Enhancement of ajoene-induced apoptosis by conjugated linoleic acid in 3T3-L1 adipocytes

Apoptosis

Volumn 12, Issue 6, 2007, Pages 1117-1128

  Yang, Jeong Yeh ^a   Della Fera, Mary Anne ^a   Hausman, Dorothy B ^b   Baile, Clifton A ^a,b  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Akt; Mitochondria; NF B; ROS; Synergy

Indexed keywords

AJOENE; ALLOGRAFT INFLAMMATORY FACTOR 1; CONJUGATED LINOLEIC ACID; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAX; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ADIPOCYTE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 7; CELL SURVIVAL; CYTOCHROMES C; DISULFIDES; DRUG SYNERGISM; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LINOLEIC ACIDS, CONJUGATED; MICE; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES;

EID: 34247871313     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-006-0043-7     Document Type: Article

References (71)

1. Hwang JT, Ha J, Park OJ (2005) Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. Biochem Biophys Res Commun 332:433-440
2. Lin LM, Li BX, Xiao JB, Lin DH, Yang BF (2005) Synergistic effect of all-trans-retinoic acid and arsenic trioxide on growth inhibition and apoptosis in human hepatoma, breast cancer, and lung cancer cells in vitro. World J Gastroenterol 11:5633-5637
3. Kim HR, Kim EJ, Yang SH et al (2006) Combination treatment with arsenic trioxide and sulindac augments their apoptotic potential in lung cancer cells through activation of caspase cascade and mitochondrial dysfunction. Int J Oncol 28:1401-1408
4. Kim KN, Pie JE, Park JH, Park YH, Kim HW, Kim MK (2006) Retinoic acid and ascorbic acid act synergistically in inhibiting human breast cancer cell proliferation. J Nutr Biochem 17:454-462
5. Mertens-Talcott SU, Percival SS (2005) Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett 218:141-151
6. Suganuma M, Okabe S, Kai Y, Sueoka N, Sueoka E, Fujiki H (1999) Synergistic effects of (-)-epigallocatechin gallate with (-)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. Cancer Res 59:44-47
7. Chan MM, Fong D, Soprano KJ, Holmes WF, Heverling H (2003) Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents. J Cell Physiol 194:63-70
8. Lin J, Della-Fera MA, Baile CA (2005) Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes. Obes Res 13:982-990
9. Kim H-K, Nelson-Dooley C, Della-Fera MA et al (2006) Genistein decreases food intake, body weight and fat pad weight and causes adipose tissue apoptosis in Ovariectomized female mice. J Nutr 136:409-414
10. Yang J-Y, Della-Fera MA, Baile CA (2006) Esculetin induces mitochondria-mediated apoptosis in 3T3-L1 adipocytes. Apoptosis 11:1371-1378
11. Yang J-Y, Della-Fera MA, Hartzell DL, Nelson-Dooley C, Hausman DB, Baile CA (2006) Esculetin induces apoptosis and inhibits adipogenesis in 3T3-L1 cells. Obes Res 14:1691-1699
12. Yang JY, Della-Fera MA, Nelson-Dooley C, Baile CA (2006) Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes. Obesity (Silver Spring) 14:388-397
13. Hargrave KM, Meyer BJ, Li C, Azain MJ, Baile CA, Miner JL (2004) Influence of dietary conjugated linoleic Acid and fat source on body fat and apoptosis in mice. Obes Res 12:1435-1444
14. Rodriguez M, Schaper J (2005) Apoptosis: measurement and technical issues. J Mol Cell Cardiology 38:15-20
15. Hassan HT (2004) Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy. Leuk Res 28:667-671
16. Dirsch VM, Gerbes AL, Vollmar AM (1998) Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB. Mol Pharmacol 53:402-407
17. Gaullier JM, Halse J, Hoye K et al (2005) Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 135:778-784
18. Gaullier JM, Halse J, Hoye K et al (2004) Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 79:1118-1125
19. Riserus U, Berglund L, Vessby B (2001) Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int J Obes Relat Metab Disord 25:1129-1135
20. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O (2000) Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 130:2943-2948
21. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K et al (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49:1534-1542
22. Hargrave KM, Miner JL (2003) Effect of conjugated linoleic acid on DNA fragmentation of preadipocytes in culture. J Anim Sci 81
23. Evans M, Geigerman C, Cook J, Curtis L, Kuebler B, McIntosh M (2000) Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes. Lipids 35:899-910
24. House RL, Cassady JP, Eisen EJ, McIntosh MK, Odle J (2005) Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue. Obes Rev 6:247-258
25. Hargrave KM, Li C, Meyer BJ et al (2002) Adipose depletion and apoptosis induced by trans-10, cis-12 conjugated linoleic Acid in mice. Obes Res 10:1284-1290
26. Chung S, Brown JM, Provo JN, Hopkins R, McIntosh MK (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. J Biol Chem
27. Kim EJ, Kang IJ, Cho HJ, Kim WK, Ha YL, Park JH (2003) Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. J Nutr 133:2675-2681
28. Yamasaki M, Miyamoto Y, Chujo H, Nishiyama K, Tachibana H, Yamada K (2005) Trans10, cis12-conjugated linoleic acid induces mitochondria-related apoptosis and lysosomal destabilization in rat hepatoma cells. Biochim Biophys Acta 1735:176-184
