Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease

British Journal of Ophthalmology

Volumn 89, Issue 9, 2005, Pages 1131-1133

  Head, M W ^a,c   Peden, A H ^a   Yull, H M ^a   Ritchie, D L ^a   Bonshek, R E ^b   Tullo, A B ^b   Ironside, J W ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b MANCHESTER ROYAL EYE HOSPITAL   (United Kingdom)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PARAFFIN; PRION PROTEIN;

ARTICLE; BLOTTING; CREUTZFELDT JAKOB DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; RETINA; RETINA DISEASE; RETINA PLEXIFORM LAYER; WESTERN BLOTTING;

AGED; BLOTTING, WESTERN; CREUTZFELDT-JAKOB SYNDROME; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PARAFFIN EMBEDDING; PRPSC PROTEINS; RETINA;

EID: 24044500298     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2004.063495     Document Type: Article

References (13)

1. Brown P, Preece M, Brandel J-P, et al. Iatrogenic Creutzfeldt-Jakob disease at the millennium. Neurology 2000;55:1075-81.
2. Llewelyn CA, Hewitt PE, Knight RSG, et al. Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet 2004;363:417-21.
3. Peden AH, Head MW, Ritchie D, et al. Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet 2004;364:527-9.
4. S-Juan P, Ward HJT, De Silva R, et al. Ophthalmic surgery and Creutzfeldt-Jakob disease. Br J Ophthalmol 2004;88:446-9.
5. Brown P, Gibbs G, Rodgers-Johnson P, et al. Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease. Ann Neurol 1994;35:513-29.
6. Wadsworth JDF, Joiner S, Hill AF, et al. Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay. Lancet 2001;358:171-80.
7. Head MW, Ritchie D, Smith N, et al. Peripheral tissue involvement in sporadic, iatrogenic, and variant Creutzfeldt-Jakob disease. Am J Pathol 2004;164:143-53.
8. Head MW, Northcott V, Rennison K, et al. Prion protein accumulation in eyes of patients with sporadic and variant Creutzfeldt-Jakob disease. Invest Ophthalmol Vis Sci 2003;44:342-6.
9. Parchi P, Giese A, Capellari S, et al. Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects. Ann Neurol 1999;46:224-33.
10. Glatzel M, Abela E, Maissen M, et al. Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease. N Engl J Med 2004;350:732-3.
11. Ritchie D, Head MW, Ironside J. Advances in the detection of prion protein in peripheral tissues of variant Creutzfeldt-Jakob disease patients using paraffin-embeded tissue blotting. Neuropathol Applied Neurobiol 2004;30:360-8.
12. Beekes M, Baldauf E, Diringer H. Sequential appearance and accumulation of pathognomonic markers in the nervous system of hamsters orally infected with scrapie. J Gen Virol 1996;77:1925-34.
13. Pocchiari M, Puopolo M, Croes EA, et al. Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. Brain 2004;127:2348-59.