Subchronic exposure of rats to sublethal dose of microcystin-YR induces DNA damage in multiple organs

Radiology and Oncology

Volumn 41, Issue 1, 2007, Pages

  Filipič, Metka ^a   Žegura, Bojana ^a   Sedmak, Bojan ^a   Horvat Žnidaršič, Irena ^b   Milutinovič, Aleksandra ^b   Šuput, Dušan ^b  

^a NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Bacterial toxins; Comet assay; Cyanobacteria; DNA damage; Rats, inbred F344

Indexed keywords

CLOSTRIDIOPEPTIDASE A; CYANOGINOSIN; CYANOGINOSIN YR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CHRONIC DRUG ADMINISTRATION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; GENOTOXICITY; KIDNEY; LIVER; LUNG; LYMPHOCYTE; MALE; NONHUMAN; RAT; SPLEEN;

EID: 34248184444     PISSN: 13182099     EISSN: 15813207     Source Type: Journal    
DOI: 10.2478/v10019-007-0003-z     Document Type: Article

References (37)

1. McElhiney J, Lawton LA. Detection of the cyanobacterial hepatotoxins microcystins. Toxicol Appl Pharmacol 2005; 203: 219-30.
2. Dawson RM. Toxicology of microcystins. Toxicon 1998; 7: 953-62.
3. Sedmak B, Kosi, G. Microcystins in Slovene freshwaters (Central Europe): first report. Nat Toxins 1997; 5: 64-73.
4. Codd GA, Bell SG, Kaya K, Ward CJ, Beattie KA, Metcalf JS. Cyanobacterial toxins, exposure routes and human health. Eur J Physiol 1999; 34: 405-15.
5. Carmichael WW. Azevedo SMFO, An JS, Molica RJR, Jochimsen EM, Lau S, et al. Human fatalities from cyanobacteria: Chemical and biological evidence for cyanotoxins. Environ Health Perspect 2001; 109: 663-8.
6. Ueno Y, Nagata S, Tsutsumi T, Hasegawa A, Watanabe M.F, Park HD, et al. Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis 1996; 17: 1317-21.
7. Nishiwaki R, Ohta T, Suoeka E, Suganuma M, Harada KI, Watanebae MF, et al. Two significant aspect of microcystin-LR: specific binding and liver specificity. Cancer Lett 1994; 83: 283-9.
8. Ito E, Kondo F, Harada KI. First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method. Toxicon 2000; 38: 37-48.
9. Eriksson JE, Gronberg L, Nygård S, Slotte JP, Meriluoto JA. Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin. Biochim Biophy Acta 1990; 1025: 60-6.
10. Carmichael WW, Falconer IR. Diseases related to freshwater blue-green algal toxins and control measures. In: Falconer IR, editor. Algal toxins in seafood and drinking water. London: Academic Press; 1993. p. 187-209.
11. Chong MW, Gu KD, Lam PK, Yang M, Fong WF. Study on the cytotoxicity of microcystin-LR on cultured cells. Chemosphere 2000; 41: 143-7.
12. McDermott CM, Nho CW, Howard W, Holton B. The cyanobacterial toxin, microcysin-LR can induce apoptosis in a variety of cell types. Toxicon 1998; 36: 1981-6.
13. Carmichael WW, Azevedo SM, An JS, Molica RJ, Jochimsen EM, Lau S, Rinehart KL, Shaw GR, Eaglesham GK. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins. Environ Health Perspect 2001; 109: 663-8.
14. Yoshizawa S, Matsushima R, Watanabe MF, Harada K-I, Ichihara A, Carmichael WW, Fujiki H. Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity. J Cancer Res Clin Oncol 1990; 116: 609-14.
15. Ding W-X, Shen H-M, Ong C-N. Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes. Hepatology 2000; 32: 547-55.
16. Bouaïcha N, Maatouk I. Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes. Toxicol Lett 2004; 148: 53-63.
