-
1
-
-
33846457870
-
Cancer statistics, 2007
-
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin 2007; 57:43-66.
-
(2007)
CA Cancer J Clin
, vol.57
, pp. 43-66
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
2
-
-
0033565561
-
The biology of chronic myeloid leukemia
-
Faderl S, Talpaz M, Estrov Z, et al. The biology of chronic myeloid leukemia. N Engl J Med 1999; 341:164-172.
-
(1999)
N Engl J Med
, vol.341
, pp. 164-172
-
-
Faderl, S.1
Talpaz, M.2
Estrov, Z.3
-
3
-
-
0036435579
-
Cytogenetic and molecular genetic aspects of chronic myeloid leukaemia
-
Barnes DJ, Melo JV. Cytogenetic and molecular genetic aspects of chronic myeloid leukaemia. Acta Haematol 2002; 108:180-202.
-
(2002)
Acta Haematol
, vol.108
, pp. 180-202
-
-
Barnes, D.J.1
Melo, J.V.2
-
4
-
-
0015694748
-
A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
Rowley JD. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973; 243:290-293.
-
(1973)
Nature
, vol.243
, pp. 290-293
-
-
Rowley, J.D.1
-
5
-
-
32844461437
-
Chronic myeloid leukemia: Why does it evolve from chronic phase to blast transformation?
-
Mughal TI, Goldman JM. Chronic myeloid leukemia: why does it evolve from chronic phase to blast transformation? Front Biosci 2006; 11:198-208.
-
(2006)
Front Biosci
, vol.11
, pp. 198-208
-
-
Mughal, T.I.1
Goldman, J.M.2
-
6
-
-
33748885930
-
Novel tyrosine kinase inhibitors in chronic myelogenous leukemia
-
Jabbour E, Cortes J, Kantarjian H. Novel tyrosine kinase inhibitors in chronic myelogenous leukemia. Curr Opin Oncol 2006; 18:578-583.
-
(2006)
Curr Opin Oncol
, vol.18
, pp. 578-583
-
-
Jabbour, E.1
Cortes, J.2
Kantarjian, H.3
-
7
-
-
0022622360
-
Marrow transplantation for the treatment of chronic myelogenous leukemia
-
Thomas ED, Clift RA, Fefer A, et al. Marrow transplantation for the treatment of chronic myelogenous leukemia. Ann Intern Med 1986; 104:155-163.
-
(1986)
Ann Intern Med
, vol.104
, pp. 155-163
-
-
Thomas, E.D.1
Clift, R.A.2
Fefer, A.3
-
8
-
-
0037441629
-
Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis
-
Kantarjian HM, O'Brien S, Cortes J, et al. Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis. Cancer 2003; 97:1033-1041.
-
(2003)
Cancer
, vol.97
, pp. 1033-1041
-
-
Kantarjian, H.M.1
O'Brien, S.2
Cortes, J.3
-
9
-
-
0141528828
-
Chronic myeloid leukemia - advances in biol ogy and new approaches to treatment
-
Goldman JM, Melo JV. Chronic myeloid leukemia - advances in biol ogy and new approaches to treatment. N Engl J Med 2003; 349:1451-1464.
-
(2003)
N Engl J Med
, vol.349
, pp. 1451-1464
-
-
Goldman, J.M.1
Melo, J.V.2
-
10
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002; 346:645-652.
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
11
-
-
4644359704
-
Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-{alpha}
-
Kantarjian HM, Cortes JE, O'Brien S, et al. Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-{alpha}. Blood 2004; 104:1979-1988.
-
(2004)
Blood
, vol.104
, pp. 1979-1988
-
-
Kantarjian, H.M.1
Cortes, J.E.2
O'Brien, S.3
-
12
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348:994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
13
-
-
11144354274
-
High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia
-
Kantarjian H, Talpaz M, O'Brien S, et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood 2004; 103:2873-2878.
