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Volumn 252, Issue 1, 2007, Pages 147-156

TGF-β-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cells

Author keywords

AP 1; ATF2; Breast epithelial cells; MMP; p38 MAPK; TGF

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GELATINASE A; PROTEIN P53; TRANSCRIPTION FACTOR PEA3; TRANSFORMING GROWTH FACTOR BETA;

EID: 34248401646     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2006.12.016     Document Type: Article
Times cited : (96)

References (45)
  • 3
    • 0034176764 scopus 로고    scopus 로고
    • Matrix metalloproteinases: multifunctional contributors to tumor progression
    • McCawley L.J., and Matrisian L.M. Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol. Med. Today 4 (2000) 149-156
    • (2000) Mol. Med. Today , vol.4 , pp. 149-156
    • McCawley, L.J.1    Matrisian, L.M.2
  • 4
    • 0025222517 scopus 로고
    • The transforming growth factor-beta family
    • Massague J. The transforming growth factor-beta family. Annu. Rev. Cell Biol. 6 (1990) 597-641
    • (1990) Annu. Rev. Cell Biol. , vol.6 , pp. 597-641
    • Massague, J.1
  • 5
    • 0029073142 scopus 로고
    • Transforming growth factor-beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto M.B., Li Y., Panus J.F., Howe D.J., Xiong Y., and Wang X.F. Transforming growth factor-beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92 (1995) 5545-5549
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 6
    • 0030793645 scopus 로고    scopus 로고
    • Transforming growth factor-beta in breast cancer: a working hypothesis
    • Reiss M., and Barcellos-Hoff M.H. Transforming growth factor-beta in breast cancer: a working hypothesis. Breast Cancer Res. Treat. 45 (1997) 81-95
    • (1997) Breast Cancer Res. Treat. , vol.45 , pp. 81-95
    • Reiss, M.1    Barcellos-Hoff, M.H.2
  • 7
    • 0032909086 scopus 로고    scopus 로고
    • Genetic events and the role of TGF-beta in epithelial tumour progression
    • Akhurst R.J., and Balmain A. Genetic events and the role of TGF-beta in epithelial tumour progression. J. Pathol. 187 (1999) 82-90
    • (1999) J. Pathol. , vol.187 , pp. 82-90
    • Akhurst, R.J.1    Balmain, A.2
  • 8
    • 10344255835 scopus 로고    scopus 로고
    • TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells
    • Kim E.S., Kim M.S., and Moon A. TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells. Int. J. Oncol. 25 (2004) 1375-1382
    • (2004) Int. J. Oncol. , vol.25 , pp. 1375-1382
    • Kim, E.S.1    Kim, M.S.2    Moon, A.3
  • 9
    • 10344249892 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-β in conjunction with H-Ras activation promotes malignant progression of MCF10A breast epithelial cells
    • Kim E.S., Kim M.S., and Moon A. Transforming growth factor (TGF)-β in conjunction with H-Ras activation promotes malignant progression of MCF10A breast epithelial cells. Cytokine 29 (2005) 84-91
    • (2005) Cytokine , vol.29 , pp. 84-91
    • Kim, E.S.1    Kim, M.S.2    Moon, A.3
  • 11
    • 0034023127 scopus 로고    scopus 로고
    • Role of Ras and Mapks in TGF-beta signaling
    • Mulder K. Role of Ras and Mapks in TGF-beta signaling. Cytokine Growth Factor Rev. 11 (2000) 23-25
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 23-25
    • Mulder, K.1
  • 12
    • 0037099745 scopus 로고    scopus 로고
    • TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
    • Yu L., Hebert M.C., and Zhang Y.E. TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J. 21 (2002) 3749-3759
    • (2002) EMBO J. , vol.21 , pp. 3749-3759
    • Yu, L.1    Hebert, M.C.2    Zhang, Y.E.3
  • 13
    • 0026334362 scopus 로고
    • Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor-beta
    • Keeton M.R., Curriden S.A., Van Zonneveld A.J., and Loskutoff D.J. Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor-beta. J. Biol. Chem. 266 (1991) 23048-23052
    • (1991) J. Biol. Chem. , vol.266 , pp. 23048-23052
    • Keeton, M.R.1    Curriden, S.A.2    Van Zonneveld, A.J.3    Loskutoff, D.J.4
  • 14
    • 0025740859 scopus 로고
    • Identification of a serum- and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene
    • Campbell C.E., Flenniken A.M., Skup D., and Williams B.R. Identification of a serum- and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene. J. Biol. Chem. 266 (1991) 7199-7206
    • (1991) J. Biol. Chem. , vol.266 , pp. 7199-7206
    • Campbell, C.E.1    Flenniken, A.M.2    Skup, D.3    Williams, B.R.4
  • 15
    • 0029916877 scopus 로고    scopus 로고
    • Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes
    • Mauviel A., Chung K.Y., Agarwal A., Tamai K., and Uitto J. Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes. J. Biol. Chem. 271 (1996) 10917-10923
    • (1996) J. Biol. Chem. , vol.271 , pp. 10917-10923
    • Mauviel, A.1    Chung, K.Y.2    Agarwal, A.3    Tamai, K.4    Uitto, J.5
  • 16
    • 0030047646 scopus 로고    scopus 로고
    • An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta
    • Chung K.Y., Agarwal A., Uitto J., and Mauviel A. An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta. J. Biol. Chem. 271 (1996) 3272-3278
    • (1996) J. Biol. Chem. , vol.271 , pp. 3272-3278
    • Chung, K.Y.1    Agarwal, A.2    Uitto, J.3    Mauviel, A.4
  • 17
    • 0032849239 scopus 로고    scopus 로고
    • Interaction between the (-170) CRE and the (-150) CCAAT box is necessaryfor efficient activation of the fibronectin gene promoter by cAMP and ATF-2
    • Pesce C.G., Nogues G., Alonso C.R., Baralle F.E., and Kornblihtt A.R. Interaction between the (-170) CRE and the (-150) CCAAT box is necessaryfor efficient activation of the fibronectin gene promoter by cAMP and ATF-2. FEBS Lett. 457 (1999) 445-451
    • (1999) FEBS Lett. , vol.457 , pp. 445-451
    • Pesce, C.G.1    Nogues, G.2    Alonso, C.R.3    Baralle, F.E.4    Kornblihtt, A.R.5
  • 18
    • 0033573913 scopus 로고    scopus 로고
    • Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes
    • Beier F., Lee R.J., Taylor A.C., Pestell R.G., and LuValle P. Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes. Proc. Natl. Acad. Sci. USA 96 (1999) 1433-1438
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1433-1438
    • Beier, F.1    Lee, R.J.2    Taylor, A.C.3    Pestell, R.G.4    LuValle, P.5
  • 19
    • 0034725079 scopus 로고    scopus 로고
    • Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes
    • Beier F., Taylor A.C., and LuValle P. Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes. J. Biol. Chem. 275 (2000) 12948-12953
    • (2000) J. Biol. Chem. , vol.275 , pp. 12948-12953
    • Beier, F.1    Taylor, A.C.2    LuValle, P.3
  • 20
    • 0033605562 scopus 로고    scopus 로고
    • ATF2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
    • Sano Y., Harada J., Tashiro S., Gotoh-Mandeville R., Maekawa T., and Ishii S. ATF2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling. J. Biol. Chem. 274 (1999) 8949-8957
    • (1999) J. Biol. Chem. , vol.274 , pp. 8949-8957
    • Sano, Y.1    Harada, J.2    Tashiro, S.3    Gotoh-Mandeville, R.4    Maekawa, T.5    Ishii, S.6
  • 22
    • 33751270700 scopus 로고    scopus 로고
    • Activating transcription factor (ATF)2 mediates MMP-2 transcriptional activation induced by p38 MAPK in breast epithelial cells
    • Song H., Ki S.H., Kim S.G., and Moon A. Activating transcription factor (ATF)2 mediates MMP-2 transcriptional activation induced by p38 MAPK in breast epithelial cells. Cancer Res. 66 (2006) 10487-10496
    • (2006) Cancer Res. , vol.66 , pp. 10487-10496
    • Song, H.1    Ki, S.H.2    Kim, S.G.3    Moon, A.4
  • 23
    • 0025129726 scopus 로고
    • Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
    • Soule H.D., Maloney T.M., Wolman S.R., Peterson W.D., Brenz Jr. R., and McGrath C.M. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res. 50 (1990) 6075-6086
    • (1990) Cancer Res. , vol.50 , pp. 6075-6086
    • Soule, H.D.1    Maloney, T.M.2    Wolman, S.R.3    Peterson, W.D.4    Brenz Jr., R.5    McGrath, C.M.6
  • 24
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • Raingeaud J., Gupta S., Rogers J.S., Dickens M., Han J., Ulevitch R.J., and Davis R.J. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270 (1995) 7420-7426
    • (1995) J. Biol. Chem. , vol.270 , pp. 7420-7426
