Type I interferon signaling and B cells maintain hemopoiesis during Pneumocystis infection of the lung

Journal of Immunology

Volumn 178, Issue 10, 2007, Pages 6604-6615

  Meissners, Nicole ^a   Rutkowski, Melanie ^a   Harmsen, Ann L ^a   Hau, Soo ^a   Harmsen, Allen G ^a  

^a MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE MARROW; BONE MARROW DEPRESSION; CELL LOSS; EXTRAMEDULLARY HEMATOPOIESIS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; LIVER; LUNG INFECTION; LYMPHOCYTE; MOUSE; NONHUMAN; PANCYTOPENIA; PNEUMOCYSTIS; PNEUMOCYSTOSIS; PNEUMONIA; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; WILD TYPE;

EID: 34248206184     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.10.6604     Document Type: Article

References (64)

1. Siegal, F. 2003. Interferon-producing plasmacytoid dendritic cells and the pathogenesis of AIDS. Res. Initiat. Treat. Action 8: 10-13.
2. Soumelis, V., I. Scott, F. Gheyas, D. Bouhour, G. Cozon, L. Cotte, L. Huang, J. A. Levy, and Y. J. Liu. 2001. Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood 98: 906-912.
3. Levy, J. A., I. Scott, and C. Mackewicz. 2003. Protection from HIV/AIDS: the importance of innate immunity. Clin. Immunol. 108: 167-174.
4. Sepkowitz, K. A. 2002. Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome. Clin. Infect. Dis. 34: 1098-1107.
5. Levine, A. M., D. T. Scadden, J. A. Zaia, and A. Krishnan. 2001. Hematologic Aspects of HIV/AIDS. Hematology Am. Soc. Hematol. Educ. Program 463-478.
6. Belperio, P. S., and D. C. Rhew. 2004. Prevalence and outcomes of anemia in individuals with human immunodeficiency virus: a systematic review of the literature. Am. J. Med. 116(Suppl. 7A): 27S-43S.
7. Malyangu, E., E. A. Abayomi, J. Adewuyi, and A. M. Coutts. 2000. AIDS is now the commonest clinical condition associated with multilineage blood cytopenia in a central referral hospital in Zimbabwe. Cent. Afr. J. Med. 46: 59-61.
8. Kondo, M., A. J. Wagers, M. G. Manz, S. S. Prohaska, D. C. Scherer, G. F. Beilhack, J. A. Shizuru, and I. L. Weissman. 2003. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu. Rev. Immunol. 21: 759-806.
9. Weiss, G., and L. T. Goodnough. 2005. Anemia of chronic disease. N. Engl. J. Med. 352: 1011-1023.
10. LaMonte, A. C., M. E. Paul, J. S. Read, M. M. Frederick, D. D. Erdman, L. L. Han, and L. J. Anderson. 2004. Persistent parvovirus B19 infection without the development of chronic anemia in HIV-infected and -uninfected children: the Women and Infants Transmission Study. J. Infect. Dis. 189: 847-851.
11. Evatt, B. L. 2005. HIV infection and thrombocytopenia. Curr. Hematol. Rep. 4: 149-153.
12. Moses, A., J. Nelson, and G. C. Bagby, Jr. 1998. The influence of human immunodeficiency virus-1 on hemopoiesis. Blood 91: 1479-1495.
13. MacGregor, R. R., R. Hafner, J. W. Wu, R. L. Murphy, D. C. Perlman, L. E. Bermudez, C. B. Inderlied, L. J. Picker, R. S. Wallis, J. W. Andersen, et al. 2005. Clinical, microbiological, and immunological characteristics in HIV-infected subjects at risk for disseminated Mycobacterium avium complex disease: an AACTG study. AIDS Res. Hum. Retroviruses 21: 689-695.
14. Meira, D. G., I. Lorand-Metze, A. D. Toro, M. T. Silva, and M. M. Vilela. 2005. Bone marrow features in children with HIV infection and peripheral blood cytopenias. J. Trop. Pediatr. 51: 114-119.
15. Gill, P. S., M. Rarick, R. K. Brynes, D. Causey, C. Loureiro, and A. M. Levine. 1987. Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med. 107: 502-505.
16. Isgro, A., A. Aiuti, W. Leti, C. Gramiccioni, A. Esposito, I. Mezzaroma, and F. Aiuti. 2005. Immunodysregulation of HIV disease at bone marrow level. Autoimmun. Rev. 4: 486-490.
