch, Markus ^a   Kilter, Heiko ^a   Philipson, Kenneth D ^b   Böhm, Michael ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Heart failure; Myocardial contractility; Na+ Ca2+ exchanger; Transgenic animals

Indexed keywords

4 [3 (1 BENZHYDRYL 3 AZETIDINYLOXY) 2 HYDROXYPROPOXY] 1H INDOLE 2 CARBONITRILE; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALSEQUESTRIN; CARRIER PROTEIN; ISOPRENALINE; PHOSPHOLAMBAN; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CHANNEL; SODIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG; AZETIDINE DERIVATIVE; CALCIUM BINDING PROTEIN; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE OVEREXPRESSION; HEART MUSCLE CONTRACTILITY; IMMUNOBLOTTING; IMMUNOREACTIVITY; INOTROPISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; TRANSGENIC MOUSE; ANIMAL; C3H MOUSE; C57BL MOUSE; DOG; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION; GENETICS; HEART CONTRACTION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; METABOLISM; PHYSIOLOGY;

ANIMALIA; MUS MUSCULUS;

ANIMALS; AZETIDINES; CALCIUM-BINDING PROTEINS; CALCIUM-TRANSPORTING ATPASES; CALSEQUESTRIN; DOGS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; ISOPROTERENOL; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; PROTEINS; SARCOPLASMIC RETICULUM; SODIUM CHANNELS; SODIUM-CALCIUM EXCHANGER;

EID: 0032575386     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1998.9248     Document Type: Article

References (29)

1. Bers D. M., Lederer W. J., Berlin J. R. Am. J. Physiol. 258:1990;C944-C954.
2. Bers D. M., Bridge J. H. Circ. Res. 65:1989;334-342.
3. Reeves J. P., Hale C. C. J. Biol. Chem. 259:1984;7733-7739.
4. Berlin J. R., Cannell M. B., Lederer W. Am. J. Physiol. 253:1987;H1540-H1547.
5. Litwin S., Kohmoto O., Levi A. J., Spitzer K. W., Bridge J. H. Ann. N.Y. Acad. Sci. 779:1996;451-463.
6. Vites A. M., Wasserstrom J. A. Ann. N.Y. Acad. Sci. 779:1996;521-524.
7. Schwinger R. H., Böhm M., Schmidt U., Karczewski P., Bavendiek U., Flesch M., Krause E. G., Erdmann E. Circulation. 92:1995;3220-3228.
8. Hasenfuss G., Reinecke H., Studer R., Meyer M., Pieske B., Holtz J., Holubarsch C., Posival H., Just H., Drexler H. Circ. Res. 75:1994;434-442.
9. Wankerl M., Schwartz K. J. Mol. Med. 73:1995;487-496.
10. Studer R., Reinecke H., Bilger J., Eschenhagen T., Böhm M., Hasenfuss G., Just H., Holtz J., Drexler H. Circ. Res. 75:1994;443-453.
11. Flesch M., Schwinger R. H., Schiffer F., Frank K., Sudkamp M., Kuhn-Regnier F., Arnold G., Böhm M. Circulation. 94:1996;992-1002.
12. Schwinger R. H., Böhm M., Mittmann C., La Rosee K., Erdmann E. J. Mol. Cell. Cardiol. 23:1991;461-471.
13. Philipson K. D., Longoni S., Ward R. Biochim. Biophys. Acta. 945:1988;298-306.
14. Adachi-Akahane S., Philipson K., Morad M. Biophys. J. 70:1996;A1-A502.
15. Adachi-Akahane S., Lu L., Li Z., Frank J. S., Philipson K. D., Morad M. J. Gen. Physiol. 109:1997;717-729.
16. Nicoll D. A., Longoni S., Philipson K. D. Science. 250:1990;562-565.
17. Laemmli U. K. Nature. 227:1970;680-685.
18. Lowry O. H., Rosebrough N. J., Farr N. J., Randall R. J. J. Biol. Chem. 193:1951;265-275.
19. Zolk O., Kilter H., Flesch M., Mansier P., Swynghedauw B., Schnabel P., Böhm M. Biochem. Biophys. Res. Commun. 1998.
20. Lederer W. J., He S., Luo S., du Bell W., Kofuji P., Kieval R., Neubauer C. F., Ruknudin A., Cheng H., Cannell M. B., Rogers T. B., Schulze D. H. Ann. N.Y. Acad. Sci. 779:1996;7-17.
21. Assayag P., Charlemagne D., de Leiris J., Boucher F., Valere P. E., Lortet S., Swynghedauw B., Besse S. Hypertension. 29:1997;15-21.
22. Artman M. Am. J. Physiol. 623:1998;H1506-H1513.
23. Vetter R., Studer R., Reinecke H., Kolar F., Ostadalova I., Drexler H. J. Mol. Cell. Cardiol. 27:1995;1689-1701.
24. Hoey A., Amos G. J., Ravens U. J. Mol. Cell. Cardiol. 26:1994;985-994.
25. Ravens U., Wettwer E. J. Cardiovasc. Pharmacol. 14:1989;S30-S35.
26. Scholtysik G. J. Cardiovasc. Pharmacol. 14:1989;S24-S29.
27. Lederer W. J., Niggli E., Hadley R. W. Science. 248:1990;283.
28. Bers D. M. J. Gen. Physiol. 90:1987;479-504.
29. Yao A., Su Z., Nonaka A., Zubair I., Lu L., Philipson K. D., Bridge J. H. B., Barry W. H. Circ. Res. 82:1998;657-665.