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Volumn 67, Issue 7, 2007, Pages 701-713

IRL-1620, a tumor selective vasodilator, augments the uptake and efficacy of chemotherapeutic agents in prostate tumor rats

Author keywords

5 flurouracil; Chemotherapy; Doxorubicin; Endothelin; IRL 1620; Tumor blood flow

Indexed keywords

DOXORUBICIN; FLUOROURACIL; PLACEBO; SUCCINYLENDOTHELIN 1 [8-21][9 GLUTAMIC ACID 11,15 ALANINE];

EID: 34248209225     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.20556     Document Type: Article
Times cited : (12)

References (76)
  • 1
    • 0031788360 scopus 로고    scopus 로고
    • Drug targeting systems for cancer chemotherapy
    • Sachdeva MS. Drug targeting systems for cancer chemotherapy. Expert Opin Investig Drugs 1998;7:1849-1864.
    • (1998) Expert Opin Investig Drugs , vol.7 , pp. 1849-1864
    • Sachdeva, M.S.1
  • 2
    • 0017094626 scopus 로고
    • Doxorubicin hydrochloride, cyclophosphamide, and 5-fluorouracil combination in advanced prostate and transitional cell carcinoma
    • Collier D, Soloway MS. Doxorubicin hydrochloride, cyclophosphamide, and 5-fluorouracil combination in advanced prostate and transitional cell carcinoma. Urology 1976;8:459-464.
    • (1976) Urology , vol.8 , pp. 459-464
    • Collier, D.1    Soloway, M.S.2
  • 3
    • 0018577627 scopus 로고
    • Cyclophosphamide, doxorubicin hydrochloride and 5-fluorouracil in advanced carcinoma of the prostate
    • Soloway MS, Shippel RM, Ikard M. Cyclophosphamide, doxorubicin hydrochloride and 5-fluorouracil in advanced carcinoma of the prostate. J Urol 1979;122:637-639.
    • (1979) J Urol , vol.122 , pp. 637-639
    • Soloway, M.S.1    Shippel, R.M.2    Ikard, M.3
  • 4
    • 0035021709 scopus 로고    scopus 로고
    • A pilot study of AFL-T (doxorubicin, 5-fluorouracil, leucovorin, and tamoxifen) combination chemotherapy for hormone-refractory prostate cancer
    • Lin CC, Hsu CH, Chen J, Tsai TC, Cheng AL, Pu YS. A pilot study of AFL-T (doxorubicin, 5-fluorouracil, leucovorin, and tamoxifen) combination chemotherapy for hormone-refractory prostate cancer. Anticancer Res 2001;21:1385-1390.
    • (2001) Anticancer Res , vol.21 , pp. 1385-1390
    • Lin, C.C.1    Hsu, C.H.2    Chen, J.3    Tsai, T.C.4    Cheng, A.L.5    Pu, Y.S.6
  • 5
    • 0019450418 scopus 로고    scopus 로고
    • Smalley RV, Bartolucci AA, Hemstreet G, Hester M. A Phase II evaluation of a 3-drug combination of cyclophosphamide, doxorubicin and 5-fluorouracil and of 5-fluorouracil in patients with advanced bladder carcinoma or stage D prostatic carcinoma. J Urol 1981;125:191-195.
    • Smalley RV, Bartolucci AA, Hemstreet G, Hester M. A Phase II evaluation of a 3-drug combination of cyclophosphamide, doxorubicin and 5-fluorouracil and of 5-fluorouracil in patients with advanced bladder carcinoma or stage D prostatic carcinoma. J Urol 1981;125:191-195.
  • 6
    • 0031913993 scopus 로고    scopus 로고
    • Pharmacodynamics of doxorubicin in human prostate tumors
    • Chen CT, Au JL, Wientjes MG. Pharmacodynamics of doxorubicin in human prostate tumors. Clin Cancer Res 1998;4:277-282.
    • (1998) Clin Cancer Res , vol.4 , pp. 277-282
    • Chen, C.T.1    Au, J.L.2    Wientjes, M.G.3
  • 9
    • 0025605930 scopus 로고
    • Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
    • Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature 1990;348:732-735.