17. Bianco, P., M. Rimirateci, S. Gronthos, and P. G. Robey. 2001. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19: 180-192.
18. Calvi, L. M. 2006. Osteoblastic activation in the hematopoietic stem cell niche. Ann. NY Acad. Sci. 1068: 477-488.
19. Calvi, L. M., G. B. Adams, K. W. Weibrecht, J. M. Weber, D. P. Olson, M. C. Knight, R. P. Martin, E. Schipani, P. Divieti, F. R. Bringhurst, et al. 2003. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425: 841-846.
20. Wilson, A., and A. Trumpp. 2006. Bone marrow haematopoietic-stem-cell niches. Nat. Rev. Immunol. 6: 93-106.
21. Xing, L., E. M. Schwarz, and B. F. Boyce. 2005. Osteoclast precursors, RANKL/RANK, and immunology. Immunol. Rev. 208: 19-29.
22. Tanaka, S., K. Nakamura, N. Takahasi, and T. Suda. 2005. Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol. Rev. 208: 30-49.
23. Takayanagi, H., K. Sato, A. Takaoka, and T. Taniguchi. 2005. Interplay between interferon and other cytokine systems in bone metabolism. Immunol. Rev. 208: 181-193.
24. Muller, U., U. Steinhoff, L. F. Reis, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264: 1918-1921.
25. + cells in resistance to Pneumocystis carinii pneumonia in mice. J. Exp. Med. 172: 937-945.
26. Bolliger, A. P. 2004. Cytologic evaluation of bone marrow in rats: indications, methods, and normal morphology. Vet. Clin. Pathol. 33: 58-67.
27. Meissner, N. N., F. E. Lund, S. Han, and A. Harmsen. 2005. CD8 T cell-mediated lung damage in response to the extracellular pathogen Pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells. J. Immunol. 175: 8271-8279.
28. Wright, T. W., F. Gigliotti, J. N. Finkelstein, J. T. McBride, C. L. An, and A. G. Harmsen. 1999. Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia. J. Clin. Invest. 104: 1307-1317.
29. Kasper, L. H., and D. Buzoni-Gatel. 1998. Some opportunistic parasitic infections in AIDS: candidiasis, pneumocystosis, cryptosporidiosis, toxoplasmosis. Parasitol. Today 14: 150-156.
30. Sainz, B., Jr., and W. P. Halford. 2002. α/β interferon and γ interferon synergize to inhibit the replication of herpes simplex virus type 1. J. Virol. 76: 11541-11550.
31. Segal, B. H., and T. J. Walsh. 2006. Current approaches to diagnosis and treatment of invasive aspergillosis. Am. J. Respir. Crit. Care Med. 173: 707-717.
32. Bonnett, C. R., E. J. Cornish, A. G. Harmsen, and J. B. Burritt. 2006. Early neutrophil recruitment and aggregation in the murine lung inhibit germination of Aspergillus fumigatus conidia. Infect. Immun. 74: 6528-6539.
33. Siegal, F. P., P. Fitzgerald-Bocarsly, B. K. Holland, and M. Shodell. 2001. Interferon-α generation and immune reconstitution during antiretroviral therapy for human immunodeficiency virus infection. AIDS 15: 1603-1612.
34. Broxmeyer, H. E., L. Lu, E. Platzer, C. Feit, L. Juliano, and B. Y. Rubin. 1983. Comparative analysis of the influences of human γ, α and β interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells. J. Immunol. 131: 1300-1305.
35. Samuel, C. E. 2001. Antiviral actions of interferons. Clin. Microbiol. Rev. 14: 778-809.
36. Belardelli, F., M. Ferrantini, E. Proietti, and J. M. Kirkwood. 2002. Interferon-α in tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 13: 119-134.
37. Kirkwood, J. M., C. Bender, S. Agarwala, A. Tarhini, J. Shipe-Spotloe, B. Smelko, S. Donnelly, and L. Stover. 2002. Mechanisms and management of toxicities associated with high-dose interferon α-2b therapy. J. Clin. Oncol. 20: 3703-3718.
38. Verma, A., D. K. Deb, A. Sassano, S. Uddin, J. Varga, A. Wickrema, and L. C. Platanias. 2002. Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-β on normal hemopoiesis. J. Biol. Chem. 277: 7726-7735.
