Distinct tissue and cellular distribution of two major isoforms of calcineurin

Molecular Immunology

Volumn 34, Issue 8-9, 1997, Pages 663-669

  Jiang, Hongsi ^a,b   Xiong, Fei ^a,b   Kong, Suming ^a,b   Ogawa, Toshikazu ^a,b   Kobayashi, Masakazu ^a,b   Liu, Jun O ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Antibodies; Calcineurin; Immunosuppression; T cell signaling

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; TACROLIMUS;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; ENZYME SPECIFICITY; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CALCINEURIN; CATALYSIS; CYCLOSPORINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; JURKAT CELLS; KIDNEY; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; RABBITS; TACROLIMUS; TISSUE DISTRIBUTION;

ANIMALIA; MURINAE;

EID: 0030856223     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00054-0     Document Type: Article

References (34)

1. Alexander D. R., Hexham J. M. and Crumpton M. J. (1988) The association of type l, type 2A and type 2B phosphatases with the human T lymphocyte plasma membrane. Biochem. J. 256, 885-892.
2. Buttini M., Luyten M., Limonta S. and Boddeke H. (1994) Distribution of calcineurin Aβ isoenzyme mRNAs in rat brain: comparison with the distribution of calcineurin A α isoenzyme mRNAs. Neurosci. Res. Commun. 14, 9-16.
3. Buttini M., Luyten M., Limonta S. and Boddeke H. (1995) Distribution of calcineurin A isoenzyme mRNAs in rat thymus and kidney. Histochem. J. 27, 291-299.
4. Chantler P. D. (1985) Calcium-dependent association of a protein complex with the lymphocyte plasma membrane: probable identity with calmodulin - calcineurin. J. Cell Biol. 101, 207-216.
5. Clipstone N. A. and Crabtree G. R. (1992) Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697.
6. Cohen P. (1989) The structure and regulation of protein phosphatases. A. Rev. Biochem. 58, 453-508.
7. Crabtree G. R. and Clipstone N. A. (1994) A. Rev. Biochem. 63, 1045-1083.
8. Demetris A. J., Banner B., Fung J., Shapiro R., Jordan M. and Starzl T. E. (1991) Histopathology of human renal allograft rejection under FK506: a comparison with cyclosporine. Transplant. Proc. 23, 944-946.
9. Dumont F. J., Staruch M. J., Koprak S. L., Siekierka J. J., Lin C. S., Harrison R., Sewell T., Kindt V. M., Beattie T. R., Wyvratt M. and Sigal N. H. (1992) The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. J. exp. Med. 176, 751-760.
10. Friedman J. and Weissman I. (1991) Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA. Cell 66, 799-806.
11. Fruman D. A., Klee C. B., Bierer B. E. and Burakoff S. J. (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc. natn. Acad. Sci. U.S.A. 89, 3686-3690.
12. Giri P. R., Higuchi S. and Kincaid R. L. (1991) Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. Biochem. Biophys. Res. Commun. 181, 252-258.
13. Guerini D. and Klee C. B. (1989) Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain. Proc. natn. Acad. Sci. U.S.A. 86, 9183-9187.
14. Harlow E. and Lane D. (1988) Antibodies, a Laboratory Manual. Cold Spring Harbor Laboratory, New York.
15. Kincaid R. L., Giri P. R., Higuchi S., Tamura J., Dixon S. C., Marietta C. A., Amorese D. A. and Martin B. M. (1990) Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. J. biol. Chem. 265, 11312-11319.
16. Klee C. B., Draetta G. F. and Hubbard M. J. (1988) Calcineurin. Adv. Enzymol. Relat. Areas Molec. Biol. 61, 149-209.
17. Kuno T., Mukai H., Ito A., Chang C.-D., Kishima K., Saito N. and Tanaka C. (1992) Distinct cellular expression of calcineurin Aα and Aβ in rat brain. J. Neurochem. 58, 1643-1651.
18. Liu J. (1993) FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. Immun. Today 14, 290-296.
19. Liu J., Farmer J. D., Lane W. S., Friedman J., Weissman I. and Schreiber S. L. (1991) Calcineurin is a common target of cyclophilin - cyclosporin A and FKBP - FK506 complexes. Cell 66, 807-815.
20. Mason J. (1990) The pathophysiology of Sandimmune (cyclosporine) in man and animals. Pediatr. Nephrol. 4, 554-574.
21. McPartlin A. E., Barker H. M. and Cohen P. T. W. (1991) Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B β. Biochim. Biophys. Acta 1088, 308-310.
22. Mihatsch M. J., Ryffel B., Gudat F. and Thiel G. (1988) Cyclosporine nephropathy. In Renal Pathology, (Edited by C. Fischer and B. M. Brenner), Vol. 2, pp. 1555-1586. Lippincott, Philadelphia, PA.
23. Moutabarrik A., Ishibashi M., Kameoka H., Ogata A., Kawaguchi N., Takano Y., Kokado Y., Takahara S., Jiang H., Onishi S., Sonoda T. and Okuyama A. (1991) In vitro FK506 kidney tubular cell toxicity. Transplant. Proc. 23, 3137-3140.
24. Mukai H., Kuno T., Chang C. D., Lane B., Luly J. R. and Tanaka C. (1993) FKBP12-FK506 complex inhibits phosphatase activity of two mammalian isoforms of calcineurin irrespective of their substrates or activation mechanisms. J. Biochem. 113, 292-298.
25. Muramatsu T. and Kincaid R. L. (1992) Molecular cloning and chromosomal mapping of the human gene for the testisspecific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A). Biochem. Biophys. Res. Commun. 188, 265-271.
26. Muramatsu T. and Kincaid R. L. (1993) Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin Aa). Biochim. Biophys. Acta 1178, 117-120.
27. O'Keefe S. J., Tamura J., Kincaid R. L., Tocci M. and O'Neil E. A. (1992) FK-506-and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357, 692-694.
28. Randhawa P. S., Shapiro R., Jordan M., Starzl T. E. and Demetris A. J. (1993) The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Am. J. Surg. Pathol. 17, 60-68.
29. Schreiber S. L. and Crabtree G. R. (1992) The mechanism of action of cyclosporin A and FK506. Immun. Today 13, 136142.
30. Shenolikar S. S. and Nairn A. C. (1990) Protein phosphatases: recent progress. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 23, 1-121.
31. Smith D. B. and Johnson K. S. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene 67, 31-40.
32. Su Q., Weber L., LeHir M., Zenke G. and Ryffel B. (1995) Nephrotoxicity of cylcosporin A and FK506: inhibition of calcineurin phosphatase. Renal Physiol. Biochem. 18, 128-139.
33. + thymocytes undergoing thymic selection, requirement of calcineurin activation for thymic positive selection but not negative selection. J. exp. Med. 181, 927-941.
34. Zhang W., Zimmer G., Chen J., Ladd D., Li E., Alt F. W., Wiederrecht G., Cryan J., O'Neill E. A., Seidman C. E., Abbas A. K. and Seidman J. G. (1996) T cell responses in calcineurin A α-deficient mice. J. exp. Med. 183, 413-420.