    • (1990) Nature , vol.348 , pp. 732-735
    • Sakurai, T.1    Yanagisawa, M.2    Takuwa, Y.3    Miyazaki, H.4    Kimura, S.5    Goto, K.6    Masaki, T.7
  • 10
    • 0004559340 scopus 로고
    • Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor
    • de Nucci G, Thomas R, D'Orleans-Juste P, Antunes E, Walder C, Warner TD, Vane JR. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci USA 1988;85:9797-9800.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9797-9800
    • de Nucci, G.1    Thomas, R.2    D'Orleans-Juste, P.3    Antunes, E.4    Walder, C.5    Warner, T.D.6    Vane, J.R.7
  • 11
    • 0034660606 scopus 로고    scopus 로고
    • Endothelium-derived factors as paracrine mediators of prostate cancer progression
    • Pirtskhalaishvili G, Nelson JB. Endothelium-derived factors as paracrine mediators of prostate cancer progression. Prostate 2000;44:77-87.
    • (2000) Prostate , vol.44 , pp. 77-87
    • Pirtskhalaishvili, G.1    Nelson, J.B.2
  • 12
    • 0019478990 scopus 로고
    • A new approach to cancer chemotherapy: Selective enhancement of tumor blood flow with angiotensin II
    • Suzuki M, Hori K, Abe I, Saito S, Sato H. A new approach to cancer chemotherapy: Selective enhancement of tumor blood flow with angiotensin II. J Natl Cancer Inst 1981;67:663-669.
    • (1981) J Natl Cancer Inst , vol.67 , pp. 663-669
    • Suzuki, M.1    Hori, K.2    Abe, I.3    Saito, S.4    Sato, H.5
  • 15
    • 2942659890 scopus 로고    scopus 로고
    • Targeting endothelin axis in cancer
    • Bagnato A, Natali PG. Targeting endothelin axis in cancer. Cancer Treat Res 2004;119:293-314.
    • (2004) Cancer Treat Res , vol.119 , pp. 293-314
    • Bagnato, A.1    Natali, P.G.2
  • 17
    • 27944449731 scopus 로고    scopus 로고
    • Endothelin B receptor agonist, IRL-1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats
    • Rajeshkumar NV, Rai A, Gulati A. Endothelin B receptor agonist, IRL-1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats. Breast Cancer Res Treat 2005;94:237-247.
    • (2005) Breast Cancer Res Treat , vol.94 , pp. 237-247
    • Rajeshkumar, N.V.1    Rai, A.2    Gulati, A.3
  • 18
    • 0036083070 scopus 로고    scopus 로고
    • BQ-788, a selective endothelin ET(B) receptor antagonist
    • Okada M, Nishikibe M. BQ-788, a selective endothelin ET(B) receptor antagonist. Cardiovasc Drug Rev 2002;20:53-66.
    • (2002) Cardiovasc Drug Rev , vol.20 , pp. 53-66
    • Okada, M.1    Nishikibe, M.2
  • 21
  • 22
    • 0035133490 scopus 로고    scopus 로고
    • Expression of endothelin receptor a associated with prostate cancer progression
    • Gohji K, Kitazawa S, Tamada H, Katsuoka Y, Nakajima M. Expression of endothelin receptor a associated with prostate cancer progression. J Urol 2001;165:1033-1036.
    • (2001) J Urol , vol.165 , pp. 1033-1036
    • Gohji, K.1    Kitazawa, S.2    Tamada, H.3    Katsuoka, Y.4    Nakajima, M.5
  • 23
    • 33750728404 scopus 로고    scopus 로고
    • Targeting bone metastasis in prostate cancer with endothelin receptor antagonists
    • s
    • Carducci MA, Jimeno A. Targeting bone metastasis in prostate cancer with endothelin receptor antagonists. Clin Cancer Res 2006;12:6296s-6300s.
    • (2006) Clin Cancer Res , vol.12
    • Carducci, M.A.1    Jimeno, A.2
  • 24
    • 0023025173 scopus 로고
    • Establishment and characterization of seven Dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers
    • Isaacs JT, Isaacs WB, Feitz WF, Scheres J. Establishment and characterization of seven Dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers. Prostate 1986;9:261-281.
    • (1986) Prostate , vol.9 , pp. 261-281
    • Isaacs, J.T.1    Isaacs, W.B.2    Feitz, W.F.3    Scheres, J.4
  • 26
    • 0037222445 scopus 로고    scopus 로고
    • Evidence for the involvement of ET(B) receptors in ET-1-induced changes in blood flow to the rat breast tumor
    • Rai A, Gulati A. Evidence for the involvement of ET(B) receptors in ET-1-induced changes in blood flow to the rat breast tumor. Cancer Chemother Pharmacol 2003;51:21-28.
