Overexpression of the Na+/Ca2+ exchanger and inhibition of the sarcoplasmic reticulum Ca2+-ATPase in ventricular myocytes from transgenic mice

Cardiovascular Research

Volumn 49, Issue 1, 2001, Pages 38-47

  Terracciano, Cesare M N ^a   Philipson, Kenneth D ^b   MacLeod, Kenneth T ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcium (cellular); e c coupling; Myocytes; Na Ca exchanger; SR (function)

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ION; CARRIER PROTEIN; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME INHIBITION; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE WALL; MOUSE; MUSCLE TWITCH; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; TRANSGENIC MOUSE;

ANIMALS; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CELL CULTURE TECHNIQUES; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; MICE; MICE, TRANSGENIC; MYOCARDIUM; SARCOPLASMIC RETICULUM; SODIUM-CALCIUM EXCHANGER; THAPSIGARGIN;

EID: 0034747690     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00205-4     Document Type: Article

References (37)

1. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum
2. Intracellular calcium homeostasis in cardiac myocytes
3. Flux of Ca across the sarcoplasmic reticulum of guinea-pig cardiac cells during excitation-contraction coupling
4. Abnormal intracellular calcium handling in the myocardium from patients with end-stage heart failure
5. Calcium transport proteins in the nonfailing and failing heart: Gene expression and function
6. Alterations of calcium-regulatory proteins in heart failure
7. 2+ exchanger in end-stage human heart failure
8. 2+-exchanger protein levels and diastolic function of failing human myocardium
9. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure. I. Experimental studies
10. The sarcoplasmic reticulum and the Na/Ca exchanger both contribute to the Ca transient of failing human ventricular myocytes
11. Ca handling and sarcoplasmic reticulum Ca content in isolated failing and nonfailing human myocardium
12. 2+ exchanger
13. 2+](i) transients in murine ventricular myocytes
14. 2+ exchanger
15. 2+ exchanger
16. A video system for measuring motion in contracting heart cells
17. 2+ extrusion mechanisms to relaxation in guinea-pig ventricular myocytes
18. Relaxation in rabbit and rat cardiac cells: Species-dependent differences in cellular mechanisms
19. Temperature and relative contributions of Ca transport systems in cardiac myocyte relaxation
20. Effects of rest interval on the release of calcium from the sarcoplasmic reticulum in isolated guinea pig ventricular myocytes
21. Passive Ca buffering and SR Ca uptake in permeabilized rabbit ventricular myocytes
22. Kinetics of [Ca](i) decline in cardiac myocytes depend on peak [Ca](i)
23. Rate of diastolic Ca release from the sarcoplasmic reticulum of intact rabbit and rat ventricular myocytes
24. Intrinsic cytosolic calcium buffering properties of single rat cardiac myocytes
25. The effects of changes to action potential duration on the calcium content of the sarcoplasmic reticulum in isolated guinea-pig ventricular myocytes
26. An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytes
27. Steady-state twitch Ca fluxes and cytosolic Ca buffering in rabbit ventricular myocytes
28. Inotropic response to hypothermia and the temperature- dependence of ryanodine action in isolated rabbit and rat ventricular muscle: Implications for excitation-contraction coupling
29. Adenovirus-mediated Na/Ca exchanger overexpression reduces sarcoplasmic reticulum (SR) Ca content in adult rabbit cardiomyocytes
30. Excitation-contraction coupling in ventriculocytes from transgenic mice with high level expression of canine sarcolemmal sodium-calcium exchange
31. The relative contributions of different intracellular and sarcolemmal systems to relaxation in rat ventricular myocytes
32. 2+ current in cardiac cells
33. Myocardial dysfunction in donor hearts. A possible etiology
34. 2+ exchange in the dog with chronic complete atrioventricular block (AVB) and proarrhytmia
35. Cardiac myocyte calcium transport in phospholamban knockout mouse: Relaxation and endogenous CaMKII effects
36. Phosphorylation of phospholamban and troponin I in β-adrenergic- induced acceleration of cardiac relaxation