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Volumn 81, Issue 5, 2007, Pages 1165-1175

Pivotal Advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection

Author keywords

CD4; CD8; LCMV; Vaccinia

Indexed keywords

BROXURIDINE; CD28 ANTIGEN; CD3 ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; CELL ANTIBODY; CTLA4 ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; UNCLASSIFIED DRUG;

EID: 34247868749     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0806535     Document Type: Article
Times cited : (11)

References (51)
  • 2
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • Chen, L. (2004) Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 4, 336-347.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 336-347
    • Chen, L.1
  • 5
    • 0034176037 scopus 로고    scopus 로고
    • Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses
    • Andreasen, S. O., Christensen, J. E., Marker, O., Thomsen, A. R. (2000) Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J. Immunol. 164, 3689-3697.
    • (2000) J. Immunol , vol.164 , pp. 3689-3697
    • Andreasen, S.O.1    Christensen, J.E.2    Marker, O.3    Thomsen, A.R.4
  • 6
    • 0031048036 scopus 로고    scopus 로고
    • Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes
    • Liu, Y., Wenger, R. H., Zhao, M., Nielsen, P. J. (1997) Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J. Exp. Med. 185, 251-262.
    • (1997) J. Exp. Med , vol.185 , pp. 251-262
    • Liu, Y.1    Wenger, R.H.2    Zhao, M.3    Nielsen, P.J.4
  • 10
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E. A., Borriello, F., Schweitzer, A. N., Lynch, W. P., Bluestone, J. A., Sharpe, A. H. (1995) Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 12
    • 0031405867 scopus 로고    scopus 로고
    • Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation- dependent activation of CD4+ T cells
    • Chambers, C. A., Sullivan, T. J., Allison, J. P. (1997) Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation- dependent activation of CD4+ T cells. Immunity 7, 885-895.
    • (1997) Immunity , vol.7 , pp. 885-895
    • Chambers, C.A.1    Sullivan, T.J.2    Allison, J.P.3
  • 14
    • 0345368071 scopus 로고    scopus 로고
    • Is CTLA-4 a negative regulator for T-cell activation?
    • Liu, Y. (1997) Is CTLA-4 a negative regulator for T-cell activation? Immunol. Today 18, 569-572.
    • (1997) Immunol. Today , vol.18 , pp. 569-572
    • Liu, Y.1
  • 17
    • 0033213599 scopus 로고    scopus 로고
    • CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism
    • Shrikant, P., Khoruts, A., Mescher, M. F. (1999) CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism. Immunity 11, 483-493.
    • (1999) Immunity , vol.11 , pp. 483-493
    • Shrikant, P.1    Khoruts, A.2    Mescher, M.F.3
  • 18
    • 0033613173 scopus 로고    scopus 로고
    • In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
    • Sotomayor, E. M., Borrello, I., Tubb, E., Allison, J. P., Levitsky, H. I. (1999) In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance. Proc. Natl. Acad. Sci. USA 96, 11476-11481.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11476-11481
    • Sotomayor, E.M.1    Borrello, I.2    Tubb, E.3    Allison, J.P.4    Levitsky, H.I.5
  • 20
    • 0030740572 scopus 로고    scopus 로고
    • Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice
    • Waterhouse, P., Bachmann, M. F., Penninger, J. M., Ohashi, P. S., Mak, T. W. (1997) Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur. J. Immunol. 27, 1887-1892.
    • (1997) Eur. J. Immunol , vol.27 , pp. 1887-1892
    • Waterhouse, P.1    Bachmann, M.F.2    Penninger, J.M.3    Ohashi, P.S.4    Mak, T.W.5
  • 21
    • 0033587768 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses
    • Chambers, C. A., Kuhns, M. S., Allison, J. P. (1999) Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses. Proc. Natl. Acad. Sci. USA 96, 8603-8608.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8603-8608
    • Chambers, C.A.1    Kuhns, M.S.2    Allison, J.P.3
  • 22
    • 0344299189 scopus 로고    scopus 로고
    • Cutting edge: Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous
    • Bachmann, M. F., Kohler, G., Ecabert, B., Mak, T. W., Kopf, M. (1999) Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J. Immunol. 163, 1128-1131.
    • (1999) J. Immunol , vol.163 , pp. 1128-1131
    • Bachmann, M.F.1    Kohler, G.2    Ecabert, B.3    Mak, T.W.4    Kopf, M.5
  • 23
    • 0035107510 scopus 로고    scopus 로고
    • Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: A paradigm reconsidered