17. Guzman ER, Solter PF. Hepatic oxidative stress following prolonged sublethal microcystin-LR exposure. Toxicol Pathol 1999; 27: 582-8.
18. Žegura B, Lah TT, Filipič M. The role of reactive oxygen species in microcystin-LR-induced DNA damage. Toxicology 2004; 200: 59-68.
19. Rao PV, Bhattacharaya R. The cyanobacteria toxin microcystin-LR induced DNA damage in mouse liver in vivo. Toxicology 1996; 114: 29-36.
20. 32P-postlabelling of 8-oxo-7,8-dihydro-2′-deoxyguanosine in DNA as biomarker of microcystin-LR- and nodularin-induced DNA damage in vitro in primary cultured rat hepatocytes and in vivo in rat liver. Mutat Res 2004; 564: 9-20.
21. Ding W-X, Shen H-M, Zhu H-G, Lee B-L. Genotoxicity of microcystic cyanobacteria extract of a water source in China. Mutat Res 1999; 442: 69-77.
22. Rao PV, Bhattacharaya R, Parida M M, Jana A M, Bhaskar A S. Freshwater cyanobacterium Microcystis aeruginasa (UTEX 2385) induced DNA damage in vivo and in vitro. Environ Toxicol Pharmacol 1998; 5: 1-6.
23. Žegura B, Sedmak B, Filipič M. Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2. Toxicon 2003; 41: 41-8.
24. Lankoff A, Krzowski L, Glab J, Banasik A, Lisowska H, Kuszewski T, et al. DNA damage and repair in human peripheral blood lymphocytes following treatment with microcystin-LR. Mutat Res 2004; 559: 131-42.
25. Zhan L, Sakamoto H, Sakuraba M, Wu D-S, Zhang L-S, Suzuki T, et al. Genotoxicity of microcystin-LR in human lymphoblastoid TK6 cells. Mutat Res 2004; 557: 1-6.
26. Suzuki H, Watanabe MF, Wu Y, Sugita T, Kita K, Sato T, et al. Mutagenicity of microcystin-LR in human RSa cells. Int J Mol Med 1998; 2: 109-12.
27. Tice RR, Agurel, E, Anderson D, Burlinson B., Hartmann A, Kobayashi H, et al. Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000; 35: 206-21.
28. Harada KI, Matusura K, Suzuki M, Oka H, Watanabe MF, Oishi S, et al. Analysis and purification of toxic peptides from cyanobacteria by reversed-phase high-performance liquid chromatography. J Chromatogr 1988; 448: 275-84.
29. de Sousa G, Delescluse C, Pralavorio M, Perichaud M, Avon M, Lafaurie M, Rahmani R. Toxic effects of several types of antifouling paints in human and rat hepatic or epidermal cells. Toxicol Lett 1998; 96-97: 41-6.
30. Pool-Zobel BL, Guigas C, Klein RG, Neudecker CH, Renner HW, Schnezer, P. Assessment of genotoxic effect by lindane. Food Chem Toxicol 1993; 31: 271-83.
31. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175: 184-91.
32. Milutinović A, Živin M, Zorc-Pleskovič R, Sedmak B, Šuput D. Nephrotoxic effects of chronic administration of microcystins -LR and -YR. Toxicon 2003; 42: 281-8.
33. Moreno I, Pichardo S, Jos A, Gomez-Amores L, Mate A, Vazquez CM, Camean AM. Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally. Toxicon 2005; 45: 395-402.
34. Maidana M, Carlis V, Galhardi FG, Yunes JS, Geracitano LA, Monserrat JM, Barros DM. Effects of microcystins over short- and long-term memory and oxidative stress generation in hippocampus of rats. Chem Biol Interact 2006; 159: 223-34.
35. Fischer WJ, Altheimer S, Cattori V, Meier PJ, Dietrich DR, Hagenbuch B. Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin, Toxicol Appl Pharmacol 2005; 203: 257-63.
36. Walker AP, Bacherald HS. Studies on DNA damage and repair in mammalian brain, J Neurochem 1988; 51: 1394-9.
37. Gupta N, Pant SC, Vijayaraghavan R, Lakshmana Rao PV. Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 2003; 188: 285-96.