Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency

Clinical and Experimental Immunology

Volumn 148, Issue 3, 2007, Pages 450-460

  Okamoto, H ^a   Arii, C ^a   Shibata, F ^a   Toma, T ^a   Wada, T ^a   Inoue, M ^a   Tone, Y ^a   Kasahara, Y ^a   Koizumi, S ^a   Kamachi, Y ^b   Ishida, Y ^c   Inagaki, J ^d   Kato, M ^e   Morio, T ^f   Yachie, A ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c EHIME UNIVERSITY   (Japan)

^d NARA MEDICAL UNIVERSITY   (Japan)

^e Gumna Children S Medical Center   (Japan)

^f TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

HSCT; SCID; T cell reconstitution; TCR diversity

Indexed keywords

BUSULFAN; CYCLOSPORIN A; FLUDARABINE; METHOTREXATE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ARTICLE; ATYPICAL MYCOBACTERIOSIS; BLOOD DONOR; CLINICAL ARTICLE; CLINICAL FEATURE; CLONOGENIC ASSAY; COMBINED IMMUNODEFICIENCY; FLOW CYTOMETRY; GENE SEQUENCE; GENETIC VARIABILITY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INFANT; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR CLONING; MYCOBACTERIUM INTRACELLULARE AVIUM; NONMYELOABLATIVE CONDITIONING; OMENN SYNDROME; PRIORITY JOURNAL; SEPSIS; STRUCTURAL HOMOLOGY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS; UMBILICAL CORD BLOOD;

AMINO ACID SEQUENCE; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFANT; MALE; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEVERE COMBINED IMMUNODEFICIENCY; T-LYMPHOCYTE SUBSETS;

EID: 34247889955     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03378.x     Document Type: Article

References (38)