-
(2004)
Blood
, vol.103
, pp. 2873-2878
-
-
Kantarjian, H.1
Talpaz, M.2
O'Brien, S.3
-
14
-
-
20944442975
-
Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate
-
Cortes J, Talpaz M, O'Brien S, et al. Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate. Clin Cancer Res 2005; 11:3425-3432.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3425-3432
-
-
Cortes, J.1
Talpaz, M.2
O'Brien, S.3
-
15
-
-
10744229080
-
Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
-
Hughes TP, Kaeda J, Branford S, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003; 349:1423-1432.
-
(2003)
N Engl J Med
, vol.349
, pp. 1423-1432
-
-
Hughes, T.P.1
Kaeda, J.2
Branford, S.3
-
16
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996; 2:561-566.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
17
-
-
15444350807
-
Selective inhibition of cell proliferation and Bcr-Abl phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 Bcr-Abl protein by a tyrosine kinase inhibitor (CGP-57148)
-
Beran M, Cao X, Estrov Z, et al. Selective inhibition of cell proliferation and Bcr-Abl phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 Bcr-Abl protein by a tyrosine kinase inhibitor (CGP-57148). Clin Cancer Res 1998; 4:1661-1672.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 1661-1672
-
-
Beran, M.1
Cao, X.2
Estrov, Z.3
-
18
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344:1031-1037.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
19
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002; 346:645-652.
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
20
-
-
4644359704
-
Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-alpha
-
Kantarjian HM, Cortes JE, O'Brien S, et al. Long-term survival benefit and improved complete cytogenetic and molecular response rates with imatinib mesylate in Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia after failure of interferon-alpha. Blood 2004; 104:1979-1988.
-
(2004)
Blood
, vol.104
, pp. 1979-1988
-
-
Kantarjian, H.M.1
Cortes, J.E.2
O'Brien, S.3
-
21
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
-
Talpaz M, Silver RT, Druker BJ, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 2002; 99:1928-1937.
-
(2002)
Blood
, vol.99
, pp. 1928-1937
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
-
22
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
Sawyers CL, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002; 99:3530-3539.
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
23
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348:994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
24
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker BJ, Guilhot F, O'Brien S, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355:2408-2417.
-
(2006)
N Engl J Med
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.3
-
25
-
-
33644535340
-
Continuing reduction in level of residual disease after 4 years in patients with CML in chronic phase responding to first-line imatinib in the IRIS study
-
Abstract
-
Goldman JM, Hughes T, Radich J, et al. Continuing reduction in level of residual disease after 4 years in patients with CML in chronic phase responding to first-line imatinib in the IRIS study. Blood 2005; 106:51a (Abstract #163).
-
(2005)
Blood
, vol.106
, Issue.163
-
-
Goldman, J.M.1
Hughes, T.2
Radich, J.3
-
26
-
-
10744225099
-
Imatinib mesylate therapy improves survival in patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in the chronic phase. Comparison with historic data
-
Kantarjian HM, O'Brien S, Cortes J, et al. Imatinib mesylate therapy improves survival in patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in the chronic phase. Comparison with historic data. Cancer 2003; 98:2636-2642.
-
(2003)
Cancer
, vol.98
, pp. 2636-2642
-
-
Kantarjian, H.M.1
O'Brien, S.2
Cortes, J.3
-
27
-
-
33748696341
-
Survival benefit with imatinib mesylate versus interferon alpha-based regimens in newly diagnosed chronic phase chronic myelogenous leukemia
-
Kantarjian HM, Talpaz M, O'Brien S, et al. Survival benefit with imatinib mesylate versus interferon alpha-based regimens in newly diagnosed chronic phase chronic myelogenous leukemia. Blood 2006; 108:1835-1840.