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3    Dickens, M.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 25
    • 0031883280 scopus 로고    scopus 로고
    • A dominant-negative inhibitor of CREN reveals that it is a general mediator of stimulus-dependent transcription of c-fos
    • Ahn S., Olive M., Aggarwal S., Krylov D., Ginty D.D., and Vinson C. A dominant-negative inhibitor of CREN reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol. Cell Biol. 2 (1998) 967-977
    • (1998) Mol. Cell Biol. , vol.2 , pp. 967-977
    • Ahn, S.1    Olive, M.2    Aggarwal, S.3    Krylov, D.4    Ginty, D.D.5    Vinson, C.6
  • 27
    • 0141482096 scopus 로고    scopus 로고
    • p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells
    • Kim M.S., Lee E.J., Kim H.R., and Moon A. p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells. Cancer Res. 63 (2003) 5454-5461
    • (2003) Cancer Res. , vol.63 , pp. 5454-5461
    • Kim, M.S.1    Lee, E.J.2    Kim, H.R.3    Moon, A.4
  • 28
    • 0034650586 scopus 로고    scopus 로고
    • H-Ras, but not N-Ras, induces an invasive phenotype in human breast epithelial cells: a role for MMP-2 in the H-Ras-induced invasive phenotype
    • Moon A., Kim M.S., Kim T.G., Kim S.H., Kim H.E., Chen Y.Q., and Kim H.R. H-Ras, but not N-Ras, induces an invasive phenotype in human breast epithelial cells: a role for MMP-2 in the H-Ras-induced invasive phenotype. Int. J. Cancer 85 (2000) 176-181
    • (2000) Int. J. Cancer , vol.85 , pp. 176-181
    • Moon, A.1    Kim, M.S.2    Kim, T.G.3    Kim, S.H.4    Kim, H.E.5    Chen, Y.Q.6    Kim, H.R.7
  • 29
    • 0030826510 scopus 로고    scopus 로고
    • Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter
    • Bian J., and Sun Y. Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter. Mol. Cell Biol. 17 (1997) 6330-6338
    • (1997) Mol. Cell Biol. , vol.17 , pp. 6330-6338
    • Bian, J.1    Sun, Y.2
  • 30
    • 0032857460 scopus 로고    scopus 로고
    • The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells
    • Qin H., Sun Y., and Benveniste E.N. The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells. J. Biol. Chem. 274 (1999) 29130-29137
    • (1999) J. Biol. Chem. , vol.274 , pp. 29130-29137
    • Qin, H.1    Sun, Y.2    Benveniste, E.N.3
  • 31
    • 0035500287 scopus 로고    scopus 로고
    • Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-gamma and IFN-beta: critical role of STAT-1alpha
    • Ma Z., Qin H., and Benveniste E.N. Transcriptional suppression of matrix metalloproteinase-9 gene expression by IFN-gamma and IFN-beta: critical role of STAT-1alpha. J. Immunol. 167 (2001) 5150-5159
    • (2001) J. Immunol. , vol.167 , pp. 5150-5159
    • Ma, Z.1    Qin, H.2    Benveniste, E.N.3
  • 32
    • 18144417838 scopus 로고    scopus 로고
    • Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression
    • Ki S.H., Cho I.J., Choi D.W., and Kim S.G. Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol. Cell Biol. 10 (2005) 4150-4165
    • (2005) Mol. Cell Biol. , vol.10 , pp. 4150-4165
    • Ki, S.H.1    Cho, I.J.2    Choi, D.W.3    Kim, S.G.4
  • 33
    • 0032918016 scopus 로고    scopus 로고
    • Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines
    • Sehgal I., and Thompson T.C. Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines. Mol. Biol. Cell 10 (1999) 407-416
    • (1999) Mol. Biol. Cell , vol.10 , pp. 407-416
    • Sehgal, I.1    Thompson, T.C.2
  • 34
    • 0037328007 scopus 로고    scopus 로고
    • A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers
    • Bergma M.R., Cheng S., Honbo N., Piacentini L., Karliner J.S., and Lovett D.H. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Biochem. J. 369 (2003) 485-496
    • (2003) Biochem. J. , vol.369 , pp. 485-496
    • Bergma, M.R.1    Cheng, S.2    Honbo, N.3    Piacentini, L.4    Karliner, J.S.5    Lovett, D.H.6
  • 35
    • 0034623147 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor
    • Finlay G.A., Thannickal V.J., Fanburg B.L., and Paulson K.E. Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor. J. Biol. Chem. 275 (2000) 27650-27656
    • (2000) J. Biol. Chem. , vol.275 , pp. 27650-27656