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 21-28
    • Rai, A.1    Gulati, A.2
  • 27
    • 33745001797 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution studies of Doxorubicin loaded poly(butyl cyanoacrylate) nanoparticles synthesized by two different techniques
    • Reddy LH, Murthy RS. Pharmacokinetics and biodistribution studies of Doxorubicin loaded poly(butyl cyanoacrylate) nanoparticles synthesized by two different techniques. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2004;148:161-166.
    • (2004) Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , vol.148 , pp. 161-166
    • Reddy, L.H.1    Murthy, R.S.2
  • 28
  • 30
    • 0037426058 scopus 로고    scopus 로고
    • Prostate cancer epidemiology
    • Gronberg H. Prostate cancer epidemiology. Lancet 2003;361:859-864.
    • (2003) Lancet , vol.361 , pp. 859-864
    • Gronberg, H.1
  • 33
    • 10344233659 scopus 로고    scopus 로고
    • Atrasentan: Targeting the endothelin axis in prostate cancer
    • Jimeno A, Carducci M. Atrasentan: Targeting the endothelin axis in prostate cancer. Expert Opin Investig Drugs 2004;13:1631-1640.
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 1631-1640
    • Jimeno, A.1    Carducci, M.2
  • 34
    • 21244445833 scopus 로고    scopus 로고
    • Atrasentan: A novel and rationally designed therapeutic alternative in the management of cancer
    • Jimeno A, Carducci M. Atrasentan: A novel and rationally designed therapeutic alternative in the management of cancer. Expert Rev Anticancer Ther 2005;5:419-427.
    • (2005) Expert Rev Anticancer Ther , vol.5 , pp. 419-427
    • Jimeno, A.1    Carducci, M.2
  • 35
    • 33645116422 scopus 로고    scopus 로고
    • Atrasentan for metastatic hormone refractory prostate cancer
    • Murphy G. Atrasentan for metastatic hormone refractory prostate cancer. Issues Emerg Health Technol 2005; 1-4.
    • (2005) Issues Emerg Health Technol , pp. 1-4
    • Murphy, G.1
  • 37
    • 17844385064 scopus 로고    scopus 로고
    • Update in the management of patients with hormone-refractory prostate cancer
    • Moore CN, George DJ. Update in the management of patients with hormone-refractory prostate cancer. Curr Opin Urol 2005;15:157-162.
    • (2005) Curr Opin Urol , vol.15 , pp. 157-162
    • Moore, C.N.1    George, D.J.2
  • 38
    • 16244378263 scopus 로고    scopus 로고
    • Clinical trials in metastatic prostate cancer - Has there been real progress in the past decade?
    • Bhandari MS, Petrylak DP, Hussain M. Clinical trials in metastatic prostate cancer - Has there been real progress in the past decade? Eur J Cancer 2005;41:941-953.
    • (2005) Eur J Cancer , vol.41 , pp. 941-953
    • Bhandari, M.S.1    Petrylak, D.P.2    Hussain, M.3
  • 41
    • 0032514402 scopus 로고    scopus 로고
    • Vascular targeting as a strategy for cancer therapy
    • Schnitzer JE. Vascular targeting as a strategy for cancer therapy. N Engl J Med 1998;339:472-474.
    • (1998) N Engl J Med , vol.339 , pp. 472-474
    • Schnitzer, J.E.1
  • 42
    • 0032525740 scopus 로고    scopus 로고
    • Tumor vasculature targeted therapies: Getting the players organized
    • Molema G, Meijer DK, de Leij LF. Tumor vasculature targeted therapies: Getting the players organized. Biochem Pharmacol 1998;55:1939-1945.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1939-1945
    • Molema, G.1    Meijer, D.K.2    de Leij, L.F.3
  • 43
    • 4544333732 scopus 로고    scopus 로고
    • Targeting the tumor vascular compartment to improve conventional cancer therapy
    • Feron O. Targeting the tumor vascular compartment to improve conventional cancer therapy. Trends Pharmacol Sci 2004;25:536-542.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 536-542
    • Feron, O.1
  • 44
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 2005;307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 45
    • 0031042534 scopus 로고    scopus 로고
    • Tumor vascular endothelium: Barrier or target in tumor directed drug delivery and immunotherapy
    • Molema G, de Leij LF, Meijer DK. Tumor vascular endothelium: Barrier or target in tumor directed drug delivery and immunotherapy. Pharm Res 1997;14:2-10.
    • (1997) Pharm Res , vol.14 , pp. 2-10
    • Molema, G.1    de Leij, L.F.2    Meijer, D.K.3
  • 46
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002;2:795-803.