-
(2006)
Blood
, vol.108
, pp. 1835-1840
-
-
Kantarjian, H.M.1
Talpaz, M.2
O'Brien, S.3
-
28
-
-
33748133844
-
Survival advantage from imatinib compared to the combination interferon-{alpha} plus cytarabine in chronic phase CML: Historical comparison between two phase III trials
-
Roy L, Guilhot J, Kranhke T, et al. Survival advantage from imatinib compared to the combination interferon-{alpha} plus cytarabine in chronic phase CML: historical comparison between two phase III trials. Blood 2006; 108:1478-1484.
-
(2006)
Blood
, vol.108
, pp. 1478-1484
-
-
Roy, L.1
Guilhot, J.2
Kranhke, T.3
-
29
-
-
33746845181
-
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
-
Kerkela R, Grazette L, Yacobi R, et al. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 2006; 12:908-916.
-
(2006)
Nat Med
, vol.12
, pp. 908-916
-
-
Kerkela, R.1
Grazette, L.2
Yacobi, R.3
-
30
-
-
34249109333
-
Congestive heart failure is a rare event in patients receiving imatinib therapy
-
Abstract
-
Atallah E, Durand JB, Kantarjian H, et al. Congestive heart failure is a rare event in patients receiving imatinib therapy. Blood 2006; 108:609a (Abstract #2146).
-
(2006)
Blood
, vol.108
, Issue.2146
-
-
Atallah, E.1
Durand, J.B.2
Kantarjian, H.3
-
31
-
-
0038518619
-
Practical management of patients with chronic myeloid leukemia receiving imatinib
-
Deininger MW, O'Brien SG, Ford JM, et al. Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol 2003; 21:1637-1647.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1637-1647
-
-
Deininger, M.W.1
O'Brien, S.G.2
Ford, J.M.3
-
32
-
-
2642553015
-
Granulocyte-colony- stimulating factor (filgrastin) may overcome imatinib-induced neutropenia in patients with chronic-phase chronic myelogenous leukemia
-
Quintas-Cardama A, Kantarjian H, O'Brien S, et al. Granulocyte-colony- stimulating factor (filgrastin) may overcome imatinib-induced neutropenia in patients with chronic-phase chronic myelogenous leukemia. Cancer 2004; 100:2592-2597.
-
(2004)
Cancer
, vol.100
, pp. 2592-2597
-
-
Quintas-Cardama, A.1
Kantarjian, H.2
O'Brien, S.3
-
33
-
-
79960971752
-
Myeloid growth factors for neutropenia during imatinib mesylate therapy for CML: Preliminary evidence of safety and efficacy
-
Abstract
-
Mauro MJ, Kurilik G, Balleisen S, et al. Myeloid growth factors for neutropenia during imatinib mesylate therapy for CML: preliminary evidence of safety and efficacy. Blood 2001; 98:139a (Abstract #584).
-
(2001)
Blood
, vol.98
, Issue.584
-
-
Mauro, M.J.1
Kurilik, G.2
Balleisen, S.3
-
34
-
-
24444438738
-
G-CSF reverses cytopenia and may increase cytogenetic responses in patients with CML treated with imatinib mesylate
-
Abstract
-
Marin D, Marktel S, Foot N, et al. G-CSF reverses cytopenia and may increase cytogenetic responses in patients with CML treated with imatinib mesylate. Blood 2002; 100:782a (Abstract #3093).
-
(2002)
Blood
, vol.100
, Issue.3093
-
-
Marin, D.1
Marktel, S.2
Foot, N.3
-
35
-
-
2142699732
-
Interleukin 11 may improve thrombocytopenia associated with imatinib mesylate therapy in chronic myelogenous leukemia
-
Ault P, Kantarjian H, Welch MA, et al. Interleukin 11 may improve thrombocytopenia associated with imatinib mesylate therapy in chronic myelogenous leukemia. Leuk Res 2004; 28:613-618.
