Bone marrow features in children with HIV infection and peripheral blood cytopenias

Journal of Tropical Pediatrics

Volumn 51, Issue 2, 2005, Pages 114-119

  Meira, D G ^a   Lorand Metze, I ^a   Toro, A D C ^a   Silva, M T N ^a   Vilela, Maria Marluce Dos Santos ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CYANOCOBALAMIN; DIDANOSINE; FERRITIN; FOLIC ACID; FOLINIC ACID; IMMUNOGLOBULIN; LAMIVUDINE; NELFINAVIR; STAVUDINE; ZIDOVUDINE;

ANEMIA; ARTICLE; B LYMPHOCYTE; BLOOD CELL COUNT; BLOOD TRANSFUSION; BONE MARROW CULTURE; BONE MARROW EXAMINATION; BONE MARROW TOXICITY; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CORRELATION FUNCTION; CYTOPENIA; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG EXPOSURE; FEMALE; FERRITIN BLOOD LEVEL; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; GRANULOCYTE PRECURSOR; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; IRON DEFICIENCY; LYMPHOCYTE SUBPOPULATION; MALE; MEGAKARYOCYTE; MYCOBACTERIOSIS; MYCOBACTERIUM INTRACELLULARE AVIUM; NEUTROPENIA; PANCYTOPENIA; PERIPHERAL LYMPHOCYTE; THROMBOCYTOPENIA; VIRUS LOAD; VITAMIN BLOOD LEVEL;

ANEMIA, APLASTIC; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BONE MARROW; BRAZIL; CHILD; CHILD, PRESCHOOL; FEMALE; HEMATOLOGIC DISEASES; HIV INFECTIONS; HUMANS; INFANT; MALE; STATISTICS, NONPARAMETRIC; VIRAL LOAD;

EID: 20444392014     PISSN: 01426338     EISSN: None     Source Type: Journal    
DOI: 10.1093/tropej/fmh096     Document Type: Article

References (27)

1. Bain BJ. The haematological features of HIV infection. Br J Haematol 1997; 99: 1-8.
2. Zhao X, Sun NCJ, Witt MD, Keller M, Niihara Y. Changing pattern of AIDS: a bone marrow study. Am J Clin Pathol 2004; 121: 393-401.
3. Lorand-Metze I, Arruda VR, Vassallo J. Differential diagnosis between HIV-related marrow abnormalities and primary myelodysplasia. Pathol Res Pract 1991; 187: 719.
4. Domachowske JB. Pediatric human immunodeficiency virus infection. Clin Microbiol Rev 1996; 9: 448-69.
5. Mueller BU, Tannenba UMS, Pizzo PA. Bone marrow aspirates and biopsies in children with human immunodeficiency virus infection. J Pediatr Hematol/Oncol 1996; 18: 266-71.
6. Adewuyi J, Chitsike I. Haematologic features of the human immunodeficiency virus infection in black children in Harare. Central Afr J Med 1994; 40: 333-36.
7. Candido A, Rossi P, Menichella G, et al. Indicative morphological myelodysplastic alterations of bone marrow in overt AIDS. Haematologica. 1990; 75: 327-33.
8. Sociedade Brasileira de Pediatria e Ministério da Saúde. Estudo colaborativo multicêntrico para avaliar as taxas de transmissão vertical do HIV 2003. Available at www.aids.gov.br
9. Silva EB, Grotto HZW, Vilela MMS. Complete blood counts in children exposed to HIV-1: Comparison between infected and seroreverters. J Pediatria (Rio J) 2001; 77: 503-11.
10. Silva EB, Silva MTN, Vilela MMS. Evolution of hematological parameters in a group of children with human immunodeficiency virus infection - HIV 1. J Pediatria (Rio J) 1999; 75: 442-48.
11. Centers for Disease Control. Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. Morbid Mortality Wkly Report 1994; 43: 1-10.
12. Kievits T, Van Gemen B, Van Strip D, et al. Nasba isothermal enzymatic in vitro nucleic acid amplification optimized for the diagnosis of HIV-1 infection. J Virol Meth 1991; 35: 273-86.
13. Albert J, Fenyö EM. Simple, sensitive, and specific detection of human immunodeficiency vírus type 1 in clinical specimens by polymerase chain reaction with nested primers. J Clin Microbiol 1990; 28: 1560-64.
14. Dallalio G, North M, McKenzie SW, Means RT. Cytokine and cytokine receptor concentrations in bone marrow supernatant from patients with HIV: correlation with hematologic parameters. J Invest Med 1999; 47: 477-83.
15. Thiele J, Zirbes TK, Bertsch HP, Titius BR, Lorenzen J, Fischer R. AIDS-related bone marrow lesions - myelodysplastic features or predominant inflammatory-reactive changes (HIV-myelopathy)? A comparative morphometric study by immunohistochemistry with special emphasis on apoptosis and PCNA-labeling. Analyt Cell Pathol 1996; 11: 141-57.
16. Isgro A, Mezzaroma I, Aiuti A, et al. Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type 1-infected patients during highly active antiretroviral therapy. AIDS 2000; 16: 14791-99.
17. Moses A, Nelson J, Bagby GC Jr. The influence of human immunodeficiency virus-1 on hemopoiesis. Blood 1998; 91: 1479-95.
18. Dickover RE, Dilon M, Gillette SG, et al. Rapid increases in load of human immunodeficiency virus correlate with early disease progression and loss of CD4 cells in vertically infected infants. J Infect Dis 1994; 170: 1279-84.
19. De Rossi A, Masiero S, Giaquinto C, et al. Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection. J Clin Invest 1996; 97: 323-30.
20. + T cell proliferation is coupled to perforin expression and is maintained in non-progressors. Nature 2002; 3:1061-68.
21. Rego EM, Garcia AB, Viana SR, Falcão RP. Age-related changes of lymphocyte subsets in normal bone marrow biopsies. Cytometry 1998; 34: 22-9.
22. Nielsen SD, Jeppesen DL, Kolte L, et al. Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts. Blood 2001; 98: 398-404.
23. Clerici M, Saresella M, Colombo F, et al. T-lymphocyte maturation abnormalities in uninfected newborns and children with vertical exposure to HIV. Blood 2000; 96: 3866-71.
24. Tess BH, Rodrigues LC, Newell ML, Dunn DT, Lago TDG. Breastfeeding, genetic, obstetric and other risk factors associated with mother-to-child transmission of HIV-1 in São Paulo State, Brazil. AIDS 1998; 12: 513-20.
25. Kulkosky J, Bouhamdan M, Geist A, Nunnari G, Phinney DG, Pomerantz RJ. Pathogenesis of HIV-1 infection within bone marrow cells. Leukemia Lymphoma 2000; 37: 497-515.
26. Brook MG, Ayles H, Harrison C, Rowntree C, Miller RF. Diagnostic utility of bone marrow sampling in HIV positive patients. Genitourin Med 1997; 73: 117-21.
27. Hussong J, Peterson LR, Warren JR, Peterson LC. Detecting disseminated Mycobacterium avium complex infections in HIV-positive patients. Am J Chn Pathol 1998; 110: 806-09.