    • (2002) Nat Rev Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 48
    • 20344367537 scopus 로고    scopus 로고
    • Tumour vascular targeting
    • Neri D, Bicknell R. Tumour vascular targeting. Nat Rev Cancer 2005;5:436-446.
    • (2005) Nat Rev Cancer , vol.5 , pp. 436-446
    • Neri, D.1    Bicknell, R.2
  • 49
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of human primary tumors in mice
    • O'Reilly MS, Holmgren L, Chen C, Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 1996;2:689-692.
    • (1996) Nat Med , vol.2 , pp. 689-692
    • O'Reilly, M.S.1    Holmgren, L.2    Chen, C.3    Folkman, J.4
  • 52
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, Meropol NJ, Novotny WF, Lieberman G, Griffing S, Bergsland E. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003;21:60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3    Meropol, N.J.4    Novotny, W.F.5    Lieberman, G.6    Griffing, S.7    Bergsland, E.8
  • 54
    • 0038172576 scopus 로고    scopus 로고
    • Cancer: Out of air is not out of action
    • Bottaro DP, Liotta LA. Cancer: Out of air is not out of action. Nature 2003;423:593-595.
    • (2003) Nature , vol.423 , pp. 593-595
    • Bottaro, D.P.1    Liotta, L.A.2
  • 55
    • 0037703383 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Motivators of metastasis?
    • Steeg PS. Angiogenesis inhibitors: Motivators of metastasis? Nat Med 2003;9:822-823.
    • (2003) Nat Med , vol.9 , pp. 822-823
    • Steeg, P.S.1
  • 57
    • 0023895209 scopus 로고
    • Chemical modification of tumour blood flow
    • Jirtle RL. Chemical modification of tumour blood flow. Int J Hyperthermia 1988;4:355-371.
    • (1988) Int J Hyperthermia , vol.4 , pp. 355-371
    • Jirtle, R.L.1
  • 58
    • 0023909330 scopus 로고
    • Determinants of rumor blood flow: A review
    • Jain RK. Determinants of rumor blood flow: A review. Cancer Res 1988;48:2641-2658.
    • (1988) Cancer Res , vol.48 , pp. 2641-2658
    • Jain, R.K.1
  • 59
    • 0031926037 scopus 로고    scopus 로고
    • Modification of tumor blood flow: Current status and future directions
    • Chaplin DJ, Hill SA, Bell KM, Tozer GM. Modification of tumor blood flow: Current status and future directions. Semin Radiat Oncol 1998;8:151-163.
    • (1998) Semin Radiat Oncol , vol.8 , pp. 151-163
    • Chaplin, D.J.1    Hill, S.A.2    Bell, K.M.3    Tozer, G.M.4
  • 60
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999;103:159-165.
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 63
    • 0033579958 scopus 로고    scopus 로고
    • Modification of blood flow in the HSN tumour and normal tissues of the rat by the endothelin ET(B) receptor agonist, IRL 1620
    • Bell KM, Chaplin DJ, Poole BA, Prise VE, Tozer GM. Modification of blood flow in the HSN tumour and normal tissues of the rat by the endothelin ET(B) receptor agonist, IRL 1620. Int J Cancer 1999;80:295-302.
    • (1999) Int J Cancer , vol.80 , pp. 295-302
    • Bell, K.M.1    Chaplin, D.J.2    Poole, B.A.3    Prise, V.E.4    Tozer, G.M.5
  • 64
    • 23044437711 scopus 로고    scopus 로고
    • The endothelin B (ET(B)) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: Potential for selective tumour blood flow modification
    • Cemazar M, Wilson I, Prise VE, Bell KM, Hill SA, Tozer GM. The endothelin B (ET(B)) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: Potential for selective tumour blood flow modification. Br J Cancer 2005;93:98-106.
    • (2005) Br J Cancer , vol.93 , pp. 98-106
    • Cemazar, M.1    Wilson, I.2    Prise, V.E.3    Bell, K.M.4    Hill, S.A.5    Tozer, G.M.6
  • 65
    • 0029884517 scopus 로고    scopus 로고
    • Tumour blood flow modification by endothelin-related peptides in the rat HSN fibrosarcoma
    • Bell KM, Prise VE, Chaplin DJ, Tozer GM. Tumour blood flow modification by endothelin-related peptides in the rat HSN fibrosarcoma. Br J Cancer Suppl 1996;27:S161-S163.