-
(2004)
Leuk Res
, vol.28
, pp. 613-618
-
-
Ault, P.1
Kantarjian, H.2
Welch, M.A.3
-
36
-
-
2442669344
-
Erythropoietin is effective in improving the anemia induced by imatinib mesylate therapy in patients with chronic myeloid leukemia in chronic phase
-
Cortes J, O'Brien S, Quintas A, et al. Erythropoietin is effective in improving the anemia induced by imatinib mesylate therapy in patients with chronic myeloid leukemia in chronic phase. Cancer 2004; 100:2396-2402.
-
(2004)
Cancer
, vol.100
, pp. 2396-2402
-
-
Cortes, J.1
O'Brien, S.2
Quintas, A.3
-
37
-
-
5344234977
-
Erythropoietin for anemia during imatinib mesylate (STI571) thetapy for CML: Preliminary evidence of safety and efficacy
-
Abstract
-
Mauro MJ, Blasdel C, O'Dwyer ME, et al. Erythropoietin for anemia during imatinib mesylate (STI571) thetapy for CML: preliminary evidence of safety and efficacy. Proc Am Soc Clin Oncol 2002; 21:27a (Abstract #106).
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, Issue.106
-
-
Mauro, M.J.1
Blasdel, C.2
O'Dwyer, M.E.3
-
38
-
-
2142806893
-
Use of darbepoetin alfa for the treatment of anemia occurring during imatinib therapy for CML: Preliminary evidence of safely and efficacy
-
Abstract
-
Ault P, Kantarjian H, Kurzrock R, et al. Use of darbepoetin alfa for the treatment of anemia occurring during imatinib therapy for CML: preliminary evidence of safely and efficacy. Proc Am Soc Clin Oncol 2003; 22:613 (Abstract #2467).
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, Issue.2467
, pp. 613
-
-
Ault, P.1
Kantarjian, H.2
Kurzrock, R.3
-
39
-
-
1542608328
-
Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients
-
Peng B, Hayes M, Resta D, et al. Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients. J Clin Oncol 2004; 22:935-942.
-
(2004)
J Clin Oncol
, vol.22
, pp. 935-942
-
-
Peng, B.1
Hayes, M.2
Resta, D.3
-
40
-
-
21744449067
-
Population pharmacokinetics of imatinib mesylate in patients with chronic-phase chronic myeloid leukaemia: Results of a phase III study
-
Schmidli H, Peng B, Riviere GJ, et al. Population pharmacokinetics of imatinib mesylate in patients with chronic-phase chronic myeloid leukaemia: results of a phase III study. Br J Clin Pharmacol 2005; 60:35-44.
-
(2005)
Br J Clin Pharmacol
, vol.60
, pp. 35-44
-
-
Schmidli, H.1
Peng, B.2
Riviere, G.J.3
-
41
-
-
10744231480
-
Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-α
-
Cortes J, Giles F, O'Brien S, et al. Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-α. Blood 2003; 102:83-86.
-
(2003)
Blood
, vol.102
, pp. 83-86
-
-
Cortes, J.1
Giles, F.2
O'Brien, S.3
-
42
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
-
O'Hare T, Walters DK, Stoffregen EP, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005; 65:4500-4505.
-
(2005)
Cancer Res
, vol.65
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
-
43
-
-
0037438467
-
Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia
-
Kantarjian H, Talpaz M, O'Brien S, et al. Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia. Blood 2003; 101:473-475.
-
(2003)
Blood
, vol.101
, pp. 473-475
-
-
Kantarjian, H.1
Talpaz, M.2
O'Brien, S.3
-
44
-
-
3042636353
-
Trial of higher dose imatinib with selective intensification in newly diagnosed CML patients in chronic phase
-
Hughes TP, Branford S, Matthews J, et al. Trial of higher dose imatinib with selective intensification in newly diagnosed CML patients in chronic phase. Blood 2003; 102:31a.
