Effects of dietary equol on the pituitary of the ovariectomized rats

Hormone and Metabolic Research

Volumn 39, Issue 4, 2007, Pages 256-261

  Rachon D ^a,b   Vortherms, T ^a   Seidlova Wuttke D ^a   Wuttke, W ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Equol; Estrogen receptors; LH; Phytoestrogens; Pituitary; Prolactin; TERP 1

Indexed keywords

EQUOL; ESTRADIOL BENZOATE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LUTEINIZING HORMONE; MESSENGER RNA; PROLACTIN; TRUNCATED ESTROGEN RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; DRUG MEGADOSE; FEMALE; GENE EXPRESSION; HYPOPHYSIS; LOW DRUG DOSE; LUTEINIZING HORMONE RELEASE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROLACTIN RELEASE; PROTEIN EXPRESSION; RAT; UTERUS WEIGHT;

ANIMALS; DIET; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS, NON-STEROIDAL; FEMALE; ISOFLAVONES; LUTEINIZING HORMONE; ORGAN SIZE; OVARIECTOMY; PITUITARY GLAND; PROLACTIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UTERUS;

RATTUS;

EID: 34248191198     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-973074     Document Type: Article

References (41)

1. Lieberman ME, Maurer RA, Claude P, Wiklund J, Wertz N, Gorski J: Regulation of pituitary growth and prolactin gene expression by estrogen. Adv Exp Med Biol 1981; 138: 151-163
2. Lieberman ME, Maurer RA, Gorski J: Estrogen control of prolactin synthesis in vitro. Proc Natl Acad Sci USA 1978; 75: 5946-5949
3. Nedvidkova J, Kasafirek E, Dlabac A: Effect of enkephalin analogues Tyr-D-Ala-Gly-Phe-Cys(Et) and Tyr-D-Ala-Gly-Phe-Cys(Bu) on prolactin and growth hormone release in rats. Endocrinol Exp 1988; 22: 255-259
4. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM: The nuclear receptor superfamily: the second decade. Cell 1995; 83: 835-839
5. Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M, Gustafsson JA: Mechanisms of estrogen action. Physiol Rev 2001; 81: 1535-1565
6. Mitchner NA, Garlick C, Ben-Jonathan N: Cellular distribution and gene regulation of estrogen receptors alpha and beta in the rat pituitary gland. Endocrinology 1998; 139: 3976-3983
7. Wilson ME, Price RH, Jr, Handa RJ: Estrogen receptor-beta messenger ribonucleic acid expression in the pituitary gland. Endocrinology 1998; 139: 5151-5156
8. Friend KE, Ang LW, Shupnik MA: Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary. Proc Natl Acad Sci USA 1995; 92: 4367-4371
9. Resnick EM, Schreihofer DA, Periasamy A, Shupnik MA: Truncated estrogen receptor product-1 suppresses estrogen receptor transactivation by dimerization with estrogen receptors alpha and beta. J Biol Chem 2000; 275: 7158-7166
10. Friend KE, Resnick EM, Ang LW, Shupnik MA: Specific modulation of estrogen receptor mRNA isoforms in rat pituitary throughout the estrous cycle and in response to steroid hormones. Mol Cell Endocrinol 1997; 131: 147-155
11. Schreihofer DA, Resnick EM, Soh AY, Shupnik MA: Transcriptional regulation by a naturally occurring truncated rat estrogen receptor (ER), truncated ER product-1 (TERP-1). Mol Endocrinol 1999; 13: 320-329
12. Wuttke W, Jarry H, Westphalen S, Christoffel V, Seidlova-Wuttke D: Phytoestrogens for hormone replacement therapy? J Steroid Biochem Mol Biol 2002; 83: 133-147
13. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998; 139: 4252-4263
14. Miksicek RJ: Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. J Steroid Biochem Mol Biol 1994; 49: 153-160
15. Marrian G, Haslewood G: Equol, a new inactive phenol isolated from the ketohydroxyoestrin fraction of mares urine. Biochem J 1932; 26: 1227-1232
16. Muthyala RS, Ju YH, Sheng S, Williams LD, Doerge DR, Katzenellenbogen BS, Helferich WG, Katzenellenbogen JA: Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem 2004; 12: 1559-1567
17. Rowland IR, Wiseman H, Sanders TA, Adlercreutz H, Bowey EA: Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer 2000; 36: 27-32
