Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection

Infection and Immunity

Volumn 75, Issue 5, 2007, Pages 2260-2268

  Anis, Mursalin M ^a,b   Fulton, Scott A ^b   Reba, Scott M ^b   Harding, Clifford V ^a   Boom, W Henry ^b,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BCG VACCINE; FLUORESCEIN DIACETATE; GLYCOPROTEIN P 15095; OVALBUMIN; SUCCINIMIDE DERIVATIVE;

AEROSOL; AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; IMMUNOMODULATION; LUNG INFECTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MEDIASTINUM LYMPH NODE; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM BOVIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE ACTIVATION; TH1 CELL;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS; ANTIGENS, CD11C; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; LUNG; LYMPH NODES; LYMPHOCYTE ACTIVATION; MEDIASTINUM; MICE; MICE, INBRED BALB C; MYCOBACTERIUM BOVIS; OVALBUMIN; TH1 CELLS; TUBERCULOSIS, PULMONARY;

EID: 34248398461     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01709-06     Document Type: Article

References (45)

1. Aida, Y., and M. J. Pabst. 1990. Removal of endotoxin from protein solutions by phase separation using Triton X-114. J. Immunol. Methods 132:191-195.
2. Bhatt, K., S. P. Hickman, and P. Salgame. 2004. Cutting edge: a new approach to modeling early lung immunity in murine tuberculosis. J. Immunol. 172:2748-2751.
3. Bingisser, R. M., and P. G. Holt. 2001. Immunomodulating mechanisms in the lower respiratory tract: nitric oxide mediated interactions between alveolar macrophages, epithelial cells, and T cells. Swiss Med. Wkly. 131:171-179.
4. Byersdorfer, C. A., and D. D. Chaplin. 2001. Visualization of early APC/T cell interactions in the mouse lung following intranasal challenge. J. Immunol. 167:6756-6764.
5. + T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central-memory cells. J. Exp. Med. 203:1045-1054.
6. Chan, J., and J. Flynn. 2004. The immunological aspects of latency in tuberculosis. Clin. Immunol. 110:2-12.
7. Constant, S. L., J. L. Brogdon, D. A. Piggott, C. A. Herrick, I. Visintin, N. H. Ruddle, and K. Bottomly. 2002. Resident lung antigen-presenting cells have the capacity to promote Th2 T-cell differentiation in situ. J. Clin. Investig. 110:1441-1448.
8. Curtis, J. L. 2005. Cell-mediated adaptive immune defense of the lungs. Proc. Am. Thorac. Soc. 2:412-416.
9. Eisenbarth, S. C., D. A. Piggott, J. W. Huleatt, I. Visintin, C. A. Herrick, and K. Bottomly. 2002. Lipopolysaccharide-enhanced, Toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196:1645-1651.
10. Erb, K. J., J. W. Holloway, A. Sobeck, H. Moll, and G. Le Gros. 1998. Infection of mice with Mycobacterium bovis-bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia. J. Exp. Med. 187:561-569.
11. Fulton, S. A., T. D. Martin, R. W. Redline, and W. Henry Boom. 2000. Pulmonary immune responses during primary Mycobacterium bovis-Calmette-Guerin bacillus infection in C57BL/6 mice. Am. J. Respir. Cell Mol. Biol. 22:333-343.
12. Fulton, S. A., S. M. Reba, T. D. Martin, and W. H. Boom. 2002. Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice. Infect. Immun. 70:5322-5327.
13. Gonzalez-Juarrero, M., and I. M. Orme. 2001. Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis. Infect. Immun. 69:1127-1133.
14. Honer zu Bentrup, K., and D. G. Russell. 2001. Mycobacterial persistence: adaptation to a changing environment. Trends Microbiol. 9:597-605.
15. Humphreys, I. R., G. R. Stewart, D. J. Turner, J. Patel, D. Karamanou, R. J. Snelgrove, and D. B. Young. 2006. A role for dendritic cells in the dissemination of mycobacterial infection. Microbes Infect. 8:1339-1346.
16. Itano, A. A., S. J. McSorley, R. L. Reinhardt, B. D. Ehst, E. Ingulli, A. Y. Rudensky, and M. K. Jenkins. 2003. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19:47-57.
17. Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5:987-995.
18. Jelley-Gibbs, D. M., D. M. Brown, J. P. Dibble, L. Haynes, S. M. Eaton, and S. L. Swain. 2005. Unexpected prolonged presentation of influenza antigens promotes CD4 T-cell memory generation. J. Exp. Med. 202:697-706.
19. Jenkins, M. K., A. Khoruts, E. Ingulli, D. L. Mueller, S. J. McSorley, R. L. Reinhardt, A. Itano, and K. A. Pape. 2001. In vivo activation of antigen-specific CD4 T cells. Annu. Rev. Immunol. 19:23-45.