-
(2003)
Blood
, vol.102
-
-
Hughes, T.P.1
Branford, S.2
Matthews, J.3
-
45
-
-
33645339019
-
High-dose (HD) imatinib in patients with previously untreated chronic myeloid leukemia (CML) in early chronic phase (CP): Preliminary results of a multicenter community based trial
-
Cortes J, Giles F, Salvado A, et al. High-dose (HD) imatinib in patients with previously untreated chronic myeloid leukemia (CML) in early chronic phase (CP): preliminary results of a multicenter community based trial. J Clin Oncol 2005; 23:564a.
-
(2005)
J Clin Oncol
, vol.23
-
-
Cortes, J.1
Giles, F.2
Salvado, A.3
-
46
-
-
33745601635
-
Imatinib 800 mg: Preliminary results of a phase II trial of the GIMEMA CML working party in intermediate sokal risk patients and status-of-the-art of an ongoing multinational, prospective randomized trial of imatinib standard dose (400 mg daily) vs high dose (800 mg daily) in high sokal risk patients
-
Abstract
-
Rosti G, Martinelli G, Castagnetti F, et al. Imatinib 800 mg: preliminary results of a phase II trial of the GIMEMA CML working party in intermediate sokal risk patients and status-of-the-art of an ongoing multinational, prospective randomized trial of imatinib standard dose (400 mg daily) vs high dose (800 mg daily) in high sokal risk patients. Blood 2005; 106:320a (Abstract #1098).
-
(2005)
Blood
, vol.106
, Issue.1098
-
-
Rosti, G.1
Martinelli, G.2
Castagnetti, F.3
-
47
-
-
34249789985
-
-
Aoki E, Kantarjian H, O'Brien S, et al. High-dose imatinib mesylate treatment in patients (pts) with untreated early chronic phase (CP) chronic myeloid leukemia (CML): 2.5-year follow-up. J Clin Oncol 2006; 24(18 suppl):345s (Abstract #6535).
-
Aoki E, Kantarjian H, O'Brien S, et al. High-dose imatinib mesylate treatment in patients (pts) with untreated early chronic phase (CP) chronic myeloid leukemia (CML): 2.5-year follow-up. J Clin Oncol 2006; 24(18 suppl):345s (Abstract #6535).
-
-
-
-
48
-
-
33747154547
-
Evolving concepts in the management of chtonic myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
-
Baccarani M, Saglio G, Goldman J, et al. Evolving concepts in the management of chtonic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2006; 108:1809-1820.
-
(2006)
Blood
, vol.108
, pp. 1809-1820
-
-
Baccarani, M.1
Saglio, G.2
Goldman, J.3
-
49
-
-
0028946866
-
-
Radich JP, Gehly G, Gooley T, et al. Polymerase chain reaction detection of the Bcr-Abl fusion transcript aftet allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood 1995; 85:2632-2638.
-
Radich JP, Gehly G, Gooley T, et al. Polymerase chain reaction detection of the Bcr-Abl fusion transcript aftet allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood 1995; 85:2632-2638.
-
-
-
-
50
-
-
33745603988
-
Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting Bcr-Abl transcripts and kinase domain mutations and for expressing results
-
Hughes TP, Deininger MW, Hochhaus A, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting Bcr-Abl transcripts and kinase domain mutations and for expressing results. Blood 2006; 108:28-37.
-
(2006)
Blood
, vol.108
, pp. 28-37
-
-
Hughes, T.P.1
Deininger, M.W.2
Hochhaus, A.3
-
51
-
-
8644286697
-
Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib
-
Loriaux M, Deininger M. Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib. Leuk Lymphoma 2004; 45:2197-2203.
-
(2004)
Leuk Lymphoma
, vol.45
, pp. 2197-2203
-
-
Loriaux, M.1
Deininger, M.2
-
52
-
-
0030940742
-
Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: Report of three cases
-
Fayad L, Kantarjian H, O'Brien S, et al. Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases. Leukemia 1997; 11:767-771.
-
(1997)
Leukemia
, vol.11
, pp. 767-771
-
-
Fayad, L.1
Kantarjian, H.2
O'Brien, S.3
-
53
-
-
0142243204
-
Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase
-
Medina J, Kantarjian H, Talpaz M, et al. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Cancer 2003; 98:1905-1911.