    • Finlay, G.A.1    Thannickal, V.J.2    Fanburg, B.L.3    Paulson, K.E.4
  • 36
    • 0034666152 scopus 로고    scopus 로고
    • Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter
    • Brodin G., Ahgren A., ten Dijke P., Heldin C.H., and Heuchel R. Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter. J. Biol. Chem. 275 (2000) 29023-29030
    • (2000) J. Biol. Chem. , vol.275 , pp. 29023-29030
    • Brodin, G.1    Ahgren, A.2    ten Dijke, P.3    Heldin, C.H.4    Heuchel, R.5
  • 37
    • 0035971493 scopus 로고    scopus 로고
    • AP-1 in cell proliferation and survival
    • Shaulian E., and Karin M. AP-1 in cell proliferation and survival. Oncogene 20 (2001) 2390-2400
    • (2001) Oncogene , vol.20 , pp. 2390-2400
    • Shaulian, E.1    Karin, M.2
  • 38
    • 0032444348 scopus 로고    scopus 로고
    • Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
    • Review
    • Herdegen T., and Leah J.D. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res. Rev. 28 (1998) 370-490 Review
    • (1998) Brain Res. Rev. , vol.28 , pp. 370-490
    • Herdegen, T.1    Leah, J.D.2
  • 39
    • 0034680856 scopus 로고    scopus 로고
    • Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling
    • Lai C.F., Feng X., Nishimura R., Teitelbaum S.L., Avioli L.V., Ross F.P., and Cheng S.L. Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling. J. Biol. Chem. 275 (2000) 36400-36406
    • (2000) J. Biol. Chem. , vol.275 , pp. 36400-36406
    • Lai, C.F.1    Feng, X.2    Nishimura, R.3    Teitelbaum, S.L.4    Avioli, L.V.5    Ross, F.P.6    Cheng, S.L.7
  • 40
    • 0034703083 scopus 로고    scopus 로고
    • Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta
    • Pardali K., Kurisaki A., Moren A., ten Dijke P., Kardassis D., and Moustakas A. Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta. J. Biol. Chem. 275 (2000) 29244-29256
    • (2000) J. Biol. Chem. , vol.275 , pp. 29244-29256
    • Pardali, K.1    Kurisaki, A.2    Moren, A.3    ten Dijke, P.4    Kardassis, D.5    Moustakas, A.6
  • 41
    • 33750092367 scopus 로고    scopus 로고
    • Smad-Sp1 complexes mediate TGF-beta-induced early transcription of oncogenic Smad7 in pancreatic cancer cells
    • Jungert K., Buck A., Buchholz M., Wagner M., Adler G., Gress T.M., and Ellenrieder V. Smad-Sp1 complexes mediate TGF-beta-induced early transcription of oncogenic Smad7 in pancreatic cancer cells. Carcinogenesis (2006) 2392-2401
    • (2006) Carcinogenesis , pp. 2392-2401
    • Jungert, K.1    Buck, A.2    Buchholz, M.3    Wagner, M.4    Adler, G.5    Gress, T.M.6    Ellenrieder, V.7
  • 42
    • 0036084359 scopus 로고    scopus 로고
    • TGF-beta antagonists: why suppress a tumor suppressor?
    • Akhurst R.J. TGF-beta antagonists: why suppress a tumor suppressor?. J. Clin. Invest. 109 (2002) 533-1536
    • (2002) J. Clin. Invest. , vol.109 , pp. 533-1536
    • Akhurst, R.J.1
  • 43
    • 0036467496 scopus 로고    scopus 로고
    • TGF-beta signaling: positive and negative effects on tumorigenesis
    • Wakefield L.M., and Roberts A.B. TGF-beta signaling: positive and negative effects on tumorigenesis. Curr. Opin. Genet. Dev. 12 (2002) 22-29
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 44
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
    • Bhowmick N.A., Ghiassi M., Bakin A., Aakre M., Lundquist C.A., and Engel M.E. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol. Biol. Cell 12 (2001) 27-36
    • (2001) Mol. Biol. Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1    Ghiassi, M.2    Bakin, A.3    Aakre, M.4    Lundquist, C.A.5    Engel, M.E.6
  • 45
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor-beta-mediated epithelial to mesenchymal transition and cell migration
    • Bakin A.V., Tomlinson A.K., Bhowmick N.A., Moses H.L., and Arteaga C.L. Phosphatidylinositol 3-kinase function is required for transforming growth factor-beta-mediated epithelial to mesenchymal transition and cell migration. J. Biol. Chem. 275 (2000) 36803-36810
    • (2000) J. Biol. Chem. , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5


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