39. Castell, J. V., M. J. Gomez-Lechon, M. David, R. Fabra, R. Trullenque, and P. C. Heinrich. 1990. Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 12: 1179-1186.
40. Heinrich, P. C., J. V. Castell, and T. Andus. 1990. Interleukin-6 and the acute phase response. Biochem J. 265: 621-636.
41. Heinrich, P. C., I. Behrmann, S. Haan, H. M. Hermanns, G. Muller-Newen, and F. Schaper. 2003. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
42. Levy, D. E., I. Marie, and A. Prakash. 2003. Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity. Curr. Opin. Immunol. 15: 52-58.
43. Stetson, D. B., and R. Medzhitov. 2006. Type I interferons in host defense. Immunity 25: 373-381.
44. Meissner, N. N., S. Swain, M. Tighe, and A. Harmsen. 2005. Role of type I IFNs in pulmonary complications of Pneumocystis murina infection. J. Immunol. 174: 5462-5471.
45. Brodsky, R. A., and R. J. Jones. 2005. Aplastic anaemia. Lancet 365: 1647-1656.
46. Young, N. S. 2002. Acquired aplastic anemia. Ann. Intern. Med. 136: 534-546.
47. + cells of aplastic anaemia patients: relationship with increased apoptosis and upregulation of Fas antigen. Br. J. Haematol. 113: 706-712.
48. Zandman-Goddard, G., and Y. Shoenfeld. 2002. HIV and autoimmunity. Autoimmun Rev. 1: 329-337.
49. Borkow, G., and Z. Bentwich. 2004. Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy. Clin. Microbiol. Rev. 17: 1012-1030.
50. Shah, I., and A. K. Murthy. 2005. Aplastic anemia in an HIV infected child. Indian J. Pediatr. 72: 359-361.
51. Fagerlie, S. R., and G. C. Bagby. 2006. Immune defects in Fanconi anemia. Crit. Rev. Immunol. 26: 81-96.
52. Suda, T., F. Arai, and A. Hirao. 2005. Hematopoietic stem cells and their niche. Trends Immunol. 26: 426-433.
53. Takayanagi, H., K. Ogasawara, S. Hida, T. Chiba, S. Murata, K. Sato, A. Takaoka, T. Yokochi, H. Oda, K. Tanaka, et al. 2000. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ. Nature 408: 600-605.
54. Takaoka, A., and T. Taniguchi. 2003. New aspects of IFN-α/β signalling in immunity, oncogenesis and bone metabolism. Cancer Sci. 94: 405-411.
55. Horowitz, M. C., A. L. Bothwell, D. G. Hesslein, D. L. Pflugh, and D. G. Schatz. 2005. B cells and osteoblast and osteoclast development. Immunol. Rev. 208: 141-153.
56. Levis, M., and D. Small. 2003. FLT3: ITDoes matter in leukemia. Leukemia 17: 1738-1752.
57. McKenna, H. J. 2001. Role of hematopoietic growth factors/flt3 ligand in expansion and regulation of dendritic cells. Curr. Opin. Hematol. 8: 149-154.
58. Brasel, K., T. De Smedt, J. L. Smith, and C. R. Maliszewski. 2000. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood 96: 3029-3039.
59. Onai, N., A. Obata-Onai, R. Tussiwand, A. Lanzavecchia, and M. G. Manz. 2006. Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J. Exp. Med. 203: 227-238.
60. Stahl, D., S. Lacroix-Desmazes, N. Misra, M. Karmochkine, S. V. Kaveri, D. Costagliola, W. Sibrowski, and M. D. Kazatchkine. 2005. Alterations of self-reactive antibody repertoires in HIV disease: an insight into the role of T cells in the selection of autoreactive B cells. Immunol. Lett. 99: 198-208.
61. Marone, G., G. Florio, A. Petraroli, and A. de Paulis. 2001. Dysregulation of the IgE/Fc εRI network in HIV-1 infection. J. Allergy Clin. Immunol. 107: 22-30.
62. Thomas, C. F., Jr., and A. H. Limper. 2004. Pneumocystis pneumonia. N. Engl. J. Med. 350: 2487-2498.
63. Festic, E., O. Gajic, A. H. Limper, and T. R. Aksamit. 2005. Acute respiratory failure due to Pneumocystis pneumonia in patients without human immunodeficiency virus infection: outcome and associated features. Chest 128: 573-579.
64. Grubb, J. R., A. C. Moorman, R. K. Baker, and H. Masur. 2006. The changing spectrum of pulmonary disease in patients with HIV infection on antiretroviral therapy. AIDS 20: 1095-1107.