-
(2003)
Cancer
, vol.98
, pp. 1905-1911
-
-
Medina, J.1
Kantarjian, H.2
Talpaz, M.3
-
54
-
-
0038092769
-
Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority
-
Bumm T, Muller C, Al-Ali HK, et al. Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 2003; 101:1941-1949.
-
(2003)
Blood
, vol.101
, pp. 1941-1949
-
-
Bumm, T.1
Muller, C.2
Al-Ali, H.K.3
-
55
-
-
33748707712
-
Chromosomal abnormalities in Philadelphia chromosome (Ph)-negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase
-
Jabbout E, Kantrjian H, O'Brien S, et al. Chromosomal abnormalities in Philadelphia chromosome (Ph)-negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Blood 2005; 106:1090.
-
(2005)
Blood
, vol.106
, pp. 1090
-
-
Jabbout, E.1
Kantrjian, H.2
O'Brien, S.3
-
56
-
-
33750615550
-
Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia
-
Kovitz C, Kantarjian H, Garcia-Manero G, et al. Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia. Blood 2006; 108:2811-2813.
-
(2006)
Blood
, vol.108
, pp. 2811-2813
-
-
Kovitz, C.1
Kantarjian, H.2
Garcia-Manero, G.3
-
57
-
-
79959308232
-
Loss of response to imatinib: Mechanisms and management
-
Shah NP. Loss of response to imatinib: mechanisms and management. Hematol Am Soc Hematol Educ Program 2005; 183-187.
-
(2005)
Hematol Am Soc Hematol Educ Program
, pp. 183-187
-
-
Shah, N.P.1
-
58
-
-
3242816121
-
Clinical resistance to imatinib: Mechanisms and implications
-
Hochhaus A, Hughes T. Clinical resistance to imatinib: mechanisms and implications. Hematol Oncol Clin N 2004; 18:641-656.
-
(2004)
Hematol Oncol Clin N
, vol.18
, pp. 641-656
-
-
Hochhaus, A.1
Hughes, T.2
-
59
-
-
0036850514
-
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
-
Hochhaus A, Kreil S, Corbin AS, et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 16:2190-2196.
-
(2002)
Leukemia
, vol.16
, pp. 2190-2196
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.S.3
-
60
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005; 105:2640-2653.
-
(2005)
Blood
, vol.105
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
61
-
-
0001686739
-
Multiple Bcr-Abl kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B, et al. Multiple Bcr-Abl kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002; 2:117-125.
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
-
62
-
-
0037045583
-
BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
-
von Bubnoff N, Schneller F, Peschel C, et al. BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet 2002; 359:487-491.
-
(2002)
Lancet
, vol.359
, pp. 487-491
-
-
von Bubnoff, N.1
Schneller, F.2
Peschel, C.3
-
63
-
-
0037199996
-
Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571
-
Corbin AS, Buchdunger E, Pascal F, et al. Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571. J Biol Chem 2002; 277:32214-32219.
-
(2002)
J Biol Chem
, vol.277
, pp. 32214-32219
-
-
Corbin, A.S.1
Buchdunger, E.2
Pascal, F.3
-
64
-
-
0037459344
-
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of Bcr-Abl
-
Azam M, Latek RR, Daley GQ, et al. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of Bcr-Abl. Cell 2003; 112:831-843.
-
(2003)
Cell
, vol.112
, pp. 831-843
-
-
Azam, M.1
Latek, R.R.2
Daley, G.Q.3
-
65
-
-
33745603988
-
Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting Bcr-Abl transcripts and kinase domain mutations and for expressing results
-
Hughes TP, Deininger MW, Hochhaus A, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting Bcr-Abl transcripts and kinase domain mutations and for expressing results. Blood 2006; 108:28-37.