29. Miglietta A, Bozzo F, Bocca C et al (2005) Conjugated linoleic acid induces apoptosis in MDA-MB-231 breast cancer cells through ERK/MAPK signalling and mitochondrial pathway. Cancer Lett 234:149-157
30. Hemati N, Ross SE, Erickson RL, Groblewski GE, MacDougald OA (1997) Signaling pathways through which insulin regulates CCAAT/enhancer binding protein alpha (C/EBPalpha) phosphorylation and gene expression in 3T3-L1 adipocytes. Correlation with GLUT4 gene expression. J Biol Chem 272:25913-25919
31. Frankfurt OS, Krishan A (2001) Identification of apoptotic cells by formamide-induced dna denaturation in condensed chromatin. J Histochem Cytochem 49:369-378
32. Frankfurt OS (2004) Immunoassay for single-stranded DNA in apoptotic cells. Methods Mol Biol 282:85-101
33. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
34. Jacobson MD, Raff MC (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374:814-816
35. Holgado-Madruga M, Wong AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol 23:4471-4484
36. Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 95:4997-5002
37. Ormerod MG, Sun XM, Snowden RT, Davies R, Fearnhead H, Cohen GM (1993) Increased membrane permeability of apoptotic thymocytes: a flow cytometric study. Cytometry 14:595-602
38. Mow BM, Blajeski AL, Chandra J, Kaufmann SH (2001) Apoptosis and the response to anticancer therapy. Curr Opin Oncol 13:453-462
39. Kroemer G, Zamzami N, Susin SA (1997) Mitochondrial control of apoptosis. Immunol Today 18:44-51
40. Adams JM, Cory S (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281:1322-1326
41. Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912
42. Lei K, Davis RJ (2003) JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci USA 100:2432-2437
43. Tournier C, Hess P, Yang DD et al (2000) Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288:870-874
44. Hei TK, Liu SX, Waldren C (1998) Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species. Proc Natl Acad Sci USA 95:8103-8107
45. Adler V, Yin Z, Tew KD, Ronai Z (1999) Role of redox potential and reactive oxygen species in stress signaling. Oncogene 18:6104-6111
46. Pei ZM, Murata Y, Benning G et al (2000) Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells. Nature 406:731-734
47. Gao N, Ding M, Zheng JZ et al (2002) Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J Biol Chem 277:31963-31971
48. Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82:47-95
49. Baeuerle PA, Henkel T (1994) Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12:141-179
50. Schulze-Osthoff K, Los M, Baeuerle PA (1995) Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes. Biochem Pharmacol 50:735-741
51. Grimm S, Bauer MK, Baeuerle PA, Schulze-Osthoff K (1996) Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. J Cell Biol 134:13-23
52. Kasibhatla S, Genestier L, Green DR (1999) Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB. J Biol Chem 274:987-992
53. Andjelkovic M, Maira SM, Cron P, Parker PJ, Hemmings BA (1999) Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase. Mol Cell Biol 19:5061-5072
54. Kasof GM, Lu JJ, Liu D et al (2001) Tumor necrosis factor-alpha induces the expression of DR6, amember of the TNF receptor family, through activation of NF-kappaB. Oncogene 20:7965-7975
55. Bessho R, Matsubara K, Kubota M et al (1994) Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem Pharmacol 48:1883-1889
56. Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS Jr, Mayo MW (2000) Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 20:1626-1638
57. Marinovich M, Viviani B, Corsini E, Ghilardi F, Galli CL (1996) NF-kappaB activation by triphenyltin triggers apoptosis in HL-60 cells. Exp Cell Res 226:98-104
58. 2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. Embo J 12:2005-2015
59. Wu H, Lozano G (1994) NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress. J Biol Chem 269:20067-20074
60. La Rosa FA, Pierce JW, Sonenshein GE (1994) Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors. Mol Cell Biol 14:1039-1044
61. Franke TF, Kaplan DR, Cantley LC (1997) PI3K: downstream AKTion blocks apoptosis. Cell 88:435-437
62. Burgering BM, Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602
63. Franke TF, Yang SI, Chan TO et al (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736
64. Brunet A, Bonni A, Zigmond MJ et al (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868
65. Cardone MH, Roy N, Stennicke HR et al (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321
66. Romashkova JA, Makarov SS (1999) NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401:86-90
67. Rommel C, Clarke BA, Zimmermann S et al (1999) Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 286:1738-1741
68. Kim AH, Khursigara G, Sun X, Franke TF, Chao MV (2001) Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21:893-901
69. Yu Y, Correll PH, Vanden Heuvel JP (2002) Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. Biochim Biophys Acta 1581:89-99
70. Elstner E, Muller C, Koshizuka K et al (1998) Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 95:8806-8811
71. Cho HJ, Kim WK, Jung JI et al (2005) Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cells. World J Gastroenterol 11:5142-5150