20. Kipnis, A., S. Irwin, A. A. Izzo, R. J. Basaraba, and I. M. Orme. 2005. Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 Ligandhi population. Infect. Immun. 73:7759-7764.
21. Kuchtey, J., S. A. Fulton, S. M. Reba, C. V. Harding, and W. H. Boom. 2006. Interferon-alphabeta mediates partial control of early pulmonary Mycobacterium bovis bacillus Calmette-Guerin infection. Immunology 118:39-49.
22. Ladel, C. H., S. Daugelat, and S. H. Kaufmann. 1995. Immune response to Mycobacterium bovis bacille Calmette-Guerin infection in major histocompatibility complex class I- and II-deficient knockout mice: contribution of CD4 and CD8 T cells to acquired resistance. Eur. J. Immunol. 25:377-384.
23. + T cells during pulmonary influenza virus infection. J. Immunol. 173:1209-1218.
24. Lund, F. E., S. Partida-Sanchez, B. O. Lee, K. L. Kusser, L. Hartson, R. J. Hogan, D. L. Woodland, and T. D. Randall. 2002. Lymphotoxin-alpha- deficient mice make delayed, but effective, T and B cell responses to influenza. J. Immunol. 169:5236-5243.
25. Lyons, A. B. 2000. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J. Immunol. Methods 243: 147-154.
26. MartIn-Fontecha, A., S. Sebastiani, U. E. Hopken, M. Uguccioni, M. Lipp, A. Lanzavecchia, and F. Sallusto. 2003. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J. Exp. Med. 198:615-621.
27. Mempel, T. R., S. E. Henrickson, and U. H. Von Andrian. 2004. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427:154-159.
28. + T-cell activation by dendritic cells in lymph nodes. J. Exp. Med. 200:847-856.
29. Mojtabavi, N., G. Dekan, G. Stingl, and M. M. Epstein. 2002. Long-lived Th2 memory in experimental allergic asthma. J. Immunol. 169:4788-4796.
30. Moyron-Quiroz, J. E., J. Rangel-Moreno, K. Kusser, L. Hartson, F. Sprague, S. Goodrich, D. L. Woodland, F. E. Lund, and T. D. Randall. 2004. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat. Med. 10:927-934.
31. lo thymocytes in vivo. Science 250:1720-1723.
32. Roman, E., E. Miller, A. Harmsen, J. Wiley, U. H. Von Andrian, G. Huston, and S. L. Swain. 2002. CD4 effector T-cell subsets in the response to influenza: heterogeneity, migration, and function. J. Exp. Med. 196:957-968.
33. Sano, K., K. Haneda, G. Tamura, and K. Shirato. 1999. Ovalbumin (OVA) and Mycobacterium tuberculosis bacilli cooperatively polarize anti-OVA T-helper (Th) cells toward a Th1-dominant phenotype and ameliorate murine tracheal eosinophilia. Am. J. Respir. Cell Mol. Biol. 20:1260-1267.
34. Schreiber, T., S. Ehlers, S. Aly, A. Holscher, S. Hartmann, M. Lipp, J. B. Lowe, and C. Holscher. 2006. Selectin ligand-independent priming and maintenance of T-cell immunity during airborne tuberculosis. J. Immunol. 176: 1131-1140.
35. Shi, L., R. North, and M. L. Gennaro. 2004. Effect of growth state on transcription levels of genes encoding major secreted antigens of Mycobacterium tuberculosis in the mouse lung. Infect. Immun. 72:2420-2424.
36. Shiow, L. R., D. B. Rosen, N. Brdickova, Y. Xu, J. An, L. L. Lanier, J. G. Cyster, and M. Matloubian. 2006. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440:540-544.
37. Soderberg, K. A., G. W. Payne, A. Sato, R. Medzhitov, S. S. Segal, and A. Iwasaki. 2005. Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc. Natl. Acad. Sci. USA 102:16315-16320.
38. + cells of memory phenotype. Eur. J. Immunol. 27:2225-2232.
39. + T cells to the lung during influenza pneumonia. J. Immunol. 167:6983-6990.
40. + T cells. J. Immunol. 163:2592-2600.
41. Uehori, J., M. Matsumoto, S. Tsuji, T. Akazawa, O. Takeuchi, S. Akira, T. Kawata, I. Azuma, K. Toyoshima, and T. Seya. 2003. Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guerin peptidoglycan. Infect. Immun. 71:4238-4249.
42. Vermaelen, K. Y., I. Carro-Muino, B. N. Lambrecht, and R. A. Pauwels. 2001. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193:51-60.
43. Wells, A. D., H. Gudmundsdottir, and L. A. Turka. 1997. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T-cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J. Clin. Investig. 100:3173-3183.
44. + T cell activation during the primary response to airborne allergen. J. Immunol. 177:913-924.
45. Xia, W., C. E. Pinto, and R. L. Kradin. 1995. The antigen-presenting activities of Ia+ dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen. J. Exp. Med. 181:1275-1283.