-
(2006)
Blood
, vol.108
, pp. 28-37
-
-
Hughes, T.P.1
Deininger, M.W.2
Hochhaus, A.3
-
66
-
-
33750077276
-
Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
-
Jabbour E, Kantarjian H, Jones D, et al. Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia 2006; 20:1767-1773.
-
(2006)
Leukemia
, vol.20
, pp. 1767-1773
-
-
Jabbour, E.1
Kantarjian, H.2
Jones, D.3
-
67
-
-
20844447330
-
Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have Bcr-Abl kinase domain mutations
-
Branford S, Rudzki Z, Parkinson I, et al. Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have Bcr-Abl kinase domain mutations. Blood 2004; 104:2926-2932.
-
(2004)
Blood
, vol.104
, pp. 2926-2932
-
-
Branford, S.1
Rudzki, Z.2
Parkinson, I.3
-
68
-
-
4644341516
-
Discontinuation of imatinib therapy after achieving a molecular response
-
Cortes J, O'Brien S, Kantarjian H. Discontinuation of imatinib therapy after achieving a molecular response. Blood 2004; 104:2204-2205.
-
(2004)
Blood
, vol.104
, pp. 2204-2205
-
-
Cortes, J.1
O'Brien, S.2
Kantarjian, H.3
-
69
-
-
1342343034
-
Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission
-
Mauro MJ, Druker BJ, Maziarz RT. Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission. Leukemia Research 2004; 28:71-73.
-
(2004)
Leukemia Research
, vol.28
, pp. 71-73
-
-
Mauro, M.J.1
Druker, B.J.2
Maziarz, R.T.3
-
70
-
-
2542594648
-
Sustained cytogenetic response after discontinuation of imatinib mesylate in a patient with chronic myeloid leukaemia
-
Ghanima W, Kahrs J, Dahl TG III, et al. Sustained cytogenetic response after discontinuation of imatinib mesylate in a patient with chronic myeloid leukaemia. Eur J Haematol 2004; 72:441-443.
-
(2004)
Eur J Haematol
, vol.72
, pp. 441-443
-
-
Ghanima, W.1
Kahrs, J.2
Dahl III, T.G.3
-
71
-
-
33846023983
-
Imatinib mesylate discontinuation in patients with chronic myelogenous leukaemia in complete molecular remission for more than two years
-
Rousselot P, Huguet, F, Rea D, et al. Imatinib mesylate discontinuation in patients with chronic myelogenous leukaemia in complete molecular remission for more than two years. Blood 2007; 109:58-60.
-
(2007)
Blood
, vol.109
, pp. 58-60
-
-
Rousselot, P.1
Huguet, F.2
Rea, D.3
-
72
-
-
0036090222
-
Primitive quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham SM, Jorgensen HG, Allan E, et al. Primitive quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002; 99:319-325.
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
-
73
-
-
33644984830
-
Pregnancy among patients with chronic myeloid leukemia treated with imatinib
-
Ault P, Kantarjian H, O'Brien S, et al. Pregnancy among patients with chronic myeloid leukemia treated with imatinib. J Clin Oncol 2006; 24:1204-1208.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1204-1208
-
-
Ault, P.1
Kantarjian, H.2
O'Brien, S.3
-
74
-
-
34249814744
-
The effects of imatinib mesylate treatment before allogeneic transplant for chronic myeloid leukemia
-
Epub ahead of print
-
Oehler VG, Gooley T, Snyder DS, et al. The effects of imatinib mesylate treatment before allogeneic transplant for chronic myeloid leukemia. Blood 2006. [Epub ahead of print]
-
(2006)
Blood
-
-
Oehler, V.G.1
Gooley, T.2
Snyder, D.S.3
-
75
-
-
33747156914
-
Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure
-
Jabbour E, Cortes J, Kantarjian HM, et al. Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure. Blood 2006; 108:1421-1423.