    • (1996) Br J Cancer Suppl , vol.27
    • Bell, K.M.1    Prise, V.E.2    Chaplin, D.J.3    Tozer, G.M.4
  • 66
    • 0030052256 scopus 로고    scopus 로고
    • Unique response of human arteries to endothelin B receptor agonist and antagonist
    • Liu JJ, Chen JR, Buxton BF. Unique response of human arteries to endothelin B receptor agonist and antagonist. Clin Sci (Lond) 1996;90:91-96.
    • (1996) Clin Sci (Lond) , vol.90 , pp. 91-96
    • Liu, J.J.1    Chen, J.R.2    Buxton, B.F.3
  • 67
    • 0030972887 scopus 로고    scopus 로고
    • Endothelium-dependent relaxation counteracting the contractile action of endothelin-1 is partly due to ETB receptor activation
    • Feger GI, Schilling L, Ehrenreich H, Wahl M. Endothelium-dependent relaxation counteracting the contractile action of endothelin-1 is partly due to ETB receptor activation. Res Exp Med (Berl) 1997;196:327-337.
    • (1997) Res Exp Med (Berl) , vol.196 , pp. 327-337
    • Feger, G.I.1    Schilling, L.2    Ehrenreich, H.3    Wahl, M.4
  • 68
    • 0018836769 scopus 로고
    • Intra-arterial infusion of anticancer drugs: Theoretic aspects of drug delivery and review of responses
    • Chen HS, Gross JF. Intra-arterial infusion of anticancer drugs: Theoretic aspects of drug delivery and review of responses. Cancer Treat Rep 1980;64:31-40.
    • (1980) Cancer Treat Rep , vol.64 , pp. 31-40
    • Chen, H.S.1    Gross, J.F.2
  • 71
    • 0034743359 scopus 로고    scopus 로고
    • Effects of PR-350, a newly developed radiosensitizer, on dihydropyrimidine dehydrogenase activity and 5-fluorouracil pharmacokinetics
    • Watanabe M, Tateishi T, Takezawa N, Tanaka M, Kumai T, Nakaya S, Kobayashi S. Effects of PR-350, a newly developed radiosensitizer, on dihydropyrimidine dehydrogenase activity and 5-fluorouracil pharmacokinetics. Cancer Chemother Pharmacol 2001;47:250-254.
    • (2001) Cancer Chemother Pharmacol , vol.47 , pp. 250-254
    • Watanabe, M.1    Tateishi, T.2    Takezawa, N.3    Tanaka, M.4    Kumai, T.5    Nakaya, S.6    Kobayashi, S.7
  • 72
    • 0037089470 scopus 로고    scopus 로고
    • Urokinase receptor antibody can reduce tumor volume and detect the presence of occult tumor metastases in vivo
    • Rabbani SA, Gladu J. Urokinase receptor antibody can reduce tumor volume and detect the presence of occult tumor metastases in vivo. Cancer Res 2002;62:2390-2397.
    • (2002) Cancer Res , vol.62 , pp. 2390-2397
    • Rabbani, S.A.1    Gladu, J.2
  • 73
    • 0034661755 scopus 로고    scopus 로고
    • Synthetic inhibitor of matrix metalloproteases decreases tumor growth and metastases in a syngeneic model of rat prostate cancer in vivo
    • Rabbani SA, Harakidas P, Guo Y, Steinman D, Davidsen SK, Morgan DW. Synthetic inhibitor of matrix metalloproteases decreases tumor growth and metastases in a syngeneic model of rat prostate cancer in vivo. Int J Cancer 2000;87:276-282.
    • (2000) Int J Cancer , vol.87 , pp. 276-282
    • Rabbani, S.A.1    Harakidas, P.2    Guo, Y.3    Steinman, D.4    Davidsen, S.K.5    Morgan, D.W.6
  • 74
    • 0029900738 scopus 로고    scopus 로고
    • Quantitation and physiological characterization of angiogenic vessels in mice: Effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment
    • Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK. Quantitation and physiological characterization of angiogenic vessels in mice: Effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. Am J Pathol 1996;149:59-71.
    • (1996) Am J Pathol , vol.149 , pp. 59-71
    • Dellian, M.1    Witwer, B.P.2    Salehi, H.A.3    Yuan, F.4    Jain, R.K.5
  • 75
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986;46:6387-6392.
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 76
    • 0034000453 scopus 로고    scopus 로고
    • Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review. J Control Release 2000;65:271-284
    • Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review. J Control Release 2000;65:271-284.


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