1. Auletta JJ, Lazarus HM. Immune restoration following hematopoietic stem cell transplantation: an evolving target. Bone Marrow Transplant 2005 35:835 57.
2. Isaacs JD, Thiel A. Stem cell transplantation for autoimmune disorders. Immune reconstitution. Best Pract Res Clin Hematol 2004 17:345 58.
3. Nash RA. Allogeneic HSCT for autoimmune diseases: conventional conditioning regimens. Bone Marrow Transplant 2003 32 (Suppl. 1 S77 80.
4. Buckley RH, Schiff SE, Schiff RI et al. Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. N Engl J Med 1999 340:508 16.
5. Slatter MA, Gennery AR. Umbilical cord stem cell transplantation for primary immunodeficiencies. Exp Opin Biol Ther 2006 6:555 65.
6. Grunebaum E, Mazzolari E, Porta F et al. Bone marrow transplantation for severe combined immunodeficiency. JAMA 2006 295:508 18.
7. Müller SM, Kohn T, Schulz AS, Debatin K-M, Friedrich W. Similar pattern of thymic-dependent T-cell reconstitution in infants with severe combined immunodeficiency after human leukocyte antigen (HLA)-identical and HLA-nonidentical stem cell transplantation. Blood 2000 96:4344 9.
8. Lewin SR, Heller G, Zhang L et al. Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations. Blood 2002 100:2235 42.
9. Patel DD, Gooding ME, Parrott RE, Curtis KM, Haynes BF, Buckley RH. Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. N Engl J Med 2000 342:1325 32.
10. Myers LA, Patel DD, Puck JM, Buckley RH. Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival. Blood 2002 99:872 8.
11. Sarzotti N, Patel D, Li X et al. T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation. J Immunol 2003 170:2711 8.
12. Roux E, Dumont-Girard F, Starobinski M et al. Recovery of immune activity after T-cell-depleted bone marrow transplantation depends on thymic activity. Blood 2000 96:2299 303.
13. Chen X, Barfield R, Benaim E et al. Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood 2005 105:886 93.
14. Borghans JA, Bredius RG, Hazenberg MD et al. Early determinants of long-term T-cell reconstitution after hematopoietic stem cell transplantation for severe combined immunodeficiency. Blood 2006 108:763 9.
15. van Leeuwen JEM, van Tol MJD, Joosten AM et al. Relationship between patterns of engraftment in peripheral blood and immune reconstitution after allogeneic bone marrow transplantation for (severe) combined immunodeficiency. Blood 1994 84:3936 47.
16. Roux E, Helg C, Dumont-Girard F, Chapuis B, Jeannet M, Roosnek E. Analysis of T-cell repopulation after allogeneic bone marrow transplantation: significant differences between recipients of T-cell depleted and unmanipulated grafts. Blood 1996 87:3984 92.
17. Wu CJ, Chillemi A, Alyea EP et al. Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism. Blood 2000 95:352 9.
18. Wada T, Toma T, Okamoto H et al. Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency. Blood 2005 106:2099 101.
19. Mizuno K, Toma T, Tsukiji H et al. Selective expansion of CD16high CCR2- subpopulation of circulating monocytes with preferential production of haem oxygenase (HO)-1 in response to acute inflammation. Clin Exp Immunol 2005 49:1030 43.
20. Mizuno K, Yachie A, Nagaoki S et al. Oligoclonal expansion of circulating and tissue-infiltrating CD8+ T cells with killer/effector phenotypes in juvenile dermatomyositis syndrome. Clin Exp Immunol 2004 137:187 94.
21. Konno A, Okada K, Mizuno K et al. CD8αα memory effector T cells descend directly from clonally expanded CD8α+βhigh TCRαβ T cells in vivo. Blood 2002 100:4090 7.
22. Wada T, Schuman SH, Garabedian EK, Yachie A, Candotti F. Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome. Blood 2005 106:3895 7.
23. Yawalkar N, Ferenczi Jones DA et al. Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood 2003 102:4059 66.
24. Patel SR, Ridwan RU, Ortin M. Cytomegalovirus reactivation in pediatric hemopoietic progenitors transplant: a retrospective study on the risk factors and the efficacy of treatment. J Pediatr Hematol Oncol 2005 27:411 5.
25. Shimoni A, Yashurun M, Hardan I, Avigdor A, Ben-Bassat I, Nagler A. Thrombotic microangiopathy after allogeneic stem cell transplantation in the era of reduced-intensity conditioning: the incidence is not reduced. Biol Blood Marrow Transplant 2004 10:484 93.
26. Antin JH, Deeg HJ. Clinical spectrum of acute graft-vs.-host disease. In:Ferrara JLM, Cooke KR, Deeg HJ, eds. Graft-vs-host disease. New York:Marcel Dekker, 2005:369 81.
27. Liu C, He M, Rooney B, Kepler TB, Chao NJ. Longitudinal analysis of T-cell receptor variable β chain repertoire in patients with acute graft-versus-host disease after allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2006 12:335 45.
28. Zorn E. CD4+ CD25+ regulatory T cells in human hematopoietic cell transplantation. Semin Cancer Biol 2006 16:150 9.
29. Barrett J. Improving outcome of allogeneic stem cell transplantation by immunomodulation of the early post-transplant environment. Curr Opin Immunol 2006 18:592 8.
30. Elmaagacli AH, Peceny R, Steckel N et al. Outcome of transplantation of highly purified peripheral blood CD34+ cells with T-cell add-back compared with unmanipulated bone marrow or peripheral blood stem cells from HLA-identical sibling donors in patients with first chronic myeloid leukemia. Blood 2003 101:446 53.
31. Bhattacharya A, Slatter MA, Chapman CE et al. Single centre experience of umbilical cord stem cell transplantation for primary immunodeficiency. Bone Marrow Transplant 2005 36:295 9.
32. Cavadini P, Vermi W, Facchetti F et al. AIRE deficiency in thymus of 2 patients with Omenn syndrome. J Clin Invest 2005 115:728 32.
33. Mostoslavsky G, Fabian AJ, Rooney S, Alt FW, Mulligan RC. Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proc Natl Acad Sci USA 2006 103:16406 11.
34. McFarland RD, Douek DC, Koup RA, Picker LJ. Identification of a human recent thymic emigrant phenotype. Proc Natl Acad Sci USA 2000 97:4215 20.
35. Hess AD. Modulation of graft-versus-host disease: role of regulatory T lymphocytes. Biol Blood Marrow Transplant 2006 12:13 22.
36. Rezvani K, Mielke S, Ahmadzadeh M et al. High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 2006 108:1291 7.
37. Barber LD, Madrigal JA. Exploiting beneficial alloreactive T cells. Vox Sang 2006 91:20 7.
38. Karim M, Feng G, Wood KJ, Bushell AR. CD25+ CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulation. Blood 2005 105:4871 7.