-
(2006)
Blood
, vol.108
, pp. 1421-1423
-
-
Jabbour, E.1
Cortes, J.2
Kantarjian, H.M.3
-
76
-
-
0037255789
-
Allogeneic stem cell transplantation for chronic myeloid leukemia
-
Barrett J. Allogeneic stem cell transplantation for chronic myeloid leukemia. Semin Hematol'2003; 40:59-71.
-
(2003)
Semin Hematol
, vol.40
, pp. 59-71
-
-
Barrett, J.1
-
77
-
-
0031796063
-
Interferon-alpha: Mechanisms of action in chronic myelogenous leukemia in chronic phase
-
Guilhot F, Lacotte-Thierry L. Interferon-alpha: mechanisms of action in chronic myelogenous leukemia in chronic phase. Hematol Cell Ther 1998; 40:237-239.
-
(1998)
Hematol Cell Ther
, vol.40
, pp. 237-239
-
-
Guilhot, F.1
Lacotte-Thierry, L.2
-
78
-
-
0034161533
-
Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses
-
Pinilla-Ibarz J, Cathcart K, Korontsvit T, et al. Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses. Blood 2000; 95:1781-1787.
-
(2000)
Blood
, vol.95
, pp. 1781-1787
-
-
Pinilla-Ibarz, J.1
Cathcart, K.2
Korontsvit, T.3
-
79
-
-
1642500316
-
A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia
-
Cathcart K, Pinilla-Ibarz J, Korontsvit T, et al. A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia. Blood 2004; 103:1037-1042.
-
(2004)
Blood
, vol.103
, pp. 1037-1042
-
-
Cathcart, K.1
Pinilla-Ibarz, J.2
Korontsvit, T.3
-
80
-
-
13844312036
-
Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: A multicentre observational trial
-
Bocchia M, Gentili S, Abruzzese E, et al. Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial. Lancet 2005; 365:657-662.
-
(2005)
Lancet
, vol.365
, pp. 657-662
-
-
Bocchia, M.1
Gentili, S.2
Abruzzese, E.3
-
81
-
-
29844437061
-
Vaccination with the PR1 leukemia-associated antigen can induce complete remission in patients with myeloid leukemia
-
Abstract
-
Qazilbash MH, Weider E, Rios R, et al. Vaccination with the PR1 leukemia-associated antigen can induce complete remission in patients with myeloid leukemia. Blood 2004; 104:77a (Abstract #259).
-
(2004)
Blood
, vol.104
, Issue.259
-
-
Qazilbash, M.H.1
Weider, E.2
Rios, R.3
-
82
-
-
3242732550
-
Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein 70 vaccine for chronic myelogenous leukemia
-
Abstract
-
Li Z, Qiao Y, Laska E, et al. Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein 70 vaccine for chronic myelogenous leukemia. Proc Am Soc Clin Oncol 2003; 22:166 (Abstract #664).
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, Issue.664
, pp. 166
-
-
Li, Z.1
Qiao, Y.2
Laska, E.3
-
83
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006; 354:2531-2541.
-
(2006)
N Engl J Med
, vol.354
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
-
84
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006; 354:2542-2551.
-
(2006)
N Engl J Med
, vol.354
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
-
85
-
-
34249798317
-
-
Jabbour E, Giles F, Cortes J, et al. Preliminary activity of AMN107, a novel potent oral selective Bcr-Abl tyrosine kinase inhibitor, in newly diagnosed Philadelphia chromosome (Ph)-positive chronic phase chronic myelogenous leukaemia (CML-CP). J Clin Oncol 2006; 24(18 suppl):358s (Abstract #6591).
-
Jabbour E, Giles F, Cortes J, et al. Preliminary activity of AMN107, a novel potent oral selective Bcr-Abl tyrosine kinase inhibitor, in newly diagnosed Philadelphia chromosome (Ph)-positive chronic phase chronic myelogenous leukaemia (CML-CP). J Clin Oncol 2006; 24(18 suppl):358s (Abstract #6591).
-
-
-
|