18. Setchell KD, Brown NM, Desai PB, Zimmer-Nechimias L, Wolfe B, Jakate AS, Creutzinger V, Heubi JE: Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes. J Nutr 2003; 133: 1027-1035
19. Morito K, Hirose T, Kinjo J, Hirakawa T, Okawa M, Nohara T, Ogawa S, Inoue S, Muramatsu M, Masamune Y: Interaction of phytoestrogens with estrogen receptors alpha and beta. Biol Pharm Bull 2001; 24: 351-356
20. Kaziro R, Kennedy JP, Cole ER, Southwell-Keely PT: The oestrogenicity of equol in sheep. J Endocrinol 1984; 103: 395-399
21. Selvaraj V, Zakroczymski MA, Naaz A, Mukai M, Ju YH, Doerge DR, Katzenellenbogen JA, Helferich WG, Cooke PS: Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice. Biol Reprod 2004; 71: 966-972
22. Rachon D, Vortherms T, Seidlova-Wuttke D, Wuttke W: Effects of dietary equol on body weight gain, intraabdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats. Menopause 2007; 12: 1-8
23. Roth C, Schricker M, Lakomek M, Strege A, Heiden I, Luft H, Munzel U, Wuttke W, Jarry H: Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model. J Endocrinol 2001; 169: 361-371
24. Heid CA, Stevens J, Livak KJ, Williams PM: Real time quantitative PCR. Genome Res 1996; 6: 986-994
25. Seidlova-Wuttke D, Hesse O, Jarry H, Christoffel V, Spengler B, Becker T, Wuttke W: Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta. Eur J Endocrinol 2003; 149: 351-362
26. Odum J, Lefevre PA, Tittensor S, Paton D, Routledge EJ, Beresford NA, Sumpter JP, Ashby J: The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay. Regul Toxicol Pharmacol 1997; 25: 176-188
27. Tang BY, Adams NR: Effect of equol on oestrogen receptors and on synthesis of DNA and protein in the immature rat uterus. J Endocrinol 1980; 85: 291-297
28. Chen HT: Postnatal development of pituitary lactotropes in the rat measured by reverse hemolytic plaque assay. Endocrinology 1987; 120: 247-253
29. Dada MO, Campbell GT, Blake CA: A quantitative immunocytochemical study of the luteinizing hormone and follicle-stimulating hormone cells in the adenohypophysis of adult male rats and adult female rats throughout the estrous cycle. Endocrinology 1983; 113: 970-984
30. Levine JE: New concepts of the neuroendocrine regulation of gonadotropin surges in rats. Biol Reprod 1997; 56: 293-302
31. Shupnik MA, Gordon MS, Chin WW: Tissue-specific regulation of rat estrogen receptor mRNAs. Mol Endocrinol 1989; 3: 660-665
32. Schreihofer DA, Stoler MH, Shupnik MA: Differential expression and regulation of estrogen receptors (ERs) in rat pituitary and cell lines: estrogen decreases ERalpha protein and estrogen responsiveness. Endocrinology 2000; 141: 2174-2184
33. Smith MS, Freeman ME, Neill JD: The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy. Endocrinology 1975; 96: 219-226
34. Scully KM, Gleiberman AS, Lindzey J, Lubahn DB, Korach KS, Rosenfeld MG: Role of estrogen receptor-alpha in the anterior pituitary gland. Mol Endocrinol 1997; 11: 674-681
35. Arai Y, Uehara M, Sato Y, Kimira M, Eboshida A, Adlercreutz H, Watanabe S: Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. J Epidemiol 2000; 10: 127-135
36. Faure ED, Chantre P, Mares P: Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2002; 9: 329-334
37. Upmalis DH, Lobo R, Bradley L, Warren M, Cone FL, Lamia CA: Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause 2000; 7: 236-242
38. Quella SK, Loprinzi CL, Barton DL, Knost JA, Sloan JA, LaVasseur BI, Swan D, Krupp KR, Miller KD, Novotny PJ: Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial. J Clin Oncol 2000; 18: 1068-1074
39. Davidson IW, Parker JC, Beliles RP: Biological basis for extrapolation across mammalian species. Regul Toxicol Pharmacol 1986; 6: 211-237
40. Vocci F, Farber T: Extrapolation of animal toxicity data to man. Regul Toxicol Pharmacol 1988; 8: 389-398
41. Setchell KD, Clerici C, Lephart ED, Cole SJ, Heenan C, Castellani D, Wolfe BE, Nechemias-Zimmer L, Brown NM, Lund TD, Handa RJ, Heubi JE: S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr 2005; 81: 1072-1079