IGF-I differentially regulates Bcl-xL and Bax and confers myocardial protection in the rat heart

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 3 49-3, 2001, Pages

  Yamamura, Tadashi ^a   Otani, Hajime ^a,b   Nakao, Yoshihisa ^a   Hattori, Reiji ^a   Osako, Motohiko ^a   Imamura, Hiroji ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b Dept of Thoracic and Cardiovascular Surgery ^*  (Japan)

Author keywords

Apoptosis; Bcl 2 family proteins; Insulin like growth factor I

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CREATINE KINASE; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL X; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENZYME RELEASE; GENE EXPRESSION REGULATION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISOLATED HEART; MALE; MITOCHONDRION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

EID: 0034967477     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.3.h1191     Document Type: Article

References (51)

1. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
2. Programmed myocyte cell death affects the viable myocardium after infarction in rats
3. Persistence of cytochrome c binding to membranes at physiological mitochondrial intermembrane space ionic strength
4. On the involvement of a mitochondrial pore in reperfusion injury
5. Mitochondrial oxidative phosphorylation in heart from stressed cardiomyopathic hamsters
6. On the involvement of a cyclosporin. A sensitive mitochondrial pore in myocardial reperfusion injury
7. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells
8. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy
9. Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes
10. Actions of insulin-like growth factors
11. Mitochondrial nonspecific pores remain closed during cardiac ischemia, but open upon reperfusion
12. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
13. The CARD domain: A new apoptotic signaling motif
14. Bax directly induces release of cytochrome c from isolated mitochondria
15. Apoptotic and necrotic myocyte cell death are independent contributing variables of infarct size in rats
16. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis
17. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
18. The mitochondrial death/life regulation in apoptosis and necrosis
19. In bone marrow derived Baf-3 cells, inhibition of apoptosis by IL-3 is mediated by two independent pathways
20. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy
21. Bcl-2 and Bax expression in adult rat hearts after coronary occlusion: Age-associated differences
22. Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function
23. The permeability transition pore complex: A target for apoptosis regulation by caspases and Bcl-2-related proteins
24. Insulin-like growth factor I reduces SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death
25. Mitochondria and apoptosis
26. IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors
27. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction
28. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
29. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
30. Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy
31. "Apoptotic" myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation
32. A spectrophotometric method for the determination of creatine phosphokinase and myokinase
33. bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death
34. Role of calcium in the pathogenesis of myocardial reperfusion injury
35. + exchange inhibitor car cariporide (HOE 642) on cardiac function and cardiomyocyte cell death in rat ischaemic-reperfused heart
36. Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene product
37. Bcl-xL is phosphorylated in malignant cells following microtubule disruption
38. Bcl-2 family proteins and mitochondria
39. The amino acid sequence of insulin-like growth factor-1 and its structural homology with proinsulin
40. Cardiac performance: Growth hormone enter the race
41. Multiple Bcl-2 family members demonstrate selective dimerization with Bax
42. Type I insulin-like growth factor receptor activation regulates apoptotic proteins
43. Insulin-like growth factor-1 attenuates apoptosis in hipocampal neurons caused by cerebral ischemia and reperfusion in stroke prone of spontaneously hypertensive rats
44. Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I
45. Insulin-like growth factor I modulates induction of apoptotic signaling in H9C2 cardiac muscle cells
46. Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces Bax and promotes cell death
47. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
48. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor
49. Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol
50. Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins
51. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3