Protective effect of a polyherbal preparation, Brahma rasayana against tumor growth and lung metastasis in rat prostate model system

Journal of Experimental Therapeutics and Oncology

Volumn 4, Issue 3, 2004, Pages 203-212

  Gaddipati, Jaya P ^a   Rajeshkumar, N V ^a   Thangapazham, Rajesh L ^a   Sharma, Anuj ^a   Warren, James ^a   Mog, Steven R ^b   Singh, Anoop K ^a   Maheshwari, Radha K ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

Author keywords

Ayurveda; Brahma rasayana; Copenhagen rats; MAT LyLu; Polyherbal; Prostate cancer

Indexed keywords

AYURVEDIC DRUG; BRAHMA RASAYANA EXTRACT; HERBACEOUS AGENT; TESTOSTERONE; UNCLASSIFIED DRUG;

ALTERNATIVE MEDICINE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; BRAHMA RASAYANA; CANCER INCIDENCE; CANCER INHIBITION; CANCER PREVENTION; CANCER SURVIVAL; CHEMOPROPHYLAXIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; DRUG MECHANISM; GOOD LABORATORY PRACTICE; GOOD MANUFACTURING PRACTICE; HERBAL MEDICINE; HISTOPATHOLOGY; IMMUNOSTIMULATION; IN VIVO STUDY; LUNG METASTASIS; MALE; METASTASIS; NONHUMAN; PLANT; PRIORITY JOURNAL; PROSTATE CANCER; RAT; RAT STRAIN; SURVIVAL TIME; TESTOSTERONE BLOOD LEVEL; TUMOR GROWTH; TUMOR REGRESSION; TUMOR VOLUME;

ANIMALS; BODY WEIGHT; CHEMOPREVENTION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; INJECTIONS, INTRAVENOUS; LUNG NEOPLASMS; MALE; NEOPLASM METASTASIS; PLANT EXTRACTS; PROSTATIC NEOPLASMS; RATS; TESTOSTERONE;

EID: 9344233881     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Mettlin C. Recent developments in the epidemiology of prostate cancer. Eur J Cancer 33:340-347, 1997.
2. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Rompay MV, Kessler RC. Trends in alternative medicine use in the United States, 1990-1997. Results of a follow-up national survey. JAMA 280:1569-1575, 1998.
3. Glazier A. A landmark in the history of Ayurveda. The Lancet 356:1119, 2000.
4. Bloomfield HH. Ayurveda. Total Health 22:46-47, 2000.
5. Sharma HM, Hanna AN, Kauffman EM, Newman HAI. Effect of herbal mixture student Rasayana on lipoxygenase activity and lipid peroxidation. Free Radic Biol Med 18:687-697, 1995.
6. Sharma HM, Hanna AN, Kauffman EM, Newman HAI. Inhibition of human low-density lipoprotein oxidation in vitro by Maharshi Ayurveda herbal mixtures. Pharmacol Biochem Behavior 43:1175-1182, 1992.
7. Kumar VP, Kuttan R, Kuttan G. Effect of "rasayanas" a herbal drug preparation on cell-mediated immune responses in tumour bearing mice. Indian J Exp Biol 37:23-26, 1999.
8. Kumar VP, Kuttan R, Kuttan G. Effect of "rasayanas", a herbal drug preparation on immune responses and its significance in cancer treatment. Indian J Exp Biol 37:27-31, 1999.
9. Sharma PV. Charaka-Samhita II. Chaukhambha Orientalia, Varanasi, 1983.
10. Tiwari RK, Geliebter J, Garikapaty VP, Yedavelli SP, Chen S, Mittelman A. Anti-tumor effects of PC-SPES, an herbal formulation in prostate cancer. Int J Oncol 14:713-719, 1999.
11. Cleave ME, Hsieh JT, Wu HC, von Eschenbach AC, Chung LW. Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors. Cancer Res 52:1598-1605, 1992.
12. Zimmerman RA, Thompson IM. Prevalence of complementary medicine in urologic practice: A review of recent studies with emphasis on use among prostate cancer patients. Urol Clin North Am 29:1-9, 2002.
13. Schraub S. Unproven methods in cancer: a worldwide problem. Support Care Cancer 8:10-15, 2000.
14. Cassileth BR. Complementary therapies: Overview and state of the art. Cancer Nursing 22:85-90, 1999.
15. Nam RK, Fleshner N, Rakovitch E, Kltz L, Trachtenberg J, Choo R, Morton G, Danjoux C. Prevalence and patterns of the use of complementary therapies among prostate cancer patients: An epidemiological analysis. J Urol 161:1521-1524, 1999.
16. Monfort H. A new homeopathic approach to neoplastic diseases: from cell destruction to carcinogen induced apoptosis. Br Homeo J 89:78-83, 2000.
17. Singh RH. An assessment of the ayurvedic concept of cancer and a new paradigm of anticancer treatment in ayurveda. J Altern Complement Med 8:609-614, 2002.
18. Wu J. Apoptosis and angiogenesis: two promising tumor markers in breast cancer (review). Anticancer Res 16:2233-2239, 1996.
19. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100:57-70, 2000.
20. Chopra A, Doiphode VV. Ayurvedic medicine. Core concept, therapeutic principles, and current relevance. Med Clin North Am 86:75-89, 2002.
21. De Smet PA. Herbal remedies. N Engl J Med 347:2046-20562002.
22. Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 13:275-291, 1999.
23. Scartezzini P, Speroni E. Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol 71:23-43, 2000.
24. Vayalil PK, Kuttan G, Kuttan R. Rasayanas: evidence for the concept of prevention of diseases. Am J Chinese Med 30:155-171, 2002.
25. Jose JK, Kuttan G, Kuttan R. Antitumour activity of Emblica officinalis. J Ethnopharmacol 75:65-69, 2001.
26. Jeena KJ, Joy KL, Kuttan R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett 136:11-16, 1999.
27. Ihantola-Vormisto A, Summanen J, Kankaanranta H, Vuorela H, Asmawi ZM, Moilanen E. Anti-inflamrnatory activity of extracts from leaves of Phyllanthus emblica. Planta Med 63:518-524, 1997.
28. Bhattacharya A, Chatterjee A, Ghosal S, Bhattacharya SK. Antioxidant activity of active tannoid principles of Emblica officinalis (amla). Indian J Exp Biol 37:676-680, 1999.
29. Khan MT, Lampronti I, Martello D, Bianchi N, Jabbar S, Choudhuri MS, Datta BK, Gambari R. Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: Effects on in vitro cell growth of human tumor cell lines. Int J Oncol 21:187-192, 2002.
30. Naik GH, Priyadarsini KI, Satav JG, Banavalikar MM, Sohoni DP, Biyani MK, Mohan H. Comparative antioxidant activity of individual herbal components used in Ayurvedic medicine. Phytochemistry 63:97-104, 2003.
31. Saleem A, Husheem M, Harkonen P, Pihlaja K. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz, fruit. J. Ethnopharmacol 81:327-336, 2002.
32. Lin LT, Liu LT, Chiang LC, Lin CC. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother. Res 16:440-444, 2002.
33. Babu TD, Kuttan G, Padikkala J. Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban. J Ethnopharmacol 48:53-57, 1995.
34. Barnes S. Role of phytochemicals in prevention and treatment of prostate cancer. Epidemiol Rev 23:102-105, 2001.
35. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768-780, 2003.
36. Zhang PL, Rosen S, Veeramachaneni R, Kao J, DeWolf WC, Bubley G. Association between prostate cancer and serum testosterone levels. Prostate 53:179-182, 2002.