Effect of macrolide antibiotics on uptake of digoxin into rat liver

Biopharmaceutics and Drug Disposition

Volumn 28, Issue 3, 2007, Pages 113-123

  Ito, Suwako ^a   Nasu, Risa ^a   Tsujimoto, Masayuki ^a   Murakami, Hideyasu ^a   Ohtani, Hisakazu ^b   Sawada, Yasufumi ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Digoxin; Drug interaction; Hepatic uptake; Liver uptake index; Macrolide antibiotics

Indexed keywords

AZITHROMYCIN; CLARITHROMYCIN; DIGOXIN; ERYTHROMYCIN; HISTONE H3; JOSAMYCIN; MACROLIDE; ROXITHROMYCIN; UNCLASSIFIED DRUG; VERAPAMIL; ZITHROMAC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW VELOCITY; CELL ISOLATION; CLINICAL OBSERVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG INHIBITION; DRUG PENETRATION; DRUG UPTAKE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER BLOOD FLOW; LIVER CELL; MALE; MICHAELIS CONSTANT; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BIOLOGICAL TRANSPORT; BLOOD FLOW VELOCITY; CARDIOTONIC AGENTS; CLARITHROMYCIN; DIGOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ERYTHROMYCIN; HEPATOCYTES; JOSAMYCIN; LIVER; MACROLIDES; MALE; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; ROXITHROMYCIN; TISSUE DISTRIBUTION;

EID: 34248384071     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.537     Document Type: Article

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