SIAH1 causes growth arrest and apoptosis in hepatoma cells through β-catenin degradation-dependent and -independent mechanisms

Oncology Reports

Volumn 17, Issue 3, 2007, Pages 549-556

  Yoshibayashi, Hiroshi ^a   Okabe, Hiroshi ^a   Satoh, Seiji ^a   Hida, Koya ^a   Kawashima, Kazuhiko ^a   Hamasu, Shinya ^a   Nomura, Akinari ^a   Hasegawa, Suguru ^a   Ikai, Iwao ^a   Sakai, Yoshiharu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Hepatocellular carcinoma; PEG10; SIAH1; catenin

Indexed keywords

BETA CATENIN; NUCLEAR PROTEIN; SEVEN IN ABSENTIA PROTEINS; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; FLOW CYTOMETRY; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

APOPTOSIS; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UBIQUITIN-PROTEIN LIGASES;

EID: 34247892310     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.17.3.549     Document Type: Article

References (22)

1. Tanaka S, Toh Y, Adachi E, Matsumata T, Mori R and Sugimachi K: Tumor progression in hepatocellular carcinoma may be mediated by p53 mutation. Cancer Res 53: 2884-2887, 1993.
2. Miyoshi Y, Iwao K, Nagasawa Y, Aihara T, Sasaki Y, Imaoka S, Murata M, Shimano T and Nakamura Y: Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 58: 2524-2527, 1998. (Pubitemid 28275419)
3. Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y and Nakamura Y: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 24: 245-250, 2000.
4. de La Coste A, Romagnolo B, Billuart P, Renard CA, Buendia MA, Soubrane O, Fabre M, Chelly J, Beldjord C, Kahn A and Perret C: Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 95: 8847-8851, 1998.
5. Matsuo K, Satoh S, Okabe H, Nomura A, Maeda T, Yamaoka Y and Ikai I: SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas. Genes Chromosomes Cancer 36: 283-291, 2003. (Pubitemid 36158201)
6. Carthew RW and Rubin GM: Seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Cell 63: 561-577, 1990.
7. Hu G and Fearon ER: Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Mol Cell Biol 19: 724-732, 1999. (Pubitemid 29018473)
8. Okabe H, Satoh S, Furukawa Y, Kato T, Hasegawa S, Nakajima Y, Yamaoka Y and Nakamura Y: Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. Cancer Res 63: 3043-3048, 2003. (Pubitemid 36735848)
9. Matsuzawa S, Takayama S, Froesch BA, Zapata JM and Reed JC: p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth suppression by BAG-1. EMBO J 17: 2736-2747, 1998.
10. Peifer M and Polakis P: Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 287: 1606-1609, 2000. (Pubitemid 30127755)
11. Yost C, Torres M, Miller JR, Huang E, Kimelman D and Moon RT: The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev 10: 1443-1454, 1996. (Pubitemid 26260702)
12. Hart MJ, de los Santos R, Albert IN, Rubinfeld B and Polakis P: Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β. Curr Biol 8: 573-581, 1998. (Pubitemid 28222891)
13. Matsuzawa S and Reed JC: Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses. Mol Cell 7: 915-926, 2001. (Pubitemid 32525739)
14. Kim CJ, Cho YG, Park CH, Jeong SW, Nam SW, Kim SY, Lee SH, Yoo NJ, Lee JY and Park WS: Inactivating mutations of the Siah-1 gene in gastric cancer. Oncogene 23: 8591-8596, 2004. (Pubitemid 39576465)
15. Stordeur P, Poulin LF, Craciun L, Zhou L, Schandene L, de Lavareille A, Goriely S and Goldman M: Cytokine mRNA quantification by real-time PCR. J Immunol Methods 259: 55-64, 2002. (Pubitemid 33124384)
16. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B and Kinzler KW: Identification of c-MYC as a target of the APC pathway. Science 281: 1509-1512, 1998. (Pubitemid 28425575)
17. Ihara A, Koizumi H, Hashizume R and Uchikoshi T: Expression of epithelial cadherin and α- and β-catenins in nontumoral livers and hepatocellular carcinomas. Hepatology 23: 1441-1447, 1996. (Pubitemid 26181227)
18. Legoix P, Bluteau O, Bayer J, Perret C, Balabaud C, Belghiti J, Franco D, Thomas G, Laurent-Puig P and Zucman-Rossi J: Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity. Oncogene 18: 4044-4046, 1999. (Pubitemid 29361344)
19. Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA and Liu W: Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 21: 4863-4871, 2002. (Pubitemid 34879463)
20. Jang KL, Shackelford J, Seo SY and Pagano JS: Up-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells. Proc Natl Acad Sci USA 102: 18431-18436, 2005. (Pubitemid 43011243)
21. Li CM, Margolin AA, Salas M, Memeo L, Mansukhani M, Hibshoosh H, Szabolcs M, Klinakis A and Tycko B: PEG10 is a c-MYC target gene in cancer cells. Cancer Res 66: 665-672, 2006. (Pubitemid 43165928)
22. Tsou AP, Chuang YC, Su JY, Yang CW, Liao YL, Liu WK, Chiu JH and Chou CK: Overexpression of a novel imprinted gene, PEG10, in human hepatocellular carcinoma and in regenerating mouse livers. J Biomed Sci 10: 625-635, 2003.