    • Bachmann, M. F., Gallimore, A., Jones, E., Ecabert, B., Acha-Orbea, H., Kopf, M. (2001) Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered. Eur. J. Immunol. 31, 450-458.
    • (2001) Eur. J. Immunol , vol.31 , pp. 450-458
    • Bachmann, M.F.1    Gallimore, A.2    Jones, E.3    Ecabert, B.4    Acha-Orbea, H.5    Kopf, M.6
  • 24
    • 0037103325 scopus 로고    scopus 로고
    • Re-establishing peripheral tolerance in the absence of CTLA-4: Complementation by wild-type T cells points to an indirect role for CTLA-4
    • Tivol, E. A., Gorski, J. (2002) Re-establishing peripheral tolerance in the absence of CTLA-4: complementation by wild-type T cells points to an indirect role for CTLA-4. J. Immunol. 169, 1852-1858.
    • (2002) J. Immunol , vol.169 , pp. 1852-1858
    • Tivol, E.A.1    Gorski, J.2
  • 26
    • 0035865338 scopus 로고    scopus 로고
    • Autologous regulation of naive T cell homeostasis within the T cell compartment
    • Dummer, W., Ernst, B., LeRoy, E., Lee, D., Surh, C. (2001) Autologous regulation of naive T cell homeostasis within the T cell compartment. J. Immunol. 166, 2460-2468.
    • (2001) J. Immunol , vol.166 , pp. 2460-2468
    • Dummer, W.1    Ernst, B.2    LeRoy, E.3    Lee, D.4    Surh, C.5
  • 28
    • 0032945018 scopus 로고    scopus 로고
    • CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response to Nippostrongylus brasiliensis
    • Harris, N. L., Peach, R. J., Ronchese, F. (1999) CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response to Nippostrongylus brasiliensis. Eur. J. Immunol. 29, 311-316.
    • (1999) Eur. J. Immunol , vol.29 , pp. 311-316
    • Harris, N.L.1    Peach, R.J.2    Ronchese, F.3
  • 29
    • 0021225388 scopus 로고
    • Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence
    • Ahmed, R., Salmi, A., Butler, L. D., Chiller, J. M., Oldstone, M. B. A. (1984) Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160, 521-540.
    • (1984) J. Exp. Med , vol.160 , pp. 521-540
    • Ahmed, R.1    Salmi, A.2    Butler, L.D.3    Chiller, J.M.4    Oldstone, M.B.A.5
  • 30
    • 9144235505 scopus 로고    scopus 로고
    • Activation of virus-specific CD8+ T cells by lipopolysaccharide-induced IL-12 and IL-18
    • Raue, H. P., Brien, J. D., Hammarlund, E., Slifka, M. K. (2004) Activation of virus-specific CD8+ T cells by lipopolysaccharide-induced IL-12 and IL-18. J. Immunol. 173, 6873-6881.
    • (2004) J. Immunol , vol.173 , pp. 6873-6881
    • Raue, H.P.1    Brien, J.D.2    Hammarlund, E.3    Slifka, M.K.4
  • 31
    • 0036118394 scopus 로고    scopus 로고
    • Recombinant vaccinia virus-induced T-cell immunity: Quantitation of the response to the virus vector and the foreign epitope
    • Harrington, L. E., Most Rv, R., Whitton, J. L., Ahmed, R. (2002) Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope. J. Virol. 76, 3329-3337.
    • (2002) J. Virol , vol.76 , pp. 3329-3337
    • Harrington, L.E.1    Most Rv, R.2    Whitton, J.L.3    Ahmed, R.4
  • 32
    • 0033961476 scopus 로고    scopus 로고
    • Activated and memory CD8+ T cells can be distinguished by their cytokine profiles and phenotypic markers
    • Slifka, M. K., Whitton, J. L. (2000) Activated and memory CD8+ T cells can be distinguished by their cytokine profiles and phenotypic markers. J. Immunol. 164, 208-216.
    • (2000) J. Immunol , vol.164 , pp. 208-216
    • Slifka, M.K.1    Whitton, J.L.2
  • 33
    • 0035869583 scopus 로고    scopus 로고
    • Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: Lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase
    • Gajewski, T. F., Fallarino, F., Fields, P. E., Rivas, F., Alegre, M. L. (2001) Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase. J. Immunol. 166, 3900-3907.
    • (2001) J. Immunol , vol.166 , pp. 3900-3907
    • Gajewski, T.F.1    Fallarino, F.2    Fields, P.E.3    Rivas, F.4    Alegre, M.L.5
  • 34
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • Egen, J. G., Kuhns, M. S., Allison, J. P. (2002) CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat. Immunol. 3, 611-618.
    • (2002) Nat. Immunol , vol.3 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 35
    • 0033731186 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells
    • Kuhns, M. S., Epshteyn, V., Sobel, R. A., Allison, J. P. (2000) Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells. Proc. Natl. Acad. Sci. USA 97, 12711-12716.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12711-12716
    • Kuhns, M.S.1    Epshteyn, V.2    Sobel, R.A.3    Allison, J.P.4
  • 36
    • 12844266709 scopus 로고    scopus 로고
    • Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines
    • Beadling, C., Slifka, M. K. (2005) Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines. Blood 105, 1179-1186.
    • (2005) Blood , vol.105 , pp. 1179-1186
    • Beadling, C.1    Slifka, M.K.2
  • 37
    • 0036413437 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen-4 inhibits integrin-mediated stimulation
    • Gatta, L., Calviello, G., Di Nicuolo, F., Pace, L., Ubaldi, V., Doria, G., Pioli, C. (2002) Cytotoxic T lymphocyte-associated antigen-4 inhibits integrin-mediated stimulation. Immunology 107, 209-216.
    • (2002) Immunology , vol.107 , pp. 209-216
    • Gatta, L.1    Calviello, G.2    Di Nicuolo, F.3    Pace, L.4    Ubaldi, V.5    Doria, G.6    Pioli, C.7
  • 39
    • 0034887110 scopus 로고    scopus 로고
    • Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory
    • Homann, D., Teyton, L., Oldstone, M. B. (2001) Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory. Nat. Med. 7, 913-919.
    • (2001) Nat. Med , vol.7 , pp. 913-919
    • Homann, D.1    Teyton, L.2    Oldstone, M.B.3
  • 40
    • 0034889233 scopus 로고    scopus 로고
    • Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR
    • Slifka, M. K., Whitton, J. L. (2001) Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR. Nat. Immunol. 2, 711-717.
    • (2001) Nat. Immunol , vol.2 , pp. 711-717
    • Slifka, M.K.1    Whitton, J.L.2
  • 42
    • 0347994958 scopus 로고    scopus 로고
    • B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions
    • Taylor, P. A., Lees, C. J., Fournier, S., Allison, J. P., Sharpe, A. H., Blazar, B. R. (2004) B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions. J. Immunol. 172, 34-39.
    • (2004) J. Immunol , vol.172 , pp. 34-39
    • Taylor, P.A.1    Lees, C.J.2    Fournier, S.3    Allison, J.P.4    Sharpe, A.H.5    Blazar, B.R.6
  • 44
    • 0032487574 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes
    • Cilio, C. M., Daws, M. R., Malashicheva, A., Sentman, C. L., Holmberg, D. (1998) Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes. J. Exp. Med. 188, 1239-1246.
    • (1998) J. Exp. Med , vol.188 , pp. 1239-1246
    • Cilio, C.M.1    Daws, M.R.2    Malashicheva, A.3    Sentman, C.L.4    Holmberg, D.5
  • 45
    • 9144227496 scopus 로고    scopus 로고
    • Role of CTLA-4 in the activation of single- and double-positive thymocytes
    • Kwon, H., Jun, H. S., Khil, L. Y., Yoon, J. W. (2004) Role of CTLA-4 in the activation of single- and double-positive thymocytes. J. Immunol. 173, 6645-6653.
    • (2004) J. Immunol , vol.173 , pp. 6645-6653
    • Kwon, H.1    Jun, H.S.2    Khil, L.Y.3    Yoon, J.W.4
  • 46
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • Walunas, T. L., Bakker, C. Y., Bluestone, J. A. (1996) CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183, 2541-2550.
    • (1996) J. Exp. Med , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 47
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel, M. F., Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182, 459-465.
    • (1995) J. Exp. Med , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 48
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • Krummel, M. F., Allison, J. P. (1996) CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183, 2533-2540.
    • (1996) J. Exp. Med , vol.183 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 49
    • 0026675654 scopus 로고
    • Transmembrane signaling: The joy of aggregation
    • Metzger, H. (1992) Transmembrane signaling: the joy of aggregation. J. Immunol. 149, 1477-1487.
    • (1992) J. Immunol , vol.149 , pp. 1477-1487
    • Metzger, H.1
  • 50
    • 0028518843 scopus 로고
    • Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity
    • Yoon, S. T., Dianzani, U., Bottomly, K., Janeway Jr., C. A. (1994) Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity. Immunity 1, 563-569.
    • (1994) Immunity , vol.1 , pp. 563-569
    • Yoon, S.T.1    Dianzani, U.2    Bottomly, K.3    Janeway Jr., C.A.4
  • 51
    • 2442552882 scopus 로고    scopus 로고
    • Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand
    • Madrenas, J., Chau, L. A., Teft, W. A., Wu, P. W., Jussif, J., Kasaian, M., Carreno, B. M., Ling, V. (2004) Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand. J. Immunol. 172, 5948-5956.
    • (2004) J. Immunol , vol.172 , pp. 5948-5956
    • Madrenas, J.1    Chau, L.A.2    Teft, W.A.3    Wu, P.W.4    Jussif, J.5    Kasaian, M.6    Carreno, B.M.7    Ling, V.8


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